Lista de obras -

"Hard" and "soft" lesions underlying the HLA class I alterations in cancer cells: implications for immunotherapy

scientific article published on July 2010

A Combination of Positive Tumor HLA-I and Negative PD-L1 Expression Provides an Immune Rejection Mechanism in Bladder Cancer

artículo científico publicado en 2019

A novel preclinical murine model of immune-mediated metastatic dormancy.

artículo científico publicado en 2014

A polymorphism in the interleukin-10 promoter affects the course of disease in patients with clear-cell renal carcinoma

scientific article published on 21 November 2008

Alterations of HLA class I expression in human melanoma xenografts in immunodeficient mice occur frequently and are associated with higher tumorigenicity.

artículo científico publicado en 2009

Analysis of HLA class I expression in progressing and regressing metastatic melanoma lesions after immunotherapy

scientific article published on 11 June 2008

Analysis of HLA expression in human tumor tissues

artículo científico publicado en 2002

Analysis of HLA-ABC locus-specific transcription in normal tissues.

artículo científico publicado en 2010

Analysis of HLA-E expression in human tumors

artículo científico publicado en 2003

Analysis of NK cells and chemokine receptors in tumor infiltrating CD4 T lymphocytes in human renal carcinomas

artículo científico publicado en 2005

Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer

artículo científico publicado en 2012

Bacillus Calmette-Guerin immunotherapy of bladder cancer induces selection of human leukocyte antigen class I-deficient tumor cells.

artículo científico publicado en 2011

Cancer immune escape: MHC expression in primary tumours versus metastases

artículo científico publicado en 2019

Cancer immune escape: implications for immunotherapy, Granada, Spain, October 3-5, 2011

scientific article published on 21 February 2012

Changes in activatory and inhibitory natural killer (NK) receptors may induce progression to multiple myeloma: implications for tumor evasion of T and NK cells

artículo científico publicado en 2009

Characterization of HLA class I altered phenotypes in a panel of human melanoma cell lines

artículo científico publicado en 2007

Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach

artículo científico publicado en 2015

Complete loss of HLA class I antigen expression on melanoma cells: a result of successive mutational events.

artículo científico publicado en 2003

Coordinated downregulation of the antigen presentation machinery and HLA class I/beta2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer

artículo científico publicado en 2005

Different regulation of PKC isoenzymes and MAPK by PSK and IL-2 in the proliferative and cytotoxic activities of the NKL human natural killer cell line.

artículo científico publicado en 2002

Distinct mechanisms of loss of IFN-gamma mediated HLA class I inducibility in two melanoma cell lines

artículo científico publicado en 2007

Distribution of HLA class I altered phenotypes in colorectal carcinomas: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21.

artículo científico publicado en 2004

Expression of MHC class I, MHC class II, and cancer germline antigens in neuroblastoma

scientific article published on 24 September 2004

Frequent HLA class I alterations in human prostate cancer: molecular mechanisms and clinical relevance

artículo científico publicado en 2015

Frequent loss of heterozygosity in the β2-microglobulin region of chromosome 15 in primary human tumors ⬇️

artículo científico publicado el 18 de noviembre de 2010

Generation of MHC class I diversity in primary tumors and selection of the malignant phenotype.

artículo científico publicado en 2014

Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer

artículo científico publicado en 2008

Genome-wide differential genetic profiling characterizes colorectal cancers with genetic instability and specific routes to HLA class I loss and immune escape ⬇️

artículo científico publicado el 10 de noviembre de 2011

Genomic loss of HLA alleles may affect the clinical outcome in low-risk myelodysplastic syndrome patients

artículo científico publicado en 2018

HLA Class-I Expression and Cancer Immunotherapy

artículo científico publicado en 2019

HLA Class-II Expression in Human Tumors

artículo científico publicado en 2019

HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank.

artículo científico publicado en 2009

HLA class I alterations in breast carcinoma are associated with a high frequency of the loss of heterozygosity at chromosomes 6 and 15.

artículo científico publicado en 2018

HLA class I antigen abnormalities and immune escape by malignant cells.

artículo científico publicado en 2002

HLA class I expression in metastatic melanoma correlates with tumor development during autologous vaccination.

artículo científico publicado en 2006

HLA class I loss and PD-L1 expression in lung cancer: impact on T-cell infiltration and immune escape.

artículo científico publicado en 2017

High frequency of HLA-B44 allelic losses in human solid tumors

artículo científico publicado en 2003

High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity

scholarly article by Teresa Rodriguez et al published 1 October 2004 in Cancer Immunology, Immunotherapy

High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer

IFN inducibility of major histocompatibility antigens in tumors

artículo científico publicado en 2008

Identification of different tumor escape mechanisms in several metastases from a melanoma patient undergoing immunotherapy

artículo científico publicado en 2006

Identification of the protein components of protein-bound polysaccharide (PSK) that interact with NKL cells.

artículo científico publicado en 2004

Immune escape of cancer cells with beta2-microglobulin loss over the course of metastatic melanoma

artículo científico publicado en 2013

Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors

artículo científico publicado en 2013

Immunotherapy eradicates metastases with reversible defects in MHC class I expression

artículo científico publicado en 2011

Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients

scientific article published on 12 January 2010

Impaired surface antigen presentation in tumors: implications for T cell-based immunotherapy.

artículo científico publicado en 2002

Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes ⬇️

artículo científico publicado el 26 de julio de 2012

International conference: progress in vaccination against cancer-2006 (PIVAC 6), Granada, Spain.

artículo científico publicado en 2007

Introduction

artículo científico publicado en 2019

Involvement of the chaperone tapasin in HLA-B44 allelic losses in colorectal tumors

artículo científico publicado en 2005

LOH at 6p21.3 region and HLA class I altered phenotypes in bladder carcinomas

artículo científico publicado en 2006

Late pulmonary metastases of renal cell carcinoma immediately after post-transplantation immunosuppressive treatment: a case report

artículo científico publicado en 2008

Leukocyte infiltrate in gastrointestinal adenocarcinomas is strongly associated with tumor microsatellite instability but not with tumor immunogenicity

artículo científico publicado en 2011

Low frequency of HLA haplotype loss associated with loss of heterozygocity in chromosome region 6p21 in clear renal cell carcinomas

scientific article published on 01 April 2004

MHC Intratumoral Heterogeneity May Predict Cancer Progression and Response to Immunotherapy.

artículo científico publicado en 2018

MHC class I antigens and immune surveillance in transformed cells.

artículo científico publicado en 2007

MHC class I antigens, immune surveillance, and tumor immune escape.

artículo científico publicado en 2003

MHC class I molecules act as tumor suppressor genes regulating the cell cycle gene expression, invasion and intrinsic tumorigenicity of melanoma cells.

artículo científico publicado en 2012

MHC class I-deficient metastatic tumor variants immunoselected by T lymphocytes originate from the coordinated downregulation of APM components.

artículo científico publicado en 2003

MHC/HLA Class I Loss in Cancer Cells

artículo científico publicado en 2019

Metastases in immune-mediated dormancy: a new opportunity for targeting cancer

artículo científico publicado en 2014

Multiple mechanisms generate HLA class I altered phenotypes in laryngeal carcinomas: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21

scientific article published on 28 June 2002

Negative Clinical Evolution in COVID-19 Patients Is Frequently Accompanied With an Increased Proportion of Undifferentiated Th Cells and a Strong Underrepresentation of the Th1 Subset

scientific article published on 26 November 2020

Regressing and progressing metastatic lesions: resistance to immunotherapy is predetermined by irreversible HLA class I antigen alterations

artículo científico publicado en 2008

Regression of melanoma metastases after immunotherapy is associated with activation of antigen presentation and interferon‐mediated rejection genes ⬇️

artículo científico publicado el 9 de noviembre de 2011

Rejection versus escape: the tumor MHC dilemma

artículo científico publicado en 2016

Restoration of MHC-I on Tumor Cells by Fhit Transfection Promotes Immune Rejection and Acts as an Individualized Immunotherapeutic Vaccine

artículo científico publicado en 2020

Role of altered expression of HLA class I molecules in cancer progression.

artículo científico publicado en 2007

Role of glutathione in the induction of apoptosis and c-fos and c-jun mRNAs by oxidative stress in tumor cells.

artículo científico publicado en 2004

T lymphocytes restrain spontaneous metastases in permanent dormancy.

artículo científico publicado en 2014

TAP1 and TAP2 polymorphisms and their linkage disequilibrium with HLA-DR, -DP, and -DQ in an eastern Andalusian population

artículo científico publicado en 2005

Targetless T cells in cancer immunotherapy

artículo científico publicado en 2016

The Escape of Cancer from T Cell-Mediated Immune Surveillance: HLA Class I Loss and Tumor Tissue Architecture

artículo científico publicado en 2017

The absence of HLA class I expression in non-small cell lung cancer correlates with the tumor tissue structure and the pattern of T cell infiltration

artículo científico publicado en 2016

The escape of cancer from T lymphocytes: immunoselection of MHC class I loss variants harboring structural-irreversible "hard" lesions

artículo científico publicado en 2010

The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis

artículo científico publicado en 2008

The selection of tumor variants with altered expression of classical and nonclassical MHC class I molecules: implications for tumor immune escape.

artículo científico publicado en 2004

The transition from HLA-I positive to HLA-I negative primary tumors: the road to escape from T-cell responses

artículo científico publicado en 2018

The tumour suppressor Fhit positively regulates MHC class I expression on cancer cells ⬇️

artículo científico publicado el 23 de mayo de 2012

The urgent need to recover MHC class I in cancers for effective immunotherapy

artículo científico publicado en 2016

Total loss of HLA class I expression on a melanoma cell line after growth in nude mice in absence of autologous antitumor immune response.

artículo científico publicado en 2007

Tumor genetic alterations and features of the immune microenvironment drive myelodysplastic syndrome escape and progression

scientific article published on 08 November 2019

Upregulation of HLA Class I Expression on Tumor Cells by the Anti-EGFR Antibody Nimotuzumab.

artículo científico publicado en 2017

VEGF polymorphisms are not associated with an increased risk of developing renal cell carcinoma in Spanish population ⬇️

artículo científico publicado el 13 de octubre de 2012

Lista de obras de

"Hard" and "soft" lesions underlying the HLA class I alterations in cancer cells: implications for immunotherapy

A Combination of Positive Tumor HLA-I and Negative PD-L1 Expression Provides an Immune Rejection Mechanism in Bladder Cancer

A novel preclinical murine model of immune-mediated metastatic dormancy.

A polymorphism in the interleukin-10 promoter affects the course of disease in patients with clear-cell renal carcinoma

Alterations of HLA class I expression in human melanoma xenografts in immunodeficient mice occur frequently and are associated with higher tumorigenicity.

Analysis of HLA class I expression in progressing and regressing metastatic melanoma lesions after immunotherapy

Analysis of HLA expression in human tumor tissues

Analysis of HLA-ABC locus-specific transcription in normal tissues.

Analysis of HLA-E expression in human tumors

Analysis of NK cells and chemokine receptors in tumor infiltrating CD4 T lymphocytes in human renal carcinomas

Association between C13ORF31, NOD2, RIPK2 and TLR10 polymorphisms and urothelial bladder cancer

Bacillus Calmette-Guerin immunotherapy of bladder cancer induces selection of human leukocyte antigen class I-deficient tumor cells.

Cancer immune escape: MHC expression in primary tumours versus metastases

Cancer immune escape: implications for immunotherapy, Granada, Spain, October 3-5, 2011

Changes in activatory and inhibitory natural killer (NK) receptors may induce progression to multiple myeloma: implications for tumor evasion of T and NK cells

Characterization of HLA class I altered phenotypes in a panel of human melanoma cell lines

Colorectal Cancer Classification and Cell Heterogeneity: A Systems Oncology Approach

Complete loss of HLA class I antigen expression on melanoma cells: a result of successive mutational events.

Coordinated downregulation of the antigen presentation machinery and HLA class I/beta2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer

Different regulation of PKC isoenzymes and MAPK by PSK and IL-2 in the proliferative and cytotoxic activities of the NKL human natural killer cell line.

Distinct mechanisms of loss of IFN-gamma mediated HLA class I inducibility in two melanoma cell lines

Distribution of HLA class I altered phenotypes in colorectal carcinomas: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21.

Expression of MHC class I, MHC class II, and cancer germline antigens in neuroblastoma

Frequent HLA class I alterations in human prostate cancer: molecular mechanisms and clinical relevance

Frequent loss of heterozygosity in the β2-microglobulin region of chromosome 15 in primary human tumors ⬇️

Generation of MHC class I diversity in primary tumors and selection of the malignant phenotype.

Genetic polymorphisms of RANTES, IL1-A, MCP-1 and TNF-A genes in patients with prostate cancer

Genome-wide differential genetic profiling characterizes colorectal cancers with genetic instability and specific routes to HLA class I loss and immune escape ⬇️

Genomic loss of HLA alleles may affect the clinical outcome in low-risk myelodysplastic syndrome patients

HLA Class-I Expression and Cancer Immunotherapy

HLA Class-II Expression in Human Tumors

HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank.

HLA class I alterations in breast carcinoma are associated with a high frequency of the loss of heterozygosity at chromosomes 6 and 15.

HLA class I antigen abnormalities and immune escape by malignant cells.

HLA class I expression in metastatic melanoma correlates with tumor development during autologous vaccination.

HLA class I loss and PD-L1 expression in lung cancer: impact on T-cell infiltration and immune escape.

High frequency of HLA-B44 allelic losses in human solid tumors

High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity

High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer

IFN inducibility of major histocompatibility antigens in tumors

Identification of different tumor escape mechanisms in several metastases from a melanoma patient undergoing immunotherapy

Identification of the protein components of protein-bound polysaccharide (PSK) that interact with NKL cells.

Immune escape of cancer cells with beta2-microglobulin loss over the course of metastatic melanoma

Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors

Immunotherapy eradicates metastases with reversible defects in MHC class I expression

Impact of interleukin-18 polymorphisms-607 and -137 on clinical characteristics of renal cell carcinoma patients

Impaired surface antigen presentation in tumors: implications for T cell-based immunotherapy.

Implication of the β2-microglobulin gene in the generation of tumor escape phenotypes ⬇️

International conference: progress in vaccination against cancer-2006 (PIVAC 6), Granada, Spain.

Introduction

Involvement of the chaperone tapasin in HLA-B44 allelic losses in colorectal tumors

LOH at 6p21.3 region and HLA class I altered phenotypes in bladder carcinomas

Late pulmonary metastases of renal cell carcinoma immediately after post-transplantation immunosuppressive treatment: a case report

Leukocyte infiltrate in gastrointestinal adenocarcinomas is strongly associated with tumor microsatellite instability but not with tumor immunogenicity

Low frequency of HLA haplotype loss associated with loss of heterozygocity in chromosome region 6p21 in clear renal cell carcinomas

MHC Intratumoral Heterogeneity May Predict Cancer Progression and Response to Immunotherapy.

MHC class I antigens and immune surveillance in transformed cells.

MHC class I antigens, immune surveillance, and tumor immune escape.

MHC class I molecules act as tumor suppressor genes regulating the cell cycle gene expression, invasion and intrinsic tumorigenicity of melanoma cells.

MHC class I-deficient metastatic tumor variants immunoselected by T lymphocytes originate from the coordinated downregulation of APM components.

MHC/HLA Class I Loss in Cancer Cells

Metastases in immune-mediated dormancy: a new opportunity for targeting cancer

Multiple mechanisms generate HLA class I altered phenotypes in laryngeal carcinomas: high frequency of HLA haplotype loss associated with loss of heterozygosity in chromosome region 6p21

Negative Clinical Evolution in COVID-19 Patients Is Frequently Accompanied With an Increased Proportion of Undifferentiated Th Cells and a Strong Underrepresentation of the Th1 Subset

Regressing and progressing metastatic lesions: resistance to immunotherapy is predetermined by irreversible HLA class I antigen alterations

Regression of melanoma metastases after immunotherapy is associated with activation of antigen presentation and interferon‐mediated rejection genes ⬇️

Rejection versus escape: the tumor MHC dilemma

Restoration of MHC-I on Tumor Cells by Fhit Transfection Promotes Immune Rejection and Acts as an Individualized Immunotherapeutic Vaccine

Role of altered expression of HLA class I molecules in cancer progression.

Role of glutathione in the induction of apoptosis and c-fos and c-jun mRNAs by oxidative stress in tumor cells.

T lymphocytes restrain spontaneous metastases in permanent dormancy.

TAP1 and TAP2 polymorphisms and their linkage disequilibrium with HLA-DR, -DP, and -DQ in an eastern Andalusian population

Targetless T cells in cancer immunotherapy

The Escape of Cancer from T Cell-Mediated Immune Surveillance: HLA Class I Loss and Tumor Tissue Architecture

The absence of HLA class I expression in non-small cell lung cancer correlates with the tumor tissue structure and the pattern of T cell infiltration

The escape of cancer from T lymphocytes: immunoselection of MHC class I loss variants harboring structural-irreversible "hard" lesions

The immunomodulator PSK induces in vitro cytotoxic activity in tumour cell lines via arrest of cell cycle and induction of apoptosis

The selection of tumor variants with altered expression of classical and nonclassical MHC class I molecules: implications for tumor immune escape.

The transition from HLA-I positive to HLA-I negative primary tumors: the road to escape from T-cell responses