Lista de obras -

A Vitamin E-Enriched Antioxidant Diet Interferes with the Acute Adaptation of the Liver to Physical Exercise in Mice.

artículo científico publicado en 2018

A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance

artículo científico publicado en 2006

Acute regulation of metabolic genes and insulin receptor substrates in the liver of mice by one single bout of treadmill exercise

artículo científico publicado en 2008

Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP.

artículo científico publicado en 2017

Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell lines

artículo científico publicado en 2005

Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity

artículo científico publicado en 2014

Circulating Follistatin Is Liver-Derived and Regulated by the Glucagon-to-Insulin Ratio

artículo científico publicado en 2015

Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity

artículo científico publicado en 2013

Comprehensive Profiling by Non-targeted Stable Isotope Tracing Capillary Electrophoresis-Mass Spectrometry: A New Tool Complementing Metabolomic Analyses of Polar Metabolites

artículo científico publicado en 2019

Cytokine response of primary human myotubes in an in vitro exercise model

artículo científico publicado en 2013

DEUS: an R package for accurate small RNA profiling based on differential expression of unique sequences

artículo científico publicado en 2019

Development and precise characterization of phospho-site-specific antibody of Ser(357) of IRS-1: elimination of cross reactivity with adjacent Ser(358).

artículo científico publicado en 2008

Differential regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcription

artículo científico publicado en 2007

Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells

artículo científico publicado en 2006

Divergent Roles of IRS (Insulin Receptor Substrate) 1 and 2 in Liver and Skeletal Muscle

artículo científico publicado en 2017

Do diabetes and obesity affect the metabolic response to exercise?

artículo científico publicado en 2017

Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain

scientific article published on April 2010

Evidence for a novel TGF-beta1-independent mechanism of fibronectin production in mesangial cells overexpressing glucose transporters

artículo científico publicado en 2003

Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK1 in lung fibrosis

artículo científico publicado en 2002

Exercise and diabetes: relevance and causes for response variability

artículo científico publicado en 2016

Exercise, skeletal muscle and inflammation: ARE-binding proteins as key regulators in inflammatory and adaptive networks

artículo científico

Exercise-Induced Secretion of FGF21 and Follistatin Are Blocked by Pancreatic Clamp and Impaired in Type 2 Diabetes

artículo científico publicado en 2016

Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells

artículo científico publicado en 2014

Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts

artículo científico publicado en 2010

GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis

artículo científico publicado en 2016

Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia ⬇️

artículo científico publicado el 4 de abril de 2011

Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans

artículo científico publicado en 2015

Hepatokines-a novel group of exercise factors

artículo científico publicado en 2018

How insulin receptor substrate proteins regulate the metabolic capacity of the liver--implications for health and disease

scientific article published on January 2008

Identification and regulation of xenometabolite derivatives cis- and trans-3,4-methylene-heptanoylcarnitine in plasma and skeletal muscle of exercising humans

artículo científico publicado en 2020

Identification of novel putative adipomyokines by a cross-species annotation of secretomes and expression profiles.

artículo científico publicado en 2015

Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573

scientific journal article

Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha

artículo científico publicado en 2006

Independent component analysis in non-hypothesis driven metabolomics: improvement of pattern discovery and simplification of biological data interpretation demonstrated with plasma samples of exercising humans

artículo científico publicado en 2012

Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo

artículo científico publicado en 2009

Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity

artículo científico publicado en 2008

Insulin glulisine: insulin receptor signaling characteristics in vivo

artículo científico publicado en 2005

Insulin sensitivity is reflected by characteristic metabolic fingerprints--a Fourier transform mass spectrometric non-targeted metabolomics approach

artículo científico publicado en 2010

Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907

artículo científico publicado el 23 de noviembre de 2010

Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes

artículo científico publicado en 2005

Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt.

artículo científico publicado en 2005

Interleukin-6 promotes myogenic differentiation of mouse skeletal muscle cells: role of the STAT3 pathway ⬇️

artículo científico publicado el 31 de octubre de 2012

Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cells

artículo científico publicado en 2008

Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1.

