Lista de obras -

A Pilot Study towards the Impact of Type 2 Diabetes on the Expression and Activities of Drug Metabolizing Enzymes and Transporters in Human Duodenum

scientific article published on 02 July 2019

ACE2 as a Therapeutic Target for COVID-19; its Role in Infectious Processes and Regulation by Modulators of the RAAS System

scientific article published on 03 July 2020

Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine

scientific article published on 13 April 2019

Adverse drug event risk assessment by the virtual addition of COVID-19 repurposed drugs to Medicare and commercially insured patients' drug regimens: A drug safety simulation study

artículo científico publicado en 2021

An improved HPLC assay with fluorescence detection for the determination of domperidone and three major metabolites for application to in vitro drug metabolism studies

scientific article published on 12 March 2007

Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination

artículo científico publicado en 2009

Assessing the Mechanism of Fluoxetine-Mediated CYP2D6 Inhibition ⬇️

artículo científico publicado en 2021

Assessment of competitive and mechanism-based inhibition by clarithromycin: use of domperidone as a CYP3A probe-drug substrate and various enzymatic sources including a new cell-based assay with freshly isolated human hepatocytes

artículo científico

Association of a Novel Medication Risk Score with Adverse Drug Events and Other Pertinent Outcomes Among Participants of the Programs of All-Inclusive Care for the Elderly

scientific article published on 20 May 2020

Characterization of CYP3A Isozymes Involved in the Metabolism of Domperidone: Role of Cytochrome b5 and Inhibition by Ketoconazole ⬇️

artículo científico publicado el 1 de abril de 2010

Chronic Inflammatory Status Observed in Patients with Type 2 Diabetes Induces Modulation of Cytochrome P450 Expression and Activity ⬇️

artículo científico publicado en 2021

Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy

artículo científico publicado en 2015

Clinical decision support systems: great promises for better management of patients' drug therapy

artículo científico publicado en 2016

Clinical practice guideline: CYP2D6 genotyping for safe and efficacious codeine therapy

artículo científico publicado en 2013

Combined Administration of Quinidine and Propafenone for Atrial Fibrillation: The CAQ‐PAF Study ⬇️

artículo científico publicado el 1 de febrero de 2012

Contribution of CYP2D6 Functional Activity to Oxycodone Efficacy in Pain Management: Genetic Polymorphisms, Phenoconversion, and Tissue-Selective Metabolism ⬇️

artículo científico publicado en 2021

Development and validation of an absolute protein assay for the simultaneous quantification of fourteen CYP450s in human microsomes by HPLC-MS/MS-based targeted proteomics

artículo científico publicado en 2019

Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes

artículo científico publicado en 2018

Development of a selective and sensitive high-performance liquid chromatography-tandem mass spectrometry assay to support pharmacokinetic studies of LY-487,379 in rat and marmoset

artículo científico publicado en 2018

Development of a sensitive method for the determination of oxycodone and its major metabolites noroxycodone and oxymorphone in human plasma by liquid chromatography-tandem mass spectrometry

artículo científico publicado en 2015

Disease-Induced Modulation of Drug Transporters at the Blood–Brain Barrier Level ⬇️

artículo científico publicado en 2021

Domperidone and sudden cardiac death: How much longer should we wait?

artículo científico publicado en 2013

Effectiveness of an Advanced Clinical Decision Support System on Clinical Decision-Making Skills in a Call Center Medication Therapy Management Pharmacy Setting: A Pilot Study

scientific article published on 25 November 2020

Effects of a Series of Acidic Drugs on L-Lactic Acid Transport by the Monocarboxylate Transporters MCT1 and MCT4

artículo científico publicado en 2017

Effects of β-blockers and tricyclic antidepressants on the activity of human organic anion transporting polypeptide 1A2 (OATP1A2).

artículo científico publicado en 2015

Evaluating the impact of type 2 diabetes mellitus on CYP450 metabolic activities: protocol for a case-control pharmacokinetic study

artículo científico publicado en 2018

Evaluation of Limited Sampling Methods for Oral Busulfan Pharmacokinetic Monitoring in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation

artículo científico publicado en 2016

Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors.

artículo científico publicado en 2013

HIV-1 subtype B and C integrase enzymes exhibit differential patterns of resistance to integrase inhibitors in biochemical assays

artículo científico publicado en 2010

Highly sensitive LC-MS/MS methods for the determination of seven human CYP450 activities using small oral doses of probe-drugs in human

artículo científico publicado en 2016

Impact of GSTA1 Polymorphisms on Busulfan Oral Clearance in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation

artículo científico publicado en 2019

Induction of Cardiac Angiogenesis Requires Killer Cell Lectin-Like Receptor 1 and α4β7 Integrin Expression by NK Cells ⬇️

artículo científico publicado el 22 de octubre de 2010

Inhibitory effects of propafenone on the pharmacokinetics of caffeine in humans

artículo científico publicado en 2006

Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice

artículo científico publicado en 2020

Metabolic Activity and mRNA Levels of Human Cardiac CYP450s Involved in Drug Metabolism ⬇️

artículo científico publicado el 14 de diciembre de 2010

Modulation of CYP450 activities in patients with type 2 diabetes.

artículo científico publicado en 2019

Precision medication: An illustrative case series guiding the clinical application of multi-drug interactions and pharmacogenomics

scientific article published on 23 December 2019

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models ⬇️

publication published on 09 November 2021

Risk assessment of drug-induced Long QT Syndrome for some COVID-19 repurposed drugs

artículo científico publicado en 2020

Risk of Adverse Drug Events Following the Virtual Addition of COVID-19 Repurposed Drugs to Drug Regimens of Frail Older Adults with Polypharmacy

scientific article published on 10 August 2020

Risk of drug-induced Long QT Syndrome associated with the use of repurposed COVID-19 drugs: a systematic review

artículo científico publicado en 2020

Selective metabotropic glutamate receptor 2 positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset

artículo científico publicado en 2020

Study of Statin- and Loratadine-Induced Muscle Pain Mechanisms Using Human Skeletal Muscle Cells

artículo científico publicado en 2017

The Dangers of Polypharmacy in Elderly Patients

artículo científico publicado en 2017

The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition.

artículo científico publicado en 2012

Tissue Specific Modulation of cyp2c and cyp3a mRNA Levels and Activities by Diet-Induced Obesity in Mice: The Impact of Type 2 Diabetes on Drug Metabolizing Enzymes in Liver and Extra-Hepatic Tissues.

artículo científico publicado en 2017

Use of 4β-Hydroxycholesterol Plasma Concentrations as an Endogenous Biomarker of CYP3A Activity: Clinical Validation in Individuals With Type 2 Diabetes

artículo científico publicado en 2019

Lista de obras de

A Pilot Study towards the Impact of Type 2 Diabetes on the Expression and Activities of Drug Metabolizing Enzymes and Transporters in Human Duodenum

ACE2 as a Therapeutic Target for COVID-19; its Role in Infectious Processes and Regulation by Modulators of the RAAS System

Activity and mRNA expression levels of selected cytochromes P450 in various sections of the human small intestine

Adverse drug event risk assessment by the virtual addition of COVID-19 repurposed drugs to Medicare and commercially insured patients' drug regimens: A drug safety simulation study

An improved HPLC assay with fluorescence detection for the determination of domperidone and three major metabolites for application to in vitro drug metabolism studies

Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination

Assessing the Mechanism of Fluoxetine-Mediated CYP2D6 Inhibition ⬇️

Assessment of competitive and mechanism-based inhibition by clarithromycin: use of domperidone as a CYP3A probe-drug substrate and various enzymatic sources including a new cell-based assay with freshly isolated human hepatocytes

Association of a Novel Medication Risk Score with Adverse Drug Events and Other Pertinent Outcomes Among Participants of the Programs of All-Inclusive Care for the Elderly

Characterization of CYP3A Isozymes Involved in the Metabolism of Domperidone: Role of Cytochrome b5 and Inhibition by Ketoconazole ⬇️

Chronic Inflammatory Status Observed in Patients with Type 2 Diabetes Induces Modulation of Cytochrome P450 Expression and Activity ⬇️

Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy

Clinical decision support systems: great promises for better management of patients' drug therapy

Clinical practice guideline: CYP2D6 genotyping for safe and efficacious codeine therapy

Combined Administration of Quinidine and Propafenone for Atrial Fibrillation: The CAQ‐PAF Study ⬇️

Contribution of CYP2D6 Functional Activity to Oxycodone Efficacy in Pain Management: Genetic Polymorphisms, Phenoconversion, and Tissue-Selective Metabolism ⬇️

Development and validation of an absolute protein assay for the simultaneous quantification of fourteen CYP450s in human microsomes by HPLC-MS/MS-based targeted proteomics

Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes

Development of a selective and sensitive high-performance liquid chromatography-tandem mass spectrometry assay to support pharmacokinetic studies of LY-487,379 in rat and marmoset

Development of a sensitive method for the determination of oxycodone and its major metabolites noroxycodone and oxymorphone in human plasma by liquid chromatography-tandem mass spectrometry

Disease-Induced Modulation of Drug Transporters at the Blood–Brain Barrier Level ⬇️

Domperidone and sudden cardiac death: How much longer should we wait?

Effectiveness of an Advanced Clinical Decision Support System on Clinical Decision-Making Skills in a Call Center Medication Therapy Management Pharmacy Setting: A Pilot Study

Effects of a Series of Acidic Drugs on L-Lactic Acid Transport by the Monocarboxylate Transporters MCT1 and MCT4

Effects of β-blockers and tricyclic antidepressants on the activity of human organic anion transporting polypeptide 1A2 (OATP1A2).

Evaluating the impact of type 2 diabetes mellitus on CYP450 metabolic activities: protocol for a case-control pharmacokinetic study

Evaluation of Limited Sampling Methods for Oral Busulfan Pharmacokinetic Monitoring in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation

Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors.

HIV-1 subtype B and C integrase enzymes exhibit differential patterns of resistance to integrase inhibitors in biochemical assays

Highly sensitive LC-MS/MS methods for the determination of seven human CYP450 activities using small oral doses of probe-drugs in human

Impact of GSTA1 Polymorphisms on Busulfan Oral Clearance in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation

Induction of Cardiac Angiogenesis Requires Killer Cell Lectin-Like Receptor 1 and α4β7 Integrin Expression by NK Cells ⬇️

Inhibitory effects of propafenone on the pharmacokinetics of caffeine in humans

Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice

Metabolic Activity and mRNA Levels of Human Cardiac CYP450s Involved in Drug Metabolism ⬇️

Modulation of CYP450 activities in patients with type 2 diabetes.

Precision medication: An illustrative case series guiding the clinical application of multi-drug interactions and pharmacogenomics

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models ⬇️

Risk assessment of drug-induced Long QT Syndrome for some COVID-19 repurposed drugs

Risk of Adverse Drug Events Following the Virtual Addition of COVID-19 Repurposed Drugs to Drug Regimens of Frail Older Adults with Polypharmacy

Risk of drug-induced Long QT Syndrome associated with the use of repurposed COVID-19 drugs: a systematic review

Selective metabotropic glutamate receptor 2 positive allosteric modulation alleviates L-DOPA-induced psychosis-like behaviours and dyskinesia in the MPTP-lesioned marmoset

Study of Statin- and Loratadine-Induced Muscle Pain Mechanisms Using Human Skeletal Muscle Cells

The Dangers of Polypharmacy in Elderly Patients

The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition.

Tissue Specific Modulation of cyp2c and cyp3a mRNA Levels and Activities by Diet-Induced Obesity in Mice: The Impact of Type 2 Diabetes on Drug Metabolizing Enzymes in Liver and Extra-Hepatic Tissues.

Use of 4β-Hydroxycholesterol Plasma Concentrations as an Endogenous Biomarker of CYP3A Activity: Clinical Validation in Individuals With Type 2 Diabetes