Lista de obras -

5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor

artículo científico publicado en 2009

5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical ad

artículo científico publicado en 2010

8-OH-DPAT influences extracellular levels of serotonin and dopamine in the medial preoptic area of male rats ⬇️

artículo científico publicado el 20 de abril de 1998

A Selective Novel Peroxisome Proliferator-Activated Receptor (PPAR)-α Antagonist Induces Apoptosis and Inhibits Proliferation of CLL Cells In Vitro and In Vivo

artículo científico publicado en 2015

A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye

artículo científico publicado en 2009

A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model

artículo científico publicado en 2010

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

scientific article published on 27 September 2016

Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment

artículo científico publicado en 2002

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma ⬇️

artículo científico publicado el 1 de mayo de 2011

Castration decreases extracellular, but increases intracellular, dopamine in medial preoptic area of male rats ⬇️

artículo científico publicado el 26 de enero de 1998

Comparison of the effects of diazepam, the CRF1 antagonist CP-154,526 and the group II mGlu receptor agonist LY379268 on stress-evoked extracellular norepinephrine levels

artículo científico publicado en 2005

Copulation increases dopamine activity in the medial preoptic area of male rats

artículo científico publicado en 1993

DP2 (CRTh2) Antagonism Reduces Ocular Inflammation Induced by Allergen Challenge and Respiratory Syncytial Virus ⬇️

artículo científico publicado el 28 de octubre de 2011

Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis ⬇️

artículo científico publicado el 11 de enero de 2011

Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies

scientific article published on 21 December 2018

Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition

scientific article published on 03 January 2008

Dopamine release in the medial preoptic area of female rats in response to hormonal manipulation and sexual activity

artículo científico publicado en 2000

Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.

artículo científico publicado en 2003

Effects of morphiceptin in the medial preoptic area on male sexual behavior

artículo científico publicado en 1995

Estrogen receptor (ER) subtype agonists alter monoamine levels in the female rat brain

artículo científico publicado en 2010

Extracellular Serotonin in the Lateral Hypothalamic Area Is Increased during the Postejaculatory Interval and Impairs Copulation in Male Rats ⬇️

artículo científico publicado el 1 de diciembre de 1997

Extracellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation.

artículo científico publicado en 1995

Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge

artículo científico publicado en 2003

Hormone-neurotransmitter interactions in the control of sexual behavior

artículo científico publicado en 1999

Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination.

artículo científico publicado en 2016

Identification of the first potent, selective and bioavailable PPARα antagonist

scientific article published on 04 April 2014

In vitro and in vivo pharmacology of NXT629, a novel and selective PPARα antagonist

artículo científico publicado en 2017

In vivo pharmacological characterization of (+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thiophenol hydrochloride (SIB-1553A), a novel cholinergic ligand: microdialysis studies

artículo científico publicado en 2003

Lateral hypothalamic serotonin inhibits nucleus accumbens dopamine: implications for sexual satiety

artículo científico publicado en 1999

Mesoaccumbens dopamine and the self-administration of amphetamine

artículo científico publicado en 1999

Nitric oxide increases dopamine and serotonin release in the medial preoptic area

artículo científico publicado en 1993

Nitric oxide promotes medial preoptic dopamine release during male rat copulation.

artículo científico publicado en 1996

Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis

scientific article published on 25 June 2009

Partial antagonism of 8-OH-DPAT'S effects on male rat sexual behavior with a D2, but not a 5-HT1A, antagonist

artículo científico publicado en 1999

Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP).

artículo científico publicado en 2010

Pharmacokinetic and Pharmacodynamic Characterization of an Oral Lysophosphatidic Acid Type 1 Receptor-Selective Antagonist ⬇️

artículo científico publicado el 15 de diciembre de 2010

Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung

artículo científico publicado en 2009

Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces

artículo científico publicado en 2009

Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation

artículo científico publicado en 2011

Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation

scientific journal article

Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor

artículo científico publicado en 2004

Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule

artículo científico publicado en 2000

Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine

artículo científico publicado en 2011

Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors

artículo científico publicado en 2019

Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine.

artículo científico publicado en 2002

Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist

artículo científico publicado en 2010

Testosterone, Preoptic Dopamine, and Copulation in Male Rats ⬇️

artículo científico publicado el 1 de enero de 1997

The Antinociceptive Effect of the Asthma Drug Ibudilast in Rat Models of Peripheral and Central Neuropathic Pain ⬇️

artículo científico publicado el 19 de octubre de 2011

The effect of previous exposure to amphetamine on drug-induced locomotion and self-administration of a low dose of the drug

artículo científico publicado en 1999

The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. III: The mechanistic basis for supersensitivity to the LSD stimulus following serotonin depletion

scientific article published on 01 October 1995

The roles of nitric oxide in sexual function of male rats

artículo científico publicado en 1994

Therapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammation

artículo científico publicado en 2010

Lista de obras de

5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor

5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical ad

8-OH-DPAT influences extracellular levels of serotonin and dopamine in the medial preoptic area of male rats ⬇️

A Selective Novel Peroxisome Proliferator-Activated Receptor (PPAR)-α Antagonist Induces Apoptosis and Inhibits Proliferation of CLL Cells In Vitro and In Vivo

A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye

A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment

Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma ⬇️

Castration decreases extracellular, but increases intracellular, dopamine in medial preoptic area of male rats ⬇️

Comparison of the effects of diazepam, the CRF1 antagonist CP-154,526 and the group II mGlu receptor agonist LY379268 on stress-evoked extracellular norepinephrine levels

Copulation increases dopamine activity in the medial preoptic area of male rats

DP2 (CRTh2) Antagonism Reduces Ocular Inflammation Induced by Allergen Challenge and Respiratory Syncytial Virus ⬇️

Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis ⬇️

Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies

Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition

Dopamine release in the medial preoptic area of female rats in response to hormonal manipulation and sexual activity

Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.

Effects of morphiceptin in the medial preoptic area on male sexual behavior

Estrogen receptor (ER) subtype agonists alter monoamine levels in the female rat brain

Extracellular Serotonin in the Lateral Hypothalamic Area Is Increased during the Postejaculatory Interval and Impairs Copulation in Male Rats ⬇️

Extracellular dopamine in the medial preoptic area: implications for sexual motivation and hormonal control of copulation.

Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge

Hormone-neurotransmitter interactions in the control of sexual behavior

Identification of the Kappa-Opioid Receptor as a Therapeutic Target for Oligodendrocyte Remyelination.

Identification of the first potent, selective and bioavailable PPARα antagonist

In vitro and in vivo pharmacology of NXT629, a novel and selective PPARα antagonist

In vivo pharmacological characterization of (+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thiophenol hydrochloride (SIB-1553A), a novel cholinergic ligand: microdialysis studies

Lateral hypothalamic serotonin inhibits nucleus accumbens dopamine: implications for sexual satiety

Mesoaccumbens dopamine and the self-administration of amphetamine

Nitric oxide increases dopamine and serotonin release in the medial preoptic area

Nitric oxide promotes medial preoptic dopamine release during male rat copulation.

Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis

Partial antagonism of 8-OH-DPAT'S effects on male rat sexual behavior with a D2, but not a 5-HT1A, antagonist

Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP).

Pharmacokinetic and Pharmacodynamic Characterization of an Oral Lysophosphatidic Acid Type 1 Receptor-Selective Antagonist ⬇️

Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung

Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces

Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation

Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation

Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor

Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule

Previous exposure to delta9-tetrahydrocannibinol enhances locomotor responding to but not self-administration of amphetamine

Selective Estrogen Receptor Modulators Enhance CNS Remyelination Independent of Estrogen Receptors

Sensitization of midbrain dopamine neuron reactivity promotes the pursuit of amphetamine.

Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist

Testosterone, Preoptic Dopamine, and Copulation in Male Rats ⬇️

The Antinociceptive Effect of the Asthma Drug Ibudilast in Rat Models of Peripheral and Central Neuropathic Pain ⬇️

The effect of previous exposure to amphetamine on drug-induced locomotion and self-administration of a low dose of the drug

The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. III: The mechanistic basis for supersensitivity to the LSD stimulus following serotonin depletion

The roles of nitric oxide in sexual function of male rats

Therapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammation