Lista de obras -

5-Hydroxytryptamine and the metabolism of arachidonic acid by the lipoxygenase and cyclooxygenase of washed human platelets

artículo científico publicado en 1990

Acute effects of some volatile nitrites on motor performance and lethality in mice

artículo científico publicado en 1986

Alterations in specific gene expression and focal neoplastic growth during spontaneous hepatocarcinogenesis in albumin-SV40 T antigen transgenic rats

artículo científico publicado en 2004

An Integrated Multi-Omics Analysis Defines Key Pathway Alterations in a Diet-Induced Obesity Mouse Model

artículo científico publicado en 2020

An initiation-promotion assay in rat liver as a potential complement to the 2-year carcinogenesis bioassay

artículo científico publicado en 1991

An integrated study of acute effects of valproic acid in the liver using metabonomics, proteomics, and transcriptomics platforms

artículo científico publicado en 2006

Animal studies addressing the carcinogenicity of TCDD (or related compounds) with an emphasis on tumour promotion

artículo científico publicado en 2000

Biochemical events during initiation of rat hepatocarcinogenesis

scientific article published on 01 July 1994

Biochemical markers associated with the stages of promotion and progression during hepatocarcinogenesis in the rat ⬇️

artículo científico publicado el 1 de junio de 1991

Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling

artículo científico publicado en 2005

Biomarkers of carcinogenicity and their roles in drug discovery and development.

artículo científico publicado en 2008

Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity

artículo científico publicado en 2013

Characterization of the major DNA adducts in the liver of rats chronically exposed to tamoxifen for 18 months

scientific article published on 01 April 2000

Characterization of the promotion of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the female rat

artículo científico publicado el 1 de agosto de 1992

Chemicals, cell proliferation, risk estimation, and multistage carcinogenesis

artículo científico publicado en 1991

Comparison of Basal gene expression in cultured primary rat hepatocytes and freshly isolated rat hepatocytes

scientific article published on 01 January 2004

Comparison of experimental and theoretical parameters of the Moolgavkar-Venzon-Knudson incidence function for the stages of initiation and promotion in rat hepatocarcinogenesis

artículo científico publicado en 1995

Comparison of hepatocyte phenotypes at the glutathione transferase and albumin loci in Sprague-Dawley and Nagase analbuminemic rats and F1 progeny after initiation and promotion

artículo científico publicado en 1993

Critical parameters in the quantitation of the stages of initiation, promotion, and progression in one model of hepatocarcinogenesis in the rat.

artículo científico publicado en 1989

Cytogenetic analysis of three rat liver epithelial cell lines (WBneo, WBHa-ras, and WBrasIIa) and correlation of an early chromosomal alteration with insulin-like growth factor II expression

artículo científico publicado en 1996

Developing microphysiological systems for use as regulatory tools--challenges and opportunities

artículo científico publicado en 2014

Development of dietary soluble fibres by enzymatic synthesis and assessment of their digestibility in in vitro, animal and randomised clinical trial models.

artículo científico publicado en 2017

Dietary oat lipids-induced novel DNA modifications and suppression of altered hepatic foci formation

scientific article published on 01 January 1999

Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells.

artículo científico publicado en 2006

Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists

artículo científico publicado en 2006

Doxorubicin: Comparison between 3-h continuous and bolus intravenous administration paradigms on cardio-renal axis, mitochondrial sphingolipids and pathology

artículo científico publicado en 2015

Early prediction of polymyxin-induced nephrotoxicity with next-generation urinary kidney injury biomarkers

artículo científico publicado en 2013

Effect of adenine nucleotides on cyclooxygenase and lipoxygenase enzyme products of arachidonic acid in human platelets

artículo científico publicado en 1990

Effect of chronic administration of mestranol, tamoxifen, and toremifene on hepatic ploidy in rats

artículo científico publicado en 1998

Effect of the separate and combined administration of mestranol and phenobarbital on the development of altered hepatic foci expressing placental form of glutathione S-transferase in the rat.

artículo científico publicado en 1996

Effects of chronic administration of tamoxifen and toremifene on DNA adducts in rat liver, kidney, and uterus.

artículo científico publicado en 1997

Effects of phenobarbital on I-compounds in liver DNA as a function of age in male rats fed two different diets ⬇️

artículo científico publicado el 1 de enero de 1992

Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver

scientific article published on 01 April 1995

Effects of the antiestrogens tamoxifen, toremifene, and ICI 182,780 on endometrial cancer growth

scientific article published on 01 October 1998

Evaluation of cellular impedance measures of cardiomyocyte cultures for drug screening applications

artículo científico publicado en 2012

Evaluation of temporal changes in urine-based metabolomic and kidney injury markers to detect compound induced acute kidney tubular toxicity in beagle dogs

artículo científico

Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies

artículo científico publicado en 2008

Facts and theories concerning the mechanisms of carcinogenesis ⬇️

artículo científico publicado el 1 de junio de 1991

Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury

artículo científico publicado en 2017

Focal and non-focal hepatic expression of placental glutathione S-transferase in carcinogen-treated rats

artículo científico publicado en 1994

Genome-wide loss of heterozygosity analysis of chemically induced rat hepatocellular carcinomas reveals elevated frequency of allelic imbalances on chromosomes 1, 6, 8, 11, 15, 17, and 20.

artículo científico publicado en 2000

Hazard assessment of chemical carcinogens: the impact of hormesis.

artículo científico publicado en 2000

Human induced pluripotent stem cells and their use in drug discovery for toxicity testing

artículo científico publicado en 2013

Immunohistochemical localization and semi-quantitation of hepatic tamoxifen-DNA adducts in rats exposed orally to tamoxifen

artículo científico publicado en 2001

Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B(1) as an example

artículo científico publicado en 2001

Implications of hormesis on the bioassay and hazard assessment of chemical carcinogens

artículo científico publicado en 1998

Improved cell typing by charge-state deconvolution of matrix-assisted laser desorption/ionization mass spectra

artículo científico publicado en 2006

Incorporation of bromodeoxyuridine in glutathione S-transferase-positive hepatocytes during rat multistage hepatocarcinogenesis

artículo científico publicado en 1994

Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene and idoxifene in female Sprague-Dawley rats.

artículo científico publicado en 1996

Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat.

artículo científico publicado en 2008

Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency

artículo científico publicado en 2005

Karyotypic changes in a multistage model of chemical hepatocarcinogenesis in the rat

artículo científico publicado en 1996

LETTERS TO THE EDITOR

article

Lessons learned in applying the U.S. EPA proposed cancer guidelines to specific compounds

artículo científico publicado en 2000

Mechanisms of susceptibility to mouse liver carcinogenesis

artículo científico publicado en 1998

Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS.

artículo científico publicado en 2008

Microarray Analysis Using Amplified mRNA from Laser Capture Microdissection of Microscopic Hepatocellular Precancerous Lesions and Frozen Hepatocellular Carcinomas Reveals Unique and Consistent Gene Expression Profiles ⬇️

artículo científico publicado el 1 de mayo de 2003

Minisymposium on emerging methods in cancer hazard identification

artículo científico publicado en 1997

Mode of action in relevance of rodent liver tumors to human cancer risk.

artículo científico publicado en 2005

Multiple polypeptide hormone expression in pancreatic islet cell carcinomas derived from phosphoenolpyruvatecarboxykinase-SV40 T antigen transgenic rats

artículo científico publicado en 2000

Multistage hepatocarcinogenesis in the rat: insights into risk estimation

artículo científico publicado el 1 de enero de 1992

Mutational analysis of three tumor suppressor genes in two models of rat hepatocarcinogenesis.

artículo científico publicado en 1999

Nakahara Memorial Lecture. Pathways of carcinogenesis--genetic and epigenetic

artículo científico publicado en 1991

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.

artículo científico publicado en 2017

New Phenotypic Cytotoxicity Assay for ROS-inducing Compounds using Rat Renal Epithelial Cells

scientific article published on 06 June 2020

Optimization of an assay for studying the effects of agents on cyclooxygenase and lipoxygenase metabolism of arachidonic acid in washed human platelets

artículo científico publicado en 1990

P53-M Real-Time PCR Array for Multi-Gene Expression Profiling and Microarray Data Validation: RT2 Profiler PCR Array.

artículo científico publicado en 2007

Polygenic architecture informs potential vulnerability to drug-induced liver injury

artículo científico publicado en 2020

Quality control and quality assessment of data from surface-enhanced laser desorption/ionization (SELDI) time-of flight (TOF) mass spectrometry (MS).

artículo científico publicado en 2005

Quantitation of multistage carcinogenesis in rat liver

artículo científico publicado en 1996

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-induced Liver Injury

scholarly article by Diane M Longo et al published 5 October 2018 in Toxicological Sciences

Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats.

artículo científico publicado en 1999

Quantitative comparison of initiation and mutation phenotypes in hepatocytes of the analbuminemic rat.

artículo científico publicado en 1993

Quantitative stereological studies of a 'selection' protocol of hepatocarcinogenesis following initiation in neonatal male and female rats

artículo científico publicado en 1997

Rat toxicogenomic study reveals analytical consistency across microarray platforms

artículo científico publicado en 2006

Review article: the stages of gastrointestinal carcinogenesis--application of rodent models to human disease

artículo científico publicado en 2000

Role of altered hepatic foci in the stages of carcinogenesis

artículo científico

STEREO: a program on a PC-Windows 95 platform for recording and evaluating quantitative stereologic investigations of multistage hepatocarcinogenesis in rodents

artículo científico publicado en 1998

Selective loss of nucleoside carrier expression in rat hepatocarcinomas.

artículo científico publicado en 2000

Self-self hybridization as an alternative experiment design to dye swap for two-color microarrays

scientific article published on 01 January 2007

Specific chromosomal changes in albumin simian virus 40 T antigen transgenic rat liver neoplasms ⬇️

artículo científico publicado el 15 de agosto de 1997

Stage of tumor progression, progressor agents, and human risk

artículo científico publicado en 1993

Structure-activity relationships for triphenylethylene antiestrogens on hepatic phase-I and phase-II enzyme expression

artículo científico publicado en 1998

Studies of tamoxifen as a promoter of hepatocarcinogenesis in female Fischer F344 rats

artículo científico publicado en 1994

Study of the separate and combined effects of the non-planar 2,5,2',5'- and the planar 3,4,3',4'-tetrachlorobiphenyl in liver and lymphocytes in vivo.

artículo científico publicado en 1991

Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female Sprague-Dawley rats.

artículo científico publicado en 1994

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

artículo científico publicado en 2006

The accurate prediction of protein family from amino acid sequence by measuring features of sequence fragments

artículo científico publicado en 2009

The effect of short-term fasting, phenobarbital and refeeding on apoptotic loss, cell replication and gene expression in rat liver during the promotion stage

artículo científico publicado en 1998

The effect of tamoxifen and two of its non-isomerizable fixed-ring analogs on multistage rat hepatocarcinogenesis

artículo científico publicado en 1996

The effect of the dose of diethylnitrosamine on the initiation of altered hepatic foci in neonatal female rats.

artículo científico publicado en 1993

The effect of the format of administration and the total dose of phenobarbital on altered hepatic foci following initiation in female rats with diethylnitrosamine.

artículo científico publicado en 1991

The initiation-promotion-progression model of rat hepatocarcinogenesis

artículo científico publicado en 1993

The instability of tumor promotion in relation to human cancer risk

artículo científico publicado en 1995

The multistage nature of chemically induced hepatocarcinogenesis in the rat.

artículo científico publicado en 1994

The quantitation of altered hepatic foci during multistage hepatocarcinogenesis in the rat: Transforming growth factor α expression as a marker for the stage of progression ⬇️

artículo científico publicado el 29 de junio de 1995

The role of the stages of initiation and promotion in phenotypic diversity during hepatocarcinogenesis in the rat.

artículo científico publicado en 1992

Transgene expression and repression in transgenic rats bearing the phosphoenolpyruvate carboxykinase-simian virus 40 T antigen or the phosphoenolpyruvate carboxykinase-transforming growth factor-alpha constructs

artículo científico publicado en 1999

Transgenic hepatocarcinogenesis in the rat

artículo científico publicado en 1994

Tumor promotion as a target for estrogen/antiestrogen effects in rat hepatocarcinogenesis ⬇️

artículo científico publicado el 1 de enero de 1991

Understanding drug-cytokine synergistic toxicity

artículo científico publicado en 2015

What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments?

artículo científico publicado en 2010

Lista de obras de

5-Hydroxytryptamine and the metabolism of arachidonic acid by the lipoxygenase and cyclooxygenase of washed human platelets

Acute effects of some volatile nitrites on motor performance and lethality in mice

Alterations in specific gene expression and focal neoplastic growth during spontaneous hepatocarcinogenesis in albumin-SV40 T antigen transgenic rats

An Integrated Multi-Omics Analysis Defines Key Pathway Alterations in a Diet-Induced Obesity Mouse Model

An initiation-promotion assay in rat liver as a potential complement to the 2-year carcinogenesis bioassay

An integrated study of acute effects of valproic acid in the liver using metabonomics, proteomics, and transcriptomics platforms

Animal studies addressing the carcinogenicity of TCDD (or related compounds) with an emphasis on tumour promotion

Biochemical events during initiation of rat hepatocarcinogenesis

Biochemical markers associated with the stages of promotion and progression during hepatocarcinogenesis in the rat ⬇️

Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling

Biomarkers of carcinogenicity and their roles in drug discovery and development.

Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity

Characterization of the major DNA adducts in the liver of rats chronically exposed to tamoxifen for 18 months

Characterization of the promotion of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the female rat

Chemicals, cell proliferation, risk estimation, and multistage carcinogenesis

Comparison of Basal gene expression in cultured primary rat hepatocytes and freshly isolated rat hepatocytes

Comparison of experimental and theoretical parameters of the Moolgavkar-Venzon-Knudson incidence function for the stages of initiation and promotion in rat hepatocarcinogenesis

Comparison of hepatocyte phenotypes at the glutathione transferase and albumin loci in Sprague-Dawley and Nagase analbuminemic rats and F1 progeny after initiation and promotion

Critical parameters in the quantitation of the stages of initiation, promotion, and progression in one model of hepatocarcinogenesis in the rat.

Cytogenetic analysis of three rat liver epithelial cell lines (WBneo, WBHa-ras, and WBrasIIa) and correlation of an early chromosomal alteration with insulin-like growth factor II expression

Developing microphysiological systems for use as regulatory tools--challenges and opportunities

Development of dietary soluble fibres by enzymatic synthesis and assessment of their digestibility in in vitro, animal and randomised clinical trial models.

Dietary oat lipids-induced novel DNA modifications and suppression of altered hepatic foci formation

Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells.

Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists

Doxorubicin: Comparison between 3-h continuous and bolus intravenous administration paradigms on cardio-renal axis, mitochondrial sphingolipids and pathology

Early prediction of polymyxin-induced nephrotoxicity with next-generation urinary kidney injury biomarkers

Effect of adenine nucleotides on cyclooxygenase and lipoxygenase enzyme products of arachidonic acid in human platelets

Effect of chronic administration of mestranol, tamoxifen, and toremifene on hepatic ploidy in rats

Effect of the separate and combined administration of mestranol and phenobarbital on the development of altered hepatic foci expressing placental form of glutathione S-transferase in the rat.

Effects of chronic administration of tamoxifen and toremifene on DNA adducts in rat liver, kidney, and uterus.

