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"But Dr. Old, we already have an antibody!" Reflections on Lloyd Old's "academic biotech" approach for targeted antibodies ⬇️

artículo científico publicado el 1 de enero de 2012

(124)I-huA33 antibody PET of colorectal cancer.

artículo científico publicado en 2011

A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer

artículo científico publicado en 2003

A Pilot Study of Anti-CTLA4 Antibody Ipilimumab in Patients with Synovial Sarcoma.

artículo científico publicado en 2013

A monoclonal antibody recognizing human cancers with amplification/overexpression of the human epidermal growth factor receptor

artículo científico publicado en 2003

A novel human-derived antibody against NY-ESO-1 improves the efficacy of chemotherapy

artículo científico publicado en 2013

A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors

artículo científico publicado en 2007

A phase I trial of humanized monoclonal antibody A33 in patients with colorectal carcinoma: biodistribution, pharmacokinetics, and quantitative tumor uptake

artículo científico publicado en 2005

A33 antigen displays persistent surface expression

artículo científico publicado en 2008

A33scFv-cytosine deaminase: a recombinant protein construct for antibody-directed enzyme-prodrug therapy

artículo científico publicado en 2003

An immunodominant SSX-2-derived epitope recognized by CD4+ T cells in association with HLA-DR.

artículo científico publicado en 2004

An optimized fermentation process for high-level production of a single-chain Fv antibody fragment in Pichia pastoris.

artículo científico publicado en 2004

Analysis of peripheral and local anti-tumor immune response in esophageal cancer patients after NY-ESO-1 protein vaccination

scientific article published on 01 November 2008

Analysis of the antibody response to immunization with purified O-acetyl GD3 gangliosides in patients with malignant melanoma

artículo científico publicado en 1995

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

artículo científico publicado en 2009

Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX.

artículo científico publicado en 2011

Antibody response after immunization with the gangliosides GM1, GM2, GM3, GD2 and GD3 in the mouse

artículo científico publicado en 1989

Antibody response against NY-ESO-1 in CHP-NY-ESO-1 vaccinated patients

artículo científico publicado en 2007

Antibody response to immunization with ganglioside GD3 and GD3 congeners (lactones, amide and gangliosidol) in patients with malignant melanoma

scientific article published on 01 May 1991

Antibody-Based Therapy in Colorectal Cancer ⬇️

artículo científico publicado el 1 de mayo de 2013

Antibody-targeted NY-ESO-1 to mannose receptor or DEC-205 in vitro elicits dual human CD8+ and CD4+ T cell responses with broad antigen specificity

artículo científico publicado en 2010

Arginine deiminase PEG20 inhibits growth of small cell lung cancers lacking expression of argininosuccinate synthetase ⬇️

artículo científico publicado el 17 de enero de 2012

Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1.

artículo científico publicado en 2014

Booster vaccination of cancer patients with MAGE-A3 protein reveals long-term immunological memory or tolerance depending on priming

artículo científico publicado en 2008

CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients

artículo científico publicado en 2005

CD8(+) T cell responses against a dominant cryptic HLA-A2 epitope after NY-ESO-1 peptide immunization of cancer patients

artículo científico publicado en 2002

CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit

artículo científico publicado en 2008

Cancer-related serological recognition of human colon cancer: identification of potential diagnostic and immunotherapeutic targets.

artículo científico publicado en 2002

Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation

artículo científico publicado en 2006

Cancer-testis genes are coordinately expressed and are markers of poor outcome in non-small cell lung cancer

artículo científico publicado en 2005

Cancer/testis antigen expression and autologous humoral immunity to NY-ESO-1 in gastric cancer

scientific article published on 01 November 2004

Characterization of preexisting MAGE-A3-specific CD4+ T cells in cancer patients and healthy individuals and their activation by protein vaccination

artículo científico publicado en 2009

Colon cancer associated transcript-1: a novel RNA expressed in malignant and pre-malignant human tissues.

artículo científico publicado en 2011

Combining MHC tetramer and intracellular cytokine staining for CD8(+) T cells to reveal antigenic epitopes naturally presented on tumor cells.

artículo científico publicado en 2008

Cooverexpression of chaperones for enhanced secretion of a single-chain antibody fragment in Pichia pastoris

artículo científico publicado en 2006

Correction: NY-ESO-1 Cancer Testis Antigen Demonstrates High Immunogenicity in Triple Negative Breast Cancer

Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy

artículo científico publicado en 2010

Cross-presentation of HLA class I epitopes from exogenous NY-ESO-1 polypeptides by nonprofessional APCs

artículo científico publicado en 2003

Cutting edge: nonglycosidic CD1d lipid ligands activate human and murine invariant NKT cells

artículo científico publicado en 2008

Defining the critical hurdles in cancer immunotherapy

artículo científico publicado en 2011

Development of monoclonal antibodies specific for the human sodium-dependent phosphate co-transporter NaPi2b

scientific article published on 01 August 2008

Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations

artículo científico publicado en 2002

Directed evolution for improved secretion of cancer-testis antigen NY-ESO-1 from yeast

artículo científico publicado en 2006

Dissecting cytotoxic T cell responses towards the NY-ESO-1 protein by peptide/MHC-specific antibody fragments

artículo científico publicado en 2004

Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2

artículo científico publicado en 2005

Effect of Montanide and poly-ICLC adjuvant on human self/tumor antigen-specific CD4+ T cells in phase I overlapping long peptide vaccine trial

artículo científico publicado en 2013

Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patients

artículo científico publicado en 2012

Efficient In vivo Priming by Vaccination with Recombinant NY-ESO-1 Protein and CpG in Antigen Naïve Prostate Cancer Patients ⬇️

artículo científico publicado el 16 de diciembre de 2010

Epigenetic potentiation of NY-ESO-1 vaccine therapy in human ovarian cancer

scientific article published on January 2014

Erratum: Correlationof clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy.

artículo científico publicado en 2010

Evaluation of Mut+ and MutS Pichia pastoris phenotypes for high level extracellular scFv expression under feedback control of the methanol concentration.

artículo científico publicado en 2006

Evaluation of arginine deiminase treatment in melanoma xenografts using (18)F-FLT PET.

artículo científico publicado en 2013

Ex-vivo analysis of CD8+ T cells infiltrating colorectal tumors identifies a major effector-memory subset with low perforin content.

artículo científico publicado en 2006

Expression and clinical significance of MAGE and NY-ESO-1 cancer-testis antigens in adenoid cystic carcinoma of the head and neck

artículo científico publicado en 2016

Expression and purification of cGMP grade NY‐ESO‐1 for clinical trials ⬇️

artículo científico publicado el 1 de marzo de 2011

Expression and purification of the cancer antigen SSX2: a potential cancer vaccine

artículo científico publicado en 2007

Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery

artículo científico publicado en 2004

Factors affecting endotoxin removal from recombinant therapeutic proteins by anion exchange chromatography

artículo científico publicado en 2008

Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy

artículo científico publicado en 2007

Generation of monoclonal antibodies to cancer/testis (CT) antigen CT10/MAGE-C2.

artículo científico

Glycoprotein A34, a novel target for antibody-based cancer immunotherapy

artículo científico publicado en 2006

Glycosylation profiles of the human colorectal cancer A33 antigen naturally expressed in the human colorectal cancer cell line SW1222 and expressed as recombinant protein in different insect cell lines

artículo científico publicado en 2004

HLA-DP4 expression and immunity to NY-ESO-1: correlation and characterization of cytotoxic CD4+ CD25- CD8- T cell clones.

artículo científico publicado en 2004

Heat shock protein 90-mediated peptide-selective presentation of cytosolic tumor antigen for direct recognition of tumors by CD4(+) T cells

artículo científico publicado en 2012

Heteroclitic serological response in esophageal and prostate cancer patients after NY-ESO-1 protein vaccination

artículo científico publicado en 2011

High-dose RHAMM-R3 peptide vaccination for patients with acute myeloid leukemia, myelodysplastic syndrome and multiple myeloma

artículo científico publicado en 2010

High-level expression of a phage display-derived scFv in Pichia pastoris

artículo científico publicado en 2009

Humoral immune responses of cancer patients against "Cancer-Testis" antigen NY-ESO-1: correlation with clinical events

artículo científico publicado en 1999

IFN-gamma enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation

scholarly article

Identification and characterization of epitopes of the receptor for hyaluronic acid-mediated motility (RHAMM/CD168) recognized by CD8+ T cells of HLA-A2-positive patients with acute myeloid leukemia

artículo científico publicado en 2005

Identification of B cell epitopes recognized by antibodies specific for the tumor antigen NY-ESO-1 in cancer patients with spontaneous immune responses.

artículo científico publicado en 2005

Identification of an SSX-2 epitope presented by dendritic cells to circulating autologous CD4+ T cells.

artículo científico publicado en 2004

Identification of cancer/testis genes by database mining and mRNA expression analysis

artículo científico publicado en 2002

Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor

artículo científico publicado en 2004

Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer.

artículo científico publicado en 2004

Identification of two Melan-A CD4+ T cell epitopes presented by frequently expressed MHC class II alleles

artículo científico publicado en 2006

Imaging of tumor vascularization using fluorescence molecular tomography to monitor arginine deiminase treatment in melanoma

artículo científico publicado el 1 de enero de 2013

Improved secretion of the cancer-testis antigen SSX2 in Pichia pastoris by deletion of its nuclear localization signal

artículo científico publicado en 2009

Improved survival in stage III melanoma patients with GM2 antibodies: a randomized trial of adjuvant vaccination with GM2 ganglioside

scientific article published on 01 May 1994

In silico analysis and immunohistochemical characterization of NaPi2b protein expression in ovarian carcinoma with monoclonal antibody Mx35.

artículo científico publicado en 2012

In vivo antigen delivery by a Salmonella typhimurium type III secretion system for therapeutic cancer vaccines.

artículo científico publicado en 2006

Inducing efficient cross-priming using antigen-coated yeast particles

artículo científico publicado en 2008

Induction of antibodies reactive with GM2 ganglioside after immunization with lipopolysaccharides from Camplyobacter jejuni

artículo científico publicado en 1996

Induction of immune response against NY-ESO-1 by CHP-NY-ESO-1 vaccination and immune regulation in a melanoma patient

artículo científico publicado en 2008

Induction of regulatory T cell-resistant helper CD4+ T cells by bacterial vector.

artículo científico publicado en 2007

Influence of CD4+CD25+ regulatory T cells on low/high-avidity CD4+ T cells following peptide vaccination

artículo científico publicado en 2006

Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab

artículo científico publicado en 2011

Intracellular tumor-associated antigens represent effective targets for passive immunotherapy.

artículo científico publicado en 2012

Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

artículo científico publicado en 2005

Lentivector immunization induces tumor antigen-specific B and T cell responses in vivo

scientific article published on 01 July 2008

Micro-sequencing strategies for the human A33 antigen, a novel surface glycoprotein of human gastrointestinal epithelium.

artículo científico publicado en 1998

Monitoring CD4+ T cell responses against viral and tumor antigens using T cells as novel target APC.

artículo científico publicado en 2003

Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses.

artículo científico publicado en 2000

NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells

artículo científico publicado en 2003

NY-CO-58/KIF2C is overexpressed in a variety of solid tumors and induces frequent T cell responses in patients with colorectal cancer

artículo científico publicado en 2010

NY-ESO-1 DNA vaccine induces T-cell responses that are suppressed by regulatory T cells

artículo científico publicado en 2009

NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer.

artículo científico publicado en 2003

NY-ESO-1 cancer testis antigen demonstrates high immunogenicity in triple negative breast cancer

artículo científico publicado en 2012

NY-ESO-1 mRNA expression and immunogenicity in advanced prostate cancer

artículo científico publicado en 2003

NY-ESO-1-specific immunological pressure and escape in a patient with metastatic melanoma

artículo científico publicado en 2013

NY-ESO-1: review of an immunogenic tumor antigen

artículo científico publicado en 2006

Nonglycosidic agonists of invariant NKT cells for use as vaccine adjuvants

artículo científico publicado en 2009

Novel Mechanistic Insights into Arginine Deiminase Pharmacology Suggest 18F-FDG Is Not Suitable to Evaluate Clinical Response in Melanoma ⬇️

artículo científico publicado el 6 de enero de 2012

Novel monoclonal antibody specific for the de2-7 epidermal growth factor receptor (EGFR) that also recognizes the EGFR expressed in cells containing amplification of the EGFR gene

artículo científico publicado en 2002

Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes

artículo científico publicado en 2013

PEGylated gold nanoparticles conjugated to monoclonal F19 antibodies as targeted labeling agents for human pancreatic carcinoma tissue

artículo científico publicado en 2008

PET-based compartmental modeling of (124)I-A33 antibody: quantitative characterization of patient-specific tumor targeting in colorectal cancer

artículo científico publicado en 2015

Phase 1/2 study of subcutaneous and intradermal immunization with a recombinant MAGE-3 protein in patients with detectable metastatic melanoma

artículo científico publicado en 2005

Phase I clinical trial of mixed bacterial vaccine (Coley's toxins) in patients with NY-ESO-1 expressing cancers: immunological effects and clinical activity

artículo científico publicado en 2012

Phase I clinical trial with fractionated radioimmunotherapy using 131I-labeled chimeric G250 in metastatic renal cancer

artículo científico publicado en 2004

Phase I study of anticolon cancer humanized antibody A33.

artículo científico publicado en 2003

Preliminary report of a phase I study of combination chemotherapy and humanized A33 antibody immunotherapy in patients with advanced colorectal cancer.

artículo científico publicado en 2003

Process development and production of cGMP grade Melan-A for cancer vaccine clinical trials ⬇️

artículo científico publicado el 15 de septiembre de 2013

Process development for production and purification of the Schistosoma mansoni Sm14 antigen

artículo científico publicado en 2017

Prostate cancer progression correlates with increased humoral immune response to a human endogenous retrovirus GAG protein

artículo científico publicado en 2013

Purification and characterization of a novel restricted antigen expressed by normal and transformed human colonic epithelium.

artículo científico publicado en 1996

RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses

scientific article published on 31 October 2007

Real-Time, label-free monitoring of tumor antigen and serum antibody interactions

scientific article published on 01 November 2004

Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer

artículo científico publicado en 2013

Recognition of naturally processed and ovarian cancer reactive CD8+ T cell epitopes within a promiscuous HLA class II T-helper region of NY-ESO-1.

artículo científico publicado en 2008

Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans

artículo científico publicado en 2004

Recombinant antigen expression on yeast surface (RAYS) for the detection of serological immune responses in cancer patients

article

Recombinant vaccinia/fowlpox NY-ESO-1 vaccines induce both humoral and cellular NY-ESO-1-specific immune responses in cancer patients.

artículo científico publicado en 2006

Sequential cancer immunotherapy: targeted activity of dimeric TNF and IL-8.

artículo científico publicado en 2009

Serological response patterns of melanoma patients immunized with a GM2 ganglioside conjugate vaccine

artículo científico publicado en 1995

Seromic analysis of antibody responses in non-small cell lung cancer patients and healthy donors using conformational protein arrays.

artículo científico publicado en 2008

Seromic profiling of ovarian and pancreatic cancer

artículo científico publicado en 2010

Simultaneous cytoplasmic and nuclear protein expression of melanoma antigen-A family and NY-ESO-1 cancer-testis antigens represents an independent marker for poor survival in head and neck cancer

artículo científico publicado en 2014

Specific targeting, biodistribution, and lack of immunogenicity of chimeric anti-GD3 monoclonal antibody KM871 in patients with metastatic melanoma: results of a phase I trial

artículo científico publicado en 2001

Specific tumour localisation of a huA33 antibody--carboxypeptidase A conjugate and activation of methotrexate-phenylalanine.

artículo científico publicado en 2004

Split T cell tolerance against a self/tumor antigen: spontaneous CD4+ but not CD8+ T cell responses against p53 in cancer patients and healthy donors

artículo científico publicado en 2011

Strategy for monitoring T cell responses to NY-ESO-1 in patients with any HLA class I allele.

artículo científico publicado en 2000

Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains

artículo científico publicado en 2002

Structure of human CD1b with bound ligands at 2.3 Å, a maze for alkyl chains

article by Stephan D. Gadola et al published 15 July 2002 in Nature Immunology

Survey of naturally occurring CD4+ T cell responses against NY-ESO-1 in cancer patients: correlation with antibody responses

artículo científico publicado en 2003

T cell immunomonitoring and tumor responses in patients immunized with a complex of cholesterol-bearing hydrophobized pullulan (CHP) and NY-ESO-1 protein.

artículo científico publicado en 2007

Targeted therapy of renal cell carcinoma: synergistic activity of cG250-TNF and IFNg.

artículo científico publicado en 2009

Th1/Th2 CD4+ T cell responses against NY-ESO-1 in HLA-DPB1*0401/0402 patients with epithelial ovarian cancer

artículo científico publicado en 2004

The antitumor monoclonal antibody 806 recognizes a high-mannose form of the EGF receptor that reaches the cell surface when cells over-express the receptor

artículo científico publicado en 2005

The crystal structure of human CD1d with and without alpha-galactosylceramide

artículo científico publicado en 2005

The human A33 antigen is a transmembrane glycoprotein and a novel member of the immunoglobulin superfamily

artículo científico publicado en 1997

The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies.

artículo científico publicado en 2000

The spontaneous CD8+ T-cell response to HLA-A2-restricted NY-ESO-1b peptide in hepatocellular carcinoma patients

artículo científico publicado en 2004

Toxicological and pharmacological assessment of AGEN1884, a novel human IgG1 anti-CTLA-4 antibody.

artículo científico publicado en 2018

Trypanosoma cruzi adjuvants potentiate T cell-mediated immunity induced by a NY-ESO-1 based antitumor vaccine

artículo científico publicado en 2012

Trypanosoma cruzi as an effective cancer antigen delivery vector.

artículo científico publicado en 2011

Tumor-specific crosslinking of GITR as costimulation for immunotherapy

artículo científico publicado en 2010

Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cells

artículo científico publicado en 2005

Vaccination with NY-ESO-1 protein and CpG in Montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming.

artículo científico publicado en 2007

Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer

artículo científico publicado en 2007

Vaccine-induced CD4+ T cell responses to MAGE-3 protein in lung cancer patients

artículo científico publicado en 2004

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