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A novel, potent, oral active and safe antinociceptive pyrazole targeting kappa opioid receptors.

artículo científico publicado en 2013

Action of Phα1β, a peptide from the venom of the spider Phoneutria nigriventer, on the analgesic and adverse effects caused by morphine in mice

artículo científico publicado en 2014

An Evaluation of the Antinociceptive Effects of Phα1β, a Neurotoxin from the Spider Phoneutria nigriventer, and ω-Conotoxin MVIIA, a Cone Snail Conus magus Toxin, in Rat Model of Inflammatory and Neuropathic Pain ⬇️

artículo científico publicado el 7 de agosto de 2012

Analgesic and side effects of intravenous recombinant Phα1β

artículo científico publicado en 2020

Analgesic effect in rodents of native and recombinant Ph alpha 1beta toxin, a high-voltage-activated calcium channel blocker isolated from armed spider venom

artículo científico publicado en 2008

Anandamide attenuates haloperidol-induced vacuous chewing movements in rats

scientific article published on 18 April 2014

Anti-allodynic action of the tormentic acid, a triterpene isolated from plant, against neuropathic and inflammatory persistent pain in mice.

artículo científico publicado en 2002

Anti-allodynic property of flavonoid myricitrin in models of persistent inflammatory and neuropathic pain in mice

artículo científico publicado en 2006

Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea

artículo científico publicado en 2006

Anti-inflammatory and antioxidant effects of Aloe saponaria Haw in a model of UVB-induced paw sunburn in rats

artículo científico publicado en 2014

Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea

artículo científico publicado en 2007

Anti-inflammatory effects of hydroalcoholic extract and two biflavonoids from Garcinia gardneriana leaves in mouse paw oedema

artículo científico publicado en 2008

Anti-inflammatory effects of vitamin E on adjuvant-induced arthritis in rats

artículo científico publicado en 2015

Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor

artículo científico publicado en 2012

Anti-nociceptive and anti-edematogenic effects of glibenclamide in a model of acute gouty attack in rats ⬇️

artículo científico publicado el 30 de marzo de 2013

Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain.

artículo científico publicado en 2017

Antidepressant-like effect of the novel MAO inhibitor 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mice

artículo científico publicado en 2012

Antidepressant-like effects of Trichilia catigua (Catuaba) extract: evidence for dopaminergic-mediated mechanisms

artículo científico publicado en 2005

Antiinflammatory effects of Viola tricolor gel in a model of sunburn in rats and the gel stability study.

artículo científico publicado en 2013

Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.

artículo científico publicado en 2008

Antinociceptive activity and mechanism of action of hydroalcoholic extract and dichloromethane fraction of Amphilophium crucigerum seeds in mice

artículo científico publicado en 2016

Antinociceptive activity of Mirabilis jalapa in mice

artículo científico publicado en 2008

Antinociceptive and anti-inflammatory effects of Aloe saponaria Haw on thermal injury in rats.

artículo científico publicado en 2013

Antinociceptive and antiedematogenic effect of pecan (Carya illinoensis) nut shell extract in mice: a possible beneficial use for a by-product of the nut industry

artículo científico publicado en 2014

Antinociceptive effect of 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole. A Celecoxib structural analog in models of pathological pain

artículo científico publicado en 2014

Antinociceptive effect of Brazilian armed spider venom toxin Tx3-3 in animal models of neuropathic pain.

artículo científico publicado en 2011

Antinociceptive effect of Mirabilis jalapa on acute and chronic pain models in mice

artículo científico publicado en 2013

Antinociceptive effect of a novel armed spider peptide Tx3-5 in pathological pain models in mice

artículo científico publicado en 2016

Antinociceptive effect of a novel tosylpyrazole compound in mice.

artículo científico publicado en 2008

Antinociceptive effect of novel trihalomethyl-substituted pyrazoline methyl esters in formalin and hot-plate tests in mice.

artículo científico publicado en 2007

Antinociceptive effects of 14-membered cyclopeptide alkaloids.

artículo científico publicado en 2009

Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways

artículo científico publicado en 2004

Antinociceptive properties produced by the pregnane compound velutinol A isolated from Mandevilla velutina.

artículo científico publicado en 2006

Antiplatelet, Antithrombotic, and Fibrinolytic Activities of Campomanesia xanthocarpa

artículo científico publicado en 2011

Anxiolytic-like effect of lavender essential oil inhalation in mice: Participation of serotonergic but not GABAA/benzodiazepine neurotransmission ⬇️

artículo científico publicado el 22 de marzo de 2013

Anxiolytic-like effects of acute and chronic treatment with Achillea millefolium L. extract ⬇️

artículo científico publicado el 6 de diciembre de 2011

B1 and B2 kinin receptor participation in hyperproliferative and inflammatory skin processes in mice

artículo científico publicado en 2011

Bradykinin B1 receptor expression induced by tissue damage in the rat portal vein: a critical role for mitogen-activated protein kinase and nuclear factor-kappaB signaling pathways

artículo científico publicado en 2004

Characterization of the antinociceptive effect of PhTx3-4, a toxin from Phoneutria nigriventer, in models of thermal, chemical and incisional pain in mice.

artículo científico publicado en 2015

Characterization of the kallikrein-kinin system during the bovine ovulation process.

artículo científico publicado en 2011

Contractile mechanisms coupled to TRPA1 receptor activation in rat urinary bladder.

artículo científico publicado en 2006

Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions.

artículo científico publicado en 2005

Contribution of peripheral vanilloid receptor to the nociception induced by injection of spermine in mice

artículo científico publicado en 2011

Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice.

artículo científico publicado en 2004

Creatine decreases convulsions and neurochemical alterations induced by glutaric acid in rats

artículo científico publicado en 2007

Critical Role of Protease-activated Receptor 2 Activation by Mast Cell Tryptase in the Development of Postoperative Pain ⬇️

artículo científico publicado el 1 de marzo de 2013

Cyclooxygenase-2/PGE2 pathway facilitates pentylenetetrazol-induced seizures.

artículo científico publicado en 2008

Dacarbazine alone or associated with melanoma-bearing cancer pain model induces painful hypersensitivity by TRPA1 activation in mice

artículo científico publicado en 2019

Data and calculus on isobolographic analysis to determine the antinociceptive interaction between calcium channel blocker and a TRPV1 blocker in acute pain model in mice

artículo científico publicado en 2017

Diacerein decreases TNF-alpha and IL-1beta levels in peritoneal fluid and prevents Baker's yeast-induced fever in young rats

artículo científico publicado en 2010

Differential effects of atorvastatin treatment and withdrawal on pentylenetetrazol-induced seizures

artículo científico publicado en 2011

Diosmetin as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive activity in mice

scientific article published on 14 November 2018

Diphenyl diselenide decreases the prevalence of vacuous chewing movements induced by fluphenazine in rats

artículo científico publicado en 2007

Effect of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles on chronic inflammatory pain model in rats

artículo científico publicado en 2009

Effect of Uncaria tomentosa extract on purinergic enzyme activities in lymphocytes of rats submitted to experimental adjuvant arthritis model.

artículo científico publicado en 2015

Effect of the spider toxin Tx3-3 on spinal processing of sensory information in naive and neuropathic rats: an in vivo electrophysiological study.

artículo científico publicado en 2017

Effect of ω-conotoxin MVIIA and Phα1β on paclitaxel-induced acute and chronic pain

artículo científico publicado en 2013

Effects of Campomanesia xanthocarpa on biochemical, hematological and oxidative stress parameters in hypercholesterolemic patients

artículo científico publicado en 2009

Effects of the calcium channel blockers Phα1β and ω-conotoxin MVIIA on capsaicin and acetic acid-induced visceral nociception in mice

artículo científico publicado en 2014

Efficacy of the World Health Organization analgesic ladder in the paclitaxel-induced pain syndrome in rats

scientific article published on 07 April 2020

Eriodictyol: a flavonoid antagonist of the TRPV1 receptor with antioxidant activity

scientific article published on 16 November 2010

Evidence for a role of 5-HT(1A) receptor on antinociceptive action from Geissospermum vellosii.

