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(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase

artículo científico publicado en 2000

(R)-3-Amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding mode

artículo científico publicado en 2002

3-Amidinophenylalanine-based inhibitors of urokinase

artículo científico publicado en 1999

4-amidinobenzylamine-based inhibitors of urokinase

artículo científico publicado en 2002

A new assay for the determination of factor XII in plasma using a chromogenic substrate and a selective inhibitor of plasma kallikrein

scientific article published on 01 September 1989

Acyl-kallikrein; a delivery system for the kinin-liberating enzyme

artículo científico publicado en 1984

Advances in the development of thrombin inhibitors

artículo científico publicado en 2001

Antithrombin effects of native and recombinant hirudins

artículo científico publicado en 1990

Are factor Xa inhibitors superior to thrombin inhibitors in anticoagulation?

artículo científico publicado en 1988

Are synthetic inhibitors able to improve factor Xa assays using peptide substrates?

artículo científico publicado en 1982

Assay of hirudin in plasma using a chromogenic thrombin substrate

artículo científico publicado en 1985

Blood coagulation and fibrinolysis after extreme short-term exercise

artículo científico publicado en 2003

Blood coagulation and fibrinolysis after long-duration treadmill exercise controlled by individual anaerobic threshold

artículo científico publicado en 2003

Blood coagulation and fibrinolysis before and after exhaustive exercise in patients with IDDM

artículo científico publicado en 2003

Clinical pharmacology of recombinant hirudin

artículo científico publicado en 1991

Clinico-pharmacological studies with recombinant hirudin

artículo científico publicado en 1988

Comparison of the anticoagulant and antithrombotic effects of synthetic thrombin and factor Xa inhibitors

artículo científico publicado en 1990

Complexation of the tissue plasminogen activator protease with benzamidine-type inhibitors: interference by the kringle 2 module.

artículo científico publicado en 1996

Correlating structure and ligand affinity in drug discovery: a cautionary tale involving second shell residues

artículo científico publicado en 2014

Crystallographic determination of thrombin complexes with small synthetic inhibitors as a starting point for the receptor-based design of antithrombotics

artículo científico publicado en 1993

Crystals of the urokinase type plasminogen activator variant beta(c)-uPAin complex with small molecule inhibitors open the way towards structure-based drug design

artículo científico publicado en 2000

Cyanopeptide analogues: new lead structures for the design and synthesis of new thrombin inhibitors.

artículo científico publicado en 2002

Cyclic amides of N alpha-arylsulfonylaminoacylated 4-amidinophenylalanine--tight binding inhibitors of thrombin

artículo científico publicado en 1983

Defibrinogenation by batroxobin and acylated batroxobin in rats

artículo científico publicado en 1988

Defibrinogenation with benzoyl-batroxobin

artículo científico publicado en 1985

Design and evaluation of novel bivalent thrombin inhibitors based on amidinophenylalanines

artículo científico publicado en 1999

Design of benzamidine-type inhibitors of factor Xa

artículo científico publicado en 1998

Design of novel and selective inhibitors of urokinase-type plasminogen activator with improved pharmacokinetic properties for use as antimetastatic agents

artículo científico publicado en 2004

Determination of Activated Factor IX in Factor IX Concentrates with a Chromogenic Substrate ⬇️

artículo científico publicado el 15 de octubre de 1998

Determination of factor XII in plasma using the kallikrein substrate chromozym PK

scientific article published on 01 March 1982

Determination of factor XII, plasma prekallikrein and factor V in patients with thrombophilic states

artículo científico publicado el 1 de enero de 1984

Diminished oestrogen sensitivity and increased ovulation rate in adult female rats after prepubertal treatment with oestrogen or pimozide ⬇️

artículo científico publicado el 1 de julio de 1988

Dramatic enhancement of the catalytic activity of coagulation factor IXa by alcohols

artículo científico publicado en 1997

EEG- and COR-audiometry in childhood within the frame of an age related mass screening

artículo científico publicado en 1974

Effect of medial preoptic oestradiol implants on hypothalamic beta-endorphin concentration

artículo científico

Effective inhibition of experimental metastasis and prolongation of survival in mice by a potent factor Xa-specific synthetic serine protease inhibitor with weak anticoagulant activity

scientific article published on 01 November 2005

Effects of sodium nitroprusside and other pentacyanonitrosyl complexes on platelet aggregation.

