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5-Fluorouracil (FUra) and folinic acid (FA) therapy in patients with colorectal cancer

artículo científico publicado en 1988

5-Fluorouracil and folinic acid in the treatment of metastatic colorectal cancer

scientific article published on 01 September 1987

A First-in-Human Phase I Study of the Oral p38 MAPK Inhibitor, Ralimetinib (LY2228820 Dimesylate), in Patients with Advanced Cancer

artículo científico publicado en 2015

A Phase 2 Trial of Flavopiridol (Alvocidib) and Cisplatin in Platin-Resistant Ovarian and Primary Peritoneal Carcinoma: MC0261 ⬇️

artículo científico publicado el 1 de junio de 2012

A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors

artículo científico publicado en 2017

A Phase I Study of the AKT Inhibitor MK-2206 in Combination with Hormonal Therapy in Postmenopausal Women with Estrogen Receptor-Positive Metastatic Breast Cancer

artículo científico publicado en 2016

A Phase I study of bizelesin (NSC 615291) in patients with advanced solid tumors.

artículo científico publicado en 2002

A Phase I trial of the farnesyl protein transferase inhibitor R115777 in combination with gemcitabine and cisplatin in patients with advanced cancer

artículo científico publicado en 2003

A Phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity.

artículo científico publicado en 2000

A Phase II Trial of Neoadjuvant MK-2206, an AKT Inhibitor, with Anastrozole in Clinical Stage II or III PIK3CA-Mutant ER-Positive and HER2-Negative Breast Cancer.

artículo científico publicado en 2017

A bioassay to measure cytotoxicity of plasma from patients treated with mitomycin C

scientific article published on 01 November 1985

A clinical and pharmacological study of 5-fluorouracil, leucovorin and interferon alfa in advanced colorectal cancer

artículo científico publicado en 1995

A hierarchical Bayesian design for randomized Phase II clinical trials with multiple groups

artículo científico publicado en 2017

A limited sample model to predict area under the drug concentration curve for 17-(allylamino)-17-demethoxygeldanamycin and its active metabolite 17-(amino)-17-demethoxygeldanomycin

artículo científico publicado en 2007

A measles virus vaccine strain derivative as a novel oncolytic agent against breast cancer

artículo científico publicado en 2006

A multicenter phase 2 trial of pazopanib in metastatic and progressive medullary thyroid carcinoma: MC057H.

artículo científico publicado en 2014

A multiinstitutional phase 2 trial of pazopanib monotherapy in advanced anaplastic thyroid cancer

artículo científico publicado en 2012

A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas

artículo científico publicado en 2008

A phase 2 study of temsirolimus (CCI-779) in patients with soft tissue sarcomas: a study of the Mayo phase 2 consortium (P2C).

artículo científico publicado en 2011

A phase I and pharmacokinetic study of a powder-filled capsule formulation of oral irinotecan (CPT-11) given daily for 5 days every 3 weeks in patients with advanced solid tumors

artículo científico publicado en 2005

A phase I and pharmacokinetic study of temsirolimus (CCI-779) administered intravenously daily for 5 days every 2 weeks to patients with advanced cancer

artículo científico publicado en 2006

A phase I and pharmacokinetic study of the selective, non-peptidic inhibitor of matrix metalloproteinase BAY 12-9566 in combination with etoposide and carboplatin

artículo científico publicado en 2005

A phase I and pharmacologic study of pyrazoloacridine (NSC 366140) and carboplatin in patients with advanced cancer

artículo científico publicado en 2002

A phase I and pharmacologic study of sequences of the proteasome inhibitor, bortezomib (PS-341, Velcade), in combination with paclitaxel and carboplatin in patients with advanced malignancies

artículo científico publicado en 2006

A phase I and pharmacologic trial of two schedules of the proteasome inhibitor, PS-341 (bortezomib, velcade), in patients with advanced cancer

