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A Study of Aβ Oligomers in the Temporal Cortex and Cerebellum of Patients with Neuropathologically Confirmed Alzheimer's Disease Compared to Aged Controls

artículo científico publicado en 2016

A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers

artículo científico publicado en 2017

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

artículo científico publicado en 2010

A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies

scientific article published on 29 January 2019

A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment

artículo científico publicado en 2010

AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice

artículo científico publicado en 2009

ADDLs & protofibrils--the missing links?

artículo científico publicado en 2002

ADDLs and the signaling web that leads to Alzheimer's disease

artículo científico publicado en 2010

Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

artículo científico publicado en 2007

Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets

artículo científico publicado en 2002

Accumulation of intraneuronal amyloid-β is common in normal brain.

artículo científico publicado en 2014

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease

artículo científico publicado en 2022

Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station

artículo científico publicado en 2017

Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss

artículo científico publicado en 2003

Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.

artículo científico publicado en 2014

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

artículo científico publicado en 2007

Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal

artículo científico publicado en 2009

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.

artículo científico publicado en 2015

Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease

scientific article published on 01 November 2019

Amyloid beta oligomers induce impairment of neuronal insulin receptors

artículo científico publicado en 2007

Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis

artículo científico publicado en 2015

Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans.

artículo científico publicado en 2006

Amyloid-β and Tau Pathology of Alzheimer's Disease Induced by Diabetes in a Rabbit Animal Model

artículo científico publicado el 1 de enero de 2012

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons

artículo científico publicado en 2017

Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria

artículo científico publicado en 2010

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

artículo científico publicado en 2012

Antibody Fragments as Tools for Elucidating Structure-Toxicity Relationships and for Diagnostic/Therapeutic Targeting of Neurotoxic Amyloid Oligomers

artículo científico publicado en 2020

A  Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

artículo científico publicado en 2007

Aβ Oligomers-Induced Toxicity is Attenuated in Cells Cultured with NbActiv4™ Medium

artículo científico publicado el 23 de marzo de 2012

Aβ oligomer induced cognitive impairment and evaluation of ACU193-MNS-based MRI in rabbit

artículo científico publicado en 2020

Aβ oligomer-induced synapse degeneration in Alzheimer's disease

scientific article published on 03 May 2011

Brain transit and ameliorative effects of intranasally delivered anti-amyloid-β oligomer antibody in 5XFAD mice

scientific article published on January 2013

CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction

artículo científico publicado en 2009

Communication Science

article

Concordance with BRCA1/2 testing guidelines among women in The Health of Women (HOW) Study

article

Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers

artículo científico publicado en 2009

Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease.

artículo científico publicado en 2007

Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease.

artículo científico publicado en 2009

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.

artículo científico publicado en 2017

Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5

artículo científico publicado en 2010

Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry

artículo científico publicado en 2009

Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor

artículo científico publicado en 2005

Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity

artículo científico publicado en 2011

Disruption of neocortical histone H3 homeostasis by soluble Aβ: implications for Alzheimer's disease

artículo científico publicado en 2013

Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain

scientific article published on 06 March 2020

Earthquake precursors: activation or quiescence?

article

Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes

artículo científico publicado en 2016

Elucidating molecular mass and shape of a neurotoxic Aβ oligomer.

artículo científico publicado en 2014

Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers

artículo científico publicado en 2012

FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease

artículo científico publicado en 2013

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

artículo científico publicado en 2008

Femtomole Immunodetection of Synthetic and Endogenous Amyloid-β Oligomers and Its Application to Alzheimer's Disease Drug Candidate Screening

artículo científico publicado el 1 de enero de 2003

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers

artículo científico publicado en 2018

GEM Plate Boundary Simulations for the Plate Boundary Observatory: A Program for Understanding the Physics of Earthquakes on Complex Fault Networks via Observations, Theory and Numerical Simulation

scholarly article published 2002

Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers

artículo científico publicado en 2008

How do research participants perceive "uncertainty" in genome sequencing?

artículo científico publicado en 2014

Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice

artículo científico publicado el 17 de enero de 2012

Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice

artículo científico publicado en 2008

Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability

scientific article published on 29 October 2020

Increased Protein Tyrosine Phosphorylation in Apoptotic Neural Cell Death Due to Microtubule Perturbations

artículo científico publicado en 2000

Induction of inverted morphology in brain organoids by vertical-mixing bioreactors

artículo científico publicado en 2021

Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers.

artículo científico publicado en 2012

Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}

artículo científico publicado en 2009

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.

artículo científico publicado en 2014

Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

artículo científico publicado el 16 de marzo de 2011

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.

artículo científico publicado en 2016

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

artículo científico publicado el 12 de abril de 2011

Kalirin-7 prevents dendritic spine dysgenesis induced by amyloid beta-derived oligomers

artículo científico publicado en 2019

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

artículo científico publicado en 2013

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

artículo científico publicado en 2013

Modulation of amyloid-β aggregation by histidine-coordinating Cobalt(III) Schiff base complexes.

artículo científico publicado en 2014

Monoclonal antibodies that target pathological assemblies of Abeta

artículo científico publicado en 2006

More Is Not Always Better: Intuitions About Effective Public Policy Can Lead to Unintended Consequences

artículo científico publicado en 2013

N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers

artículo científico publicado en 2010

NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer's Disease.

artículo científico publicado en 2017

Nanodisc-solubilized membrane protein library reflects the membrane proteome

artículo científico publicado en 2013

Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease

artículo científico publicado en 2005

Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers

artículo científico publicado en 2015

Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease

artículo científico publicado en 2015

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.

artículo científico publicado en 2017

New Taxa and Recombinations in Oenothera (Anogra)

artículo científico publicado en 1962

Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers

artículo científico publicado en 2010

PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42

artículo científico publicado en 2006

Pattern Dynamics and Forecast Methods in Seismically Active Regions

Per-6-substituted beta-cyclodextrin libraries inhibit formation of beta-amyloid-peptide (A beta)-derived, soluble oligomers

artículo científico publicado en 2002

Per-6-substituted-per-6-deoxy beta-cyclodextrins inhibit the formation of beta-amyloid peptide derived soluble oligomers

artículo científico publicado en 2004

Probabilities for large events in driven threshold systems

artículo científico publicado en 2012

Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols

artículo científico publicado en 2012

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers

artículo científico publicado en 2009

Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers

artículo científico publicado en 2016

Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed fibrils and protects against Abeta-induced cytotoxicty.

artículo científico publicado en 2007

Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein

artículo científico publicado en 2002

Self-assembly of Abeta(1-42) into globular neurotoxins.

artículo científico publicado en 2003

Self-rated cardiovascular risk and 15-year cardiovascular mortality

artículo científico publicado en 2008

Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus.

artículo científico publicado en 2002

Soluble proteins from rat olfactory bulb promote the survival and differentiation of cultured basal forebrain neurons

artículo científico publicado el 1 de junio de 1988

Soluble state high resolution atomic force microscopy study of Alzheimer's beta-amyloid oligomers

artículo científico publicado en 2009

Solution of a truncated Kirkwood-Salsburg equation for the hard-sphere gas

article

Space-time clustering and correlations of major earthquakes

artículo científico publicado en 2006

Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons.

artículo científico publicado en 2009

Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis

artículo científico publicado en 2014

Synapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodies

artículo científico publicado en 2012

Synaptic targeting by A beta oligomers (ADDLS) as a basis for memory loss in early Alzheimer's disease

artículo científico publicado en 2006

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

artículo científico publicado en 2004

Synaptotoxic Amyloid-β Oligomers: A Molecular Basis for the Cause, Diagnosis, and Treatment of Alzheimer's Disease?

artículo científico publicado el 1 de enero de 2013

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

artículo científico publicado en 2013

Targeting generation of antibodies specific to conformational epitopes of amyloid beta-derived neurotoxins

artículo científico publicado en 2009

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

artículo científico publicado en 2006

Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology

artículo científico publicado en 2005

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade.

artículo científico publicado en 2018

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease

artículo científico publicado en 2011

The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells

artículo científico publicado en 2009

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.

artículo científico publicado en 2018

Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease.

artículo científico publicado en 2014

Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1

artículo científico publicado en 2016

Unplanned sexual activity as a consequence of alcohol use: a prospective study of risk perceptions and alcohol use among college freshmen

artículo científico publicado en 2007

Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death

artículo científico publicado en 2012

[Comment on “Exaggerated claims about earthquake predictions: Analysis of NASA's method”] Pattern informatics and cellular seismology: A comparison of methods

article