artículo científico publicado en 1974

Experimental animal research on the thrombolytic effect of acyl-plasmin

artículo científico publicado en 1986

Experimental studies on the action mechanism of neurohormone D from Periplaneta americana (L) on the "biological model" of Bufo bufo (L) urinary bladder ⬇️

artículo científico

Expression and proteolysis of vascular endothelial growth factor is increased in chronic wounds

artículo científico publicado en 2000

Factorising ligand affinity: a combined thermodynamic and crystallographic study of trypsin and thrombin inhibition

artículo científico publicado en 2001

Fibrinogen Magdeburg I: a novel variant of human fibrinogen with an amino acid exchange in the fibrinopeptide A (Aα 9, Leu→Pro) ⬇️

artículo científico publicado el 25 de enero de 2003

Fibrinolytic activity of acyl-urokinase

artículo científico publicado en 1986

From selective substrate analogue factor Xa inhibitors to dual inhibitors of thrombin and factor Xa. Part 3

artículo científico publicado en 2007

Further experimental studies on the mechanism of action of neurohormone D from Periplaneta americana (L) on the "biologic model" of Bufo bufo urinary bladder: influencing of Na+-transport

artículo científico publicado en 1971

Geometry of GPPE binding to picrate and to the urokinase type plasminogen activator

artículo científico publicado en 2007

Geometry of binding of the N alpha-tosylated piperidides of m-amidino-, p-amidino- and p-guanidino phenylalanine to thrombin and trypsin. X-ray crystal structures of their trypsin complexes and modeling of their thrombin complexes

artículo científico publicado en 1991

Highly potent and selective substrate analogue factor Xa inhibitors containing D-homophenylalanine analogues as P3 residue: part 2

artículo científico publicado en 2007

In vitro inhibition of matriptase prevents invasive growth of cell lines of prostate and colon carcinoma

artículo científico publicado en 2005

Increase of anti-metastatic efficacy by selectivity- but not affinity-optimization of synthetic serine protease inhibitors

artículo científico publicado en 2003

Influence of indocyanine green on plasma disappearance and biliary excretion of a synthetic thrombin inhibitor of the 3-amidinophenyl-alanine piperazide-type in rats

artículo científico publicado el 1 de mayo de 1998

Influence of thrombin inhibitors on the thrombin-induced activation of human blood platelets

scientific article published on 01 January 1983

Inhibition of Urokinase Activity Reduces Primary Tumor Growth and Metastasis Formation in a Murine Lung Carcinoma Model

artículo científico publicado en 2010

Inhibition of acrosin by benzamidines

artículo científico publicado en 1981

Inhibition of activated protein C by benzamidine derivatives

scientific article published on 01 March 1993

Inhibition of batroxobin, a serine proteinase from Bothrops snake venom, by derivatives of benzamidine

artículo científico publicado en 1986

Inhibition of bovine and human thrombins by derivatives of benzamidine

artículo científico publicado en 1984

Inhibition of chymotrypsin and pancreatic elastase by 4H-3,1-benzoxazin-4-ones

artículo científico publicado en 1991

Inhibition of glandular and plasma kallikrein by benzamidine derivatives

artículo científico publicado el 1 de enero de 1992

Inhibition of human mast cell tryptase by benzamidine derivatives

artículo científico publicado el 1 de octubre de 1992

Inhibition of the protein C activator Protac, a serine proteinase from the venom of the southern copperhead snake Agkistrodon contortrix contortrix

scientific article published on 01 January 1991

Inhibition of thrombin generation in plasma by inhibitors of factor Xa

artículo científico publicado el 1 de octubre de 1997

Inhibition of trypsin and thrombin by amidinophenyl esters of aromatic carboxylic acids

artículo científico publicado el 1 de enero de 1972

Inhibition of tumour cell invasion by protease inhibitors: correlation with the protease profile

artículo científico publicado en 1998

Inhibitors of benzamidine type influence the virulence properties of Porphyromonas gingivalis strains

artículo científico publicado el 1 de enero de 2003

Inhibitors of factor XIIIa

artículo científico publicado en 2002

Interactions of thrombin with benzamidine-based inhibitors

artículo científico publicado en 1992

Isolation, Cloning and Structural Characterisation of Boophilin, a Multifunctional Kunitz-Type Proteinase Inhibitor from the Cattle Tick

artículo científico publicado en 2008

Mapping of the catalytic site of CHO‐t‐PA and the t‐PA variant BM 06.022 by synthetic inhibitors and substrates ⬇️

artículo científico publicado el 1 de agosto de 1992

Methods for Determination of Hirudin ⬇️

artículo científico publicado el 1 de abril de 1991

N alpha-arylsulfonyl-omega-(4-amidinophenyl)-alpha-aminoalkylcarboxylic acid amides--novel selective inhibitors of thrombin

artículo científico publicado en 1980

N alpha-arylsulfonyl-omega-amidinophenyl-alpha-aminoalkyl-carboxylic acid amides as specific thrombin inhibitors

artículo científico publicado el 1 de enero de 1982

New bivalent thrombin inhibitors with N(alpha)(methyl)arginine at the P1-position

artículo científico publicado en 2000

New substrate analogue inhibitors of factor Xa containing 4-amidinobenzylamide as P1 residue: part 1

artículo científico publicado en 2006

New thrombin inhibitors based on D-cha-Pro-derivatives

artículo científico publicado en 1999

Novel plasma kallikrein inhibitors of the benzamidine type

artículo científico publicado en 1994

On the question ofthe identity and occurrence of neurohormone D in different regions of the central nervous system of Periplaneta americana

artículo científico publicado en 1967

Pharmacokinetics and anticoagulant effect of hirudin in man.

artículo científico publicado en 1984

Pharmacological effect of pentacyanonitrosylferrate and similar complex compounds

artículo científico publicado el 1 de enero de 1978

Pharmacological survey of recombinant hirudin

artículo científico publicado en 1988

Preservation of in vitro function of platelets stored in the presence of a synthetic dual inhibitor of factor Xa and thrombin

scientific article published on 31 July 2007

Progress in the development of synthetic thrombin inhibitors as new orally active anticoagulants

artículo científico publicado en 2004

Proteases of Isolated Pancreatic Acinar Cells after Caerulein Hyperstimulation ⬇️

artículo científico publicado el 1 de enero de 1997

Pure eccentric exercise does not activate blood coagulation

artículo científico publicado en 2005

Refined 2.3 A X-ray crystal structure of bovine thrombin complexes formed with the benzamidine and arginine-based thrombin inhibitors NAPAP, 4-TAPAP and MQPA. A starting point for improving antithrombotics

artículo científico publicado en 1992

Retardation of preovulatory desensitization to negative oestrogen feedback: mechanism of the effect of progesterone in 5-day cyclic rats

artículo científico publicado en 1987

Role of heparin in the inactivation of thrombin, factor Xa, and plasmin by antithrombin III ⬇️

artículo científico publicado el 1 de diciembre de 1977

Role of heparin in the interaction of serine proteinases with antithrombin III

artículo científico publicado el 1 de enero de 1977

Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase

artículo científico publicado en 2006

Selective inhibition of large-to-small surfactant aggregate conversion by serine protease inhibitors of the bis-benzamidine type

artículo científico publicado en 2003

Stable acyl-derivatives of tissue-type plasminogen activator

artículo científico publicado en 1987

Stable acyl-derivatives of trypsin-like enzymes. Preparation, kinetics, application

scientific article published on 01 January 1986

Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.

artículo científico publicado en 1998

Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors

artículo científico publicado en 1997

Structure-Activity Relationships of New NAPAP-Analogs ⬇️

artículo científico publicado el 1 de enero de 2001

Structure-Activity Relationships of Recombinant Hirudins ⬇️

artículo científico publicado el 1 de abril de 1991

Structure-activity relationships of inhibitors derived from 3-amidinophenylalanine

artículo científico publicado en 1995

Structure-activity relationships of new NAPAP-analogs.