artículo científico publicado en 2005

A phase I clinical and pharmacokinetic study of CS-682 administered orally in advanced malignant solid tumors

artículo científico publicado en 2006

A phase I study of 153Sm-EDTMP with fixed high-dose melphalan as a peripheral blood stem cell conditioning regimen in patients with multiple myeloma

artículo científico publicado en 2005

A phase I study of EKB-569 in combination with capecitabine in patients with advanced colorectal cancer

artículo científico publicado en 2008

A phase I study of cilengitide and paclitaxel in patients with advanced solid tumors

artículo científico publicado en 2017

A phase I study of combined radiation therapy with 5-fluorouracil and low dose folinic acid in patients with locally advanced pancreatic or biliary carcinoma

scientific article published on 01 January 1996

A phase I study of sequential irinotecan and 5-fluorouracil/leucovorin

artículo científico publicado en 2002

A phase I trial of ISIS 2503, an antisense inhibitor of H-ras, in combination with gemcitabine in patients with advanced cancer.

artículo científico publicado en 2003

A phase I trial of MTA and gemcitabine in patients with locally advanced or metastatic cancer

artículo científico publicado en 1999

A phase I trial of the IGF-1R antibody Cixutumumab in combination with temsirolimus in patients with metastatic breast cancer ⬇️

artículo científico publicado el 19 de abril de 2013

A phase I trial of the novel farnesyl protein transferase inhibitor, BMS-214662, in combination with paclitaxel and carboplatin in patients with advanced cancer.

artículo científico publicado en 2005

A phase I trial of twice-weekly 17-allylamino-demethoxy-geldanamycin in patients with advanced cancer

artículo científico publicado en 2006

A phase IB study of the pharmacokinetics of gemcitabine and pemetrexed, when administered in rapid sequence to patients with advanced solid tumors

artículo científico publicado en 2005

A phase II safety and efficacy study of the vascular endothelial growth factor receptor tyrosine kinase inhibitor pazopanib in patients with metastatic urothelial cancer

artículo científico publicado en 2013

A phase II study of 5-fluorouracil, leucovorin and interferon-alpha in advanced pancreatic cancer

artículo científico publicado en 1993

A phase II study of AT-101 (Gossypol) in chemotherapy-sensitive recurrent extensive-stage small cell lung cancer.

artículo científico publicado en 2011

A phase II study of AZD2171 (cediranib) in the treatment of patients with acute myeloid leukemia or high-risk myelodysplastic syndrome

artículo científico publicado en 2014

A phase II study of bortezomib in the treatment of metastatic malignant melanoma

artículo científico publicado en 2005

A phase II study of gemcitabine in combination with tanespimycin in advanced epithelial ovarian and primary peritoneal carcinoma

artículo científico publicado en 2011

A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma

artículo científico publicado en 2019

A phase II trial of 17-allylamino-17- demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer

artículo científico publicado en 2005

A phase II trial of 17-allylamino-17-demethoxygeldanamycin in patients with hormone-refractory metastatic prostate cancer

artículo científico publicado en 2008

A phase II trial of 5-fluorouracil and 1-leucovorin in patients with metastatic colorectal cancer

scientific article published on 01 February 1996

A phase II trial of bevacizumab plus temsirolimus in patients with advanced hepatocellular carcinoma

artículo científico publicado en 2014

A phase II trial of tipifarnib in myelofibrosis: primary, post-polycythemia vera and post-essential thrombocythemia

article by R A Mesa et al published 21 June 2007 in Leukemia

A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma

artículo científico publicado en 1988

A randomized trial of two dose levels of cyclophosphamide, methotrexate, and fluorouracil chemotherapy for patients with metastatic breast cancer

artículo científico publicado en 1988

A study of paclitaxel, carboplatin, and bortezomib in the treatment of metastatic malignant melanoma: a phase 2 consortium study

artículo científico publicado en 2010

Abstract 1301: Investigation of a potential pharmacokinetic interaction between ABT-888 and topotecan in a phase I trial

Adjuvant therapy of colon cancer: a review

artículo científico publicado en 2002

Akt inhibitor MK-2206 in combination with bendamustine and rituximab in relapsed or refractory chronic lymphocytic leukemia: Results from the N1087 alliance study.

artículo científico publicado en 2017

Akt inhibitor MK2206 selectively targets CLL B-cell receptor induced cytokines, mobilizes lymphocytes and synergizes with bendamustine to induce CLL apoptosis

artículo científico publicado en 2013

Allopurinol mouthwash for prevention of fluorouracil-induced stomatitis

artículo científico publicado en 1989

An Evaluation of Postoperative Follow-Up Tests in Colon Cancer Patients Treated for Cure ⬇️

artículo científico publicado el 1 de julio de 1997

An International Phase 2 Study of Pazopanib in Progressive and Metastatic Thyroglobulin Antibody Negative Radioactive Iodine Refractory Differentiated Thyroid Cancer

artículo científico publicado en 2020

An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma.

artículo científico publicado en 2010

An open-label, phase I/II study of 5-fluorouracil plus leucovorin in the treatment of rheumatoid arthritis

artículo científico publicado en 2002

An overview of the clinical pharmacology of N-phosphonacetyl-L-aspartate (PALA), a new antimetabolite.

artículo científico publicado en 1980

Analysis of phosphoramide mustard by reversed-phase ion pair high pressure liquid chromatography

scientific article published on 01 June 1987

Antineoplastic drug cytotoxicity in a human bladder cancer cell line: implications for intravesical chemotherapy

artículo científico publicado en 1987

Antitumor Activity of Nivolumab in Recurrent and Metastatic Nasopharyngeal Carcinoma: An International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742)

artículo científico publicado en 2018

Antitumor activity of N-phosphonacetyl-L-aspartic acid in combination with nitrobenzylthioinosine

artículo científico publicado en 1984

Application of a simple competitive protein-binding assay technique to the pharmacokinetics of N-(phosphonacetyl)-L-aspartate in humans

artículo científico publicado en 1980

Association of DNA methylation and epigenetic inactivation of RASSF1A and beta-catenin with metastasis in small bowel carcinoid tumors

artículo científico publicado en 2006

Biochemical effects of folate-based inhibitors of thymidylate synthase in MGH-U1 cells

artículo científico publicado en 1994

Biochemical modulation of 5-fluorouracil with or without leucovorin by a low dose of brequinar in MGH-U1 cells

artículo científico publicado el 1 de enero de 1992

Biochemical modulation of iododeoxyuridine by N6-[4-(morpholinosulfonyl)benzyl]-N6-methyl-2, 6-diaminobenz[cd]indole glucuronate (AG-331) leading to enhanced cytotoxicity

artículo científico publicado en 1995

Biomarker-driven trial in metastatic pancreas cancer: feasibility in a multicenter study of saracatinib, an oral Src inhibitor, in previously treated pancreatic cancer

artículo científico publicado en 2012

Cisplatin abrogates the geldanamycin-induced heat shock response

artículo científico publicado en 2008

Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat: a phase 2 consortium/stand up 2 cancer study

artículo científico publicado en 2017

Combination studies with 3'-azido-3'-deoxythymidine (AZT) plus ICI D1694. Cytotoxic and biochemical effects

artículo científico publicado en 1993

Combined radical radiation therapy and chemotherapy for primary squamous cell carcinoma of the anal canal.

artículo científico publicado en 1982

Comparative cytotoxicity of folate-based inhibitors of thymidylate synthase and 5-fluorouracil +/- leucovorin in MGH-U1 cells

artículo científico publicado en 1994

Comparative pharmacokinetic study of continuous venous infusion fluorouracil and oral fluorouracil with eniluracil in patients with advanced solid tumors

artículo científico publicado en 2002

Comparison of potential markers of farnesyltransferase inhibition

artículo científico publicado en 2000

Competitive protein binding assay of methotrexate

artículo científico publicado en 1982

Context-dependent antagonism between Akt inhibitors and topoisomerase poisons

artículo científico publicado en 2014

Cytotoxic and biochemical implications of combining AZT and AG-331

scientific article published on 01 January 1995

Cytotoxicity of adriamycin in MGH-U1 cells grown as monolayer cultures, spheroids, and xenografts in immune-deprived mice

artículo científico publicado en 1984

Cytotoxicity of cisplatin and cisdiammine-1,1-cyclobutane dicarboxylate in MGH-U1 cells grown as monolayers, spheroids, and xenografts.

artículo científico publicado en 1985

Denileukin diftitox in combination with rituximab for previously untreated follicular B-cell non-Hodgkin's lymphoma ⬇️

artículo científico publicado el 21 de octubre de 2011

Development of a multidisciplinary, multicampus subspecialty practice in endocrine cancers

artículo científico publicado en 2012

Development of a multidisciplinary, multicampus subspecialty practice in endocrine cancers.

artículo científico publicado en 2012

Development of rational drug combinations with investigational targeted agents

artículo científico publicado en 2010

Differences between accumulation of 99mTc-MIBI and 201Tl-thallous chloride in tumour cells: role of P-glycoprotein

scientific article published on 01 June 1995

Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma.

artículo científico publicado en 2014

Disposition of cyclophosphamide on two consecutive cycles of treatment in patients with ovarian carcinoma

artículo científico publicado en 1988

Disposition of total and free cisplatin on two consecutive treatment cycles in patients with ovarian cancer

artículo científico publicado en 1987

Disruption of parallel and converging signaling pathways contributes to the synergistic antitumor effects of simultaneous mTOR and EGFR inhibition in GBM cells

artículo científico publicado en 2005

Drug efflux by breast cancer resistance protein is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924

artículo científico publicado en 2011

Early results of a phase I trial of oblimersen sodium for relapsed or refractory Waldenstrom's macroglobulinemia

artículo científico publicado en 2005

Ectopic production of human chorionic gonadotropin: A case report ⬇️

artículo científico publicado el 1 de enero de 1979

Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity

scientific article published on 01 January 1998

Effects of 5-fluorouracil and leucovorin in spheroids: a model for solid tumours

artículo científico publicado en 1991

Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression

artículo científico publicado en 1995

Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study.

artículo científico publicado en 2010

Epidermal growth factor receptor and activated epidermal growth factor receptor expression in gastrointestinal carcinoids and pancreatic endocrine carcinomas.

artículo científico publicado en 2005

Epigenetic therapy using belinostat for patients with unresectable hepatocellular carcinoma: a multicenter phase I/II study with biomarker and pharmacokinetic analysis of tumors from patients in the Mayo Phase II Consortium and the Cancer Therapeuti

artículo científico publicado en 2012

Evaluation of continuous infusion suramin in metastatic breast cancer: impact on plasma levels of insulin-like growth factors (IGFs) and IGF-binding proteins

scientific article published on 01 October 1997

Evaluation of epothilone B analog in advanced soft tissue sarcoma: a phase II study of the phase II consortium

artículo científico publicado en 2005

Evaluation of lapatinib and topotecan combination therapy: tissue culture, murine xenograft, and phase I clinical trial data

artículo científico publicado en 2008

Experience with 5FU + L-leucovorin

scientific article published on 01 January 1993

Expression of insulin receptor isoform A and insulin-like growth factor-1 receptor in human acute myelogenous leukemia: effect of the dual-receptor inhibitor BMS-536924 in vitro

scientific article published on 29 September 2009

Failure of 5-day vinblastine infusion in the treatment of patients with advanced refractory breast cancer

scientific article published on 01 September 1982

Failure of methylprednisolone acetate to prolong the antinauseant effect of intravenous methylprednisolone sodium succinate in patients receiving chemotherapy

artículo científico publicado en 1988

First-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer

artículo científico publicado en 2017

Flavopiridol in patients with relapsed or refractory multiple myeloma: a phase 2 trial with clinical and pharmacodynamic end-points.

