Lista de obras -

3Rs friendly study designs facilitate rat liver and blood micronucleus assays and Pig-a gene mutation assessments: Proof-of-concept with 13 reference chemicals

scientific article published on 26 July 2019

3Rs-friendly approach to exogenous metabolic activation that supports high-throughput genetic toxicology testing

artículo científico publicado en 2020

A proposal for a novel rationale for critical effect size in dose-response analysis based on a multi-endpoint in vivo study with methyl methanesulfonate

artículo científico publicado en 2015

A statistical approach for analyzing data from the in vivo Pig-a gene mutation assay

artículo científico publicado en 2018

Aneugen Molecular Mechanism Assay: Proof-of-Concept With 27 Reference Chemicals

artículo científico publicado en 2019

Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.

artículo científico publicado en 2014

Assessment of Systemic Genetic Damage in Pediatric Inflammatory Bowel Disease

artículo científico publicado en 2020

Assessment of genotoxicity associated with hydroxyurea therapy in children with sickle cell anemia

artículo científico publicado en 2010

Assessment of the genotoxic potential of azidothymidine in the comet, micronucleus, and Pig-a assay

artículo científico publicado en 2013

Automated human blood micronucleated reticulocyte measurements for rapid assessment of chromosomal damage

artículo científico publicado en 2006

Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells.

artículo científico publicado en 2018

Building on the past, shaping the future: the Environmental Mutagenesis and Genomics Society

artículo científico publicado en 2013

Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy

artículo científico publicado en 2003

Comparison of in vitro and in vivo clastogenic potency based on benchmark dose analysis of flow cytometric micronucleus data.

artículo científico publicado en 2015

Comparison of male versus female responses in the Pig-a mutation assay

artículo científico publicado en 2015

Continued progress in developing the Pig-a gene mutation assay

artículo científico publicado en 2015

Cross-species genetic toxicity assessment accomplished by flow cytometric analysis of blood

artículo científico publicado en 2008

Cyclophosphamide and etoposide canine studies demonstrate the cross-species potential of the flow cytometric peripheral blood micronucleated reticulocyte endpoint

artículo científico publicado en 2011

Dextran sulfate sodium mouse model of inflammatory bowel disease evaluated for systemic genotoxicity via blood micronucleus and Pig-a gene mutation assays

artículo científico publicado en 2020

Diet-induced obesity increases the frequency of Pig-a mutant erythrocytes in male C57BL/6J mice

artículo científico publicado en 2016

Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using pig-a mutation and reticulocyte micronucleus assays

artículo científico publicado en 2014

Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds

artículo científico publicado en 2012

Enumeration of micronucleated CD71-positive human reticulocytes with a single-laser flow cytometer

artículo científico publicado en 2002

Erythrocyte-Based Pig-a Gene Mutation Assay

scientific article published on 01 January 2019

Erythrocyte-based Pig-a gene mutation assay

artículo científico publicado en 2013

Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential

artículo científico publicado en 2008

Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract

scientific article published on 30 October 2019

Flow cytometric 96-well microplate-based in vitro micronucleus assay with human TK6 cells: protocol optimization and transferability assessment

artículo científico publicado en 2013

Flow cytometric analysis of Pig-a gene mutation and chromosomal damage induced by procarbazine hydrochloride in CD-1 mice

artículo científico publicado en 2013

Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future

artículo científico publicado en 2011

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes III. An efficient method of monitoring chromosomal damage in the beagle dog

scientific article published on 13 September 2007

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes IV: an index of chromosomal damage in the rhesus monkey (Macaca mulatta).

artículo científico publicado en 2008

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: I. Intra- and interlaboratory comparison with microscopic scoring

scientific article published on 03 August 2006

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat.

artículo científico publicado en 2006

Flow cytometric method for scoring rat liver micronuclei with simultaneous assessments of hepatocyte proliferation.

artículo científico publicado en 2018

Flow cytometric scoring of micronucleated erythrocytes: an efficient platform for assessing in vivo cytogenetic damage ⬇️

artículo científico publicado el 1 de enero de 2011

Gamma radiation at a human relevant low dose rate is genotoxic in mice

artículo científico publicado en 2016

Gamma-radiation induces micronucleated reticulocytes in 3D bone marrow bioreactors in vitro

artículo científico publicado en 2009

Genotoxic effects of two-generational selenium deficiency in mouse somatic and testicular cells

artículo científico publicado en 2014

Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

artículo científico publicado en 2016

Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig-a gene Mutation: Support from an in vitro assay based on L5178Y/Tk+/- cells and the CD90.2 antigen

artículo científico publicado en 2017

High content flow cytometric micronucleus scoring method is applicable to attachment cell lines

artículo científico publicado en 2010

Human blood PIG-A mutation and micronucleated reticulocyte flow cytometric assays: Method optimization and evaluation of intra- and inter-subject variation

artículo científico publicado en 2020

Human erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples

artículo científico publicado en 2014

In Vivo Pig-a gene mutation assay: Guidance for 3Rs-friendly implementation

artículo científico publicado en 2016

In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity

artículo científico publicado en 2007

In vitro micronucleus scoring by flow cytometry: differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability

artículo científico publicado en 2006

In vivo assessment of Pig‐a gene mutation—recent developments and assay validation ⬇️

artículo científico publicado el 1 de diciembre de 2011

In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test.

artículo científico publicado en 2006

In vivo flow cytometric Pig-a and micronucleus assays: highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs

scientific article published on 22 June 2012

In vivo genotoxicity testing strategies: Report from the 7th International workshop on genotoxicity testing (IWGT)

scientific article published on 25 April 2019

In vivo mutation assay based on the endogenous Pig-a locus

artículo científico publicado en 2008

In vivo pig-a and micronucleus study of the prototypical aneugen vinblastine sulfate

artículo científico publicado en 2017

Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa

artículo científico publicado en 2015

Induction of in vivo Pig-a gene mutation but not micronuclei by 5-(2-chloroethyl)-2'-deoxyuridine, an antiviral pyrimidine nucleoside analogue

artículo científico publicado en 2018

Induction of in vivo Pig-a gene mutation but not micronuclei by 5-(2-chloroethyl)-2'-deoxyuridine, an antiviral pyrimidine nucleoside analogue

artículo científico publicado en 2018

Influence of counting methodology on erythrocyte ratios in the mouse micronucleus test

artículo científico publicado en 2012

Integration of liver and blood micronucleus and Pig-a gene mutation endpoints into rat 28-day repeat-treatment studies: Proof-of-principle with diethylnitrosamine

artículo científico publicado en 2018

Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies

artículo científico publicado en 2010

Inter-laboratory validation of the in-vivo flow cytometric micronucleus analysis method (MicroFlow®) in China

artículo científico publicado en 2014

Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes.

artículo científico publicado en 2011

Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay

artículo científico publicado en 2007

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay

artículo científico publicado en 2017

Interlaboratory validation of a CD71-based flow cytometric method (Microflow) for the scoring of micronucleated reticulocytes in mouse peripheral blood

artículo científico publicado en 2005

International Pig‐a gene mutation assay trial: Evaluation of transferability across 14 laboratories ⬇️

artículo científico publicado el 11 de septiembre de 2011

Interpreting in vitro micronucleus positive results: simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents

artículo científico publicado en 2014

Intra- and inter-laboratory reproducibility of the rat blood Pig-a gene mutation assay

scientific article published on 18 March 2020

Investigating the Generalizability of the MultiFlow® DNA Damage Assay and Several Companion Machine Learning Models with a Set of 103 Diverse Test Chemicals.

artículo científico publicado en 2017

Micronucleated CD71-positive reticulocytes: a blood-based endpoint of cytogenetic damage in humans

artículo científico publicado en 2003

Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose–response relationships ⬇️

artículo científico publicado el 6 de septiembre de 2010

Miniaturized flow cytometry‐based CHO‐K1 micronucleus assay discriminates aneugenic and clastogenic modes of action ⬇️

artículo científico publicado el 24 de septiembre de 2010

Mouse Pig-a and micronucleus assays respond to N-ethyl-N-nitrosourea, benzo[a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate

artículo científico publicado en 2015

Part 2. Assessment of genotoxicity after exposure to diesel exhaust from U.S. 2007-compliant diesel engines: report on 1- and 3-month exposures in the ACES bioassay.

