Lista de obras -

A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS.

artículo científico publicado en 2009

A clinical development paradigm for cancer vaccines and related biologics

artículo científico publicado en 2007

A clinical phase I trial of gemcitabine and treosulfan in uveal melanoma and other solid tumours

artículo científico publicado en 2004

A monoclonal melanoma-specific T-cell population phenotypically indistinguishable from CD3+ LGL-leukemia

scientific article published on 01 June 2003

A phase I/IIa clinical trial of CLAOP21 and CLAOP14 in patients with high grade non-Hodgkins lymphoma.

artículo científico publicado en 2007

A phase II study of bendamustine chemotherapy as second-line treatment in metastatic uveal melanoma

artículo científico publicado en 2004

A two-cohort phase II clinical trial of gemcitabine plus treosulfan in patients with metastatic uveal melanoma

artículo científico publicado en 2005

Addition of GM-CSF to a peptide/KLH vaccine results in increased frequencies of CXCR3-expressing KLH-specific T cells

artículo científico publicado en 2006

Addition of histamine to interleukin 2 treatment augments type 1 T-cell responses in patients with melanoma in vivo: immunologic results from a randomized clinical trial of interleukin 2 with or without histamine (MP 104).

artículo científico publicado en 2005

Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial

artículo científico publicado en 2008

Adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma: a phase III randomized controlled trial of health-related quality of life and symptoms by the European Organisation for Research and Treatment of C

artículo científico publicado en 2009

Afatinib as second-line treatment in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: Subgroup analyses of treatment adherence, safety and mode of afatinib administration in the LUX-Head and Neck 1 trial

artículo científico publicado en 2019

An intron 9 containing splice variant of PAX2.

artículo científico publicado en 2009

Analysis of surrogate gene expression markers in peripheral blood of melanoma patients to predict treatment outcome of adjuvant pegylated interferon alpha 2b (EORTC 18991 side study).

artículo científico publicado en 2013

Association of epidermal growth factor receptor polymorphism, skin toxicity, and outcome in patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment

artículo científico publicado en 2009

Baseline caspase activity predicts progression free survival of temsirolimus-treated head neck cancer patients

artículo científico publicado en 2015

CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia

artículo científico publicado en 2002

Cancer testis antigen Cyclin A1 harbors several HLA-A*02:01-restricted T cell epitopes, which are presented and recognized in vivo

artículo científico publicado en 2020

Circulating Tumor-reactive CD8(+) T cells in melanoma patients contain a CD45RA(+)CCR7(-) effector subset exerting ex vivo tumor-specific cytolytic activity

artículo científico publicado en 2002

Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).

artículo científico publicado en 2009

Circulating tumor cells as prognostic factor for distant metastases and survival in patients with primary uveal melanoma.

artículo científico publicado en 2007

Clinical and immunological responses in metastatic melanoma patients vaccinated with a high-dose poly-epitope vaccine

article

Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen

artículo científico publicado en 2012

Dacarbazine, cisplatin, and interferon-alfa-2b with or without interleukin-2 in metastatic melanoma: a randomized phase III trial (18951) of the European Organisation for Research and Treatment of Cancer Melanoma Group

artículo científico publicado en 2005

Differences in T-cell immunity toward tumor-associated antigens in colorectal cancer and breast cancer patients

artículo científico publicado en 2003

Dose Seeking Evaluation of a Novel Heterologous Primeboost Immunotherapy in Stage III and IV Metastatic Melanoma Patients

Durvalumab for recurrent or metastatic head and neck squamous cell carcinoma: Results from a single-arm, phase II study in patients with ≥25% tumour cell PD-L1 expression who have progressed on platinum-based chemotherapy

artículo científico publicado en 2018

EORTC Melanoma Group achievements

artículo científico publicado en 2012

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016

artículo científico publicado en 2016

Effects of granulocyte-macrophage colony-stimulating factor and foreign helper protein as immunologic adjuvants on the T-cell response to vaccination with tyrosinase peptides.

artículo científico publicado en 2003

Enhanced detection of BRAF-mutants by pre-PCR cleavage of wild-type sequences revealed circulating melanoma cells heterogeneity

artículo científico publicado en 2011

Eradication of EGFR-positive circulating tumor cells and objective tumor response with lapatinib and capecitabine ⬇️

artículo científico publicado el 1 de noviembre de 2010

Evidence and interdisciplinary consense-based German guidelines: diagnosis and surveillance of melanoma

artículo científico publicado en 2007

Evidence and interdisciplinary consensus-based German guidelines: surgical treatment and radiotherapy of melanoma

artículo científico publicado en 2008

Evidence-based and interdisciplinary consensus-based German guidelines: systemic medical treatment of melanoma in the adjuvant and palliative setting.

artículo científico publicado en 2008

Expression and activity of EGFR in human cutaneous melanoma cell lines and influence of vemurafenib on the EGFR pathway

artículo científico publicado en 2014

Expression of Wilms' tumor gene 1 at different stages of acute myeloid leukemia and analysis of its major splice variants.

artículo científico publicado en 2004

Expression of chemokine receptors on circulating tumor cells in patients with solid tumors

artículo científico publicado en 2012

Extended schedule, escalated dose temozolomide versus dacarbazine in stage IV melanoma: final results of a randomised phase III study (EORTC 18032).

artículo científico publicado en 2011

Favorable prognostic influence of T-box transcription factor Eomesodermin in metastatic renal cell cancer patients

artículo científico publicado en 2016

Fractionated irradiation can induce functionally relevant multidrug resistance gene and protein expression in human tumor cell lines

artículo científico publicado en 2008

Functional CCR9 expression is associated with small intestinal metastasis

artículo científico publicado en 2004

Identification of a highly immunogenic HLA-A*01-binding T cell epitope of WT1.

artículo científico publicado en 2006

Identification of an immunogenic HLA-A*0201-binding T-cell epitope of the transcription factor PAX2.

artículo científico publicado en 2009

Identification of known and novel immunogenic T-cell epitopes from tumor antigens recognized by peripheral blood T cells from patients responding to IL-2-based treatment

artículo científico publicado en 2002

Ifosfamide/liposomal daunorubicin is a well tolerated and active first-line chemotherapy regimen in advanced soft tissue sarcoma: results of a phase II study

artículo científico publicado en 2005

Immune monitoring of T-cell responses in cancer vaccine development

artículo científico publicado en 2006

Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy.

artículo científico publicado en 2002

Immunological monitoring of cancer vaccine therapy

artículo científico publicado en 2004

In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor (EGFR) expression and mutational phenotype ⬇️

artículo científico publicado el 20 de octubre de 2011

Independent prognostic factors for distant metastases and survival in patients with primary uveal melanoma.

artículo científico publicado en 2004

Innovations and challenges in melanoma: summary statement from the first Cambridge conference

artículo científico publicado en 2006

LDH correlation with survival in advanced melanoma from two large, randomised trials (Oblimersen GM301 and EORTC 18951).

artículo científico publicado en 2009

Long term follow up of the EORTC 18952 trial of adjuvant therapy in resected stage IIB-III cutaneous melanoma patients comparing intermediate doses of interferon-alpha-2b (IFN) with observation: Ulceration of primary is key determinant for IFN-sensi

artículo científico publicado en 2016

Long term presence of a single predominant tyrosinase-specific T-cell clone associated with disease control in a patient with metastatic melanoma

artículo científico publicado en 2010

Long-term freedom from recurrence in 2 stage IV melanoma patients following vaccination with tyrosinase peptides

artículo científico publicado en 2002

Long-term protective effect of mature DC-LAMP+ dendritic cell accumulation in sentinel lymph nodes containing micrometastatic melanoma

artículo científico publicado en 2007

Long-term results of the randomized phase III trial EORTC 18991 of adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma

artículo científico publicado en 2012

Lymphomas are sensitive to perforin-dependent cytotoxic pathways despite expression of PI-9 and overexpression of bcl-2

artículo científico publicado en 2005

Malignant melanoma--clinical development of peptide-based melanoma vaccines

artículo científico publicado en 2006

Natural T cell immunity against cancer.

artículo científico publicado en 2003

Negative enrichment by immunomagnetic nanobeads for unbiased characterization of circulating tumor cells from peripheral blood of cancer patients

artículo científico publicado en 2011

PI3K/PTEN/AKT/mTOR polymorphisms: association with clinical outcome in patients with head and neck squamous cell carcinoma receiving cetuximab-docetaxel.

artículo científico publicado en 2015

Peptide vaccination after repeated resection of metastases can induce a prolonged relapse-free interval in melanoma patients.

artículo científico publicado en 2005

Phase II trial of carboplatin, paclitaxel plus vinorelbine in non-small cell lung cancer patients.

artículo científico publicado en 2005

Phase II trial of cisplatin, gemcitabine and treosulfan in patients with metastatic uveal melanoma

artículo científico publicado en 2005

Phase II trial of second-line bendamustine chemotherapy in relapsed small cell lung cancer patients

artículo científico publicado en 2006

Post-surgery adjuvant therapy with intermediate doses of interferon alfa 2b versus observation in patients with stage IIb/III melanoma (EORTC 18952): randomised controlled trial

artículo científico publicado en 2005

Pretreatment levels of peripheral neutrophils and leukocytes as independent predictors of overall survival in patients with American Joint Committee on Cancer Stage IV Melanoma: results of the EORTC 18951 Biochemotherapy Trial

artículo científico publicado en 2007

Prognosis of Patients With Stage III Melanoma According to American Joint Committee on Cancer Version 8: A Reassessment on the Basis of 3 Independent Stage III Melanoma Cohorts

artículo científico publicado en 2020

Quantitative detection of circulating tumor cells in cutaneous and ocular melanoma and quality assessment by real-time reverse transcriptase-polymerase chain reaction

artículo científico publicado en 2004

Quantitative nested real-time RT-PCR specific for tyrosinase transcripts to quantitate minimal residual disease

artículo científico publicado en 2002

Quantitative real-time RT-PCR for detection of disseminated tumor cells in peripheral blood of patients with colorectal cancer using different mRNA markers.

artículo científico publicado en 2004

Randomized phase II study of paclitaxel and carboplatin or vinorelbine in advanced non-small cell lung cancer

artículo científico publicado el 1 de enero de 2011

Rational peptide-based tumour vaccine development and T cell monitoring

artículo científico publicado en 2003

Relative quantification of TCR Vbeta-chain families by real time PCR for identification of clonal T-cell populations

artículo científico publicado en 2008

Restricted T-cell receptor repertoire in melanoma metastases regressing after cytokine therapy.

artículo científico publicado en 2003

Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma

artículo científico publicado en 2009

Risk stratification of sentinel node-positive melanoma patients defines surgical management and adjuvant therapy treatment considerations.

artículo científico publicado en 2018

Selection of immunostimulant AS15 for active immunization with MAGE-A3 protein: results of a randomized phase II study of the European Organisation for Research and Treatment of Cancer Melanoma Group in Metastatic Melanoma

artículo científico publicado en 2013

Sensitivity of tumor cells to proteasome inhibitors is associated with expression levels and composition of proteasome subunits

artículo científico publicado en 2008

Sex is an independent prognostic indicator for survival and relapse/progression-free survival in metastasized stage III to IV melanoma: a pooled analysis of five European organisation for research and treatment of cancer randomized controlled trials

artículo científico publicado en 2013

Short German guidelines: Merkel cell carcinoma

artículo científico publicado en 2008

Sunitinib treatment for patients with advanced clear-cell renal-cell carcinoma after progression on sorafenib

artículo científico publicado en 2009

T cell responses against tumor associated antigens and prognosis in colorectal cancer patients

artículo científico publicado en 2005

The EORTC-DeCOG nomogram adequately predicts outcomes of patients with sentinel node-positive melanoma without the need for completion lymph node dissection

artículo científico publicado en 2020

The Evolving Role of Taxanes in Combination With Cetuximab for the Treatment of Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck: Evidence, Advantages, and Future Directions

scientific article published on 21 August 2019

Transarterial chemoembolization of liver metastases from uveal melanoma after failure of systemic therapy: toxicity and outcome

artículo científico publicado en 2010

UV-induced N-ras mutations are T-cell targets in human melanoma

article

Ulceration and stage are predictive of interferon efficacy in melanoma: results of the phase III adjuvant trials EORTC 18952 and EORTC 18991.

artículo científico publicado en 2011

Wilms' tumor gene 1 (WT1) expression in subtypes of acute lymphoblastic leukemia (ALL) of adults and impact on clinical outcome

artículo científico publicado en 2009

Lista de obras de

A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS.

A clinical development paradigm for cancer vaccines and related biologics

A clinical phase I trial of gemcitabine and treosulfan in uveal melanoma and other solid tumours

A monoclonal melanoma-specific T-cell population phenotypically indistinguishable from CD3+ LGL-leukemia

A phase I/IIa clinical trial of CLAOP21 and CLAOP14 in patients with high grade non-Hodgkins lymphoma.

A phase II study of bendamustine chemotherapy as second-line treatment in metastatic uveal melanoma

A two-cohort phase II clinical trial of gemcitabine plus treosulfan in patients with metastatic uveal melanoma

Addition of GM-CSF to a peptide/KLH vaccine results in increased frequencies of CXCR3-expressing KLH-specific T cells

Addition of histamine to interleukin 2 treatment augments type 1 T-cell responses in patients with melanoma in vivo: immunologic results from a randomized clinical trial of interleukin 2 with or without histamine (MP 104).

Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial

Adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma: a phase III randomized controlled trial of health-related quality of life and symptoms by the European Organisation for Research and Treatment of C

Afatinib as second-line treatment in patients with recurrent/metastatic squamous cell carcinoma of the head and neck: Subgroup analyses of treatment adherence, safety and mode of afatinib administration in the LUX-Head and Neck 1 trial

An intron 9 containing splice variant of PAX2.

Analysis of surrogate gene expression markers in peripheral blood of melanoma patients to predict treatment outcome of adjuvant pegylated interferon alpha 2b (EORTC 18991 side study).

Association of epidermal growth factor receptor polymorphism, skin toxicity, and outcome in patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment

Baseline caspase activity predicts progression free survival of temsirolimus-treated head neck cancer patients

CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia

Cancer testis antigen Cyclin A1 harbors several HLA-A*02:01-restricted T cell epitopes, which are presented and recognized in vivo

Circulating Tumor-reactive CD8(+) T cells in melanoma patients contain a CD45RA(+)CCR7(-) effector subset exerting ex vivo tumor-specific cytolytic activity

Circulating melanoma cells and distant metastasis-free survival in stage III melanoma patients with or without adjuvant interferon treatment (EORTC 18991 side study).

Circulating tumor cells as prognostic factor for distant metastases and survival in patients with primary uveal melanoma.

Clinical and immunological responses in metastatic melanoma patients vaccinated with a high-dose poly-epitope vaccine

Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen

Dacarbazine, cisplatin, and interferon-alfa-2b with or without interleukin-2 in metastatic melanoma: a randomized phase III trial (18951) of the European Organisation for Research and Treatment of Cancer Melanoma Group

Differences in T-cell immunity toward tumor-associated antigens in colorectal cancer and breast cancer patients

Dose Seeking Evaluation of a Novel Heterologous Primeboost Immunotherapy in Stage III and IV Metastatic Melanoma Patients

Durvalumab for recurrent or metastatic head and neck squamous cell carcinoma: Results from a single-arm, phase II study in patients with ≥25% tumour cell PD-L1 expression who have progressed on platinum-based chemotherapy

EORTC Melanoma Group achievements

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016

Effects of granulocyte-macrophage colony-stimulating factor and foreign helper protein as immunologic adjuvants on the T-cell response to vaccination with tyrosinase peptides.

Enhanced detection of BRAF-mutants by pre-PCR cleavage of wild-type sequences revealed circulating melanoma cells heterogeneity

Eradication of EGFR-positive circulating tumor cells and objective tumor response with lapatinib and capecitabine ⬇️

Evidence and interdisciplinary consense-based German guidelines: diagnosis and surveillance of melanoma

Evidence and interdisciplinary consensus-based German guidelines: surgical treatment and radiotherapy of melanoma

Evidence-based and interdisciplinary consensus-based German guidelines: systemic medical treatment of melanoma in the adjuvant and palliative setting.

Expression and activity of EGFR in human cutaneous melanoma cell lines and influence of vemurafenib on the EGFR pathway

Expression of Wilms' tumor gene 1 at different stages of acute myeloid leukemia and analysis of its major splice variants.

Expression of chemokine receptors on circulating tumor cells in patients with solid tumors

Extended schedule, escalated dose temozolomide versus dacarbazine in stage IV melanoma: final results of a randomised phase III study (EORTC 18032).

Favorable prognostic influence of T-box transcription factor Eomesodermin in metastatic renal cell cancer patients

Fractionated irradiation can induce functionally relevant multidrug resistance gene and protein expression in human tumor cell lines

Functional CCR9 expression is associated with small intestinal metastasis

Identification of a highly immunogenic HLA-A*01-binding T cell epitope of WT1.

Identification of an immunogenic HLA-A*0201-binding T-cell epitope of the transcription factor PAX2.

Identification of known and novel immunogenic T-cell epitopes from tumor antigens recognized by peripheral blood T cells from patients responding to IL-2-based treatment

Ifosfamide/liposomal daunorubicin is a well tolerated and active first-line chemotherapy regimen in advanced soft tissue sarcoma: results of a phase II study

Immune monitoring of T-cell responses in cancer vaccine development

Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy.

Immunological monitoring of cancer vaccine therapy

In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor (EGFR) expression and mutational phenotype ⬇️

Independent prognostic factors for distant metastases and survival in patients with primary uveal melanoma.

Innovations and challenges in melanoma: summary statement from the first Cambridge conference

LDH correlation with survival in advanced melanoma from two large, randomised trials (Oblimersen GM301 and EORTC 18951).

Long term follow up of the EORTC 18952 trial of adjuvant therapy in resected stage IIB-III cutaneous melanoma patients comparing intermediate doses of interferon-alpha-2b (IFN) with observation: Ulceration of primary is key determinant for IFN-sensi

Long term presence of a single predominant tyrosinase-specific T-cell clone associated with disease control in a patient with metastatic melanoma

Long-term freedom from recurrence in 2 stage IV melanoma patients following vaccination with tyrosinase peptides

Long-term protective effect of mature DC-LAMP+ dendritic cell accumulation in sentinel lymph nodes containing micrometastatic melanoma

Long-term results of the randomized phase III trial EORTC 18991 of adjuvant therapy with pegylated interferon alfa-2b versus observation in resected stage III melanoma

Lymphomas are sensitive to perforin-dependent cytotoxic pathways despite expression of PI-9 and overexpression of bcl-2

Malignant melanoma--clinical development of peptide-based melanoma vaccines

Natural T cell immunity against cancer.

Negative enrichment by immunomagnetic nanobeads for unbiased characterization of circulating tumor cells from peripheral blood of cancer patients

PI3K/PTEN/AKT/mTOR polymorphisms: association with clinical outcome in patients with head and neck squamous cell carcinoma receiving cetuximab-docetaxel.

Peptide vaccination after repeated resection of metastases can induce a prolonged relapse-free interval in melanoma patients.

Phase II trial of carboplatin, paclitaxel plus vinorelbine in non-small cell lung cancer patients.

Phase II trial of cisplatin, gemcitabine and treosulfan in patients with metastatic uveal melanoma

Phase II trial of second-line bendamustine chemotherapy in relapsed small cell lung cancer patients

Post-surgery adjuvant therapy with intermediate doses of interferon alfa 2b versus observation in patients with stage IIb/III melanoma (EORTC 18952): randomised controlled trial

Pretreatment levels of peripheral neutrophils and leukocytes as independent predictors of overall survival in patients with American Joint Committee on Cancer Stage IV Melanoma: results of the EORTC 18951 Biochemotherapy Trial

Prognosis of Patients With Stage III Melanoma According to American Joint Committee on Cancer Version 8: A Reassessment on the Basis of 3 Independent Stage III Melanoma Cohorts

Quantitative detection of circulating tumor cells in cutaneous and ocular melanoma and quality assessment by real-time reverse transcriptase-polymerase chain reaction

Quantitative nested real-time RT-PCR specific for tyrosinase transcripts to quantitate minimal residual disease

Quantitative real-time RT-PCR for detection of disseminated tumor cells in peripheral blood of patients with colorectal cancer using different mRNA markers.

Randomized phase II study of paclitaxel and carboplatin or vinorelbine in advanced non-small cell lung cancer

Rational peptide-based tumour vaccine development and T cell monitoring

Relative quantification of TCR Vbeta-chain families by real time PCR for identification of clonal T-cell populations

Restricted T-cell receptor repertoire in melanoma metastases regressing after cytokine therapy.

Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma

Risk stratification of sentinel node-positive melanoma patients defines surgical management and adjuvant therapy treatment considerations.