artículo científico publicado en 2006

Fluorouracil and leucovorin for metastatic colorectal cancer

artículo científico publicado en 1990

Fluorouracil/leucovorin study update

artículo científico publicado en 1991

Gemcitabine and ISIS-2503 for patients with locally advanced or metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group phase II trial

artículo científico publicado en 2004

Gemcitabine and irinotecan as first-line therapy for carcinoma of unknown primary: results of a multicenter phase II trial

artículo científico publicado en 2012

Gene expression profiling identifies responsive patients with cancer of unknown primary treated with carboplatin, paclitaxel, and everolimus: NCCTG N0871 (alliance)

artículo científico publicado en 2015

Growth and characterization of multicellular tumor spheroids of human bladder carcinoma origin

artículo científico publicado en 1986

HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924.

artículo científico publicado en 2008

Heat shock protein 90 inhibition sensitizes acute myelogenous leukemia cells to cytarabine

artículo científico publicado en 2005

Heat shock protein inhibitors increase the efficacy of measles virotherapy

artículo científico publicado en 2008

Heterogeneous role of caspase-8 in fenretinide-induced apoptosis in epithelial ovarian carcinoma cell lines

artículo científico publicado en 2003

High-performance liquid chromatographic measurement of cyclophosphamide in serum

artículo científico publicado en 1984

ICI D1694 and idoxuridine: a synergistic antitumor combination.

artículo científico publicado en 1994

In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417.

artículo científico publicado en 2006

Irinotecan in the treatment of glioma patients: current and future studies of the North Central Cancer Treatment Group

artículo científico publicado en 2003

Irinotecan plus 5-FU and leucovorin in advanced colorectal cancer: North American trials

artículo científico publicado el 1 de agosto de 1998

Large cell carcinoma with calcitonin and vasoactive intestinal polypeptide-associated Verner-Morrison syndrome

artículo científico publicado en 2005

Levamisole and 5-fluorouracil therapy for resected colon cancer: a new indication

artículo científico publicado en 1991

Limitations of urinary mutagen assays for monitoring occupational exposure to antineoplastic drugs

artículo científico publicado en 1986

Limited sampling models for CPT-11, SN-38, and SN-38 glucuronide

artículo científico publicado en 2001

Male breast cancer: a 13-year review of 89 patients ⬇️

artículo científico publicado el 1 de agosto de 1984

Male breast cancer: an 11 year review of 66 patients

artículo científico publicado en 1996

Medical management of pancreatic neuroendocrine tumors

artículo científico publicado en 2007

Metastatic non-small cell lung carcinoma with involvement of extremity musculature: case report and review of the literature

artículo científico publicado en 2000

Microsatellite Instability in Patients With Stage III Colon Cancer Receiving Fluoropyrimidine With or Without Oxaliplatin: An ACCENT Pooled Analysis of 12 Adjuvant Trials

artículo científico publicado en 2020

Mitomycin C pharmacokinetics in patients with recurrent or metastatic colorectal carcinoma

artículo científico publicado en 1987

Modulation of the equilibrative nucleoside transporter by inhibitors of DNA synthesis.

artículo científico publicado en 1995

Molecular markers in male breast carcinoma

artículo científico publicado en 1998

Multicenter Phase II Trial of Temsirolimus and Bevacizumab in Pancreatic Neuroendocrine Tumors

artículo científico publicado en 2014

Multicenter phase II study of the AKT inhibitor MK-2206 in recurrent or metastatic nasopharyngeal carcinoma from patients in the mayo phase II consortium and the cancer therapeutics research group (MC1079).

artículo científico

Necrosis in a meningioma following systemic chemotherapy. Case report

scientific article published on 01 August 1994

New treatment options for colorectal cancer

artículo científico publicado en 2004

Novel agents in colorectal cancer

scientific article published on 01 January 2001

Novel chemotherapeutic agents in clinical development ⬇️

artículo científico publicado el 1 de diciembre de 1991

Novel therapeutics in colorectal cancer

artículo científico publicado en 2005

Open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of intravenously administered CNF1010 (17-(allylamino)-17-demethoxygeldanamycin [17-AAG]) in patients with solid tumors ⬇️

artículo científico publicado el 6 de abril de 2013

Optimal duration of fluorouracil plus levamisole colon cancer surgical adjuvant therapy

artículo científico publicado en 1996

Optimum doses of irinotecan

artículo científico publicado en 1999

Oxaliplatin in the treatment of colorectal cancer

artículo científico publicado en 2007

P-100Phase IB study of sorafenib + evofosfamide in patients (pts) with advanced hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC): NCCTG N1153 (Alliance).

artículo científico publicado en 2016

P-Glycoprotein-mediated resistance to Hsp90-directed therapy is eclipsed by the heat shock response

artículo científico publicado en 2008

Pathogenesis and risk factors of small bowel adenocarcinoma: a colorectal cancer sibling?

artículo científico publicado en 2005

Patients' willingness to enter clinical trials: measuring the association with perceived benefit and preference for decision participation

artículo científico publicado en 1991

Peripheral leukocytes as indicators of the enzymatic effects of N-(phosphonacetyl)-L-aspartic acid (PALA) on human L-aspartate transcarbamoylase (ATCase) activity

scientific article published on 01 August 1980

Phase 1 study of interleukin-12 in combination with rituximab in patients with B-cell non-Hodgkin lymphoma ⬇️

artículo científico publicado el 1 de enero de 2002

Phase 1 study of sorafenib in combination with bortezomib in patients with advanced malignancies.

scientific article published on 26 July 2013

Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer

scientific article published on 21 November 2019

Phase 1 trial of flavopiridol combined with cisplatin or carboplatin in patients with advanced malignancies with the assessment of pharmacokinetic and pharmacodynamic end points.

artículo científico publicado en 2005

Phase 2 study of bevacizumab plus erlotinib in patients with advanced hepatocellular cancer ⬇️

artículo científico publicado el 27 de septiembre de 2011

Phase 2 trial of daily, oral Polyphenon E in patients with asymptomatic, Rai stage 0 to II chronic lymphocytic leukemia

artículo científico publicado en 2012

Phase I and pharmacokinetic study of fostriecin given as an intravenous bolus daily for five consecutive days

artículo científico publicado en 2004

Phase I and pharmacokinetic study of irinotecan and docetaxel in patients with advanced solid tumors: preliminary evidence of clinical activity

scientific article published on 01 March 2000

Phase I and pharmacokinetic study of two different schedules of oxaliplatin, irinotecan, Fluorouracil, and leucovorin in patients with solid tumors

artículo científico publicado en 2003

Phase I and pharmacologic study of infusional topotecan and Carboplatin in relapsed and refractory acute leukemia

artículo científico publicado en 2005

Phase I and pharmacologic study of sequences of gemcitabine and the multitargeted antifolate agent in patients with advanced solid tumors

scientific article published on 01 April 2000

Phase I and pharmacological study of cytarabine and tanespimycin in relapsed and refractory acute leukemia

artículo científico publicado en 2011

Phase I and pharmacological trial of fazarabine (Ara-AC) with granulocyte colony-stimulating factor.

artículo científico publicado en 1997

Phase I dose escalation study of the PKCι inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer.

artículo científico publicado en 2013

Phase I dose-finding and pharmacokinetic trial of irinotecan hydrochloride (CPT-11) using a once-every-three-week dosing schedule for patients with advanced solid tumor malignancy.

artículo científico publicado en 2000

Phase I pharmacokinetic and pharmacodynamic study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an inhibitor of heat-shock protein 90, in patients with advanced solid tumors

artículo científico publicado en 2010

Phase I pharmacokinetic and pharmacodynamic study of a new anthrapyrazole, CI-937 (DUP937).

artículo científico publicado en 1991

Phase I pharmacokinetic study of cyclosporin A combined with doxorubicin

artículo científico publicado en 1993

Phase I study of 17-allylamino-17 demethoxygeldanamycin, gemcitabine and/or cisplatin in patients with refractory solid tumors

artículo científico publicado en 2010

Phase I study of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor, in patients with advanced solid tumors

artículo científico publicado en 2006

Phase I study of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with relapsed and refractory B-cell non-Hodgkin lymphoma

artículo científico publicado en 2009

Phase I study of tanespimycin in combination with bortezomib in patients with advanced solid malignancies ⬇️

artículo científico publicado el 31 de marzo de 2013

Phase I study of temsirolimus in combination with EKB-569 in patients with advanced solid tumors

artículo científico publicado en 2011

Phase I study of the duocarmycin semisynthetic derivative KW-2189 given daily for five days every six weeks ⬇️

artículo científico publicado el 1 de septiembre de 1998

Phase I study of the matrix metalloproteinase inhibitor, BAY 12-9566.

artículo científico publicado en 2001

Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer

artículo científico publicado en 2005

Phase I trial of FOLFIRI in combination with sorafenib and bevacizumab in patients with advanced gastrointestinal malignancies

artículo científico publicado en 2015

Phase I trial of N-(phosphonacetyl)-L-aspartate ⬇️

artículo científico publicado el 1 de octubre de 1979

Phase I trial of daily oral Polyphenon E in patients with asymptomatic Rai stage 0 to II chronic lymphocytic leukemia

artículo científico publicado en 2009

Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors

scientific article published on 01 March 1999

Phase I trial of everolimus, gemcitabine and cisplatin in patients with solid tumors

artículo científico publicado en 2014

Phase I trial of gemcitabine and CPT-11 given weekly for four weeks every six weeks

artículo científico publicado en 2001

Phase I trial of sequential administration of raltitrexed (Tomudex) and 5-iodo-2'-deoxyuridine (IdUrd).

artículo científico publicado en 2001

Phase I, pharmacokinetic study of temsirolimus administered orally to patients with advanced cancer.

artículo científico publicado en 2009

Phase I-II trial of ONYX-015 in combination with MAP chemotherapy in patients with advanced sarcomas

artículo científico publicado en 2005

Phase I-phase II trial of N-phosphonacetyl-L-aspartic acid given by intravenous infusion and 5-fluorouracil given by bolus injection

artículo científico publicado en 1982

Phase I/II trial of granisetron: a novel 5-hydroxytryptamine antagonist for the prevention of chemotherapy-induced nausea and vomiting

artículo científico publicado en 1990

Phase II study of Erlotinib (OSI-774) in patients with advanced hepatocellular cancer

artículo científico publicado en 2005

Phase II study of daily oral perifosine in patients with advanced soft tissue sarcoma

artículo científico publicado en 2006

Phase II study of erlotinib in patients with advanced biliary cancer

artículo científico publicado en 2006

Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer

artículo científico publicado en 2003

Phase II study of the histone deacetylase inhibitor belinostat (PXD101) for the treatment of myelodysplastic syndrome (MDS) ⬇️

artículo científico publicado el 3 de mayo de 2011

Phase II trial of 5-fluorouracil and folinic acid in the treatment of advanced breast cancer

scientific article published on 01 January 1994

Phase II trial of diaziquone in patients with colon cancer

artículo científico publicado en 1985

Phase II trial of gemcitabine and tanespimycin (17AAG) in metastatic pancreatic cancer: a Mayo Clinic Phase II Consortium study.

artículo científico publicado en 2015

Phase II trial of oxaliplatin/irinotecan/5-fluorouracil/leucovorin for metastatic colorectal cancer

artículo científico publicado en 2007

Phase II trials of single-agent anti-VEGF therapy for patients with chronic lymphocytic leukemia ⬇️

artículo científico publicado el 5 de noviembre de 2010

Plasma pharmacokinetics of 5-FU given by continuous infusion with allopurinol

artículo científico publicado en 1986

Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.

artículo científico publicado en 2011

Potential applications of therapeutic drug monitoring in treatment of neoplastic disease by antineoplastic agents

artículo científico publicado en 1986

Profound hair and skin hypopigmentation in an African American woman treated with the multi-targeted tyrosine kinase inhibitor pazopanib.

artículo científico publicado en 2010

Prognostic factors in patients with metastatic colorectal cancer receiving 5-fluorouracil and folinic acid

artículo científico publicado el 1 de enero de 1992

Prospectively randomized trial of postoperative adjuvant chemotherapy in patients with high-risk colon cancer ⬇️

artículo científico publicado el 1 de enero de 1998

RECPAM analysis of prognostic factors in patients with stage III breast cancer

artículo científico publicado en 1990

Randomized phase II study of interleukin-12 in combination with rituximab in previously treated non-Hodgkin's lymphoma patients

artículo científico publicado en 2006

Rapid development of enhanced clearance after high-dose cyclophosphamide

scientific article published on 01 December 1988

Resistance of MGH-U1 bladder cancer spheroids to vincristine.

artículo científico publicado en 1992

Review of 154 patients with non-functioning pituitary tumors ⬇️

artículo científico publicado el 1 de noviembre de 1979

Safety and activity of temsirolimus and bevacizumab in patients with advanced renal cell carcinoma previously treated with tyrosine kinase inhibitors: a phase 2 consortium study

artículo científico publicado en 2015

Sequential methotrexate-fluorouracil: the role of leucovorin in improving tumor response

artículo científico publicado en 1986

Serum uridine levels in patients receiving N-(phosphonacetyl)-L-aspartate

artículo científico publicado en 1980

Small bowel adenocarcinoma: a rare but aggressive disease

artículo científico publicado en 2004

Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine tumors

artículo científico publicado en 2005

Superiority of Granisetron to Dexamethasone Plus Prochlorperazine in the Prevention of Chemotherapy-Induced Emesis ⬇️

artículo científico publicado el 21 de agosto de 1991

Superiority of methylprednisolone sodium succinate over low dose metoclopramide hydrochloride in the prevention of nausea and vomiting produced by cancer chemotherapy

artículo científico publicado en 1986

Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines.

artículo científico publicado en 2001

Tanespimycin: the opportunities and challenges of targeting heat shock protein 90.

artículo científico publicado en 2009

Targeting of the Hedgehog/GLI and mTOR pathways in advanced pancreatic cancer, a phase 1 trial of Vismodegib and Sirolimus combination

scientific article published on 14 July 2020

Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: a phase 2 study

artículo científico publicado en 2011

The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux

artículo científico publicado en 2001

The Hsp90 chaperone complex as a novel target for cancer therapy

artículo científico publicado en 2003

The clinical case for proton beam therapy.

artículo científico publicado en 2012

The practical benefits of pharmacokinetics in the use of antineoplastic agents

artículo científico publicado en 1980

The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons

artículo científico publicado en 2005

Therapeutic drug monitoring in oncology. Problems and potential in antineoplastic therapy

artículo científico publicado en 1987

Treatment of advanced gastric carcinoma with mitomycin and doxorubicin.

artículo científico publicado en 1986

UGT1A1 genotype-guided phase I study of irinotecan, oxaliplatin, and capecitabine

artículo científico publicado en 2013

Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism

artículo científico publicado en 2006

Variability in the pharmacokinetics of cyclophosphamide, methotrexate and 5-fluorouracil in women receiving adjuvant treatment for breast cancer

scientific article published on 01 January 1994

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