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Lista de obras de Christof von Kalle

A Face-Aging App for Smoking Cessation in a Waiting Room Triggers Quitting: Pilot Study in an HIV Outpatient Clinic (Preprint)

article

A Face-Aging Smoking Prevention/Cessation Intervention for Nursery School Students in Germany: An Appearance-Focused Interventional Study

article

A Skin Cancer Prevention Facial-Aging Mobile App for Secondary Schools in Brazil: Appearance-Focused Interventional Study (Preprint)

article

A largely random AAV integration profile after LPLD gene therapy

artículo científico publicado en 2013

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

artículo científico publicado en 2003

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque

artículo científico publicado en 2006

Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle

artículo científico publicado en 2008

An unbiased genome-wide analysis of zinc-finger nuclease specificity

artículo científico publicado en 2011

Analysis of the clonal repertoire of gene-corrected cells in gene therapy

artículo científico publicado en 2012

Analyzing the number of common integration sites of viral vectors--new methods and computer programs

artículo científico publicado en 2011

Artificial riboswitches for gene expression and replication control of DNA and RNA viruses

artículo científico publicado en 2014

BRAF inhibition in hairy cell leukemia with low-dose vemurafenib

artículo científico publicado en 2016

BRAF inhibition in refractory hairy-cell leukemia.

artículo científico publicado en 2012

Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites

artículo científico publicado en 2012

Bone marrow-derived cells contribute to infarct remodelling

artículo científico publicado en 2006

CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy

artículo científico publicado en 2014

Cell cycle status of CD34(+) hemopoietic stem cells determines lentiviral integration in actively transcribed and development-related genes

artículo científico publicado en 2014

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

artículo científico publicado en 2006

Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy

artículo científico publicado en 2012

Chance or necessity? Insertional mutagenesis in gene therapy and its consequences

artículo científico publicado en 2004

Chemovirotherapy of malignant melanoma with a targeted and armed oncolytic measles virus

artículo científico publicado en 2012

Clonal evidence for the transduction of CD34+ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial

artículo científico publicado en 2004

Clonal inventory screens uncover monoclonality following serial transplantation of MGMT P140K-transduced stem cells and dose-intense chemotherapy

artículo científico publicado en 2011

Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates

artículo científico publicado en 2003

Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or a γ-retroviral LTR vector

artículo científico publicado en 2012

Comprehensive genomic access to vector integration in clinical gene therapy

artículo científico publicado en 2009

Continued response off treatment after BRAF inhibition in refractory hairy cell leukemia

artículo científico publicado en 2013

Copy number determination of genetically-modified hematopoietic stem cells.

artículo científico publicado en 2009

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

artículo científico publicado en 2006

Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning

artículo científico publicado en 2011

Corrigendum to "Long-term Regulation of Genetically Modified Primary Hematopoietic Cells in Dogs".

artículo científico publicado en 2011

Corrigendum to "Oncogenesis Following Delivery of a Nonprimate Lentiviral Gene Therapy Vector to Fetal and Neonatal Mice".

artículo científico publicado en 2005

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

artículo científico publicado en 2014

Detection of retroviral integration sites by linear amplification-mediated PCR and tracking of individual integration clones in different samples

artículo científico publicado en 2009

Dissecting the genomic complexity underlying medulloblastoma

artículo científico publicado en 2012

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells

artículo científico publicado en 2004

Drug-perturbation-based stratification of blood cancer

artículo científico publicado en 2017

Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates

artículo científico publicado en 2004

Effective gene therapy with nonintegrating lentiviral vectors

artículo científico publicado en 2006

Efficient marking of human cells with rapid but transient repopulating activity in autografted recipients

artículo científico publicado en 2005

Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV

artículo científico publicado en 2015

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

artículo científico publicado en 2014

Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice

artículo científico publicado en 2002

Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo

artículo científico publicado en 2012

Failure of SCID-X1 gene therapy in older patients

artículo científico publicado en 2005

GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy Data

artículo científico publicado en 2016

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

artículo científico publicado en 2007

Gene Therapy Targeting Hematopoietic Cells: Better Not Leave It to Chance ⬇️

artículo científico publicado el 1 de enero de 2003

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia

article

Gene and Cell Therapy in Germany

artículo científico publicado en 2017

Gene therapy for Wiskott-Aldrich Syndrome-Long-term reconstitution and clinical benefits, but increased risk for leukemogenesis

artículo científico publicado en 2014

Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity

artículo científico publicado en 2014

Gene therapy: therapeutic gene causing lymphoma

artículo científico publicado en 2006

Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation

artículo científico publicado en 2015

Genetic marking as an approach to studying in vivo hematopoiesis: progress in the non-human primate model

artículo científico publicado en 2002

Genome editing technologies: defining a path to clinic

artículo científico publicado en 2015

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

artículo científico publicado en 2014

Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification

artículo científico publicado en 2017

Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing ⬇️

artículo científico publicado el 8 de julio de 2010

Genome-wide mapping of foamy virus vector integrations into a human cell line

artículo científico publicado en 2006

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

artículo científico publicado en 2010

Granulocyte-macrophage colony-stimulating factor-armed oncolytic measles virus is an effective therapeutic cancer vaccine

scientific article published on July 2013

Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation.

artículo científico publicado en 2010

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

artículo científico publicado en 2006

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

artículo científico publicado en 2011

High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion

artículo científico publicado en 2010

High-resolution analysis of the human T-cell receptor repertoire

artículo científico publicado en 2015

High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).

artículo científico publicado en 2007

High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies

artículo científico publicado en 2015

Hot spots of retroviral integration in human CD34+ hematopoietic cells

artículo científico publicado en 2007

Identification of NY-BR-1-specific CD4(+) T cell epitopes using HLA-transgenic mice

artículo científico publicado en 2014

Identity, potency, in vivo viability, and scaling up production of lentiviral vector-induced dendritic cells for melanoma immunotherapy

artículo científico publicado en 2012

Impact of neo-adjuvant Sorafenib treatment on liver transplantation in HCC patients - a prospective, randomized, double-blind, phase III trial

artículo científico publicado en 2015

Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials.

artículo científico publicado en 2007

In vivo gene transfer into adult stem cells in unconditioned mice by in situ delivery of a lentiviral vector

artículo científico publicado en 2006

Insertion site pattern: global approach by linear amplification-mediated PCR and mass sequencing

artículo científico publicado en 2012

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy

artículo científico publicado en 2011

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

artículo científico publicado en 2008

Integration frequency and intermolecular recombination of rAAV vectors in non-human primate skeletal muscle and liver

artículo científico publicado en 2012

Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification

artículo científico publicado en 2016

Integration of retroviral vectors

artículo científico

Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell

artículo científico publicado en 2011

Integration-deficient lentiviral vectors expressing codon-optimized R338L human FIX restore normal hemostasis in Hemophilia B mice

scientific article published on 14 August 2013

Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer

artículo científico publicado en 2013

International network of cancer genome projects

artículo científico publicado en 2010

Is IL2RG oncogenic in T-cell development?: X-SCID transgene leukaemogenicity (reply)

artículo científico publicado en 2006

Lenti in red: progress in gene therapy for human hemoglobinopathies

artículo científico publicado en 2004

Lentiviral Vector Promoter is Decisive for Aberrant Transcript Formation

artículo científico

Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy

artículo científico publicado en 2013

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

artículo científico publicado en 2011

Lentiviral vector integration profiles differ in rodent postmitotic tissues

artículo científico publicado en 2011

Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis

artículo científico publicado en 2002

Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer

artículo científico publicado en 2013

Lentiviral vectors pseudotyped with murine ecotropic envelope: increased biosafety and convenience in preclinical research

artículo científico publicado en 2006

Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors

artículo científico publicado en 2010

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.

artículo científico publicado en 2005

Linear amplification mediated PCR--localization of genetic elements and characterization of unknown flanking DNA.

artículo científico publicado en 2014

Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia

artículo científico publicado en 2004

Long-term regulation of genetically modified primary hematopoietic cells in dogs

artículo científico publicado en 2011

Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs

article

Mapping the precision of genome editing.

artículo científico publicado en 2015

Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model

artículo científico publicado en 2003

MicroRNA-sensitive oncolytic measles viruses for cancer-specific vector tropism

artículo científico publicado en 2011

Mutations in ROGDI Cause Kohlschütter-Tönz Syndrome

artículo científico publicado en 2012

Next-generation sequencing of cancer consensus genes in lymphoma

artículo científico publicado en 2013

Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice

artículo científico publicado en 2005

Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation

artículo científico publicado en 2017

Outperforming Dermatologist-Level Skin Cancer Classification via Enhanced Training of Deep Neural Networks (Preprint)

Parallel assessment of globin lentiviral transfer in induced pluripotent stem cells and adult hematopoietic stem cells derived from the same transplanted β-thalassemia patient

artículo científico publicado en 2013

Patient-Centered Mobile Health Data Management Solution for the German Health Care System (The DataBox Project) (Preprint)

article

Patient-Centered Mobile Health Data Management Solution for the German Healthcare System: The DataBox Project

article

Patient-derived xenografts of gastrointestinal cancers are susceptible to rapid and delayed B-lymphoproliferation

artículo científico publicado en 2016

Pharmacologically regulated in vivo selection in a large animal

artículo científico publicado en 2002

Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells

artículo científico publicado en 2009

Polyclonal long-term repopulating stem cell clones in a primate model

artículo científico publicado en 2002

Precision oncology based on omics data: The NCT Heidelberg experience

artículo científico publicado en 2017

Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease

artículo científico publicado en 2015

Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome

artículo científico publicado en 2012

Real-time definition of non-randomness in the distribution of genomic events

artículo científico publicado en 2007

Recent developments and future perspectives of personalized oncology

artículo científico publicado en 2012

Recurrent CDKN1B (p27) mutations in hairy cell leukemia

artículo científico publicado en 2015

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells ⬇️

artículo científico publicado en 2005

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

artículo científico publicado en 2013

Reply to: NGS library preparation may generate artifactual integration sites of AAV vectors.

artículo científico publicado en 2014

Retroviral Vectors for Gene Therapy ⬇️

artículo científico publicado el 1 de octubre de 2010

Retroviral vectors: post entry events and genomic alterations

artículo científico publicado en 2011

Retrovirally transduced muscle-derived cells contribute to hematopoiesis at very low levels in the nonhuman primate model

artículo científico publicado en 2003

Safety and liver transduction efficacy of rAAV5-cohPBGD in nonhuman primates: a potential therapy for acute intermittent porphyria

artículo científico publicado en 2013

Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells

artículo científico publicado en 2005

Shifting cancer care towards Multidisciplinarity: the cancer center certification program of the German cancer society

artículo científico publicado en 2017

Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype

artículo científico publicado en 2006

Side effects of retroviral gene transfer into hematopoietic stem cells

artículo científico publicado en 2003

Skin Cancer Classification Using Convolutional Neural Networks: Systematic Review

scholarly article by Titus Josef Brinker et al published 17 October 2018 in Journal of Medical Internet Research

Skin Cancer Classification using Convolutional Neural Networks: Systematic Review (Preprint)

scholarly article published 14 August 2018

So rare we need to hunt for them: reframing the ethical debate on incidental findings

artículo científico publicado en 2015

Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression

artículo científico publicado en 2007

Stable human FIX expression after 0.9G intrauterine gene transfer of self-complementary adeno-associated viral vector 5 and 8 in macaques

artículo científico publicado en 2011

Stable long-term blood formation by stem cells in murine steady-state hematopoiesis

artículo científico publicado en 2012

Stem cell collection and gene transfer in Fanconi anemia

artículo científico publicado en 2007

Stem-cell gene therapy for the Wiskott-Aldrich syndrome

artículo científico publicado en 2010

Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts

artículo científico publicado en 2017

Systematic comparative study of computational methods for T-cell receptor sequencing data analysis

artículo científico publicado en 2017

TCR sequences and tissue distribution discriminate the subsets of naïve and activated/memory Treg cells in mice

artículo científico publicado en 2015

Targeted BiTE expression by an oncolytic vector augments therapeutic efficacy against solid tumors

artículo científico publicado en 2018

Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia

artículo científico publicado en 2013

Targeting Fibroblast Growth Factor Receptor 1 for Treatment of Soft-Tissue Sarcoma

artículo científico publicado en 2016

Teledermatology: Comparison of Store-and-Forward Versus Live Interactive Video Conferencing

article by Titus Josef Brinker et al published 24 October 2018 in Journal of Medical Internet Research

Teledermatology: Comparison of Store-and-Forward Versus Live Interactive Video Conferencing (Preprint)

article

The Contained Self-Reactive Peripheral T Cell Repertoire: Size, Diversity, and Cellular Composition

artículo científico publicado en 2015

The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis

artículo científico publicado en 2012

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

artículo científico publicado en 2009

The impact of low-dose busulfan on clonal dynamics in nonhuman primates

artículo científico publicado en 2004

The influence of low molecular weight heparin medication on plasma DNA in pregnant women

artículo científico publicado en 2015

The inherent differentiation program of short-term hematopoietic repopulating cells changes during human ontogeny

artículo científico publicado en 2010

Thymus-autonomous T cell development in the absence of progenitor import

artículo científico publicado en 2012

Transgenic expression of human glial cell line-derived neurotrophic factor from integration-deficient lentiviral vectors is neuroprotective in a rodent model of Parkinson's disease

artículo científico publicado en 2014

Ultramicroscopy as a novel tool to unravel the tropism of AAV gene therapy vectors in the brain

artículo científico publicado en 2016

Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo

artículo científico publicado en 2014

Vector integration and tumorigenesis

artículo científico publicado en 2014

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

artículo científico publicado en 2007

[Molekulargenetische Diagnostik - Was wissen die Maschinen? Was wollen wir wissen?]

artículo científico publicado en 2016

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