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A Phase IIa Controlled Human Malaria Infection and Immunogenicity Study of RTS,S/AS01E and RTS,S/AS01B Delayed Fractional Dose Regimens in Malaria-Naïve Adults

artículo científico publicado en 2020

A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines

artículo científico publicado en 2012

A monoclonal antibody-based immunoassay to measure the antibody response against the repeat region of the circumsporozoite protein of Plasmodium falciparum

artículo científico publicado en 2016

A nonhuman primate model for human cerebral malaria: effects of artesunate (qinghaosu derivative) on rhesus monkeys experimentally infected with Plasmodium coatneyi

artículo científico publicado en 1993

A novel chimeric Plasmodium vivax circumsporozoite protein induces biologically functional antibodies that recognize both VK210 and VK247 sporozoites

artículo científico publicado en 2006

A phase I/IIa safety, immunogenicity, and efficacy bridging randomized study of a two-dose regimen of liquid and lyophilized formulations of the candidate malaria vaccine RTS,S/AS02A in malaria-naïve adults

artículo científico publicado en 2007

A randomized clinical trial to compare P. falciparum gametocytaemia and infectivity following blood-stage or mosquito bite induced controlled malaria infection

scientific article published on 02 April 2020

A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

artículo científico publicado en 2018

Acute eosinophilic pneumonia among US Military personnel deployed in or near Iraq

artículo científico publicado en 2004

Ad35.CS.01-RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults

artículo científico publicado en 2015

Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults

artículo científico publicado en 2011

Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component

artículo científico publicado en 2011

Adherence of Plasmodium falciparum-infected erythrocytes to chondroitin 4-sulfate

artículo científico publicado en 1999

An open-label phase 1/2a trial of a genetically modified rodent malaria parasite for immunization against Plasmodium falciparum malaria

scientific article published on 01 May 2020

Antigen-Displaying Lipid-Enveloped PLGA Nanoparticles as Delivery Agents for a Plasmodium vivax Malaria Vaccine

artículo científico publicado el 6 de febrero de 2012

Antigenic and functional differences in adhesion of Plasmodium falciparum-infected erythrocytes to human and bovine CD36

artículo científico publicado el 1 de mayo de 1993

Baculovirus-mediated expression of Plasmodium falciparum erythrocyte binding antigen 175 polypeptides and their recognition by human antibodies

artículo científico publicado el 1 de septiembre de 1997

Blood stage malaria vaccine eliciting high antigen-specific antibody concentrations confers no protection to young children in Western Kenya

artículo científico publicado en 2009

Cellular and humoral immune effector mechanisms required for sterile protection against sporozoite challenge induced with the novel malaria vaccine candidate CelTOS

artículo científico publicado el 29 de junio de 2011

Characterization of proteoglycans of human placenta and identification of unique chondroitin sulfate proteoglycans of the intervillous spaces that mediate the adherence of Plasmodium falciparum-infected erythrocytes to the placenta

artículo científico publicado en 2000

Combining antimalarial drugs and vaccine for malaria elimination campaigns: a randomized safety and immunogenicity trial of RTS,S/AS01 administered with dihydroartemisinin, piperaquine, and primaquine in healthy Thai adult volunteers

artículo científico publicado en 2019

Common and divergent immune response signaling pathways discovered in peripheral blood mononuclear cell gene expression patterns in presymptomatic and clinically apparent malaria.

artículo científico publicado en 2006

Comparative evaluation of published real-time PCR assays for the detection of malaria following MIQE guidelines

artículo científico publicado el 8 de agosto de 2013

Comparison of the immune responses induced by soluble and particulate Plasmodium vivax circumsporozoite vaccine candidates formulated in AS01 in rhesus macaques

artículo científico publicado en 2013

Complement and Antibody-mediated Enhancement of Red Blood Cell Invasion and Growth of Malaria Parasites

artículo científico publicado en 2016

Computational and experimental validation of B and T-cell epitopes of the in vivo immune response to a novel malarial antigen

artículo científico publicado en 2013

Controlled human malaria infection

artículo científico publicado en 2014

Corrigendum to: A Randomized Clinical Trial to Compare Plasmodium falciparum Gametocytemia and Infectivity After Blood-Stage or Mosquito Bite-Induced Controlled Malaria Infection

artículo científico publicado en 2020

Cutaneous Myiasis Caused by the African Tumbu Fly (Cordylobia anthropophaga)

article by Christian F Ockenhouse published 1 February 1990 in Archives of Dermatology

DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity

artículo científico publicado en 2013

Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane Antigen 1 Vaccine, FMP2.1/AS01

artículo científico publicado en 2016

Development and pre-clinical analysis of a Plasmodium falciparum Merozoite Surface Protein-1(42) malaria vaccine

artículo científico publicado en 2003

Development of a Highly Sensitive Genus-Specific Quantitative Reverse Transcriptase Real-Time PCR Assay for Detection and Quantitation of Plasmodium by Amplifying RNA and DNA of the 18S rRNA Genes

artículo científico publicado el 8 de junio de 2011

Development of a TaqMan Allelic Discrimination Assay for detection of Single Nucleotides Polymorphisms associated with anti-malarial drug resistance

artículo científico publicado el 20 de enero de 2012

Development of a chimeric Plasmodium berghei strain expressing the repeat region of the P. vivax circumsporozoite protein for in vivo evaluation of vaccine efficacy

artículo científico publicado en 2013

Devices for rapid diagnosis of Malaria: evaluation of prototype assays that detect Plasmodium falciparum histidine-rich protein 2 and a Plasmodium vivax-specific antigen

artículo científico publicado en 2003

Double-Blind, Randomized, Placebo-Controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of treating Healthcare Professionals with the Adsorbed COVID-19 (Inactivated) Vaccine Manufactured by Sinovac - PROFISCOV: A structured summary

artículo científico publicado en 2020

Effect of codon optimization on expression levels of a functionally folded malaria vaccine candidate in prokaryotic and eukaryotic expression systems

artículo científico publicado en 2003

Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria

artículo científico publicado en 2001

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand T fh cells and promote germinal center induction

artículo científico publicado el 12 de enero de 2012

Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area.

artículo científico publicado en 2009

Evaluation of immune responses to a Plasmodium vivax CSP-based recombinant protein vaccine candidate in combination with second-generation adjuvants in mice

artículo científico publicado en 2012

Evaluation of the safety and immunogenicity in rhesus monkeys of a recombinant malaria vaccine for Plasmodium vivax with a synthetic Toll-like receptor 4 agonist formulated in an emulsion

artículo científico publicado en 2011

Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8+ T-cells induced in human volunteers immunized with a Plasmodium falciparum adenovirus-vec

artículo científico publicado en 2013

Expression of genes associated with immunoproteasome processing of major histocompatibility complex peptides is indicative of protection with adjuvanted RTS,S malaria vaccine.

artículo científico publicado en 2010

Expression, purification and characterization of a functional region of the Plasmodium vivax Duffy binding protein

artículo científico publicado en 2000

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers

artículo científico publicado en 2013

Fractional Third and Fourth Dose of RTS,S/AS01 Malaria Candidate Vaccine: A Phase 2a Controlled Human Malaria Parasite Infection and Immunogenicity Study

artículo científico publicado en 2016

Full-length Plasmodium falciparum circumsporozoite protein administered with long-chain poly(I·C) or the Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant-stable emulsion elicits potent antibody and CD4+ T cell immunity and protection in mi

artículo científico publicado en 2012

Functional genomic relationships in HIV-1 disease revealed by gene-expression profiling of primary human peripheral blood mononuclear cells

artículo científico publicado en 2005

Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine

artículo científico publicado en 2015

Genome-wide expression profiling in malaria infection reveals transcriptional changes associated with lethal and nonlethal outcomes

artículo científico publicado en 2005

History of U.S. military contributions to the study of malaria

artículo científico publicado en 2005

Host-mediated selection impacts the diversity of Plasmodium falciparum antigens within infections

artículo científico publicado en 2018

Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1

artículo científico publicado el 1 de octubre de 1992

Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

artículo científico publicado en 2010

Identification, expression, and functional characterization of MAEBL, a sporozoite and asexual blood stage chimeric erythrocyte-binding protein of Plasmodium falciparum

artículo científico publicado en 2002

IgG2 antibodies against a clinical grade Plasmodium falciparum CSP vaccine antigen associate with protection against transgenic sporozoite challenge in mice

