Lista de obras -

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

article

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

article

A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing

scientific article published on 21 September 2018

A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation

artículo científico publicado en 2004

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

artículo científico publicado en 2009

Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer

artículo científico publicado en 2018

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation.

artículo científico publicado en 2016

CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation.

artículo científico publicado en 2017

Characterizing genomic alterations in cancer by complementary functional associations

artículo científico publicado en 2016

Clonal Selection Drives NF-κB Activation in Recurrent Nasopharyngeal Carcinoma

scientific article published on 01 December 2019

Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

artículo científico publicado en 2019

Cytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors

artículo científico publicado en 2016

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

artículo científico

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

scientific article published on 01 November 2018

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

scientific article published on 01 January 2019

Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases

artículo científico publicado en 2020

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors

artículo científico publicado en 2014

Doxycycline: new tricks for an old drug.

artículo científico publicado en 2015

Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade

artículo científico publicado en 2020

ER stress signaling promotes the survival of cancer 'persister cells' tolerant to EGFR tyrosine kinase inhibitors

artículo científico publicado en 2017

EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer

artículo científico publicado en 2021

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

artículo científico publicado en 2017

Fine needle aspirate flow cytometric phenotyping characterizes immunosuppressive nature of the mesothelioma microenvironment.

artículo científico publicado en 2016

Functional genomics and cancer drug target discovery.

scientific article published on June 2010

Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors

artículo científico publicado en 2018

Highly parallel identification of essential genes in cancer cells

scholarly article

Inactivation of Fbxw7 impairs dsRNA sensing and confers resistance to PD-1 blockade

artículo científico publicado en 2020

Inflammation as a driver and vulnerability of KRAS mediated oncogenesis

artículo científico publicado en 2016

Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.

artículo científico publicado en 2014

Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer

artículo científico publicado en 2020

Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation

artículo científico publicado en 2015

Mechanisms of resistance to immune checkpoint inhibitors

artículo científico publicado en 2018

Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling

artículo científico publicado en 2015

MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6

artículo científico publicado en 2017

Molecular and Genomic Determinants of Response to Immune Checkpoint Inhibition in Cancer.

artículo científico publicado en 2017

Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107.

artículo científico publicado en 2003

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

artículo científico publicado en 2000

Nuclear organization of DNA replication in primary mammalian cells.

artículo científico publicado en 2000

Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit

artículo científico publicado en 2004

Nuclear tumor suppressors in space and time.

artículo científico publicado en 2005

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

artículo científico publicado en 2018

Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma.

artículo científico publicado en 2018

Phase 1B Study of Momelotinib Combined With Trametinib in Metastatic, Kirsten Rat Sarcoma Viral Oncogene Homolog-Mutated Non-Small-Cell Lung Cancer After Platinum-Based Chemotherapy Treatment Failure

artículo científico publicado en 2018

Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer

scientific article published on 29 October 2019

Plasma inflammatory cytokines and survival of pancreatic cancer patients.

artículo científico publicado en 2018

RASA1/NF1 mutant lung cancer: Racing to the clinic?

artículo científico publicado en 2018

RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest

artículo científico publicado en 2001

Refining Targeted Therapy Opportunities for BRAF-Mutant Melanoma

artículo científico publicado en 2017

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

artículo científico publicado en 2014

Response to Crizotinib in a Patient With Lung Adenocarcinoma Harboring a MET Splice Site Mutation

artículo científico publicado en 2015

Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

artículo científico publicado en 2019

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.

artículo científico publicado en 2016

Structure and ubiquitination-dependent activation of TANK-binding kinase 1.

scientific article published on 28 February 2013

Suppression of STING associated with LKB1 loss in KRAS-driven lung cancer

article

Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non-Small Cell Lung Cancer

artículo científico publicado en 2017

Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

artículo científico publicado en 2009

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

artículo científico publicado en 2009

Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.

artículo científico publicado en 2013

Systemic mastocytosis: current classification and novel therapeutic options.

artículo científico publicado en 2006

TBK1 Activation by VHL Loss in Renal Cell Carcinoma: A Novel HIF-Independent Vulnerability

artículo científico publicado en 2020

Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth

artículo científico publicado en 2014

Targeting cytokine networks in KRAS-driven tumorigenesis.

