Lista de obras -

4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase

artículo científico publicado en 2008

5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

artículo científico publicado en 2009

5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

artículo científico publicado en 2008

Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors

artículo científico publicado en 2008

Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

artículo científico publicado en 2004

Carbon dioxide-in-water microemulsions

artículo científico publicado en 2003

Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.

artículo científico publicado en 2004

Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine.

artículo científico publicado en 2007

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

artículo científico publicado en 2009

Electrostatic stabilization of colloids in carbon dioxide: electrophoresis and dielectrophoresis

artículo científico publicado en 2005

Energy Transfer in Molecular Layer-by-Layer Films of Water-Soluble Perylene Diimides

Functional characterization and biomarker identification in the Brown Norway model of allergic airway inflammation

artículo científico publicado en 2002

Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

artículo científico publicado en 2008

Illuminator: increasing synergies between medicinal and computational chemists

artículo científico publicado el 6 de abril de 2012

Long-ranged electrostatic repulsion and crystallization of emulsion droplets in an ultralow dielectric medium supercritical carbon dioxide

artículo científico publicado en 2006

Molecular layer-by-layer self-assembly of water-soluble perylene diimides through pi-pi and electrostatic interactions

artículo científico publicado en 2006

Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation.

artículo científico publicado en 2004

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents

artículo científico publicado en 2008

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents

artículo científico publicado en 2008

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine

artículo científico publicado en 2008

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties

artículo científico publicado en 2008

Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.

artículo científico publicado en 2004

Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure

artículo científico publicado en 2002

Oxygen saturation during transfer

scientific article published on 01 March 2002

Pharmacological assessment of the nitric-oxide synthase isoform involved in eosinophilic inflammation in a rat model of sephadex-induced airway inflammation

artículo científico publicado en 2003

Photophysics of water soluble perylene diimides in surfactant solutions

artículo científico publicado en 2007

Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.

artículo científico publicado en 2004

Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma

artículo científico publicado en 2005

Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.

artículo científico publicado en 2007

Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

artículo científico publicado en 2008

Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.

artículo científico publicado en 2018

Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase

artículo científico publicado en 2008

Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase

artículo científico publicado en 2007

Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics.

artículo científico publicado en 2006

Transcription inactivation through local refolding of the RNA polymerase structure

artículo científico publicado en 2009

Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.

artículo científico publicado en 2003

Water-in-carbon dioxide emulsions stabilized with hydrophobic silica particles

artículo científico publicado en 2007

Water-soluble perylene diimides: Solution photophysics and layer-by-layer incorporation into polyelectrolyte films

artículo científico publicado en 2006

Lista de obras de

4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase

5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors

Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

Carbon dioxide-in-water microemulsions

Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.

Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine.

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Electrostatic stabilization of colloids in carbon dioxide: electrophoresis and dielectrophoresis

Energy Transfer in Molecular Layer-by-Layer Films of Water-Soluble Perylene Diimides

Functional characterization and biomarker identification in the Brown Norway model of allergic airway inflammation

Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

Illuminator: increasing synergies between medicinal and computational chemists

Long-ranged electrostatic repulsion and crystallization of emulsion droplets in an ultralow dielectric medium supercritical carbon dioxide

Molecular layer-by-layer self-assembly of water-soluble perylene diimides through pi-pi and electrostatic interactions

Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation.

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties

Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.

Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure

Oxygen saturation during transfer

Pharmacological assessment of the nitric-oxide synthase isoform involved in eosinophilic inflammation in a rat model of sephadex-induced airway inflammation

Photophysics of water soluble perylene diimides in surfactant solutions

Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.

Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma

Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.

Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.

Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase

Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase

Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics.

Transcription inactivation through local refolding of the RNA polymerase structure

Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.

Water-in-carbon dioxide emulsions stabilized with hydrophobic silica particles

Water-soluble perylene diimides: Solution photophysics and layer-by-layer incorporation into polyelectrolyte films