artículo científico publicado en 2014

Immunization with Pre-Erythrocytic Antigen CelTOS from Plasmodium falciparum Elicits Cross-Species Protection against Heterologous Challenge with Plasmodium berghei

artículo científico publicado el 19 de agosto de 2010

Impact of antiretroviral treatment on gene expression in peripheral blood mononuclear cells from SIVmac251-infected macaques

artículo científico

Induction of crisis forms in the human malaria parasite Plasmodium falciparum by gamma-interferon-activated, monocyte-derived macrophages

artículo científico publicado en 1984

Live Attenuated Malaria Vaccine Designed to Protect Through Hepatic CD8 + T Cell Immunity

artículo científico publicado el 8 de septiembre de 2011

Long‐Term Efficacy and Immune Responses following Immunization with the RTS,S Malaria Vaccine

artículo científico publicado el 1 de octubre de 1998

Malaria rapid diagnostic devices: performance characteristics of the ParaSight F device determined in a multisite field study.

artículo científico publicado en 2001

Malaria-induced lymphokines: stimulation of macrophages for enhanced phagocytosis

artículo científico publicado el 1 de noviembre de 1983

Measurement of parasitological data by quantitative real-time PCR from controlled human malaria infection trials at the Walter Reed Army Institute of Research

artículo científico publicado en 2014

Modelling the roles of antibody titre and avidity in protection from Plasmodium falciparum malaria infection following RTS,S/AS01 vaccination

artículo científico publicado en 2020

Multiplex qPCR for detection and absolute quantification of malaria

artículo científico publicado en 2013

Naturally elicited antibodies to glycosylphosphatidylinositols (GPIs) of Plasmodium falciparum require intact GPI structures for binding and are directed primarily against the conserved glycan moiety.

artículo científico publicado en 2006

New World monkey efficacy trials for malaria vaccine development: critical path or detour?

artículo científico publicado en 2001

Oxidative killing of malaria parasites by mononuclear phagocytes.

artículo científico publicado en 1984

Oxidative killing of the intraerythrocytic malaria parasite Plasmodium yoelii by activated macrophages.

artículo científico publicado en 1984

Parasiticidal activity of macrophages against Plasmodium

artículo científico publicado en 1986

Phase 1 randomized double-blind safety and immunogenicity trial of Plasmodium falciparum malaria merozoite surface protein FMP1 vaccine, adjuvanted with AS02A, in adults in western Kenya

artículo científico publicado en 2005

Phase 1/2a Trial of Plasmodium vivax Malaria Vaccine Candidate VMP001/AS01B in Malaria-Naive Adults: Safety, Immunogenicity, and Efficacy

artículo científico publicado en 2016

Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A.

artículo científico publicado en 2009

Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research

artículo científico publicado en 2008

Phase I safety and immunogenicity trial of FMP1/AS02A, a Plasmodium falciparum MSP-1 asexual blood stage vaccine

artículo científico publicado en 2005

Phase I/IIa safety, immunogenicity, and efficacy trial of NYVAC-Pf7, a pox-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria.

artículo científico publicado en 1998

Phenotypic characterization of Plasmodium berghei responsive CD8+ T cells after immunization with live sporozoites under chloroquine cover

artículo científico publicado en 2014

Plasmodium falciparum Cytoadherence to Human Placenta: Evaluation of Hyaluronic Acid and Chondroitin 4-Sulfate for Binding of Infected Erythrocytes

artículo científico publicado el 1 de octubre de 2001

Pre-clinical evaluation of a -based whole-sporozoite malaria vaccine candidate

scholarly article by António M Mendes et al published 2018 in npj Vaccines

Predicting RTS,S Vaccine-Mediated Protection from Transcriptomes in a Malaria-Challenge Clinical Trial

artículo científico publicado en 2017

Primaquine failure and cytochrome P-450 2D6 in Plasmodium vivax malaria

artículo científico publicado en 2013

Process development for the production of an E. coli produced clinical grade recombinant malaria vaccine for Plasmodium vivax

artículo científico publicado en 2009

Protective efficacy of a Plasmodium vivax circumsporozoite protein-based vaccine in Aotus nancymaae is associated with antibodies to the repeat region

artículo científico publicado en 2014

Purification, characterization, and immunogenicity of a disulfide cross-linked Plasmodium vivax vaccine candidate antigen, merozoite surface protein 1, expressed in Escherichia coli

artículo científico publicado en 2001

RTS,S malaria vaccine efficacy and immunogenicity during Plasmodium falciparum challenge is associated with HLA genotype

artículo científico publicado en 2018

Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection

artículo científico publicado en 2009

Rapid identification of Leishmania complexes by a real-time PCR assay.

artículo científico publicado en 2005

Rapid whole genome optical mapping of Plasmodium falciparum

artículo científico

Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-gamma/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection

artículo científico publicado en 2009

Report of a consultation on the optimization of clinical challenge trials for evaluation of candidate blood stage malaria vaccines, 18-19 March 2009, Bethesda, MD, USA.

artículo científico publicado en 2009

Results from tandem Phase 1 studies evaluating the safety, reactogenicity and immunogenicity of the vaccine candidate antigen Plasmodium falciparum FVO merozoite surface protein-1 (MSP1(42)) administered intramuscularly with adjuvant system AS01.

artículo científico publicado en 2013

Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01B With Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP.

artículo científico publicado en 2016

Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission

artículo científico publicado en 2016

Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study in healthy adults

article

Sample-ready multiplex qPCR assay for detection of malaria

artículo científico publicado en 2014

Self-Adjuvanting Bacterial Vectors Expressing Pre-Erythrocytic Antigens Induce Sterile Protection Against Malaria

artículo científico publicado el 4 de julio de 2013

Sequential Phase 1 and Phase 2 randomized, controlled trials of the safety, immunogenicity and efficacy of combined pre-erythrocytic vaccine antigens RTS,S and TRAP formulated with AS02 Adjuvant System in healthy, malaria naïve adults

artículo científico publicado en 2014

Sequential waves of gene expression in patients with clinically defined dengue illnesses reveal subtle disease phases and predict disease severity

artículo científico publicado en 2013

Sequestrin, a CD36 recognition protein on Plasmodium falciparum malaria-infected erythrocytes identified by anti-idiotype antibodies

artículo científico publicado en 1991

Sialic acid-dependent binding of baculovirus-expressed recombinant antigens from Plasmodium falciparum EBA-175 to Glycophorin A.

artículo científico publicado en 2001

Structural basis for antibody recognition of the NANP repeats in Plasmodium falciparum circumsporozoite protein

artículo científico publicado en 2017

Structural requirements for the adherence of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate proteoglycans of human placenta

artículo científico publicado en 2000

Surveillance for malaria elimination in Swaziland: a national cross-sectional study using pooled PCR and serology

artículo científico publicado en 2012

Systems analysis of protective immune responses to RTS,S malaria vaccination in humans

artículo científico publicado en 2017

The RTS,S vaccine candidate for malaria

artículo científico publicado el 1 de mayo de 2011

The Ratiometric Transcript Signature MX2/GPR183 Is Consistently Associated With RTS,S-Mediated Protection Against Controlled Human Malaria Infection

artículo científico publicado en 2020

The biological function of antibodies induced by the RTS,S/AS01 malaria vaccine candidate is determined by their fine specificity

artículo científico publicado en 2016

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

artículo científico publicado el 20 de junio de 2013

The relationship between RTS,S vaccine-induced antibodies, CD4⁺ T cell responses and protection against Plasmodium falciparum infection

artículo científico publicado en 2013

Towards an RTS,S-based, multi-stage, multi-antigen vaccine against falciparum malaria: progress at the Walter Reed Army Institute of Research.

artículo científico publicado en 2005

Transfusion-associated babesiosis with an atypical time course after nonmyeloablative transplantation for sickle cell disease

artículo científico publicado en 2008

Transgenic parasites stably expressing full-length Plasmodium falciparum circumsporozoite protein as a model for vaccine down-selection in mice using sterile protection as an endpoint

artículo científico publicado en 2013

Ultrastructural Localization of CD36 in Human Hepatic Sinusoidal Lining Cells, Hepatocytes, Human Hepatoma (HepG2-A16) Cells, and C32 Amelanotic Melanoma Cells

artículo científico publicado el 1 de noviembre de 1994

Viral vectors for malaria vaccine development

artículo científico publicado en 2006

Visceral leishmaniasis: clinical observations in 4 US army soldiers deployed to Afghanistan or Iraq, 2002-2004

scientific article published on 01 September 2007