artículo científico

Part 2. Assessment of micronucleus formation in rats after chronic exposure to new-technology diesel exhaust in the ACES bioassay

artículo científico publicado en 2015

Performance of flow cytometric analysis for the micronucleus assay--a reconstruction model using serial dilutions of malaria-infected cells with normal mouse peripheral blood

artículo científico publicado en 2005

Persistence of cisplatin-induced mutagenicity in hematopoietic stem cells: implications for secondary cancer risk following chemotherapy

artículo científico publicado en 2014

Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone

artículo científico publicado en 2014

Pig-a gene mutation assay study design: critical assessment of 3- versus 28-day repeat-dose treatment schedules

artículo científico publicado en 2020

Pig-a gene mutation database

scientific article published on 07 June 2019

Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens

artículo científico publicado en 2009

Practical threshold for micronucleated reticulocyte induction observed for low doses of mitomycin C, Ara-C and colchicine

artículo científico publicado en 2005

Quantitative analysis of Howell-Jolly bodies in children with sickle cell disease

artículo científico publicado en 2007

Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate

artículo científico publicado en 2015

Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-Report from an ECVAM workshop

artículo científico publicado en 2009

Response kinetics of radiation-induced micronucleated reticulocytes in human bone marrow culture ⬇️

artículo científico publicado el 4 de noviembre de 2010

Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry

artículo científico publicado en 2007

Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age.

artículo científico publicado en 2009

Sensitivity of the erythrocyte micronucleus assay: dependence on number of cells scored and inter-animal variability

artículo científico publicado en 2007

Single cell gel electrophoresis (SCGE) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1(-/-) mice

artículo científico publicado en 2014

Sublethal radiation injury uncovers a functional transition during erythroid maturation ⬇️

artículo científico publicado el 1 de febrero de 2011

Suitability of Long-Term Frozen Rat Blood Samples for the Interrogation of Pig-a Gene Mutation by Flow Cytometry

artículo científico publicado en 2018

The Pig-a Gene Mutation Assay in Mice and Human Cells: A Review

artículo científico publicado en 2017

Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood.

artículo científico publicado en 2004

Validating high-throughput micronucleus analysis of peripheral reticulocytes for radiation biodosimetry: benchmark against dicentric and CBMN assays in a mouse model

artículo científico publicado en 2010

When pigs fly: Immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis ⬇️

artículo científico publicado el 28 de enero de 2011

γH2AX and p53 responses in TK6 cells discriminate promutagens and nongenotoxicants in the presence of rat liver S9.

artículo científico publicado en 2016

Lista de obras de

3Rs friendly study designs facilitate rat liver and blood micronucleus assays and Pig-a gene mutation assessments: Proof-of-concept with 13 reference chemicals

3Rs-friendly approach to exogenous metabolic activation that supports high-throughput genetic toxicology testing

A proposal for a novel rationale for critical effect size in dose-response analysis based on a multi-endpoint in vivo study with methyl methanesulfonate

A statistical approach for analyzing data from the in vivo Pig-a gene mutation assay

Aneugen Molecular Mechanism Assay: Proof-of-Concept With 27 Reference Chemicals

Assessment of 5-fluorouracil and 4-nitroquinoline-1-oxide in vivo genotoxicity with Pig-a mutation and micronucleus endpoints.

Assessment of Systemic Genetic Damage in Pediatric Inflammatory Bowel Disease

Assessment of genotoxicity associated with hydroxyurea therapy in children with sickle cell anemia

Assessment of the genotoxic potential of azidothymidine in the comet, micronucleus, and Pig-a assay

Automated human blood micronucleated reticulocyte measurements for rapid assessment of chromosomal damage

Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells.

Building on the past, shaping the future: the Environmental Mutagenesis and Genomics Society

Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy

Comparison of in vitro and in vivo clastogenic potency based on benchmark dose analysis of flow cytometric micronucleus data.

Comparison of male versus female responses in the Pig-a mutation assay

Continued progress in developing the Pig-a gene mutation assay

Cross-species genetic toxicity assessment accomplished by flow cytometric analysis of blood

Cyclophosphamide and etoposide canine studies demonstrate the cross-species potential of the flow cytometric peripheral blood micronucleated reticulocyte endpoint

Dextran sulfate sodium mouse model of inflammatory bowel disease evaluated for systemic genotoxicity via blood micronucleus and Pig-a gene mutation assays

Diet-induced obesity increases the frequency of Pig-a mutant erythrocytes in male C57BL/6J mice

Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using pig-a mutation and reticulocyte micronucleus assays

Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds

Enumeration of micronucleated CD71-positive human reticulocytes with a single-laser flow cytometer

Erythrocyte-Based Pig-a Gene Mutation Assay

Erythrocyte-based Pig-a gene mutation assay

Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential

Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract

Flow cytometric 96-well microplate-based in vitro micronucleus assay with human TK6 cells: protocol optimization and transferability assessment

Flow cytometric analysis of Pig-a gene mutation and chromosomal damage induced by procarbazine hydrochloride in CD-1 mice

Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes III. An efficient method of monitoring chromosomal damage in the beagle dog

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes IV: an index of chromosomal damage in the rhesus monkey (Macaca mulatta).

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: I. Intra- and interlaboratory comparison with microscopic scoring

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat.

Flow cytometric method for scoring rat liver micronuclei with simultaneous assessments of hepatocyte proliferation.

Flow cytometric scoring of micronucleated erythrocytes: an efficient platform for assessing in vivo cytogenetic damage ⬇️

Gamma radiation at a human relevant low dose rate is genotoxic in mice

Gamma-radiation induces micronucleated reticulocytes in 3D bone marrow bioreactors in vitro

Genotoxic effects of two-generational selenium deficiency in mouse somatic and testicular cells

Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig-a gene Mutation: Support from an in vitro assay based on L5178Y/Tk+/- cells and the CD90.2 antigen

High content flow cytometric micronucleus scoring method is applicable to attachment cell lines

Human blood PIG-A mutation and micronucleated reticulocyte flow cytometric assays: Method optimization and evaluation of intra- and inter-subject variation

Human erythrocyte PIG-A assay: an easily monitored index of gene mutation requiring low volume blood samples

In Vivo Pig-a gene mutation assay: Guidance for 3Rs-friendly implementation

In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity

In vitro micronucleus scoring by flow cytometry: differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability

In vivo assessment of Pig‐a gene mutation—recent developments and assay validation ⬇️

In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test.

In vivo flow cytometric Pig-a and micronucleus assays: highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated-dose designs

In vivo genotoxicity testing strategies: Report from the 7th International workshop on genotoxicity testing (IWGT)

In vivo mutation assay based on the endogenous Pig-a locus

In vivo pig-a and micronucleus study of the prototypical aneugen vinblastine sulfate

Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa

Induction of in vivo Pig-a gene mutation but not micronuclei by 5-(2-chloroethyl)-2'-deoxyuridine, an antiviral pyrimidine nucleoside analogue

Induction of in vivo Pig-a gene mutation but not micronuclei by 5-(2-chloroethyl)-2'-deoxyuridine, an antiviral pyrimidine nucleoside analogue

Influence of counting methodology on erythrocyte ratios in the mouse micronucleus test

Integration of liver and blood micronucleus and Pig-a gene mutation endpoints into rat 28-day repeat-treatment studies: Proof-of-principle with diethylnitrosamine

Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies

Inter-laboratory validation of the in-vivo flow cytometric micronucleus analysis method (MicroFlow®) in China

Interlaboratory Pig-a gene mutation assay trial: Studies of 1,3-propane sultone with immunomagnetic enrichment of mutant erythrocytes.

Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay

Interlaboratory validation of a CD71-based flow cytometric method (Microflow) for the scoring of micronucleated reticulocytes in mouse peripheral blood

International Pig‐a gene mutation assay trial: Evaluation of transferability across 14 laboratories ⬇️

Interpreting in vitro micronucleus positive results: simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents

Intra- and inter-laboratory reproducibility of the rat blood Pig-a gene mutation assay

Investigating the Generalizability of the MultiFlow® DNA Damage Assay and Several Companion Machine Learning Models with a Set of 103 Diverse Test Chemicals.

Micronucleated CD71-positive reticulocytes: a blood-based endpoint of cytogenetic damage in humans

Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose–response relationships ⬇️

Miniaturized flow cytometry‐based CHO‐K1 micronucleus assay discriminates aneugenic and clastogenic modes of action ⬇️

Mouse Pig-a and micronucleus assays respond to N-ethyl-N-nitrosourea, benzo[a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate

Part 2. Assessment of genotoxicity after exposure to diesel exhaust from U.S. 2007-compliant diesel engines: report on 1- and 3-month exposures in the ACES bioassay.

Part 2. Assessment of micronucleus formation in rats after chronic exposure to new-technology diesel exhaust in the ACES bioassay

Performance of flow cytometric analysis for the micronucleus assay--a reconstruction model using serial dilutions of malaria-infected cells with normal mouse peripheral blood

Persistence of cisplatin-induced mutagenicity in hematopoietic stem cells: implications for secondary cancer risk following chemotherapy

Pig-a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone

Pig-a gene mutation assay study design: critical assessment of 3- versus 28-day repeat-dose treatment schedules

Pig-a gene mutation database