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A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms

scientific article published on 01 August 2002

An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation

artículo científico publicado en 2015

Arterial shear stress regulates endothelial cell-directed migration, polarity, and morphology in confluent monolayers

artículo científico publicado en 2007

Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation

artículo científico publicado en 2010

Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming

artículo científico publicado en 2007

Biomechanical activation of vascular endothelium as a determinant of its functional phenotype.

artículo científico publicado en 2001

Capillary sprout endothelial cells exhibit a CD36 low phenotype: regulation by shear stress and vascular endothelial growth factor-induced mechanism for attenuating anti-proliferative thrombospondin-1 signaling

artículo científico publicado en 2008

Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis

artículo científico publicado en 2009

Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis

artículo científico publicado en 2016

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature.

scholarly article

Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice

artículo científico publicado en 2012

Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice

artículo científico publicado en 2008

Exposure of Induced Pluripotent Stem Cell-Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell-Like Phenotypes.

artículo científico publicado en 2017

GRP78 upregulation by atheroprone shear stress via p38-, alpha2beta1-dependent mechanism in endothelial cells

artículo científico publicado en 2008

Hemodynamic Activation of β-Catenin and T-Cell-Specific Transcription Factor Signaling in Vascular Endothelium Regulates Fibronectin Expression ⬇️

artículo científico publicado el 28 de abril de 2011

Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro

artículo científico publicado en 2013

Hemodynamics and Mechanobiology of Endothelium

Hemodynamics associated with atrial fibrillation directly alters thrombotic potential of endothelial cells.

artículo científico publicado en 2016

Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow

artículo científico publicado en 2009

Human haemodynamic frequency harmonics regulate the inflammatory phenotype of vascular endothelial cells

artículo científico publicado en 2013

In vitro cell shearing device to investigate the dynamic response of cells in a controlled hydrodynamic environment

artículo científico publicado en 2000

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype ⬇️

artículo científico publicado el 23 de septiembre de 2010

Matrix rigidity regulates cancer cell growth by modulating cellular metabolism and protein synthesis

artículo científico publicado en 2012

Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis.

artículo científico publicado en 2007

Mechanical properties of the extracellular matrix alter expression of smooth muscle protein LPP and its partner palladin; relationship to early atherosclerosis and vascular injury

artículo científico publicado en 2009

Mechanisms of Amplified Arteriogenesis in Collateral Artery Segments Exposed to Reversed Flow Direction

artículo científico publicado en 2015

Mechanisms of mechanotransduction.

artículo científico publicado en 2006

Mechanosensitive endothelial gene expression profiles: scripts for the role of hemodynamics in atherogenesis?

artículo científico publicado en 2001

Organotypic systems in drug metabolism and toxicity: challenges and opportunities ⬇️

artículo científico publicado el 26 de mayo de 2012

PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

artículo científico publicado en 2008

Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system

artículo científico publicado en 2016

Selective modulation of endothelial cell [Ca2+]i response to flow by the onset rate of shear stress

artículo científico publicado en 2000

Small molecule inducers of angiogenesis for tissue engineering

artículo científico publicado en 2006

Spatial and spectral heterogeneity of time-varying shear stress profiles in the carotid bifurcation by phase-contrast MRI.

artículo científico publicado en 2006

Three‐dimensional phase contrast angiography of the mouse aortic arch using spiral MRI ⬇️

artículo científico publicado el 7 de junio de 2011

Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes

artículo científico publicado en 2015

p21-activated kinase signaling regulates oxidant-dependent NF-kappa B activation by flow.

artículo científico publicado en 2008

Lista de obras de

A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms

An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation

Arterial shear stress regulates endothelial cell-directed migration, polarity, and morphology in confluent monolayers

Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation

Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming

Biomechanical activation of vascular endothelium as a determinant of its functional phenotype.

Capillary sprout endothelial cells exhibit a CD36 low phenotype: regulation by shear stress and vascular endothelial growth factor-induced mechanism for attenuating anti-proliferative thrombospondin-1 signaling

Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis

Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis

Distinct endothelial phenotypes evoked by arterial waveforms derived from atherosclerosis-susceptible and -resistant regions of human vasculature.

Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice

Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice

Exposure of Induced Pluripotent Stem Cell-Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell-Like Phenotypes.

GRP78 upregulation by atheroprone shear stress via p38-, alpha2beta1-dependent mechanism in endothelial cells

Hemodynamic Activation of β-Catenin and T-Cell-Specific Transcription Factor Signaling in Vascular Endothelium Regulates Fibronectin Expression ⬇️

Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro

Hemodynamics and Mechanobiology of Endothelium

Hemodynamics associated with atrial fibrillation directly alters thrombotic potential of endothelial cells.

Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow

Human haemodynamic frequency harmonics regulate the inflammatory phenotype of vascular endothelial cells

In vitro cell shearing device to investigate the dynamic response of cells in a controlled hydrodynamic environment

Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype ⬇️

Matrix rigidity regulates cancer cell growth by modulating cellular metabolism and protein synthesis

Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis.

Mechanical properties of the extracellular matrix alter expression of smooth muscle protein LPP and its partner palladin; relationship to early atherosclerosis and vascular injury

Mechanisms of Amplified Arteriogenesis in Collateral Artery Segments Exposed to Reversed Flow Direction

Mechanisms of mechanotransduction.

Mechanosensitive endothelial gene expression profiles: scripts for the role of hemodynamics in atherogenesis?

Organotypic systems in drug metabolism and toxicity: challenges and opportunities ⬇️

PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns

Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system

Selective modulation of endothelial cell [Ca2+]i response to flow by the onset rate of shear stress

Small molecule inducers of angiogenesis for tissue engineering

Spatial and spectral heterogeneity of time-varying shear stress profiles in the carotid bifurcation by phase-contrast MRI.

Three‐dimensional phase contrast angiography of the mouse aortic arch using spiral MRI ⬇️

Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes

p21-activated kinase signaling regulates oxidant-dependent NF-kappa B activation by flow.