Lista de obras -

A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides

artículo científico publicado en 2017

An automated system for the analysis of G protein-coupled receptor transmembrane binding pockets: alignment, receptor-based pharmacophores, and their application

artículo científico publicado en 2005

Besca, a single-cell transcriptomics analysis toolkit to accelerate translational research

artículo científico

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

artículo científico publicado en 2017

Boolean regulatory network reconstruction using literature based knowledge with a genetic algorithm optimization method

artículo científico publicado en 2016

Brain Shuttle Antibody for Alzheimer's Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode

artículo científico publicado en 2018

Cargo Delivery into the Brain by in vivo identified Transport Peptides

artículo científico publicado en 2015

Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.

artículo científico publicado en 2015

Characterization of a human pluripotent stem cell-derived model of neuronal development using multiplexed targeted proteomics

artículo científico publicado en 2015

Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis

artículo científico publicado en 2009

Correction to: Detect tissue heterogeneity in gene expression data with BioQC

artículo científico publicado en 2018

Detect tissue heterogeneity in gene expression data with BioQC.

artículo científico publicado en 2017

Detection of attractors of large Boolean networks via exhaustive enumeration of appropriate subspaces of the state space

artículo científico publicado en 2013

Development of a 5-plex SILAC method tuned for the quantitation of tyrosine phosphorylation dynamics

artículo científico publicado en 2013

Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 ( SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

scientific article published on 25 July 2018

Effects of copper on CHO cells: insights from gene expression analyses

artículo científico publicado en 2014

Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter

artículo científico publicado en 2007

Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter

artículo científico publicado en 2008

Epithelial cells as active player in fibrosis: findings from an in vitro model

artículo científico publicado en 2013

Erratum to: Pathway reporter genes define molecular phenotypes of human cells

artículo científico publicado en 2017

Evolutionary relationships of the Tas2r receptor gene families in mouse and human

scientific journal article

Expanding the Imine Reductase Toolbox by Exploring the Bacterial Protein-Sequence Space

artículo científico publicado en 2015

Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression

artículo científico publicado en 2012

Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage

artículo científico publicado en 2011

First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils.

artículo científico publicado en 2018

Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing

artículo científico publicado en 2020

Functional analysis and transcriptional output of the Göttingen minipig genome

artículo científico publicado en 2015

Genome-based analysis of the nonhuman primate Macaca fascicularis as a model for drug safety assessment

artículo científico publicado en 2011

Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model.

artículo científico publicado en 2016

Hematopoietically expressed homeobox is a target gene of farnesoid X receptor in chenodeoxycholic acid-induced liver hypertrophy

artículo científico publicado en 2009

High throughput transcriptome analysis of lipid metabolism in Syrian hamster liver in absence of an annotated genome.

artículo científico publicado en 2013

High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing.

artículo científico publicado en 2012

Highly sensitive amplicon-based transcript quantification by semiconductor sequencing

artículo científico publicado en 2014

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice.

artículo científico publicado en 2018

Image analysis for TSH mRNA in situ hybridization in pituitary glands from rats with thyroid follicular cell hypertrophy after treatment with three different test compounds

artículo científico publicado en 2017

Impaired myogenic development, differentiation and function in hESC-derived SMA myoblasts and myotubes

artículo científico publicado en 2018

In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu) and active metabolite

artículo científico publicado en 2009

Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype ⬇️

artículo científico

Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery.

artículo científico publicado en 2017

Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy

artículo científico publicado en 2014

Multiscale modelling of drug mechanism and safety

artículo científico publicado en 2019

Neuronal periodicity detection as a basis for the perception of consonance: a mathematical model of tonal fusion

artículo científico publicado en 2008

Novel sequence variants in dysferlin-deficient muscular dystrophy leading to mRNA decay and possible C2-domain misfolding.

artículo científico publicado en 2006

Pathway reporter genes define molecular phenotypes of human cells

artículo científico publicado en 2015

Rewriting the (tran)script: Application to spinal muscular atrophy

artículo científico publicado en 2019

Single base mismatches in the mRNA target site allow specific seed region-mediated off-target binding of siRNA targeting human coagulation factor 7 ⬇️

artículo científico publicado el 1 de enero de 2012

Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptor ⬇️

artículo científico publicado el 4 de abril de 2011

Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes.

artículo científico publicado en 2018

The CRTC1-SIK1 pathway regulates entrainment of the circadian clock

scientific journal article

The genomic organization and expression pattern of the low-affinity Fc gamma receptors (FcγR) in the Göttingen minipig

The immunogenicity of antibody aggregates in a novel transgenic mouse model

artículo científico publicado en 2015

The small interferon-induced transmembrane genes and proteins

artículo científico publicado en 2010

Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors

artículo científico publicado en 2005

White-to-brown metabolic conversion of human adipocytes by JAK inhibition

artículo científico publicado en 2014

mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis

artículo científico publicado en 2016

Lista de obras de

A Sensitive In Vitro Approach to Assess the Hybridization-Dependent Toxic Potential of High Affinity Gapmer Oligonucleotides

An automated system for the analysis of G protein-coupled receptor transmembrane binding pockets: alignment, receptor-based pharmacophores, and their application

Besca, a single-cell transcriptomics analysis toolkit to accelerate translational research

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

Boolean regulatory network reconstruction using literature based knowledge with a genetic algorithm optimization method

Brain Shuttle Antibody for Alzheimer's Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode

Cargo Delivery into the Brain by in vivo identified Transport Peptides

Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.

Characterization of a human pluripotent stem cell-derived model of neuronal development using multiplexed targeted proteomics

Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis

Correction to: Detect tissue heterogeneity in gene expression data with BioQC

Detect tissue heterogeneity in gene expression data with BioQC.

Detection of attractors of large Boolean networks via exhaustive enumeration of appropriate subspaces of the state space

Development of a 5-plex SILAC method tuned for the quantitation of tyrosine phosphorylation dynamics

Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 ( SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Effects of copper on CHO cells: insights from gene expression analyses

Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter

Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter

Epithelial cells as active player in fibrosis: findings from an in vitro model

Erratum to: Pathway reporter genes define molecular phenotypes of human cells

Evolutionary relationships of the Tas2r receptor gene families in mouse and human

Expanding the Imine Reductase Toolbox by Exploring the Bacterial Protein-Sequence Space

Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression

Farnesoid X receptor protects human and murine gastric epithelial cells against inflammation-induced damage

First Infusion Reactions are Mediated by FcγRIIIb and Neutrophils.

Focus on germ-layer markers: A human stem cell-based model for in vitro teratogenicity testing

Functional analysis and transcriptional output of the Göttingen minipig genome

Genome-based analysis of the nonhuman primate Macaca fascicularis as a model for drug safety assessment

Genomic analysis of the molecular neuropathology of tuberous sclerosis using a human stem cell model.

Hematopoietically expressed homeobox is a target gene of farnesoid X receptor in chenodeoxycholic acid-induced liver hypertrophy

High throughput transcriptome analysis of lipid metabolism in Syrian hamster liver in absence of an annotated genome.

High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing.

Highly sensitive amplicon-based transcript quantification by semiconductor sequencing

Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice.

Image analysis for TSH mRNA in situ hybridization in pituitary glands from rats with thyroid follicular cell hypertrophy after treatment with three different test compounds

Impaired myogenic development, differentiation and function in hESC-derived SMA myoblasts and myotubes

In vitro pharmacological selectivity profile of oseltamivir prodrug (Tamiflu) and active metabolite

Modeling the Effects of Severe Metabolic Disease by Genome Editing of hPSC-Derived Endothelial Cells Reveals an Inflammatory Phenotype ⬇️

Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery.

Motor neuron disease. SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy

Multiscale modelling of drug mechanism and safety

Neuronal periodicity detection as a basis for the perception of consonance: a mathematical model of tonal fusion

Novel sequence variants in dysferlin-deficient muscular dystrophy leading to mRNA decay and possible C2-domain misfolding.

Pathway reporter genes define molecular phenotypes of human cells

Rewriting the (tran)script: Application to spinal muscular atrophy

Single base mismatches in the mRNA target site allow specific seed region-mediated off-target binding of siRNA targeting human coagulation factor 7 ⬇️

Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptor ⬇️

Targeting RNA structure in SMN2 reverses spinal muscular atrophy molecular phenotypes.

The CRTC1-SIK1 pathway regulates entrainment of the circadian clock

The genomic organization and expression pattern of the low-affinity Fc gamma receptors (FcγR) in the Göttingen minipig

The immunogenicity of antibody aggregates in a novel transgenic mouse model

The small interferon-induced transmembrane genes and proteins

Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors

White-to-brown metabolic conversion of human adipocytes by JAK inhibition

mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis