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13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking

scientific article published on 08 May 2020

Aberrant expression of KOR-SA3544 antigen in childhood acute lymphoblastic leukemia predicts TEL-AML1 negativity. The Pediatric Hematology Working Group in the Czech Republic

artículo científico publicado en 1998

Acute leukemias with ETV6/ABL1 (TEL/ABL) fusion: poor prognosis and prenatal origin.

scientific article published on October 2010

Acute lymphoblastic leukemia incidence during socioeconomic transition: selective increase in children from 1 to 4 years

artículo científico publicado en 2002

Acute lymphoblastic leukemia incidence during socioeconomic transition: selective increase in children from 1 to 4 years

artículo científico publicado en 2002

Acute lymphoblastic leukemia with aleukemic prodrome: preleukemic dynamics and possible mechanisms of immunosurveillance

artículo científico publicado en 2017

Adaptor molecules expression in normal lymphopoiesis and in childhood leukemia

artículo científico publicado en 2009

An activating mutation of GNB1 is associated with resistance to tyrosine kinase inhibitors in ETV6-ABL1-positive leukemia

artículo científico publicado en 2017

An unusual case of high hyperdiploid childhood ALL with cryptic BCR/ABL1 rearrangement.

artículo científico publicado en 2014

Analysis of chronic myeloid leukaemia during deep molecular response by genomic PCR: a traffic light stratification model with impact on treatment-free remission

artículo científico publicado en 2020

Are we ready to curtail testing for TEL/AML1 fusion? Pediatric Hematology Working Group in the Czech Republic

scientific article published on 01 June 1999

Backtracking of ALL to cord blood.

artículo científico publicado en 2009

Blast clearance after one week of corticosteroids correlates with outcome and genetics but does not justify adding a residual disease time point in acute lymphoblastic leukemia treatment

artículo científico publicado en 2020

CD2-positive B-cell precursor acute lymphoblastic leukemia with an early switch to the monocytic lineage.

artículo científico publicado en 2013

Characterization of 46 patient-specific BCR-ABL1 fusions and detection of SNPs upstream and downstream the breakpoints in chronic myeloid leukemia using next generation sequencing.

artículo científico publicado en 2015

Characterization of leukemias with ETV6-ABL1 fusion

artículo científico publicado en 2016

Childhood secondary ALL after ALL treatment.

artículo científico publicado en 2007

Chromosome 21 gain is dispensable for transient myeloproliferative disorder driven by a novel GATA1 mutation

artículo científico publicado en 2020

Clinical Implications of Minimal Residual Disease Detection in Infants With <i>KMT2A</i>-Rearranged Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

scientific article published on 06 January 2021

Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia

scientific article published on 11 April 2011

Correction: Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1

scientific article published on 14 January 2020

Covert preleukemia driven by MLL gene fusion

artículo científico publicado en 2009

DUX4r, ZNF384r and PAX5-P80R mutated B-cell precursor acute lymphoblastic leukemia frequently undergo monocytic switch

artículo científico publicado en 2020

Development of treatment and clinical results in childhood acute myeloid leukemia in the Czech Republic

article

Distinct bilineal leukemia immunophenotypes are not genetically determined

artículo científico publicado en 2016

ERG deletion is associated with CD2 and attenuates the negative impact of IKZF1 deletion in childhood acute lymphoblastic leukemia

artículo científico publicado en 2013

ERG deletion is associated with CD2 and attenuates the negative impact of IKZF1 deletion in childhood acute lymphoblastic leukemia

artículo científico publicado en 2015

ERG deletions in childhood acute lymphoblastic leukemia with DUX4 rearrangements are mostly polyclonal, prognostically relevant and their detection rate strongly depends on screening method sensitivity

artículo científico publicado en 2019

ETV6/RUNX1 (TEL/AML1) is a frequent prenatal first hit in childhood leukemia.

artículo científico publicado en 2011

ETV6/RUNX1-like acute lymphoblastic leukemia: A novel B-cell precursor leukemia subtype associated with the CD27/CD44 immunophenotype.

artículo científico publicado en 2017

Fluorescent in situ hybridization (FISH) in the diagnosis of acute childhood lymphatic leukemia (ALL)

artículo científico publicado el 30 de agosto de 2001

Frequency and prognostic impact of ZEB2 H1038 and 1072 mutations in childhood B-other acute lymphoblastic leukemia

artículo científico publicado en 2020

Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort

scientific article published on 10 January 2019

High expression of cytoskeletal protein drebrin in TEL/AML1pos B-cell precursor acute lymphoblastic leukemia identified by a novel monoclonal antibody.

artículo científico publicado en 2011

History of treatment and long-term outcome in children with acute lymphoblastic leukemia in the Czech Republic

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions

scientific article published on 21 March 2019

Identification of Fusion Gene Breakpoints is Feasible and Facilitates Accurate Sensitive Minimal Residual Disease Monitoring on Genomic Level in Patients With PML-RARA, CBFB-MYH11, and RUNX1-RUNX1T1

artículo científico publicado en 2020

Impact of TEL/AML1-positive patients on age distribution of childhood acute lymphoblastic leukemia in Czech Republic. Pediatric Hematology Working Group in Czech Republic

artículo científico publicado en 1998

Implications of delayed bone marrow aspirations at the end of treatment induction for risk stratification and outcome in children with acute lymphoblastic leukaemia

artículo científico publicado en 2016

Importance of using comparative genomic hybridization to improve detection of chromosomal changes in childhood acute lymphoblastic leukemia

artículo científico publicado en 2000

Intragenic ERG Deletions Do Not Explain the Biology of ERG-Related Acute Lymphoblastic Leukemia.

artículo científico publicado en 2016

Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T-cell acute lymphoblastic leukemia

artículo científico publicado en 2008

Long-term remission of therapy-related acute myeloid leukemia with a new t(11;18)(q23;q21.2) translocation and KMT2A-ME2 (MLL-ME2) fusion gene

article

Molecular characterization and clinical impact of t(11;15)(q23;q14-15) MLL-CASC5 rearrangement.

artículo científico publicado en 2014

Monitoring of childhood ALL using BCR-ABL1 genomic breakpoints identifies a subgroup with CML-like biology.

artículo científico publicado en 2017

Monitoring of minimal residual disease and mixed chimerism in a case of high-risk TEL/AML1+ acute lymphoblastic leukemia pre- and post-bone marrow transplantation. Czech Pediatric Haematology Working Group

scientific article published on 01 October 2000

New biological and genetic classification and therapeutically relevant categories in childhood B-cell precursor acute lymphoblastic leukemia

artículo científico publicado en 2018

New insights to the MLL recombinome of acute leukemias

artículo científico publicado en 2009

Next-generation sequencing indicates false-positive MRD results and better predicts prognosis after SCT in patients with childhood ALL.

artículo científico publicado en 2017

No evidence for MLL/AF4 expression in normal cord blood samples

scientific article published on 01 February 1999

Pre-natal, clonal origin of acute lymphoblastic leukaemia in triplets

artículo científico

Predictive value of minimal residual disease in Philadelphia-chromosome-positive acute lymphoblastic leukemia treated with imatinib in the European intergroup study of post-induction treatment of Philadelphia-chromosome-positive acute lymphoblastic l

scholarly article by Giovanni Cazzaniga et al published January 2018 in Haematologica

Prenatal origin of childhood AML occurs less frequently than in childhood ALL.

artículo científico publicado en 2006

Prognosis of children with mixed phenotype acute leukemia treated on the basis of consistent immunophenotypic criteria

artículo científico publicado en 2010

Quantification of fusion transcript reveals a subgroup with distinct biological properties and predicts relapse in BCR/ABL-positive ALL: implications for residual disease monitoring

artículo científico publicado en 2009

Quiescent leukaemic cells account for minimal residual disease in childhood lymphoblastic leukaemia

artículo científico publicado en 2012

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

artículo científico publicado en 2014

Rapidly progressing acute myeloid leukemia with KAT6A-LEUTX fusion in a newborn

scientific article published on 11 August 2020

Real-time quantitative PCR detection of WT1 gene expression in children with AML: prognostic significance, correlation with disease status and residual disease detection by flow cytometry

article

Reappearance of acute lymphoblastic leukemia 34 years after initial diagnosis: a case report and study of the origin of the reappeared blasts ⬇️

artículo científico publicado el 19 de febrero de 2013

Relapses and treatment-related events contributed equally to poor prognosis in children with ABL-class fusion positive B-cell acute lymphoblastic leukemia treated according to AIEOP-BFM protocols

scientific article published on 10 October 2019

Significance of real-time quantitative PCR detection of p16 gene deletions in childhood acute lymphoblastic leukemia

scientific article published on 01 June 2002

Significantly lower relapse rate for TEL/AML1-positive ALL

scientific article published on 01 October 1999

Slower early response to treatment and distinct expression profile of childhood high hyperdiploid acute lymphoblastic leukaemia with DNA index < 1.16.

artículo científico publicado en 2016

Slower molecular response to treatment predicts poor outcome in patients with TEL/AML1 positive acute lymphoblastic leukemia: prospective real-time quantitative reverse transcriptase-polymerase chain reaction study.

artículo científico publicado en 2003

Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1

scientific article published on 11 March 2019

TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia

artículo científico publicado en 2004

TEL/AML 1 real-time quantitative reverse transcriptase PCR can complement minimal residual disease assessment in childhood ALL

scientific article published on 01 July 2005

TEL/AML1 and immunoreceptor gene rearrangements—which comes first?

artículo científico publicado en 2005

TEL/AML1 positivity in childhood ALL: average or better prognosis? Czech Paediatric Haematology Working Group

scientific article published on 01 January 1999

TEL/AML1-positive patients lacking TEL exon 5 resemble canonical TEL/AML1 cases.

artículo científico publicado en 2010

Temperature non-homogeneity in rapid airflow-based cycler significantly affects real-time PCR

artículo científico publicado en 2002

The MLL recombinome of acute leukemias

scientific article published on 01 May 2006

The MLL recombinome of acute leukemias in 2013.

artículo científico publicado en 2013

The MLL recombinome of acute leukemias in 2017.

artículo científico

The adaptor protein NTAL enhances proximal signaling and potentiates corticosteroid-induced apoptosis in T-ALL.

artículo científico publicado en 2012

The prospects for children with acute lymphoblastic leukemia of being cured has increased in the Czech Republic in the 21st century to 90% - outcome of the ALL-IC BFM 2002 trial

artículo científico publicado en 2015

Two novel fusion genes, AIF1L-ETV6 and ABL1-AIF1L, result together with ETV6-ABL1 from a single chromosomal rearrangement in acute lymphoblastic leukemia with prenatal origin

artículo científico publicado en 2018

[Detection of BCR/ABL, MLL/AF4 and TEL/AML1 hybrid genes and monitoring of minimal residual disease in pediatric patients with acute lymphoblastic leukemia]

scientific article published on 01 January 1999

[Monitoring minimal residual disease in pediatric patients with acute lymphoblastic leukemia]

artículo científico publicado en 2000

[The role of TEL and AML1 genes in the pathogenesis of hematologic malignancies]

artículo científico publicado en 2001

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