Lista de obras -

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

artículo científico publicado en 2016

A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss

artículo científico publicado en 2010

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors

artículo científico publicado en 2015

A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain.

artículo científico publicado en 2009

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS

artículo científico publicado en 2003

Activation of TRPA1 on dural afferents: a potential mechanism of headache pain

artículo científico publicado en 2012

Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord

artículo científico publicado en 2011

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents

scientific article published on 13 April 2020

Antinociceptive and nociceptive actions of opioids

artículo científico publicado en 2004

Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines

artículo científico publicado en 2010

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

artículo científico publicado en 2005

CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?

artículo científico publicado en 2003

CB2 cannabinoid receptor mediation of antinociception

artículo científico publicado en 2006

Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance

scientific journal article

Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists

artículo científico publicado en 2008

Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives

artículo científico publicado en 2015

Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light

scientific article published on 02 May 2019

Development of Potent μ and δ Opioid Agonists with High Lipophilicity ⬇️

artículo científico publicado el 3 de diciembre de 2010

Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands

artículo científico publicado en 2015

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies

artículo científico publicado en 2011

Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord

artículo científico publicado en 2014

Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities

artículo científico publicado en 2015

Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.

artículo científico publicado en 2017

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

artículo científico publicado en 2014

Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain

artículo científico publicado en 2011

Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain

artículo científico publicado en 2015

Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light': The Journal of Pain 20 (2019) 1293-1306

scientific article published on 01 December 2019

Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake

artículo científico publicado en 2020

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists

artículo científico publicado en 2009

Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance

artículo científico publicado en 2003

Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2Cannabinoid Receptors ⬇️

artículo científico publicado el 1 de octubre de 2003

Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain.

artículo científico publicado en 2011

Inhibition of pain responses by activation of CB(2) cannabinoid receptors

artículo científico publicado en 2002

Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?

artículo científico publicado en 2005

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

artículo científico publicado en 2017

Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery.

artículo científico publicado en 2018

Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis

artículo científico publicado en 2014

Melanocortin receptors, melanotropic peptides and penile erection

artículo científico publicado en 2007

Multiple actions of systemic artemin in experimental neuropathy ⬇️

artículo científico publicado el 5 de octubre de 2003

Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors

artículo científico publicado en 2009

New paradigms and tools in drug design for pain and addiction

artículo científico publicado en 2006

Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors

artículo científico publicado en 2008

Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain

artículo científico publicado en 2011

Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling

artículo científico publicado en 2008

Pathophysiology of pain

artículo científico publicado en 2007

Peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain

scientific article published on 01 September 2018

Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury

artículo científico publicado en 2008

Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists

artículo científico publicado en 2004

Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids

artículo científico publicado en 2011

Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist

artículo científico publicado en 2012

Role of NK-1 neurotransmission in opioid-induced hyperalgesia

artículo científico publicado en 2005

Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats

artículo científico publicado en 2021

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

scientific article published on 08 May 2019

Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways

artículo científico publicado en 2006

Sustained morphine treatment augments prostaglandin E2-evoked calcitonin gene-related peptide release from primary sensory neurons in a PKA-dependent manner ⬇️

artículo científico publicado el 15 de septiembre de 2010

Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.

artículo científico publicado en 2016

Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists

artículo científico publicado en 2016

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands ⬇️

artículo científico publicado el 24 de agosto de 2011

TRPV1 receptor in expression of opioid-induced hyperalgesia

artículo científico publicado en 2008

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation

artículo científico publicado en 2017

The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area

artículo científico publicado en 2021

The pharmacology of neurokinin receptors in addiction: prospects for therapy

artículo científico publicado en 2015

Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure

artículo científico publicado en 2005

Unmasking the tonic-aversive state in neuropathic pain

artículo científico publicado en 2009

Use of Animal Models in Understanding Cancer-induced Bone Pain

artículo científico publicado en 2015

Lista de obras de

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology

A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors

A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: therapeutic opportunity for treating skeletal pain.

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS

Activation of TRPA1 on dural afferents: a potential mechanism of headache pain

Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents

Antinociceptive and nociceptive actions of opioids

Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?

CB2 cannabinoid receptor mediation of antinociception

Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance

Constitutive activity at the cannabinoid CB1 receptor is required for behavioral response to noxious chemical stimulation of TRPV1: antinociceptive actions of CB1 inverse agonists

Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives

Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light

Development of Potent μ and δ Opioid Agonists with High Lipophilicity ⬇️

Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies

Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord

Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities

Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain

Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain

Erratum to ‛Development and Characterization of An Injury-free Model of Functional Pain in Rats by Exposure to Red Light': The Journal of Pain 20 (2019) 1293-1306

Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake

Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists

Induction of pain facilitation by sustained opioid exposure: relationship to opioid antinociceptive tolerance

Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2Cannabinoid Receptors ⬇️

Inhibition of p38-MAPK signaling pathway attenuates breast cancer induced bone pain and disease progression in a murine model of cancer-induced bone pain.

Inhibition of pain responses by activation of CB(2) cannabinoid receptors

Is paradoxical pain induced by sustained opioid exposure an underlying mechanism of opioid antinociceptive tolerance?

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery.

Mechanistic basis of altered morphine disposition in nonalcoholic steatohepatitis

Melanocortin receptors, melanotropic peptides and penile erection

Multiple actions of systemic artemin in experimental neuropathy ⬇️

Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors

New paradigms and tools in drug design for pain and addiction

Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors

Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain

Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling

Pathophysiology of pain

Peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain

Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury

Production of paradoxical sensory hypersensitivity by alpha 2-adrenoreceptor agonists

Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids

Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist

Role of NK-1 neurotransmission in opioid-induced hyperalgesia

Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways

Sustained morphine treatment augments prostaglandin E2-evoked calcitonin gene-related peptide release from primary sensory neurons in a PKA-dependent manner ⬇️

Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.

Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands ⬇️

TRPV1 receptor in expression of opioid-induced hyperalgesia

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation

The Effects of Repeated Morphine Treatment on the Endogenous Cannabinoid System in the Ventral Tegmental Area

The pharmacology of neurokinin receptors in addiction: prospects for therapy

Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure

Unmasking the tonic-aversive state in neuropathic pain

Use of Animal Models in Understanding Cancer-induced Bone Pain