artículo científico publicado en 2009

Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeydes unsaturated sesquiterpenes polygodial and drimanial in rats.

artículo científico publicado en 2004

Exercise pre-conditioning reduces brain inflammation and protects against toxicity induced by traumatic brain injury: behavioral and neurochemical approach

artículo científico publicado en 2011

Gallic acid functions as a TRPA1 antagonist with relevant antinociceptive and antiedematogenic effects in mice

artículo científico publicado en 2014

Garcinia gardneriana (Planchon & Triana) Zappi. (Clusiaceae) as a topical anti-inflammatory alternative for cutaneous inflammation

artículo científico publicado en 2011

HOE-140, an antagonist of B2 receptor, protects against memory deficits and brain damage induced by moderate lateral fluid percussion injury in mice

artículo científico publicado en 2013

High fat diet increases the incidence of orofacial dyskinesia and oxidative stress in specific brain regions of rats.

artículo científico publicado en 2005

Hippocampal PKA/CREB pathway is involved in the improvement of memory induced by spermidine in rats

artículo científico publicado en 2011

Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties

artículo científico publicado en 2012

Inhibitory effect of Scutia buxifolia extracts, fractions, and ursolic acid on Na(+), K(+)-ATPase activity in vitro in membranes purified from rat hearts.

artículo científico publicado en 2015

Involvement of hippocampal CAMKII/CREB signaling in the spatial memory retention induced by creatine ⬇️

artículo científico publicado el 5 de junio de 2012

Involvement of mast cells in a mouse model of postoperative pain

artículo científico publicado en 2011

Involvement of monoamine oxidase B on models of postoperative and neuropathic pain in mice

artículo científico publicado en 2012

Involvement of the TRPV1 receptor in plasma extravasation in airways of rats treated with an angiotensin-converting enzyme inhibitor

artículo científico publicado en 2016

Kinetic characterization of l-[(3)H]glutamate uptake inhibition and increase oxidative damage induced by glutaric acid in striatal synaptosomes of rats

artículo científico publicado en 2008

Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes

artículo científico publicado en 2004

Kinins and their B1 and B2 receptors are involved in fibromyalgia-like pain symptoms in mice

artículo científico publicado en 2019

Lipopolysaccharide enhances glutaric acid-induced seizure susceptibility in rat pups: behavioral and electroencephalographic approach

artículo científico publicado en 2010

Low concentrations of methamidophos do not alter AChE activity but modulate neurotransmitters uptake in hippocampus and striatum in vitro

artículo científico publicado en 2010

Macrophages and Schwann cell TRPA1 mediate chronic allodynia in a mouse model of complex regional pain syndrome type I

artículo científico publicado en 2020

Management of Neuropathic Chronic Pain with Methadone Combined with Ketamine: A Randomized, Double Blind, Active-Controlled Clinical Trial

artículo científico publicado en 2017

Management of chronic neuropathic pain of different causes with the combination of oral methadone along with ketamine: A report of 18 cases

artículo científico publicado en 2013

Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice

artículo científico publicado en 2003

Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice.

artículo científico publicado en 2005

Mechanisms involved in the nociception triggered by the venom of the armed spider Phoneutria nigriventer

artículo científico publicado en 2013

Mechanisms underlying the relaxation response induced by bradykinin in the epithelium-intact guinea-pig trachea in vitro.

artículo científico publicado en 2005

Methylmalonate-induced seizures are attenuated in inducible nitric oxide synthase knockout mice

artículo científico publicado en 2008

Monosodium urate crystal interleukin-1β release is dependent on Toll-like receptor 4 and transient receptor potential V1 activation

artículo científico publicado en 2020

Monosodium urate crystal interleukin-1β release is dependent on Toll-like receptor 4 and transient receptor potential V1 activation

artículo científico publicado en 2020

N-Acetylcysteine prevents baker's-yeast-induced inflammation and fever

artículo científico publicado en 2011

N-acetylcysteine prevents spatial memory impairment induced by chronic early postnatal glutaric acid and lipopolysaccharide in rat pups.

