Lista de obras - Joann B. Sweasy - Dominio Público Uruguay

3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection

artículo científico publicado en 1999

A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated Variant

artículo científico publicado en 2017

A DNA polymerase beta mutant from colon cancer cells induces mutations

scholarly article

A Triad Interaction in the Fingers Subdomain of DNA Polymerase Beta Controls Polymerase Activity ⬇️

artículo científico publicado el 31 de marzo de 2011

A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation

artículo científico publicado en 2012

A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation

artículo científico publicado en 2014

A new perspective on oxidation of DNA repair proteins and cancer

artículo científico publicado en 2019

A pre-catalytic non-covalent step governs DNA polymerase β fidelity

scientific article published on 01 December 2019

Abstract 4319: Lupus antibody-based cancer therapy

Base Excision Repair Variants in Cancer.

artículo científico publicado en 2017

Base excision repair and cancer

artículo científico publicado en 2012

Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment

scientific article published on 29 October 2012

Cellular roles of DNA polymerase beta

artículo científico

Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation

artículo científico publicado en 2012

Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position

artículo científico publicado en 2014

DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy

artículo científico publicado en 2017

DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.

artículo científico publicado en 2017

DNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damage

artículo científico publicado en 2005

DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line

artículo científico publicado en 2004

DNA polymerase beta is critical for genomic stability of sperm cells ⬇️

artículo científico publicado el 18 de febrero de 2011

DNA polymerase beta is critical for mouse meiotic synapsis

artículo científico publicado en 2009

DNA polymerase beta participates in DNA End-joining.

artículo científico publicado en 2017

DNA polymerase family X: function, structure, and cellular roles

artículo científico publicado en 2010

DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation

artículo científico publicado en 2012

DNA polymerase κ: Friend or foe?

scientific article published on 28 April 2020

DNA polymerases and human diseases

artículo científico publicado en 2006

DNA polymerases and their role in genomic stability.

artículo científico publicado en 2012

DNA repair and personalized breast cancer therapy ⬇️

artículo científico publicado el 1 de octubre de 2010

DNA repair and systemic lupus erythematosus

artículo científico publicado en 2017

Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity

artículo científico publicado en 2017

Differential immunomodulatory Effect of PARP Inhibition in BRCA1 deficient and competent tumor cells

artículo científico publicado en 2020

Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein.

artículo científico publicado en 2016

Estrogen withdrawal, increased breast cancer risk and the KRAS-variant.

artículo científico publicado en 2015

Eukaryotic gene invasion by a bacterial mobile insertion sequence element IS2 during cloning into a plasmid vector

artículo científico publicado en 2010

Evelyn M. Witkin awarded the National Medal of Science

artículo científico publicado en 2004

Evelyn Witkin and the coordinated response to DNA damage

artículo científico publicado en 2015

Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation

artículo científico publicado en 2005

Expression of a germline variant in the N-terminal domain of the human DNA glycosylase NTHL1 induces cellular transformation without impairing enzymatic function or substrate specificity

artículo científico publicado en 2020

Fidelity mechanisms of DNA polymerase beta

artículo científico publicado en 2003

Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection.

artículo científico publicado en 2014

Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks

artículo científico publicado en 2015

Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing

artículo científico publicado en 2014

Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation

artículo científico publicado en 2013

Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta

artículo científico publicado en 2010

Hinge residue Ile260 of DNA polymerase beta is important for enzyme activity and fidelity

artículo científico publicado en 2005

Human POLB gene is mutated in high percentage of colorectal tumors

artículo científico publicado en 2012

I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity

Interplay between DNA repair and inflammation, and the link to cancer

artículo científico publicado en 2014

Introduction

Is base excision repair a tumor suppressor mechanism?

artículo científico publicado en 2006

Is there a link between DNA polymerase beta and cancer?

artículo científico publicado en 2004

Kinesin 5B (KIF5B) is required for progression through female meiosis and proper chromosomal segregation in mitotic cells

artículo científico publicado en 2013

Loop II of DNA polymerase beta is important for discrimination during substrate binding

artículo científico publicado en 2008

Loop II of DNA polymerase beta is important for polymerization activity and fidelity

artículo científico publicado en 2007

MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles

artículo científico publicado en 2013

Mechanistic understanding of cellular responses to genomic stress

scientific article published on 26 December 2019

MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease

scientific article published on 08 December 2020

Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase β

artículo científico publicado en 2019

Mouse models of DNA polymerases.

artículo científico

Mutation of POLB causes lupus in mice ⬇️

scientific journal article

NTHL1 in genomic integrity, aging and cancer

artículo científico publicado en 2020

Novel SOS phenotypes caused by second-site mutations in the recA430 gene of Escherichia coli

scientific article published on 01 April 1991

Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair

artículo científico publicado en 2011

Pools and Pols: Mechanism of a mutator phenotype

artículo científico publicado en 2015

Population-specific variation in haplotype composition and heterozygosity at the POLB locus

artículo científico publicado en 2009

Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation

artículo científico publicado en 2009

Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State.

artículo científico publicado en 2018

Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator

artículo científico publicado en 2005

RecA kicks Pol V into gear.

artículo científico publicado en 2005

RecA protein of Escherichia coli has a third essential role in SOS mutator activity

artículo científico publicado en 1990

Recovery from ultraviolet light-induced inhibition of DNA synthesis requires umuDC gene products in recA718 mutant strains but not in recA+ strains of Escherichia coli

artículo científico publicado en 1987

Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β.

artículo científico publicado en 2017

Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography

scientific article published on 12 February 2020

Sequence context-specific mutagenesis and base excision repair

artículo científico publicado en 2009

Shortening of NIH RO1 grant applications: your response is important

artículo científico publicado en 2006

Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase β

artículo científico publicado en 2013

Substrate-dependent millisecond domain motions in DNA polymerase β.

artículo científico publicado en 2012

Synthesis of ortho-Formylphenylphosphonic Acids as Covalent Probes of Active Site Lysines

scientific article published on 13 February 2019

Targeting cancer with a lupus autoantibody

artículo científico publicado en 2012

The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding

artículo científico publicado en 2008

The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site

artículo científico publicado en 2003

The E249K mutator mutant of DNA polymerase beta extends mispaired termini

artículo científico publicado en 1999

The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator

artículo científico publicado en 2012

The E295K Cancer Variant of Human Polymerase Favors the Mismatch Conformational Pathway during Nucleotide Selection

artículo científico publicado en 2013

The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation

artículo científico publicado en 2007

The I260Q variant of DNA polymerase beta extends mispaired primer termini due to its increased affinity for deoxynucleotide triphosphate substrates

artículo científico publicado en 2008

The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient

artículo científico publicado en 2007

The NEIL1 G83D germline DNA glycosylase variant induces genomic instability and cellular transformation.

artículo científico publicado en 2017

The R280H X-ray cross-complementing 1 germline variant induces genomic instability and cellular transformation

artículo científico publicado en 2015

The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency

artículo científico publicado en 2014

The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype

artículo científico publicado en 2016

The cell pole: the site of cross talk between the DNA uptake and genetic recombination machinery

artículo científico publicado en 2012

The human gastric cancer-associated DNA polymerase β variant D160N is a mutator that induces cellular transformation

artículo científico publicado en 2012

The hydrophobic hinge region of rat DNA polymerase beta is critical for substrate binding pocket geometry

artículo científico publicado en 2005

The nature of the DNA substrate influences pre-catalytic conformational changes of DNA polymerase β

scientific article published on 01 August 2018

The role of cysteines in the structure and function of OGG1

scientific article published on 17 November 2020

Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site

artículo científico publicado en 2002

Timing Is Everything: Misincorporation of 8oxodG during Mitosis Is Lethal

artículo científico publicado en 2020

Tipping the balance in the powerhouse of the cell to "protect" colorectal cancer

artículo científico publicado en 2012

Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality

artículo científico publicado en 2012

Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase

artículo científico publicado en 2014

Unfavorable Electrostatic and Steric Interactions in DNA Polymerase β E295K Mutant Interfere with the Enzyme’s Pathway

artículo científico publicado en 2012

Using single-molecule FRET to probe the nucleotide-dependent conformational landscape of Pol β-DNA complexes

scientific article published on 08 May 2020

Variant base excision repair proteins: contributors to genomic instability

artículo científico publicado en 2010

Variants of DNA polymerase Beta extend mispaired DNA due to increased affinity for nucleotide substrate

artículo científico publicado en 2003

Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates

artículo científico publicado en 2012

Lista de obras de Joann B. Sweasy

3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection

A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated Variant

A DNA polymerase beta mutant from colon cancer cells induces mutations

A Triad Interaction in the Fingers Subdomain of DNA Polymerase Beta Controls Polymerase Activity ⬇️

A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation

A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation

A new perspective on oxidation of DNA repair proteins and cancer

A pre-catalytic non-covalent step governs DNA polymerase β fidelity

Abstract 4319: Lupus antibody-based cancer therapy

Base Excision Repair Variants in Cancer.

Base excision repair and cancer

Catalytic effects of mutations of distant protein residues in human DNA polymerase β: theory and experiment

Cellular roles of DNA polymerase beta

Colon cancer-associated DNA polymerase β variant induces genomic instability and cellular transformation

Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position

DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy

DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.

DNA polymerase 4 of Saccharomyces cerevisiae is important for accurate repair of methyl-methanesulfonate-induced DNA damage

DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line

DNA polymerase beta is critical for genomic stability of sperm cells ⬇️

DNA polymerase beta is critical for mouse meiotic synapsis

DNA polymerase beta participates in DNA End-joining.

DNA polymerase family X: function, structure, and cellular roles

DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation

DNA polymerase κ: Friend or foe?

DNA polymerases and human diseases

DNA polymerases and their role in genomic stability.

DNA repair and personalized breast cancer therapy ⬇️

DNA repair and systemic lupus erythematosus

Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity

Differential immunomodulatory Effect of PARP Inhibition in BRCA1 deficient and competent tumor cells

Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein.

Estrogen withdrawal, increased breast cancer risk and the KRAS-variant.

Eukaryotic gene invasion by a bacterial mobile insertion sequence element IS2 during cloning into a plasmid vector

Evelyn M. Witkin awarded the National Medal of Science

Evelyn Witkin and the coordinated response to DNA damage

Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation

Expression of a germline variant in the N-terminal domain of the human DNA glycosylase NTHL1 induces cellular transformation without impairing enzymatic function or substrate specificity

Fidelity mechanisms of DNA polymerase beta

Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection.

Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks

Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing

Germ-line variant of human NTH1 DNA glycosylase induces genomic instability and cellular transformation

Hinge residue I174 is critical for proper dNTP selection by DNA polymerase beta

Hinge residue Ile260 of DNA polymerase beta is important for enzyme activity and fidelity

Human POLB gene is mutated in high percentage of colorectal tumors

I260Q DNA polymerase β highlights precatalytic conformational rearrangements critical for fidelity

Interplay between DNA repair and inflammation, and the link to cancer

Introduction

Is base excision repair a tumor suppressor mechanism?

Is there a link between DNA polymerase beta and cancer?

Kinesin 5B (KIF5B) is required for progression through female meiosis and proper chromosomal segregation in mitotic cells

Loop II of DNA polymerase beta is important for discrimination during substrate binding

Loop II of DNA polymerase beta is important for polymerization activity and fidelity

MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles

Mechanistic understanding of cellular responses to genomic stress

MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease

Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase β

Mouse models of DNA polymerases.

Mutation of POLB causes lupus in mice ⬇️

NTHL1 in genomic integrity, aging and cancer

Novel SOS phenotypes caused by second-site mutations in the recA430 gene of Escherichia coli

Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair

Pools and Pols: Mechanism of a mutator phenotype

Population-specific variation in haplotype composition and heterozygosity at the POLB locus

Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation

Probing DNA Base-Dependent Leaving Group Kinetic Effects on the DNA Polymerase Transition State.

Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator

RecA kicks Pol V into gear.

RecA protein of Escherichia coli has a third essential role in SOS mutator activity

Recovery from ultraviolet light-induced inhibition of DNA synthesis requires umuDC gene products in recA718 mutant strains but not in recA+ strains of Escherichia coli

Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β.

Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography

Sequence context-specific mutagenesis and base excision repair

Shortening of NIH RO1 grant applications: your response is important

Structural Changes in the Hydrophobic Hinge Region Adversely Affect the Activity and Fidelity of the I260Q Mutator DNA Polymerase β

Substrate-dependent millisecond domain motions in DNA polymerase β.

Synthesis of ortho-Formylphenylphosphonic Acids as Covalent Probes of Active Site Lysines

Targeting cancer with a lupus autoantibody