Effects of phenobarbital on I-compounds in liver DNA as a function of age in male rats fed two different diets ⬇️

Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver

Effects of the antiestrogens tamoxifen, toremifene, and ICI 182,780 on endometrial cancer growth

Evaluation of cellular impedance measures of cardiomyocyte cultures for drug screening applications

Evaluation of temporal changes in urine-based metabolomic and kidney injury markers to detect compound induced acute kidney tubular toxicity in beagle dogs

Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies

Facts and theories concerning the mechanisms of carcinogenesis ⬇️

Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury

Focal and non-focal hepatic expression of placental glutathione S-transferase in carcinogen-treated rats

Genome-wide loss of heterozygosity analysis of chemically induced rat hepatocellular carcinomas reveals elevated frequency of allelic imbalances on chromosomes 1, 6, 8, 11, 15, 17, and 20.

Hazard assessment of chemical carcinogens: the impact of hormesis.

Human induced pluripotent stem cells and their use in drug discovery for toxicity testing

Immunohistochemical localization and semi-quantitation of hepatic tamoxifen-DNA adducts in rats exposed orally to tamoxifen

Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B(1) as an example

Implications of hormesis on the bioassay and hazard assessment of chemical carcinogens

Improved cell typing by charge-state deconvolution of matrix-assisted laser desorption/ionization mass spectra

Incorporation of bromodeoxyuridine in glutathione S-transferase-positive hepatocytes during rat multistage hepatocarcinogenesis

Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene and idoxifene in female Sprague-Dawley rats.

Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat.

Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency

Karyotypic changes in a multistage model of chemical hepatocarcinogenesis in the rat

LETTERS TO THE EDITOR

Lessons learned in applying the U.S. EPA proposed cancer guidelines to specific compounds

Mechanisms of susceptibility to mouse liver carcinogenesis

Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS.

Microarray Analysis Using Amplified mRNA from Laser Capture Microdissection of Microscopic Hepatocellular Precancerous Lesions and Frozen Hepatocellular Carcinomas Reveals Unique and Consistent Gene Expression Profiles ⬇️

Minisymposium on emerging methods in cancer hazard identification

Mode of action in relevance of rodent liver tumors to human cancer risk.

Multiple polypeptide hormone expression in pancreatic islet cell carcinomas derived from phosphoenolpyruvatecarboxykinase-SV40 T antigen transgenic rats

Multistage hepatocarcinogenesis in the rat: insights into risk estimation

Mutational analysis of three tumor suppressor genes in two models of rat hepatocarcinogenesis.

Nakahara Memorial Lecture. Pathways of carcinogenesis--genetic and epigenetic

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.

New Phenotypic Cytotoxicity Assay for ROS-inducing Compounds using Rat Renal Epithelial Cells

Optimization of an assay for studying the effects of agents on cyclooxygenase and lipoxygenase metabolism of arachidonic acid in washed human platelets

P53-M Real-Time PCR Array for Multi-Gene Expression Profiling and Microarray Data Validation: RT2 Profiler PCR Array.

Polygenic architecture informs potential vulnerability to drug-induced liver injury

Quality control and quality assessment of data from surface-enhanced laser desorption/ionization (SELDI) time-of flight (TOF) mass spectrometry (MS).

Quantitation of multistage carcinogenesis in rat liver

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-induced Liver Injury

Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats.

Quantitative comparison of initiation and mutation phenotypes in hepatocytes of the analbuminemic rat.

Quantitative stereological studies of a 'selection' protocol of hepatocarcinogenesis following initiation in neonatal male and female rats

Rat toxicogenomic study reveals analytical consistency across microarray platforms

Review article: the stages of gastrointestinal carcinogenesis--application of rodent models to human disease

Role of altered hepatic foci in the stages of carcinogenesis

STEREO: a program on a PC-Windows 95 platform for recording and evaluating quantitative stereologic investigations of multistage hepatocarcinogenesis in rodents

Selective loss of nucleoside carrier expression in rat hepatocarcinomas.