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Lista de obras de Christian Haass

A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration

artículo científico publicado en 2006

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

artículo científico publicado en 2002

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b

artículo científico publicado en 2006

A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation

artículo científico publicado en 2004

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

artículo científico publicado en 2000

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

artículo científico publicado en 1999

A non-amyloidogenic function of BACE-2 in the secretory pathway

artículo científico publicado en 2002

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein

artículo científico publicado en 2008

A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein.

artículo científico publicado en 2004

A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques

artículo científico publicado en 2000

A protein quality control pathway regulated by linear ubiquitination

scientific article published on 18 March 2019

A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation

artículo científico publicado en 2009

ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

artículo científico publicado en 2010

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

artículo científico publicado en 2006

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein

artículo científico publicado en 1993

Active gamma-secretase complexes contain only one of each component

artículo científico publicado en 2007

Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model

artículo científico publicado en 2019

Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice

artículo científico publicado en 2006

Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study

artículo científico publicado en 2004

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

artículo científico publicado en 2002

Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family

artículo científico publicado en 1998

Alzheimer's disease. A technical KO of amyloid-beta peptide.

artículo científico publicado en 1998

Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model

artículo científico publicado en 2004

Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis

artículo científico publicado en 2004

Amyloid beta-peptide is produced by cultured cells during normal metabolism

artículo científico publicado en 1992

Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

artículo científico publicado en 2006

Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content.

artículo científico publicado en 2007

Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein

artículo científico publicado en 2005

Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease

artículo científico publicado en 2011

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

artículo científico publicado en 1999

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

artículo científico publicado en 2003

An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.

artículo científico publicado en 2017

An amyloid-like cascade hypothesis for C9orf72 ALS/FTD

artículo científico publicado en 2016

Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins

artículo científico publicado en 2017

Apical sorting of beta-secretase limits amyloid beta-peptide production

artículo científico publicado en 2001

Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner

artículo científico publicado en 2005

Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS.

artículo científico publicado en 2012

Assembly, trafficking and function of gamma-secretase

artículo científico publicado en 2006

Asymmetry of fibrillar plaque burden in amyloid mouse models

scientific article published on 15 May 2020

Attenuated Aβ42 Responses to Low Potency γ-Secretase Modulators Can Be Overcome for Many Pathogenic Presenilin Mutants by Second-generation Compounds ⬇️

artículo científico publicado el 25 de febrero de 2011

Author Correction: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons

artículo científico publicado en 2024

Automated Spatial Brain Normalization and Hindbrain White Matter Reference Tissue Give Improved [(18)F]-Florbetaben PET Quantitation in Alzheimer's Model Mice

artículo científico publicado en 2016

BACE1 dependent neuregulin processing: review

artículo científico publicado en 2012

Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles

artículo científico publicado en 2013

Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination

artículo científico publicado en 2011

Beta-amyloid precursor protein mutants respond to gamma-secretase modulators

artículo científico publicado en 2010

Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins

artículo científico publicado en 2013

Boxing-acute complications and late sequelae: from concussion to dementia

artículo científico publicado en 2010

Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.

artículo científico publicado en 2000

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

scholarly article by Marc Suárez-Calvet et al published December 2018 in EMBO Molecular Medicine

Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling

artículo científico publicado en 1998

Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice

artículo científico publicado en 2012

Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation

artículo científico publicado en 1997

Cellular functions of gamma-secretase-related proteins

artículo científico publicado en 2006

Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease

artículo científico publicado en 2016

Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.

artículo científico publicado en 2008

Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures

artículo científico publicado en 2013

Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease

artículo científico publicado en 2013

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease

artículo científico publicado en 2008

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

artículo científico publicado en 2004

Comparison of 18F-T807 and 18F-THK5117 PET in a Mouse Model of Tau Pathology.

artículo científico publicado en 2018

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

artículo científico publicado en 2000

Control of peripheral nerve myelination by the beta-secretase BACE1

artículo científico publicado en 2006

Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models

artículo científico publicado en 2015

Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex

artículo científico publicado en 1996

Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor

artículo científico publicado en 2009

Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes

artículo científico publicado en 1992

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination

scientific article published on 20 February 2021

Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer's disease.

artículo científico publicado en 2019

Differential Effects of Parkinson's Disease-associated Mutations on Stability and Folding of DJ-1 ⬇️

artículo científico publicado el 7 de noviembre de 2003

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

artículo científico publicado en 2005

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

artículo científico publicado en 2004

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations

artículo científico publicado en 2013

Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism?

artículo científico publicado en 2000

Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase.

artículo científico publicado en 1988

Early and Longitudinal Microglial Activation but Not Amyloid Accumulation Predicts Cognitive Outcome in PS2APP Mice

scientific article published on 27 September 2018

Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury

artículo científico publicado en 2016

Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

artículo científico publicado en 2019

Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

scholarly article by Julia K Götzl published in September 2018

Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations

artículo científico publicado en 1997

Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation

scientific article published on 09 September 2018

Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish.

artículo científico publicado en 2013

Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

artículo científico publicado en 2001

Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.

artículo científico publicado en 2007

Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins

scientific article published on 01 March 1997

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region

artículo científico publicado en 2020

Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation

artículo científico publicado en 1998

Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region

artículo científico publicado en 2004

Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region

artículo científico publicado en 2010

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy

artículo científico publicado en 2013

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations

artículo científico publicado en 2011

Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).

artículo científico publicado en 2012

Frontotemporal dementia: from molecular mechanisms to therapy

artículo científico publicado en 2016

Function, regulation and therapeutic properties of beta-secretase (BACE1).

artículo científico publicado en 2009

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

artículo científico publicado en 2014

Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity

artículo científico publicado en 2006

Fused in sarcoma (FUS): an oncogene goes awry in neurodegeneration

artículo científico

GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network

artículo científico publicado en 2005

Games played by rogue proteins in prion disorders and Alzheimer's disease

artículo científico publicado en 2003

Gamma-secretase activity is associated with a conformational change of nicastrin

artículo científico publicado en 2003

Gamma-secretase complex assembly within the early secretory pathway

artículo científico publicado en 2005

Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway.

artículo científico publicado en 2009

Gel‐like inclusions of C‐terminal fragments of TDP‐43 sequester stalled proteasomes in neurons

artículo científico publicado en 2022

Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease

artículo científico publicado en 2016

Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation

artículo científico publicado en 2007

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease

artículo científico publicado en 1999

Genomic editing opens new avenues for zebrafish as a model for neurodegeneration

artículo científico publicado en 2013

Glial Activation Markers in CSF and Serum From Patients With Primary Progressive Multiple Sclerosis: Potential of Serum GFAP as Disease Severity Marker?

Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study

artículo científico publicado en 2016

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

artículo científico publicado en 2000

Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration

artículo científico publicado en 2017

Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology

artículo científico publicado en 2015

Heterogeneous ribonuclear protein A3 (hnRNP A3) is present in dipeptide repeat protein containing inclusions in Frontotemporal Lobar Degeneration and Motor Neurone disease associated with expansions in C9orf72 gene

artículo científico publicado en 2017

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

artículo científico publicado en 2020

Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration

artículo científico publicado en 2020

Highly efficient targeted mutagenesis in mice using TALENs

artículo científico publicado en 2013

How does parkin ligate ubiquitin to Parkinson's disease?

artículo científico publicado en 2004

Human BACE forms dimers and colocalizes with APP.

artículo científico publicado en 2004

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

artículo científico publicado en 1997

Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes

artículo científico publicado en 2002

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

artículo científico publicado en 2002

Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects

scientific article published on 20 September 2019

Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model

artículo científico publicado en 2006

Identification of distinct gamma-secretase complexes with different APH-1 variants

artículo científico publicado en 2004

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

artículo científico publicado en 2004

Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity

artículo científico publicado en 2016

Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [(18)F]-florbetaben PET.

artículo científico publicado en 2013

Impaired protein degradation in FTLD and related disorders

artículo científico publicado en 2016

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.

artículo científico publicado en 2013

Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis

artículo científico publicado en 2017

Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage ⬇️

artículo científico publicado el 15 de octubre de 1992

Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease

scientific article published on 01 August 2019

Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides

artículo científico publicado en 2006

Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF.

artículo científico publicado en 1996

Inhibition of amyloid-β plaque formation by α-synuclein

artículo científico publicado en 2015

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

artículo científico publicado en 2010

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

scientific journal article

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

artículo científico publicado en 1997

Intramembrane proteolysis by gamma-secretase

artículo científico publicado en 2008

Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases

artículo científico publicado en 2009

Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation

artículo científico publicado en 2008

Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains

artículo científico publicado en 2015

Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains

artículo científico publicado en 2013

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease

artículo científico publicado en 2018

Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments

artículo científico publicado en 2005

Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques.

artículo científico publicado en 2000

Longitudinal assessment of cerebral β-amyloid deposition in mice overexpressing Swedish mutant β-amyloid precursor protein using 18F-florbetaben PET.

artículo científico publicado en 2013

Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth

artículo científico publicado en 2013

Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes

artículo científico publicado en 2013

Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice

scientific article published on 14 September 2020

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

scientific article published on 07 January 2019

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing

artículo científico publicado en 2012

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

artículo científico publicado en 2009

Masking of transmembrane-based retention signals controls ER export of gamma-secretase

artículo científico publicado en 2009

Massachusetts Alzheimer's Disease Research Center: progress and challenges

artículo científico publicado en 2015

Maturation and pro-peptide cleavage of beta-secretase

artículo científico publicado en 2000

Mechanisms of granulin deficiency: lessons from cellular and animal models

artículo científico publicado en 2013

Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration

artículo científico publicado en 2012

Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells

artículo científico publicado en 1994

Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish

artículo científico publicado en 2010

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

artículo científico publicado en 2010

Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies

artículo científico publicado en 2002

Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion.

artículo científico publicado en 2007

Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

artículo científico

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation

artículo científico publicado en 2012

Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS.

artículo científico publicado en 2016

Motor neuron intrinsic and extrinsic mechanisms contribute to the pathogenesis of FUS-associated amyotrophic lateral sclerosis

artículo científico publicado en 2017

Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain

artículo científico publicado en 1998

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor.

artículo científico publicado en 1994

N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase.

artículo científico publicado en 2006

Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway

artículo científico publicado en 2003

New hope for Alzheimer disease vaccine

artículo científico publicado en 2002

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists

artículo científico publicado en 2004

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

artículo científico publicado en 2003

Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules

artículo científico publicado en 1993

Novel γ-secretase enzyme modulators directly target presenilin protein

artículo científico publicado en 2011

Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila

artículo científico publicado en 2014

O2-03-08 Glycosphingolipids regulate subcellular transport of the β-amyloid procursor protein and the generation of amyloid β-peptide

Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice

artículo científico publicado en 2006

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.

artículo científico publicado en 2019

Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy

artículo científico

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

artículo científico publicado en 2002

Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling

artículo científico publicado en 2012

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy

artículo científico publicado en 2009

Parkin is protective against proteotoxic stress in a transgenic zebrafish model

artículo científico publicado en 2010

Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity

artículo científico publicado en 2004

Parkinson's pathology in a fly.

artículo científico publicado en 2000

Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes

artículo científico publicado en 2007

Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease

artículo científico publicado en 2004

Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis

artículo científico publicado en 2003

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

artículo científico publicado en 1999

Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2

artículo científico publicado en 2000

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

artículo científico publicado en 2008

Phosphorylation regulates intracellular trafficking of beta-secretase

artículo científico publicado en 2001

Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.

artículo científico publicado en 2000

Pore-forming scissors? A first structural glimpse of gamma-secretase.

artículo científico publicado en 2006

Posttranslational Modifications of Amyloid Precursor Protein: Ectodomain Phosphorylation and Sulfation

artículo científico publicado el 1 de enero de 2000

Potential Link between Amyloid β-Protein 42 and C-terminal Fragment γ 49–99 of β-Amyloid Precursor Protein ⬇️

artículo científico publicado el 21 de abril de 2003

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

article by Marcia B. Podlisny et al published January 1997 in Neurobiology of Disease

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

artículo científico publicado en 2002

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

artículo científico publicado en 2002

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

artículo científico publicado en 2000

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

artículo científico publicado en 2002

Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.

artículo científico publicado en 2006

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

artículo científico publicado en 2002

Presenilins Are Processed by Caspase-type Proteases ⬇️

artículo científico publicado el 15 de agosto de 1997

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

artículo científico publicado en 2002

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion ⬇️

artículo científico publicado el 1 de diciembre de 1991

Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596

artículo científico publicado en 1993

Progranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression

artículo científico publicado en 2014

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases

artículo científico publicado en 2015

Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms

artículo científico publicado en 1998

Proteolytic processing and degradation of Alzheimer's disease relevant proteins

artículo científico publicado en 1999

Proteolytic processing of Alzheimer's disease associated proteins.

artículo científico publicado en 1998

Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin

artículo científico publicado en 2009

Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C.

artículo científico publicado en 1997

Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase

artículo científico publicado en 2009

Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease

artículo científico publicado en 2015

Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected].

artículo científico publicado en 2013

Reconstitution of gamma-secretase activity

artículo científico publicado en 2003

Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition

artículo científico publicado en 2016

Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin

artículo científico publicado en 2015

Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death

artículo científico publicado en 2002

Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage.

artículo científico publicado en 2004

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

artículo científico publicado en 2008

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

artículo científico publicado en 2007

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

scientific article published on 14 April 2011

Regulatory RNA goes awry in Alzheimer's disease

artículo científico publicado en 2008

Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage

artículo científico publicado en 2009

Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex

artículo científico publicado en 2004

Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43)

artículo científico publicado en 2012

Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators.

artículo científico publicado en 2006

Secretion of the Notch-1 Abeta-like peptide during Notch signaling

artículo científico publicado en 2006

Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways

artículo científico publicado en 2015

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

artículo científico publicado en 2012

Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model

artículo científico publicado en 2001

Semagacestat's fall: where next for AD therapies?

artículo científico publicado en 2013

Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

artículo científico publicado en 2001

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

artículo científico publicado en 2000

Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43.

artículo científico publicado en 2005

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation

artículo científico publicado en 2014

Signal peptide peptidases and gamma-secretase: cousins of the same protease family?

artículo científico publicado en 2007

Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models

artículo científico publicado en 2016

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

artículo científico publicado en 2007

SorLA signaling by regulated intramembrane proteolysis

artículo científico publicado en 2006

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

artículo científico publicado en 2016

Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition

artículo científico publicado en 1997

Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment

artículo científico publicado en 2005

Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma

artículo científico

Structure/function of alpha-synuclein in health and disease: rational development of animal models for Parkinson's and related diseases

artículo científico publicado en 2002

Substitution of phenylalanine by proline at position 19 of amyloid β peptide results in an increased production of amyloid β peptides with alternative N-termini after protein kinase C stimulation

article

Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis

artículo científico publicado en 2009

TRAP1 rescues PINK1 loss-of-function phenotypes

artículo científico publicado en 2013

TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury.

artículo científico publicado en 2017

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

artículo científico publicado en 2016

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

artículo científico publicado en 2014

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

artículo científico publicado en 2004

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

artículo científico publicado en 1992

The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system

artículo científico publicado en 2009

The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2.

artículo científico publicado en 2016

The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum

artículo científico publicado en 1996

The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease

scientific article published on 21 March 2019

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

artículo científico publicado en 2013

The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.

artículo científico publicado en 2017

The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes

artículo científico publicado en 2014

The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk

scientific article published on 01 August 2019

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding ⬇️

artículo científico publicado el 6 de octubre de 2010

The Nicastrin ectodomain adopts a highly thermostable structure

artículo científico publicado en 2011

The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex

artículo científico publicado en 2007

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

artículo científico publicado en 1995

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

artículo científico publicado en 2017

The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

scholarly article by Xianyuan Xiang published in September 2018

The biochemical and genetic odyssey to the function of a nicastrin-like protein

artículo científico publicado en 2004

The biological and pathological function of presenilin proteins--simple cell systems and a worm in Alzheimer's disease research

artículo científico publicado en 1999

The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing

artículo científico publicado en 1999

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

artículo científico publicado en 2003

The cell biology of Alzheimer's disease: uncovering the secrets of secretases

artículo científico publicado en 2001

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

artículo científico publicado en 1997

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

artículo científico publicado en 2004

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

artículo científico publicado en 1998

The role of APP processing and trafficking pathways in the formation of amyloid beta-protein

artículo científico publicado en 1996

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

scientific article published on January 2008

The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein

artículo científico publicado en 1995

The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects

artículo científico publicado en 2017

The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b)

artículo científico publicado en 2012

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis

artículo científico publicado en 2010

Time Courses of Cortical Glucose Metabolism and Microglial Activity Across the Life Span of Wild-Type Mice: A PET Study

artículo científico publicado en 2017

Trafficking and proteolytic processing of APP

artículo científico publicado en 2012

Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region

artículo científico publicado en 2011

Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex

artículo científico publicado en 2010

Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40

scientific article published on 01 October 1998

What do we learn from a few familial Alzheimer's disease cases?

artículo científico publicado en 1998

White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease

article by Miguel Ángel Araque Caballero et al published 1 October 2018 in Brain

Young microglia restore amyloid plaque clearance of aged microglia.

artículo científico publicado en 2016

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

artículo científico publicado en 1999

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.

artículo científico publicado en 1993

beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice

artículo científico publicado en 2004

hFE65L influences amyloid precursor protein maturation and secretion

artículo científico publicado en 1999

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations

artículo científico publicado en 2013

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers

artículo científico publicado en 2016

γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics

artículo científico publicado en 2020

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