artículo científico publicado en 2013

Neuromodulatory effect of creatine on extracellular action potentials in rat hippocampus: role of NMDA receptors.

artículo científico publicado en 2008

Neuroprotective effects of agmatine in mice infused with a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

artículo científico publicado en 2012

Nociception in a Progressive Multiple Sclerosis Model in Mice Is Dependent on Spinal TRPA1 Channel Activation

artículo científico publicado en 2020

Participation of the TRPV1 receptor in the development of acute gout attacks

scientific article published on 31 October 2013

Participation of transient receptor potential vanilloid 1 in paclitaxel-induced acute visceral and peripheral nociception in rodents

artículo científico publicado en 2018

PhKv a toxin isolated from the spider venom induces antinociception by inhibition of cholinesterase activating cholinergic system

artículo científico publicado en 2017

Pharmacological analysis of paregoric elixir and its constituents: in vitro and in vivo studies

artículo científico publicado en 2007

Pharmacological and molecular characterization of the mechanisms involved in prostaglandin E2-induced mouse paw edema

scientific article published on 27 April 2006

Pharmacological and neurochemical evidence for antidepressant-like effects of the herbal product Catuama.

artículo científico publicado en 2004

Pharmacological characterisation of the plant sesquiterpenes polygodial and drimanial as vanilloid receptor agonists

artículo científico publicado en 2006

Pharmacological characterisation of the rat brachial plexus avulsion model of neuropathic pain.

artículo científico publicado en 2004

Phoneutria toxin PnTx3-5 inhibits TRPV1 channel with antinociceptive action in an orofacial pain model

artículo científico publicado en 2019

Phα1β toxin prevents capsaicin-induced nociceptive behavior and mechanical hypersensitivity without acting on TRPV1 channels ⬇️

artículo científico publicado el 15 de abril de 2013

Phα1β, a dual blocker of TRPA1 and Cav2.2, as an adjuvant drug in opioid therapy for postoperative pain

artículo científico publicado en 2020

Phα1β, a peptide from the venom of the spider Phoneutria nigriventer shows antinociceptive effects after continuous infusion in a neuropathic pain model in rats

scientific article published on 01 July 2014

Polyaminergic agents modulate contextual fear extinction in rats.

artículo científico publicado en 2010

Potentiation of Paclitaxel-Induced Pain Syndrome in Mice by Angiotensin I Converting Enzyme Inhibition and Involvement of Kinins.

artículo científico publicado en 2016

Prostaglandin E2 modulates Na+,K+-ATPase activity in rat hippocampus: implications for neurological diseases.

artículo científico publicado en 2009

Reduced Nerve Injury-Induced Neuropathic Pain in Kinin B1 Receptor Knock-Out Mice

scientific article published on 01 March 2005

Role of TRPA1 receptors in skin inflammation induced by volatile chemical irritants in mice

scientific article published on 20 June 2019

Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats

artículo científico publicado en 2011

Role of peripheral polyamines in the development of inflammatory pain

artículo científico publicado en 2011

Role of transient receptor potential ankyrin 1 (TRPA1) on nociception caused by a murine model of breast carcinoma

scientific article published on 29 November 2019

Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice

artículo científico publicado en 2017

Selegiline reverses aβ₂₅₋₃₅-induced cognitive deficit in male mice.

artículo científico publicado en 2013

Spermidine decreases Na⁺,K⁺-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats.

artículo científico publicado en 2012

Spermidine-induced improvement of memory involves a cross-talk between protein kinases C and A.

artículo científico publicado en 2012

Spider peptide Phα1β induces analgesic effect in a model of cancer pain.

artículo científico publicado en 2013

Spinal levels of nonprotein thiols are related to nociception in mice

artículo científico publicado en 2010

Structural improvement of compounds with analgesic activity: AC-MPF4, a compound with mixed anti-inflammatory and antinociceptive activity via opioid receptor

artículo científico publicado en 2014

Synergistic antinociceptive effect of a calcium channel blocker and a TRPV1 blocker in an acute pain model in mice

artículo científico publicado en 2017

Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors.

artículo científico publicado en 2007

TRPA1 activation mediates nociception behaviors in a mouse model of relapsing-remitting experimental autoimmune encephalomyelitis

artículo científico publicado en 2020

TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress

artículo científico publicado en 2016

TRPA1 receptor stimulation by hydrogen peroxide is critical to trigger hyperalgesia and inflammation in a model of acute gout

artículo científico publicado en 2014

TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice

artículo científico publicado en 2018

Tabernaemontana catharinensis leaves effectively reduce the irritant contact dermatitis by glucocorticoid receptor-dependent pathway in mice

artículo científico publicado en 2018

Tabernaemontana catharinensis leaves exhibit topical anti-inflammatory activity without causing toxicity

artículo científico publicado en 2018

The Effect of Spider Toxin PhTx3-4, ω-Conotoxins MVIIA and MVIIC on Glutamate Uptake and on Capsaicin-Induced Glutamate Release and [Ca2+]i in Spinal cord Synaptosomes

artículo científico publicado en 2010

The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model

artículo científico publicado en 2012

The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model

artículo científico publicado en 2013

The effect of NADPH-oxidase inhibitor apocynin on cognitive impairment induced by moderate lateral fluid percussion injury: role of inflammatory and oxidative brain damage

artículo científico publicado en 2013

The effects of Phα1β, a spider toxin, calcium channel blocker, in a mouse fibromyalgia model

artículo científico publicado en 2014

The inhibitory effect of Phα1β toxin on diabetic neuropathic pain involves the CXCR4 chemokine receptor

artículo científico publicado en 2020

The involvement of TRPA1 channel activation in the inflammatory response evoked by topical application of cinnamaldehyde to mice.

artículo científico publicado en 2011

The involvement of the TRPA1 receptor in a mouse model of sympathetically maintained neuropathic pain

scientific article published on 10 December 2014

The involvement of the polyamines binding sites at the NMDA receptor in creatine-induced spatial learning enhancement.

artículo científico publicado en 2007

The peptide Phα1β, from spider venom, acts as a TRPA1 channel antagonist with antinociceptive effects in mice

artículo científico publicado en 2016

The potential antidepressant-like effect of imidazoline I2 ligand 2-BFI in mice

artículo científico publicado en 2011

The role of kinin B1 receptor and the effect of angiotensin I-converting enzyme inhibition on acute gout attacks in rodents

artículo científico publicado en 2014

The role of kinin B1 receptors in the nociception produced by peripheral protein kinase C activation in mice

artículo científico publicado en 2007

The selective A-type K+ current blocker Tx3-1 isolated from the Phoneutria nigriventer venom enhances memory of naïve and Aβ(25-35)-treated mice.

artículo científico publicado en 2013

The spider toxin Phα1β recombinant possesses strong analgesic activity

scientific article published on 17 May 2017

The use of kinin B1 and B2 receptor knockout mice and selective antagonists to characterize the nociceptive responses caused by kinins at the spinal level

article

Transient receptor potential ankyrin 1 (TRPA1) plays a critical role in a mouse model of cancer pain

article

Transient receptor potential ankyrin 1 receptor stimulation by hydrogen peroxide is critical to trigger pain during monosodium urate-induced inflammation in rodents

artículo científico publicado en 2013

Triterpene 3β, 6β, 16β trihidroxilup-20(29)-ene protects against excitability and oxidative damage induced by pentylenetetrazol: the role of Na(+),K(+)-ATPase activity.

artículo científico publicado en 2012

Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors

artículo científico publicado en 2008

Valeriana officinalis does not alter the orofacial dyskinesia induced by haloperidol in rats: role of dopamine transporter

artículo científico publicado en 2007

α-Spinasterol: a COX inhibitor and a transient receptor potential vanilloid 1 antagonist presents an antinociceptive effect in clinically relevant models of pain in mice.

artículo científico publicado en 2017

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