artículo científico publicado en 2006

Letter to the Editor: Comment on “FGF21 Response to Critical Illness: Effect of Blood Glucose Control and Relation With Cellular Stress and Survival” by Thiessen S.E., et al

article

Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints

scientific article published on 18 June 2019

Lipidomics analysis reveals efficient storage of hepatic triacylglycerides enriched in unsaturated fatty acids after one bout of exercise in mice

artículo científico publicado en 2010

Liver and Muscle Contribute Differently to the Plasma Acylcarnitine Pool During Fasting and Exercise in Humans

artículo científico publicado en 2016

Lysophosphatidylcholines activate PPARδ and protect human skeletal muscle cells from lipotoxicity

artículo científico publicado en 2016

Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation

artículo científico publicado en 2010

Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals

artículo científico publicado en 2014

Methods for Proteomics-Based Analysis of the Human Muscle Secretome Using an In Vitro Exercise Model

article

Mice Lacking Free Fatty Acid Receptor 1 (GPR40/FFAR1) are Protected Against Conjugated Linoleic Acid-Induced Fatty Liver but Develop Inflammation and Insulin Resistance in the Brain

artículo científico publicado en 2015

Mitochondrial substrate availability and its role in lipid-induced insulin resistance and proinflammatory signaling in skeletal muscle.

artículo científico publicado en 2013

Muscle and liver-specific alterations in lipid and acylcarnitine metabolism after a single bout of exercise in mice

artículo científico publicado en 2016

Muscle-Liver Substrate Fluxes in Exercising Humans and Potential Effects on Hepatic Metabolism

scientific article published on 01 April 2020

Nasal insulin administration does not affect hepatic glucose production at systemic fasting insulin levels

artículo científico publicado en 2019

PI3K-resistant GSK3 controls adiponectin formation and protects from metabolic syndrome

artículo científico publicado en 2016

PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38

scientific journal article

Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB.

artículo científico publicado en 2004

Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferase

artículo científico publicado en 2003

Partial characterisation of the human GFAT promoter: effect of single nucleotide polymorphisms on promoter function

artículo científico publicado en 2005

Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells

artículo científico publicado en 2008

Phosphorylation of Serine 1137/1138 of Mouse Insulin Receptor Substrate (IRS) 2 Regulates cAMP-dependent Binding to 14-3-3 Proteins and IRS2 Protein Degradation ⬇️

artículo científico publicado el 24 de abril de 2013

Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis

Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors

artículo científico publicado en 2013

Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1

artículo científico publicado en 2004

Purity matters: A workflow for the valid high-resolution lipid profiling of mitochondria from cell culture samples

artículo científico publicado en 2016

Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood

artículo científico publicado en 2018

Regulation of cytosolic pH and lactic acid release in mesangial cells overexpressing GLUT1.

artículo científico publicado en 2003

Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects

artículo científico publicado en 2020

Role of glucoxidation and lipid oxidation in the development of atherosclerosis.

artículo científico publicado en 2005

Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation

artículo científico publicado en 2006

Secretome profiling of primary human skeletal muscle cells

artículo científico publicado en 2013

Sense or antisense? False priming reverse transcription controls are required for determining sequence orientation by reverse transcription-PCR

scientific article published on 05 July 2007

Simultaneous extraction of metabolome and lipidome with methyl tert-butyl ether from a single small tissue sample for ultra-high performance liquid chromatography/mass spectrometry ⬇️

artículo científico publicado el 13 de mayo de 2013

Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations

artículo científico publicado en 2017

Stable isotope-assisted lipidomics combined with nontargeted isotopomer filtering, a tool to unravel the complex dynamics of lipid metabolism

artículo científico publicado en 2013

Suitability of hepatocyte cell lines HepG2, AML12 and THLE-2 for investigation of insulin signalling and hepatokine gene expression

article

TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle

artículo científico publicado en 2016

The -913 G/A glutamine:fructose-6-phosphate aminotransferase gene polymorphism is associated with measures of obesity and intramyocellular lipid content in nondiabetic subjects

artículo científico publicado en 2005

The CCR2 promoter polymorphism T-960A, but not the serum MCP-1 level, is associated with endothelial function in prediabetic individuals

artículo científico publicado en 2007

The effect of differentiation and TGFβ on mitochondrial respiration and mitochondrial enzyme abundance in cultured primary human skeletal muscle cells

artículo científico publicado en 2018

The impact of insulin resistance on the kidney and vasculature

artículo científico publicado en 2016

The lipid profile of brown adipose tissue is sex-specific in mice

artículo científico publicado en 2014

The phosphorylation of Ser318 of insulin receptor substrate 1 is not per se inhibitory in skeletal muscle cells but is necessary to trigger the attenuation of the insulin-stimulated signal

artículo científico publicado en 2005

The role of interleukin-6 in insulin resistance, body fat distribution and energy balance

artículo científico publicado en 2007

The secretome of the working human skeletal muscle--a promising opportunity to combat the metabolic disaster?

artículo científico

The stress response of the liver to physical exercise

artículo científico publicado el 1 de enero de 2010

Toll‐like receptors 2 and 4 impair insulin‐mediated brain activity by interleukin‐6 and osteopontin and alter sleep architecture ⬇️

artículo científico publicado el 25 de enero de 2012

Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery

artículo científico publicado en 2015

Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells: role of IL-6 mRNA stabilization and Ca2+-dependent mechanisms.

artículo científico publicado en 2007

Upstream stimulatory factor (USF) proteins induce human TGF-beta1 gene activation via the glucose-response element-1013/-1002 in mesangial cells: up-regulation of USF activity by the hexosamine biosynthetic pathway

artículo científico publicado en 2004

c-Fos-driven transcriptional activation of transforming growth factor β-1: inhibition of high glucose-induced promoter activity by thiazolidinediones ⬇️

artículo científico publicado el 2 de mayo de 2003

cGMP-dependent protein kinase I (cGKI) modulates human hepatic stellate cell activation

scientific article published on 06 September 2018

Lista de obras de

A Vitamin E-Enriched Antioxidant Diet Interferes with the Acute Adaptation of the Liver to Physical Exercise in Mice.

A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance

Acute regulation of metabolic genes and insulin receptor substrates in the liver of mice by one single bout of treadmill exercise

Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP.

Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell lines

Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity

Circulating Follistatin Is Liver-Derived and Regulated by the Glucagon-to-Insulin Ratio

Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity

Comprehensive Profiling by Non-targeted Stable Isotope Tracing Capillary Electrophoresis-Mass Spectrometry: A New Tool Complementing Metabolomic Analyses of Polar Metabolites

Cytokine response of primary human myotubes in an in vitro exercise model

DEUS: an R package for accurate small RNA profiling based on differential expression of unique sequences

Development and precise characterization of phospho-site-specific antibody of Ser(357) of IRS-1: elimination of cross reactivity with adjacent Ser(358).

Differential regulation of serum- and glucocorticoid-inducible kinase 1 (SGK1) splice variants based on alternative initiation of transcription

Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells

Divergent Roles of IRS (Insulin Receptor Substrate) 1 and 2 in Liver and Skeletal Muscle

Do diabetes and obesity affect the metabolic response to exercise?

Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain

Evidence for a novel TGF-beta1-independent mechanism of fibronectin production in mesangial cells overexpressing glucose transporters

Excessive transcription of the human serum and glucocorticoid dependent kinase hSGK1 in lung fibrosis

Exercise and diabetes: relevance and causes for response variability

Exercise, skeletal muscle and inflammation: ARE-binding proteins as key regulators in inflammatory and adaptive networks

Exercise-Induced Secretion of FGF21 and Follistatin Are Blocked by Pancreatic Clamp and Impaired in Type 2 Diabetes

Fetuin-A influences vascular cell growth and production of proinflammatory and angiogenic proteins by human perivascular fat cells

Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts

GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis

Genetic Ablation of cGMP-Dependent Protein Kinase Type I Causes Liver Inflammation and Fasting Hyperglycemia ⬇️

Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans

Hepatokines-a novel group of exercise factors

How insulin receptor substrate proteins regulate the metabolic capacity of the liver--implications for health and disease

Identification and regulation of xenometabolite derivatives cis- and trans-3,4-methylene-heptanoylcarnitine in plasma and skeletal muscle of exercising humans

Identification of novel putative adipomyokines by a cross-species annotation of secretomes and expression profiles.

Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573

Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha

Independent component analysis in non-hypothesis driven metabolomics: improvement of pattern discovery and simplification of biological data interpretation demonstrated with plasma samples of exercising humans

Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo

Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity

Insulin glulisine: insulin receptor signaling characteristics in vivo

Insulin sensitivity is reflected by characteristic metabolic fingerprints--a Fourier transform mass spectrometric non-targeted metabolomics approach

Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907

Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes

Interleukin-6 acts as insulin sensitizer on glycogen synthesis in human skeletal muscle cells by phosphorylation of Ser473 of Akt.

Interleukin-6 promotes myogenic differentiation of mouse skeletal muscle cells: role of the STAT3 pathway ⬇️

Interplay and effects of temporal changes in the phosphorylation state of serine-302, -307, and -318 of insulin receptor substrate-1 on insulin action in skeletal muscle cells

Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1.

Letter to the Editor: Comment on “FGF21 Response to Critical Illness: Effect of Blood Glucose Control and Relation With Cellular Stress and Survival” by Thiessen S.E., et al

Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints

Lipidomics analysis reveals efficient storage of hepatic triacylglycerides enriched in unsaturated fatty acids after one bout of exercise in mice

Liver and Muscle Contribute Differently to the Plasma Acylcarnitine Pool During Fasting and Exercise in Humans

Lysophosphatidylcholines activate PPARδ and protect human skeletal muscle cells from lipotoxicity

Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation

Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals

Methods for Proteomics-Based Analysis of the Human Muscle Secretome Using an In Vitro Exercise Model

Mice Lacking Free Fatty Acid Receptor 1 (GPR40/FFAR1) are Protected Against Conjugated Linoleic Acid-Induced Fatty Liver but Develop Inflammation and Insulin Resistance in the Brain

Mitochondrial substrate availability and its role in lipid-induced insulin resistance and proinflammatory signaling in skeletal muscle.

Muscle and liver-specific alterations in lipid and acylcarnitine metabolism after a single bout of exercise in mice

Muscle-Liver Substrate Fluxes in Exercising Humans and Potential Effects on Hepatic Metabolism

Nasal insulin administration does not affect hepatic glucose production at systemic fasting insulin levels

PI3K-resistant GSK3 controls adiponectin formation and protects from metabolic syndrome

PKC zeta enhances insulin-like growth factor 1-dependent mitogenic activity in the rat clonal beta cell line RIN 1046-38

Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB.

Palmitate-induced activation of the hexosamine pathway in human myotubes: increased expression of glutamine:fructose-6-phosphate aminotransferase

Partial characterisation of the human GFAT promoter: effect of single nucleotide polymorphisms on promoter function

Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells

Phosphorylation of Serine 1137/1138 of Mouse Insulin Receptor Substrate (IRS) 2 Regulates cAMP-dependent Binding to 14-3-3 Proteins and IRS2 Protein Degradation ⬇️

Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis

Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors

Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1

Purity matters: A workflow for the valid high-resolution lipid profiling of mitochondria from cell culture samples

Quality Control of Serum and Plasma by Quantification of (4E,14Z)-Sphingadienine-C18-1-Phosphate Uncovers Common Preanalytical Errors During Handling of Whole Blood

Regulation of cytosolic pH and lactic acid release in mesangial cells overexpressing GLUT1.

Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects

Role of glucoxidation and lipid oxidation in the development of atherosclerosis.

Saturated, but not unsaturated, fatty acids induce apoptosis of human coronary artery endothelial cells via nuclear factor-kappaB activation

Secretome profiling of primary human skeletal muscle cells

Sense or antisense? False priming reverse transcription controls are required for determining sequence orientation by reverse transcription-PCR

Simultaneous extraction of metabolome and lipidome with methyl tert-butyl ether from a single small tissue sample for ultra-high performance liquid chromatography/mass spectrometry ⬇️

Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations

Stable isotope-assisted lipidomics combined with nontargeted isotopomer filtering, a tool to unravel the complex dynamics of lipid metabolism

Suitability of hepatocyte cell lines HepG2, AML12 and THLE-2 for investigation of insulin signalling and hepatokine gene expression