artículo científico publicado en 2014

Targeting pathways downstream of KRAS in lung adenocarcinoma

artículo científico publicado en 2014

Targeting the mutant p53 secretome

artículo científico publicado en 2021

Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor

artículo científico publicado en 2014

The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity.

artículo científico publicado en 2017

The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy

artículo científico publicado en 2018

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

artículo científico publicado en 2020

Tumor SQSTM1 (p62) expression and T cells in colorectal cancer.

artículo científico publicado en 2017

Tumor cGAMP Awakens the Natural Killers

artículo científico publicado en 2018

Tumor-Derived cGAMP Regulates Activation of the Vasculature

scientific article published on 04 September 2020

Turnaround Time of Plasma Next-Generation Sequencing in Thoracic Oncology Patients: A Quality Improvement Analysis

artículo científico publicado en 2020

Use of Ex Vivo Patient-Derived Tumor Organotypic Spheroids to Identify Combination Therapies for HER2 Mutant Non-Small Cell Lung Cancer

artículo científico publicado en 2020

Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine

artículo científico publicado en 2014

Lista de obras de

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

A High-Throughput Immune-Oncology Screen Identifies EGFR Inhibitors as Potent Enhancers of Antigen-Specific Cytotoxic T-lymphocyte Tumor Cell Killing

A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation.

CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation.

Characterizing genomic alterations in cancer by complementary functional associations

Clonal Selection Drives NF-κB Activation in Recurrent Nasopharyngeal Carcinoma

Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer

Cytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors

Doxycycline: new tricks for an old drug.

Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade

ER stress signaling promotes the survival of cancer 'persister cells' tolerant to EGFR tyrosine kinase inhibitors

EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Fine needle aspirate flow cytometric phenotyping characterizes immunosuppressive nature of the mesothelioma microenvironment.

Functional genomics and cancer drug target discovery.

Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors

Highly parallel identification of essential genes in cancer cells

Inactivation of Fbxw7 impairs dsRNA sensing and confers resistance to PD-1 blockade

Inflammation as a driver and vulnerability of KRAS mediated oncogenesis

Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.

Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer

Long-term Benefit of PD-L1 Blockade in Lung Cancer Associated with JAK3 Activation

Mechanisms of resistance to immune checkpoint inhibitors

Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling

MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6

Molecular and Genomic Determinants of Response to Immune Checkpoint Inhibition in Cancer.

Mullerian Inhibiting Substance inhibits cervical cancer cell growth via a pathway involving p130 and p107.

NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription

Nuclear organization of DNA replication in primary mammalian cells.

Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit

Nuclear tumor suppressors in space and time.

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma.

Phase 1B Study of Momelotinib Combined With Trametinib in Metastatic, Kirsten Rat Sarcoma Viral Oncogene Homolog-Mutated Non-Small-Cell Lung Cancer After Platinum-Based Chemotherapy Treatment Failure

Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer

Plasma inflammatory cytokines and survival of pancreatic cancer patients.

RASA1/NF1 mutant lung cancer: Racing to the clinic?

RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest

Refining Targeted Therapy Opportunities for BRAF-Mutant Melanoma

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia

Response to Crizotinib in a Patient With Lung Adenocarcinoma Harboring a MET Splice Site Mutation

Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.

Structure and ubiquitination-dependent activation of TANK-binding kinase 1.

Suppression of STING associated with LKB1 loss in KRAS-driven lung cancer

Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non-Small Cell Lung Cancer

Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.

Systemic mastocytosis: current classification and novel therapeutic options.

TBK1 Activation by VHL Loss in Renal Cell Carcinoma: A Novel HIF-Independent Vulnerability

Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth

Targeting cytokine networks in KRAS-driven tumorigenesis.

Targeting pathways downstream of KRAS in lung adenocarcinoma

Targeting the mutant p53 secretome

Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor

The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity.

The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

Tumor SQSTM1 (p62) expression and T cells in colorectal cancer.

Tumor cGAMP Awakens the Natural Killers

Tumor-Derived cGAMP Regulates Activation of the Vasculature

Turnaround Time of Plasma Next-Generation Sequencing in Thoracic Oncology Patients: A Quality Improvement Analysis

Use of Ex Vivo Patient-Derived Tumor Organotypic Spheroids to Identify Combination Therapies for HER2 Mutant Non-Small Cell Lung Cancer

Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine