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A central role for plasminogen in the inflammatory response to biomaterials

artículo científico publicado en 2004

A coagulation factor VII deficiency protects against acute inflammatory responses in mice

artículo científico publicado en 2006

A deficiency of uPAR alters endothelial angiogenic function and cell morphology ⬇️

artículo científico publicado en 2011

A fibrin specific monoclonal antibody which interferes with the fibrinolytic effect of tissue plasminogen activator

scientific article published on 01 June 1988

A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice

artículo científico publicado en 2006

A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection

artículo científico publicado en 2013

A local α-helix drives structural evolution of streptococcal M-protein affinity for host human plasminogen

scientific article published on 09 April 2020

A monoclonal antibody which recognises an epitopic region unique to the intact fibrin polymeric structure

artículo científico

A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes

artículo científico publicado en 2013

A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells

artículo científico publicado en 2006

A role of plasminogen in atherosclerosis and restenosis models in mice

artículo científico publicado en 1999

A severe deficiency of coagulation factor VIIa results in attenuation of the asthmatic response in mice

artículo científico publicado en 2009

A total fibrinogen deficiency is compatible with the development of bleomycininduced pulmonary fibrosis in mice

artículo científico

A total fibrinogen deficiency is compatible with the development of pulmonary fibrosis in mice

artículo científico publicado en 2000

A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice

scientific journal article

Abnormal whole blood thrombi in humans with inherited platelet receptor defects

artículo científico publicado en 2012

Abrogation of plasminogen activator inhibitor-1-vitronectin interaction ameliorates acute kidney injury in murine endotoxemia ⬇️

artículo científico publicado en 2015

Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice

artículo científico publicado en 2001

Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis

artículo científico publicado en 2016

An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia

artículo científico publicado en 2010

Attenuation of neointima formation following arterial injury in PAI-1 deficient mice.

artículo científico publicado en 2001

Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination

artículo científico publicado en 2012

Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography ⬇️

artículo científico publicado el 1 de septiembre de 2011

Calorimetric evaluation of the existence of separate domains in bovine prothrombin

artículo científico publicado en 1981

Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia.

artículo científico publicado en 2018

Characterization of streptokinases from group A Streptococci reveals a strong functional relationship that supports the coinheritance of plasminogen-binding M protein and cluster 2b streptokinase

artículo científico publicado en 2012

Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection

artículo científico publicado en 2019

Coagulation factor Xa modulates airway remodeling in a murine model of asthma

artículo científico publicado en 2006

Combined factor VII/protein C deficiency results in intrauterine coagulopathy in mice

artículo científico publicado en 2000

Comparative pathogenomic characterization of a non-invasive serotype M71 strain Streptococcus pyogenes NS53 reveals incongruent phenotypic implications from distinct genotypic markers

artículo científico publicado en 2017

Comparative studies of the physical state of the lipid phase of normal and hypercholesterolemic very low density lipoprotein ⬇️

artículo científico publicado el 1 de enero de 1979

Complement-mediated opsonization of invasive group A Streptococcus pyogenes strain AP53 is regulated by the bacterial two-component cluster of virulence responder/sensor (CovRS) system

artículo científico publicado en 2013

Conformationally organized lysine isosteres in Streptococcus pyogenes M protein mediate direct high-affinity binding to human plasminogen.

artículo científico publicado en 2017

Conservation of critical functional domains in murine plasminogen activator inhibitor-1.

artículo científico publicado en 2004

Contributions of different modules of the plasminogen-binding Streptococcus pyogenes M-protein that mediate its functional dimerization

artículo científico publicado en 2018

CovRS-Regulated Transcriptome Analysis of a Hypervirulent M23 Strain of Group A Streptococcus pyogenes Provides New Insights into Virulence Determinants

artículo científico publicado en 2015

Delayed inflammatory responses to endotoxin in fibrinogen-deficient mice

artículo científico publicado en 2006

Development of pulmonary fibrosis in fibrinogen-deficient mice

artículo científico publicado en 2001

Dimerization is not a determining factor for functional high affinity human plasminogen binding by the group A streptococcal virulence factor PAM and is mediated by specific residues within the PAM a1a2 domain.

artículo científico publicado en 2014

Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein

artículo científico publicado en 2015

Draft Genome Sequences of Six Skin Isolates of Streptococcus pyogenes.

artículo científico publicado en 2018

Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury.

artículo científico publicado en 2016

Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans

artículo científico publicado en 2013

Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma.

artículo científico publicado en 2012

Effect of sulindac sulfide on metallohydrolases in the human colon cancer cell line HT-29.

artículo científico publicado en 2011

Effects of Disruption of The Plasminogen Gene on Thrombosis, Growth, and Health in Mice ⬇️

artículo científico publicado el 1 de noviembre de 1995

Effects of altered plasminogen activator inhibitor-1 expression on cardiovascular disease ⬇️

artículo científico publicado el 1 de noviembre de 2011

Endoluminal arterial injury in plasminogen-deficient mice.

artículo científico publicado en 2000

Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice.

artículo científico publicado en 2003

Expression of foreign epitopes on recombinant occlusion bodies of baculoviruses

artículo científico publicado el 1 de enero de 1992

Expression of human plasminogen cDNA in a baculovirus vector-infected insect cell system.

artículo científico publicado en 1989

Factor VII deficiency impairs cutaneous wound healing in mice

artículo científico publicado en 2010

Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden.

artículo científico publicado en 2010

Fibrinogen facilitates the anti-tumor effect of nonnative endostatin

artículo científico publicado en 2009

Fibrinogen has chaperone-like activity

artículo científico publicado en 2008

Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse

artículo científico publicado en 2002

Fibrinolysis in Trauma: "Myth," "Reality," or "Something in Between".

artículo científico publicado en 2017

Focal arterial inflammation is augmented in mice with a deficiency of the protein C gene

artículo científico publicado en 2006

Functional differences between Streptococcus pyogenes cluster 1 and cluster 2b streptokinases are determined by their β-domains

artículo científico publicado en 2013

Gene targeting in hemostasis. plasminogen

artículo científico publicado en 2001

Gene targeting of components of the fibrinolytic system

artículo científico publicado en 2002

Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity

artículo científico publicado en 2016

Glomerulonephritis in mice with genetic deficiencies of the plasminogen system

artículo científico

Growth and behavioral development in plasminogen gene-targeted mice.

artículo científico publicado en 1999

Host Pathways of Hemostasis that Regulate Group A Streptococcus pyogenes Pathogenicity

artículo científico publicado en 2020

Humoral immune response to 2,4-dinitrophenyl--keyhole limpet hemocyanin in antigen-free, germ-free and conventional BALB/c mice

artículo científico publicado en 1994

Immunochemical evidence for intramolecular interaction of the carboxy terminal A??-appendages of plasma fibrinogen ⬇️

artículo científico publicado el 1 de octubre de 1990

Impaired arterial neointima formation in mice with disruption of the plasminogen gene ⬇️

artículo científico publicado en 1997

Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.

artículo científico publicado en 2002

Initiation of the extrinsic pathway of coagulation. Association of factor VIIa with a cell line expressing tissue factor

artículo científico publicado en 1987

Interaction between group A streptococci and the plasmin(ogen) system promotes virulence in a mouse skin infection model

artículo científico publicado en 1999

Interspecies cross-reactivity of monoclonal antibodies to various epitopes of human plasminogen ⬇️

artículo científico publicado el 1 de abril de 1984

Microviscosity of the lipid domains of normal and hypercholesterolemic very low density lipoprotein ⬇️

artículo científico publicado el 25 de abril de 1977

Monoclonal antibodies to discrete regions of human Glu1-plasminogen ⬇️

artículo científico publicado el 9 de noviembre de 1982

Mutations in the control of virulence sensor gene from Streptococcus pyogenes after infection in mice lead to clonal bacterial variants with altered gene regulatory activity and virulence

artículo científico publicado en 2014

Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection

scientific article published on 03 July 2018

Nonfibrinolytic functions of plasminogen

artículo científico publicado en 2000

Novel genomic rearrangements mediated by multiple genetic elements in Streptococcus pyogenes M23ND confer potential for evolutionary persistence

artículo científico publicado en 2016

Ovulation in plasminogen-deficient mice

artículo científico publicado en 1999

Past and Present Behçet's Disease Animal Models

artículo científico publicado en 2020

Pathological consequences associated with altered expression of components of the plasminogen system in bleomycin induced pulmonary fibrosis

artículo científico

Phenotypic differentiation of Streptococcus pyogenes populations is induced by recombination-driven gene-specific sweeps

artículo científico publicado en 2016

Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation.

artículo científico publicado en 2017

Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture

artículo científico publicado en 2009

Plasminogen activator inhibitor-1 potentiates LPS-induced neutrophil activation through a JNK-mediated pathway.

artículo científico publicado en 2006

Plasminogen activator inhibitor-1 stimulates macrophage activation through Toll-like Receptor-4.

artículo científico publicado en 2016

Plasminogen activator inhibitor-1: the double-edged sword in apoptosis

artículo científico publicado en 2008

Plasminogen activators are not required in the erythrocytic life cycle of malaria parasites

artículo científico publicado en 1998

Plasminogen and cell migration in vivo

artículo científico

Plasminogen and plasminogen activators protect against renal injury in crescentic glomerulonephritis

artículo científico publicado en 1997

Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice ⬇️

artículo científico publicado el 15 de marzo de 1998

Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy.

artículo científico publicado en 2013

Rapid selection of Drosophila S2 cells with the puromycin resistance gene ⬇️

artículo científico publicado el 1 de septiembre de 2003

Rational design of syn-safencin, a novel linear antimicrobial peptide derived from the circular bacteriocin safencin AS-48.

artículo científico publicado en 2018

Receptor-independent plasminogen activation by urokinase-type plasminogen activator promotes, and adenoviral pai-1 gene transfer inhibits arterial neointima formation in mice

artículo científico

Remodeling of the vessel wall after copper-induced injury is highly attenuated in mice with a total deficiency of plasminogen activator inhibitor-1

artículo científico publicado en 2001

Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen

artículo científico publicado en 1996

Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice

artículo científico publicado en 2009

Solution structural model of the complex of the binding regions of human plasminogen with its M-protein receptor from Streptococcus pyogenes

artículo científico publicado en 2019

Spleen cells from antigen-minimized mice are superior to spleen cells from germ-free and conventional mice in the stimulation of primary in vitro proliferative responses to nominal antigens

artículo científico publicado en 1995

Stable genetic integration of a red fluorescent protein in a virulent Group A Streptococcus strain

scientific article published on 25 September 2019

Streptococcus co-opts a conformational lock in human plasminogen to facilitate streptokinase cleavage and bacterial virulence

artículo científico publicado en 2020

Streptococcus pyogenes Employs Strain-dependent Mechanisms of C3b Inactivation to Inhibit Phagocytosis and Killing of Bacteria

artículo científico publicado en 2016

Structure and function of the plasminogen/plasmin system

artículo científico publicado en 2005

Sulindac treatment alters collagen and matrilysin expression in adenomas of ApcMin/+ mice

artículo científico publicado en 2008

Synthetic Antimicrobial Peptide Tuning Permits Membrane Disruption and Interpeptide Synergy

scientific article published on 21 February 2020

Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury

artículo científico publicado en 2014

Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy

artículo científico publicado en 2016

Targeting plasminogen activator inhibitor-1: role in cell signaling and the biology of domain-specific knock-in mice

artículo científico publicado en 2007

The M-protein of Streptococcus pyogenes strain AP53 retains cell surface functional plasminogen binding after inactivation of the sortase A gene

artículo científico publicado en 2020

The Streptococcal protease SpeB antagonizes the biofilms of the human pathogen Staphylococcus aureus USA300 through cleavage of the Staphylococcal SdrC protein

artículo científico publicado en 2020

The characterization of mice with a targeted combined deficiency of protein c and factor XI.

artículo científico publicado en 2001

The development of bleomycin-induced pulmonary fibrosis in mice deficient for components of the fibrinolytic system

artículo científico publicado en 2000

The ex vivo reversibility of dabigatran-induced whole-blood coagulopathy as monitored by thromboelastography: mechanistic implications for clinical medicine

artículo científico publicado en 2012

The existence of independent domain structures in human Lys77-plasminogen ⬇️

artículo científico publicado el 25 de mayo de 1981

The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection

artículo científico publicado en 2003

The generation and characterization of mice expressing a plasmin-inactivating active site mutation

artículo científico publicado en 2010

The hemostasis system in murine atherosclerosis

artículo científico publicado en 2008

The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.

artículo científico publicado en 2007

The plasminogen system and cell migration during an inflammatory response

artículo científico

The plasminogen system in pulmonary fibrosis

artículo científico

The protein C pathway and pathologic processes

artículo científico publicado en 2009

The urokinase plasminogen activator receptor (uPAR) controls macrophage phagocytosis in intestinal inflammation

scientific article published on 21 May 2014

The vitronectin-binding domain of plasminogen activator inhibitor-1 plays an important functional role in lipopolysaccharide-induced lethality in mice

artículo científico publicado en 2012

The β-domain of cluster 2b streptokinase is a major determinant for the regulation of its plasminogen activation activity by cellular plasminogen receptors

artículo científico publicado en 2014

Thromboelastography in Orthopaedic Trauma Acute Pelvic Fracture Resuscitation: A Descriptive Pilot Study.

artículo científico publicado en 2016

Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model.

artículo científico publicado en 2003

Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse

artículo científico publicado en 2003

Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats.

artículo científico publicado en 2014

Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1.

artículo científico publicado en 2000

Two novel vascular injury models demonstrate a role for urokinase in early vascular repair events

artículo científico

Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation

artículo científico publicado en 2011

Unique genomic arrangements in an invasive serotype M23 strain of Streptococcus pyogenes identify genes that induce hypervirulence

artículo científico publicado en 2014

Use of Viscoelastography in Malignancy-Associated Coagulopathy and Thrombosis: A Review

scientific article published on 20 May 2019

Using technetium-99m MH-1 monoclonal antibody to image thrombi in a rabbit jugular vein

artículo científico

Variable region in streptococcal M-proteins provides stable binding with host fibrinogen for plasminogen-mediated bacterial invasion

artículo científico publicado en 2017

Variations in the secondary structures of PAM proteins influence their binding affinities to human plasminogen

scientific article published on 14 March 2019

gamma-Glutamate and beta-hydroxyaspartate in proteins

artículo científico publicado en 2008

gamma-glutamate and beta-hydroxyaspartate in proteins

scientific article published on 01 January 2002

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