Lista de obras -

"Lineage addiction" in human cancer: lessons from integrated genomics

artículo científico publicado en 2005

A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

artículo científico publicado en 2017

ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens

artículo científico publicado en 2012

Absolute quantification of somatic DNA alterations in human cancer

artículo científico publicado en 2012

Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

artículo científico publicado en 2005

Allele-specific amplification in cancer revealed by SNP array analysis

artículo científico publicado en 2005

Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers

artículo científico publicado en 2011

Amplification of chromosomal segment 4q12 in non-small cell lung cancer

artículo científico publicado en 2009

An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer.

artículo científico publicado en 2013

BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS.

artículo científico publicado en 2017

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

artículo científico publicado en 2017

Cancer vulnerabilities unveiled by genomic loss

artículo científico publicado en 2012

Characterizing genomic alterations in cancer by complementary functional associations

artículo científico publicado en 2016

Characterizing the cancer genome in lung adenocarcinoma

artículo científico publicado en 2007

Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma

artículo científico publicado en 2009

Clinical, epidemiologic and bacteriologic observations of an outbreak of methicillin-resistant Staphylococcus aureus at a large community hospital

artículo científico publicado el 1 de septiembre de 1976

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

artículo científico publicado en 2017

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.

artículo científico publicado en 2017

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

artículo científico

Defining a Cancer Dependency Map.

artículo científico publicado en 2017

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

artículo científico publicado en 2015

Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

artículo científico publicado en 2008

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

artículo científico publicado en 2016

Genomic approaches to lung cancer

artículo científico publicado en 2006

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

artículo científico publicado en 2016

Highly parallel identification of essential genes in cancer cells

scholarly article

Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis

artículo científico publicado en 2005

Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy

artículo científico publicado en 2015

In Situ Evidence of KRAS Amplification and Association With Increased p21 Levels in Non–Small Cell Lung Carcinoma

article

In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene

artículo científico publicado en 2014

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

artículo científico publicado en 2010

Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.

artículo científico publicado en 2014

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

article published in 2018

Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

artículo científico publicado en 2012

MEDULLOBLASTOMA

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

artículo científico publicado en 2016

Major copy proportion analysis of tumor samples using SNP arrays

artículo científico publicado en 2008

Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe

artículo científico publicado en 2004

Next-generation characterization of the Cancer Cell Line Encyclopedia

artículo científico publicado en 2019

PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

artículo científico publicado en 2012

PDTM-36. FUNCTIONAL GENOMIC ANALYSIS OF -AMPLIFIED MEDULLOBLASTOMA NOMINATES THE TGFB PATHWAY AS A CLINICALLY VIABLE TARGET

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

artículo científico publicado en 2017

PLASQ: a generalized linear model-based procedure to determine allelic dosage in cancer cells from SNP array data

artículo científico publicado en 2006

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

artículo científico publicado en 2017

PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR

artículo científico publicado en 2009

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

artículo científico publicado en 2014

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

artículo científico publicado en 2014

Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions

scientific article published on 18 May 2009

Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer

artículo científico publicado en 2010

Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer

artículo científico publicado en 2013

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas ⬇️

artículo científico publicado en 2009

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

scientific article published on 01 August 2019

Small-molecule targeting of brachyury transcription factor addiction in chordoma

scientific article published on 21 January 2019

Somatic alterations in the human cancer genome

artículo científico publicado en 2004

Somatic mutations affect key pathways in lung adenocarcinoma

artículo científico publicado en 2008

Standard Specimens for Stain Calibration: Application to Romanowsky-Giemsa Staining ⬇️

artículo científico publicado el 1 de enero de 1990

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

artículo científico publicado en 2010

Synthetic lethality between CCNE1 amplification and loss of BRCA1.

artículo científico publicado en 2013

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

artículo científico publicado en 2009

Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.

artículo científico publicado en 2013

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

artículo científico publicado en 2011

TTF1 expression in non-small cell lung carcinoma: association with TTF1 gene amplification and improved survival

artículo científico publicado en 2009

Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4

artículo científico publicado en 2012

The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.

artículo científico publicado en 2016

The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer

artículo científico publicado en 2014

The landscape of somatic copy-number alteration across human cancers

artículo científico publicado en 2010

The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272.

artículo científico publicado en 2007

Towards patient-based cancer therapeutics

artículo científico publicado en 2010

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

artículo científico publicado en 2012

Lista de obras de

"Lineage addiction" in human cancer: lessons from integrated genomics

A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines

ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens

Absolute quantification of somatic DNA alterations in human cancer

Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis

Allele-specific amplification in cancer revealed by SNP array analysis

Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers

Amplification of chromosomal segment 4q12 in non-small cell lung cancer

An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer.

BIOL-04. INTEGRATED COPY-NUMBER AND CANCER DEPENDENCY ANALYSIS REVEALS ALTERED SPLICEOSOME STOICHIOMETRY AS A NOVEL VULNERABILITY IN GENOMICALLY DISRUPTED CANCERS.

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

Cancer vulnerabilities unveiled by genomic loss

Characterizing genomic alterations in cancer by complementary functional associations

Characterizing the cancer genome in lung adenocarcinoma

Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma

Clinical, epidemiologic and bacteriologic observations of an outbreak of methicillin-resistant Staphylococcus aureus at a large community hospital

Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells.

Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

Defining a Cancer Dependency Map.

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

Genomic approaches to lung cancer

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

Highly parallel identification of essential genes in cancer cells

Homozygous deletions and chromosome amplifications in human lung carcinomas revealed by single nucleotide polymorphism array analysis

Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy

In Situ Evidence of KRAS Amplification and Association With Increased p21 Levels in Non–Small Cell Lung Carcinoma

In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene

Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1

Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

MEDULLOBLASTOMA

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

Major copy proportion analysis of tumor samples using SNP arrays

Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast Schizosaccharomyces pombe

Next-generation characterization of the Cancer Cell Line Encyclopedia

PAK1 is a breast cancer oncogene that coordinately activates MAPK and MET signaling

PDTM-36. FUNCTIONAL GENOMIC ANALYSIS OF -AMPLIFIED MEDULLOBLASTOMA NOMINATES THE TGFB PATHWAY AS A CLINICALLY VIABLE TARGET

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

PLASQ: a generalized linear model-based procedure to determine allelic dosage in cancer cells from SNP array data

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions

Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer

Resistance to CDK2 inhibitors is associated with selection of polyploid cells in CCNE1-amplified ovarian cancer

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas ⬇️

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

Small-molecule targeting of brachyury transcription factor addiction in chordoma

Somatic alterations in the human cancer genome

Somatic mutations affect key pathways in lung adenocarcinoma

Standard Specimens for Stain Calibration: Application to Romanowsky-Giemsa Staining ⬇️

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

Synthetic lethality between CCNE1 amplification and loss of BRCA1.

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.

Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

TTF1 expression in non-small cell lung carcinoma: association with TTF1 gene amplification and improved survival

Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4

The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.

The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer

The landscape of somatic copy-number alteration across human cancers

The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272.

Towards patient-based cancer therapeutics

β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis