Lista de obras -

A biophysical analysis of the tetratricopeptide repeat-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable, and unfolds via a multistate pathway

artículo científico publicado en 2004

A common fold mediates vertebrate defense and bacterial attack

artículo científico publicado en 2007

A family of E. coli expression vectors for laboratory scale and high throughput soluble protein production

artículo científico publicado en 2006

A method for the incremental expansion of polyglutamine repeats in recombinant proteins

artículo científico publicado en 2013

A protein family under 'stress' - serpin stability, folding and misfolding

artículo científico publicado en 2005

A structural basis for loop C-sheet polymerization in serpins

artículo científico publicado en 2008

Acid Denaturation of alpha1-antitrypsin: characterization of a novel mechanism of serpin polymerization.

artículo científico publicado en 2002

Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap

artículo científico publicado en 2007

Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection

artículo científico publicado en 2005

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

artículo científico publicado en 2009

Antithrombin: in control of coagulation

artículo científico publicado en 2004

Cleaved antitrypsin polymers at atomic resolution

artículo científico publicado en 2000

Conformational change in the chromatin remodelling protein MENT

artículo científico publicado en 2009

Conformational properties of the disease-causing Z variant of α1-antitrypsin revealed by theory and experiment

artículo científico publicado en 2012

Crystal structure of a UDP-glucose-specific glycosyltransferase from a Mycobacterium species

artículo científico publicado en 2008

Crystallization and X-ray analysis of a single fab binding domain from protein L of Peptostreptococcus magnus

artículo científico publicado en 1995

DNA accelerates the inhibition of human cathepsin V by serpins

artículo científico publicado en 2007

Destabilization of a non-pathological variant of ataxin-3 results in fibrillogenesis via a partially folded intermediate: a model for misfolding in polyglutamine disease.

artículo científico publicado en 2004

Determination of the P1', P2' and P3' subsite-specificity of factor Xa.

artículo científico publicado en 2003

Different conformational changes within the F-helix occur during serpin folding, polymerization, and proteinase inhibition

artículo científico publicado en 2004

Discovery of amino acid motifs for thrombin cleavage and validation using a model substrate

artículo científico publicado en 2011

Dissection of Protease-Activated Receptor-1-Dependent and -Independent Responses to Thrombin in Skeletal Myoblasts

article

Enhanced molecular mobility of ordinarily structured regions drives polyglutamine disease

artículo científico publicado en 2015

Enhancing the stability and solubility of TEV protease using in silico design

artículo científico publicado en 2007

Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases

artículo científico publicado en 2002

Expression and purification of the human thrombin receptor

artículo científico publicado en 1998

Expression, purification and characterization of recombinant Z alpha(1)-antitrypsin--the most common cause of alpha(1)-antitrypsin deficiency.

artículo científico publicado en 2009

Flanking domain stability modulates the aggregation kinetics of a polyglutamine disease protein

artículo científico publicado en 2011

Functional insights from the distribution and role of homopeptide repeat-containing proteins

artículo científico publicado en 2005

Generation and expression of a minimal hybrid Ig-receptor formed between single domains from proteins L and G.

artículo científico publicado en 2007

Human embryonic stem cell models of Huntington disease.

artículo científico publicado en 2009

Identification and Characterization of a Misfolded Monomeric Serpin Formed at Physiological Temperature ⬇️

artículo científico publicado el 17 de septiembre de 2010

Identification of residual structure within denatured antichymotrypsin: implications for serpin folding and misfolding

artículo científico publicado en 2004

In vitro and in silico design of alpha1-antitrypsin mutants with different conformational stabilities

artículo científico publicado en 2003

Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation

artículo científico publicado en 2002

Intracellular Production of Recombinant Serpins in Yeast

article

Introduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability

artículo científico publicado en 2003

Kinetic instability of the serpin Z alpha1-antitrypsin promotes aggregation.

artículo científico publicado en 2009

Mechanisms of Ataxin-3 Misfolding and Fibril Formation: Kinetic Analysis of a Disease-associated Polyglutamine Protein

article

Methods to Measure the Kinetics of Protease Inhibition by Serpins

article

Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide

artículo científico publicado en 2002

Molecular gymnastics: serpin structure, folding and misfolding

artículo científico publicado en 2006

Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion

artículo científico publicado en 2004

Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin

artículo científico publicado en 2012

Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase.

artículo científico publicado en 2014

PFD: a database for the investigation of protein folding kinetics and stability

artículo científico publicado en 2005

Physical characterization of serpin conformations

artículo científico publicado en 2004

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells.

artículo científico publicado en 2016

PolyQ: a database describing the sequence and domain context of polyglutamine repeats in proteins ⬇️

artículo científico publicado el 8 de noviembre de 2010

Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease.

artículo científico publicado en 2004

Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding

artículo científico publicado en 2008

Probing the folding pathway of a consensus serpin using single tryptophan mutants

artículo científico publicado en 2018

Probing the role of the F-helix in serpin stability through a single tryptophan substitution

artículo científico publicado en 2002

Probing the unfolding pathway of alpha1-antitrypsin.

artículo científico publicado en 1999

Production of recombinant serpins in Escherichia coli.

artículo científico publicado en 2004

Promiscuous beta-strand interactions and the conformational diseases.

artículo científico publicado en 2004

Protease-activated receptor-2 mediates proliferative responses in skeletal myoblasts

scientific article published on 01 December 2000

Protein expression and refolding--a practical guide to getting the most out of inclusion bodies

artículo científico publicado en 2004

Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin.

artículo científico publicado en 2015

Purification of polyglutamine proteins.

artículo científico publicado en 2006

REFOLD: an analytical database of protein refolding methods

artículo científico publicado en 2005

Recombinant caspase-3 expressed in Pichia pastoris is fully activated and kinetically indistinguishable from the native enzyme.

artículo científico publicado en 1997

Recombinant protein quality evaluation: proposal for a minimal information standard

artículo científico publicado en 2011

Refolding Your Protein with a Little Help from REFOLD

artículo científico publicado en 2011

Serpin acceleration of amyloid fibril formation: a role for accessory proteins

artículo científico publicado en 2006

Serpin polymerization and its role in disease--the molecular basis of alpha1-antitrypsin deficiency

artículo científico publicado en 2009

Serpins 2005 - fun between the beta-sheets. Meeting report based upon presentations made at the 4th International Symposium on Serpin Structure, Function and Biology (Cairns, Australia).

artículo científico publicado en 2005

Serpins flex their muscle. I. PUTTING THE CLAMPS ON PROTEOLYSIS IN DIVERSE BIOLOGICAL SYSTEMS.

artículo científico publicado en 2010

Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems

artículo científico publicado en 2010

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions

artículo científico publicado en 2010

Serpins in Prokaryotes

Serpins in the Caenorhabditis elegans genome

scientific article published on 01 July 1999

Serpins in theCaenorhabditis elegans genome

scholarly article by James C. Whisstock published in July 1999

Serpins' mystery solved

artículo científico publicado en 2008

Serpins: finely balanced conformational traps

artículo científico publicado en 2002

Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation.

artículo científico publicado en 2010

Smoothing a rugged protein folding landscape by sequence-based redesign

artículo científico publicado en 2016

Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis

artículo científico publicado en 2008

Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3

article

Structural change in β-sheet A of Z α(1)-antitrypsin is responsible for accelerated polymerization and disease

artículo científico publicado en 2011

Structure of a serpin-enzyme complex probed by cysteine substitutions and fluorescence spectroscopy

artículo científico publicado en 2001

The 1.5 A crystal structure of a prokaryote serpin: controlling conformational change in a heated environment

artículo científico publicado en 2003

The 1.5 Å Crystal Structure of a Prokaryote Serpin

article

The N terminus of the serpin, tengpin, functions to trap the metastable native state

artículo científico publicado en 2007

The REFOLD database: a tool for the optimization of protein expression and refolding

artículo científico publicado en 2006

The Rate of PolyQ-Mediated Aggregation Is Dramatically Affected by the Number and Location of Surrounding Domains

artículo científico publicado en 2011

The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes

artículo científico publicado en 2009

The Subtilisin-Like Protease AprV2 Is Required for Virulence and Uses a Novel Disulphide-Tethered Exosite to Bind Substrates

artículo científico publicado en 2010

The Z mutation alters the global structural dynamics of α1-antitrypsin

artículo científico publicado en 2014

The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition

artículo científico publicado en 2004

The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix

artículo científico publicado en 2005

The human serpin proteinase inhibitor-9 self-associates at physiological temperatures

artículo científico publicado en 2004

The inositol polyphosphate 5-phosphatases and the apurinic/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis

artículo científico publicado en 2000

The loss of tryptophan 194 in antichymotrypsin lowers the kinetic barrier to misfolding

artículo científico publicado en 2007

The matrix refolded

article

The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins

artículo científico publicado en 2005

The role of protein misfolding in the pathogenesis of human diseases.

artículo científico publicado en 2004

The role of strand 1 of the C beta-sheet in the structure and function of alpha(1)-antitrypsin

artículo científico publicado en 2001

The roles of helix I and strand 5A in the folding, function and misfolding of α1-antitrypsin

artículo científico publicado en 2013

The selective inhibition of serpin aggregation by the molecular chaperone, alpha-crystallin, indicates a nucleation-dependent specificity

artículo científico publicado en 2003

The structural impact of a polyglutamine tract is location-dependent

artículo científico publicado en 2008

The structure of H-2K(b) and K(bm8) complexed to a herpes simplex virus determinant: evidence for a conformational switch that governs T cell repertoire selection and viral resistance

artículo científico publicado en 2004

The two-stage pathway of ataxin-3 fibrillogenesis involves a polyglutamine-independent step.

artículo científico publicado en 2006

Thrombin, a Survival Factor for Cultured Myoblasts

scientific article published in Journal of Biological Chemistry

Tracking the unfolding pathway of a multirepeat protein via tryptophan scanning: evidence of localized instability in the mitochondrial import receptor Tom70.

artículo científico publicado en 2006

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation

artículo científico publicado en 2006

α1-Antitrypsin Polymerisation Can Occur by both Loop A and C Sheet Mechanisms

artículo científico publicado en 1998

Lista de obras de

A biophysical analysis of the tetratricopeptide repeat-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable, and unfolds via a multistate pathway

A common fold mediates vertebrate defense and bacterial attack

A family of E. coli expression vectors for laboratory scale and high throughput soluble protein production

A method for the incremental expansion of polyglutamine repeats in recombinant proteins

A protein family under 'stress' - serpin stability, folding and misfolding

A structural basis for loop C-sheet polymerization in serpins

Acid Denaturation of alpha1-antitrypsin: characterization of a novel mechanism of serpin polymerization.

Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap

Antagonism of antiviral and allogeneic activity of a human public CTL clonotype by a single altered peptide ligand: implications for allograft rejection

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

Antithrombin: in control of coagulation

Cleaved antitrypsin polymers at atomic resolution

Conformational change in the chromatin remodelling protein MENT

Conformational properties of the disease-causing Z variant of α1-antitrypsin revealed by theory and experiment

Crystal structure of a UDP-glucose-specific glycosyltransferase from a Mycobacterium species

Crystallization and X-ray analysis of a single fab binding domain from protein L of Peptostreptococcus magnus

DNA accelerates the inhibition of human cathepsin V by serpins

Destabilization of a non-pathological variant of ataxin-3 results in fibrillogenesis via a partially folded intermediate: a model for misfolding in polyglutamine disease.

Determination of the P1', P2' and P3' subsite-specificity of factor Xa.

Different conformational changes within the F-helix occur during serpin folding, polymerization, and proteinase inhibition

Discovery of amino acid motifs for thrombin cleavage and validation using a model substrate

Dissection of Protease-Activated Receptor-1-Dependent and -Independent Responses to Thrombin in Skeletal Myoblasts

Enhanced molecular mobility of ordinarily structured regions drives polyglutamine disease

Enhancing the stability and solubility of TEV protease using in silico design

Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases

Expression and purification of the human thrombin receptor

Expression, purification and characterization of recombinant Z alpha(1)-antitrypsin--the most common cause of alpha(1)-antitrypsin deficiency.

Flanking domain stability modulates the aggregation kinetics of a polyglutamine disease protein

Functional insights from the distribution and role of homopeptide repeat-containing proteins

Generation and expression of a minimal hybrid Ig-receptor formed between single domains from proteins L and G.

Human embryonic stem cell models of Huntington disease.

Identification and Characterization of a Misfolded Monomeric Serpin Formed at Physiological Temperature ⬇️

Identification of residual structure within denatured antichymotrypsin: implications for serpin folding and misfolding

In vitro and in silico design of alpha1-antitrypsin mutants with different conformational stabilities

Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation

Intracellular Production of Recombinant Serpins in Yeast

Introduction of a mutation in the shutter region of antithrombin (Phe77 --> Leu) increases affinity for heparin and decreases thermal stability

Kinetic instability of the serpin Z alpha1-antitrypsin promotes aggregation.

Mechanisms of Ataxin-3 Misfolding and Fibril Formation: Kinetic Analysis of a Disease-associated Polyglutamine Protein

Methods to Measure the Kinetics of Protease Inhibition by Serpins

Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide

Molecular gymnastics: serpin structure, folding and misfolding

Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion

Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin

Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase.

PFD: a database for the investigation of protein folding kinetics and stability

Physical characterization of serpin conformations

Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells.

PolyQ: a database describing the sequence and domain context of polyglutamine repeats in proteins ⬇️

Polyglutamine expansion in ataxin-3 does not affect protein stability: implications for misfolding and disease.

Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding

Probing the folding pathway of a consensus serpin using single tryptophan mutants

Probing the role of the F-helix in serpin stability through a single tryptophan substitution

Probing the unfolding pathway of alpha1-antitrypsin.

Production of recombinant serpins in Escherichia coli.

Promiscuous beta-strand interactions and the conformational diseases.

Protease-activated receptor-2 mediates proliferative responses in skeletal myoblasts

Protein expression and refolding--a practical guide to getting the most out of inclusion bodies

Protein unfolding is essential for cleavage within the α-helix of a model protein substrate by the serine protease, thrombin.

Purification of polyglutamine proteins.

REFOLD: an analytical database of protein refolding methods

Recombinant caspase-3 expressed in Pichia pastoris is fully activated and kinetically indistinguishable from the native enzyme.

Recombinant protein quality evaluation: proposal for a minimal information standard

Refolding Your Protein with a Little Help from REFOLD

Serpin acceleration of amyloid fibril formation: a role for accessory proteins

Serpin polymerization and its role in disease--the molecular basis of alpha1-antitrypsin deficiency

Serpins 2005 - fun between the beta-sheets. Meeting report based upon presentations made at the 4th International Symposium on Serpin Structure, Function and Biology (Cairns, Australia).

Serpins flex their muscle. I. PUTTING THE CLAMPS ON PROTEOLYSIS IN DIVERSE BIOLOGICAL SYSTEMS.

Serpins flex their muscle: I. Putting the clamps on proteolysis in diverse biological systems

Serpins flex their muscle: II. Structural insights into target peptidase recognition, polymerization, and transport functions

Serpins in Prokaryotes

Serpins in the Caenorhabditis elegans genome

Serpins in theCaenorhabditis elegans genome

Serpins' mystery solved

Serpins: finely balanced conformational traps

Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation.

Smoothing a rugged protein folding landscape by sequence-based redesign

Structural and biochemical characterization of the oxidoreductase NmDsbA3 from Neisseria meningitidis

Structural and functional analysis of the Josephin domain of the polyglutamine protein ataxin-3