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A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors

artículo científico publicado en 2005

Adenoviral expression of CREB protects neurons from apoptotic and excitotoxic stress

artículo científico publicado en 2004

Estrogen-related receptor alpha expression and function is associated with the transcriptional coregulator AIB1 in breast carcinoma

artículo científico publicado en 2009

FXR Controls the Tumor Suppressor NDRG2 and FXR Agonists Reduce Liver Tumor Growth and Metastasis in an Orthotopic Mouse Xenograft Model ⬇️

artículo científico publicado el 9 de octubre de 2012

Gas1 is induced by VE-cadherin and vascular endothelial growth factor and inhibits endothelial cell apoptosis

artículo científico publicado en 2004

Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol

artículo científico publicado en 2003

Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties

artículo científico publicado en 2016

Panning for SNuRMs: using cofactor profiling for the rational discovery of selective nuclear receptor modulators.

artículo científico publicado en 2007

Reprogramming of the ERRα and ERα target gene landscape triggers tamoxifen resistance in breast cancer

artículo científico publicado en 2015

Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists

artículo científico publicado en 2010

Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-)

artículo científico publicado en 2012

The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction

artículo científico publicado en 2016

The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein

artículo científico publicado en 2014

Tsumura-Suzuki obese diabetic mice-derived hepatic tumors closely resemble human hepatocellular carcinomas in metabolism-related genes expression and bile acid accumulation

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