artículo científico publicado en 2002

Structure-based Design of a Potent Chimeric Thrombin Inhibitor ⬇️

artículo científico publicado el 8 de agosto de 1997

Suppression of rat breast cancer metastasis and reduction of primary tumour growth by the small synthetic urokinase inhibitor WX-UK1

artículo científico publicado en 2005

Synthesis and Structure−Activity Relationships of Potent Thrombin Inhibitors: Piperazides of 3-Amidinophenylalanine ⬇️

artículo científico publicado el 12 de septiembre de 1997

Synthetic inhibitors of bovine factor Xa and thrombin comparison of their anticoagulant efficiency

artículo científico publicado en 1989

Synthetic inhibitors of serine proteinases XIV.+) inhibition of Factor Xa by derivatives of benzamidine

artículo científico publicado el 1 de diciembre de 1976

Synthetic inhibitors of serine proteinases. 10. The inhibition of trypsin, plasmin and thrombin by 4-amidinophenylaralkanone

artículo científico publicado el 1 de enero de 1976

Synthetic inhibitors of serine proteinases. 11.Report: The inhibition of trypsin, plasmin and thrombin by new bisamidino compounds

artículo científico publicado el 1 de enero de 1976

Synthetic inhibitors of serine proteinases. 12. The inhibition of trypsin, plasmin and thrombin by 3-[amidinophenyl]-1-phenyl-propanone-(1) with substituents in the aliphatic intermediate chain

artículo científico publicado el 1 de junio de 1976

Synthetic inhibitors of serine proteinases. 13. Quantitative structure-activity relationship for inhibition of trypsin and thrombin by 4-amidinophenyl compounds with a ketone structure

artículo científico publicado el 1 de enero de 1976

Synthetic inhibitors of serine proteinases. 15. Antitrypsin, antiplasmin and antithrombin effect of 2-amino-6-alkoxy- and aralkoxynaphthalenes

artículo científico publicado el 1 de diciembre de 1977

Synthetic inhibitors of serine proteinases. 17. The effect of benzamidine derivatives on the activity of urokinase and the reduction of fibrinolysis

artículo científico publicado el 1 de septiembre de 1978

Synthetic inhibitors of serine proteinases. 18. Inhibition of trypsin, plasmin and thrombin by derivatives of naphthamidine and ketone structure

artículo científico publicado el 1 de noviembre de 1978

Synthetic inhibitors of serine proteinases. 20. The inhibitory effect of benzo condensed lactam derivatives of benzamidine on trypsin, plasmin and thrombin

artículo científico publicado el 1 de enero de 1979

Synthetic inhibitors of serine proteinases. 22. Inhibition of acrosin by benzamidine derivatives

scientific article published on 01 January 1980

Synthetic inhibitors of serine proteinases. 31. The inhibition of trypsin, plasmin and thrombin by isomeric compounds of N alpha -arylsulfonylated omega-amidinophenyl-alpha-aminoalkylcarboxylic acid amides

artículo científico publicado el 1 de junio de 1984

Synthetic inhibitors of serine proteinases. 34. The effect of modification of the amidino function of N-alpha-substituted 4-amidinophenylalanine amides on inhibitory activity

artículo científico publicado en 1988

Synthetic inhibitors of serine proteinases. 5. The inhibition of trypsin, plasmin and thrombin caused by aliphatic amidino compounds having ether structure as well as esters of the 3- and 4-amidinophenoxyfacetic acid

artículo científico publicado el 1 de junio de 1975

Synthetic inhibitors of serine proteinases. 7. Inhibition of trypsin, plasmin and thrombin by amidinobenzylarylsulfides and -sulfones as well as N-(amidinobenzyl)-N-(aryl)- and N-(amidinobenzyl)-N-(arylalkyl)amines

artículo científico publicado el 1 de enero de 1976

Synthetic inhibitors of serine proteinases. 8. Inhibition of trypsin, plasmin and thrombin by means of amidinophenyl-derivatives with ketonic-structure

artículo científico publicado el 1 de julio de 1976

Synthetic inhibitors of serine proteinases. 9. The inhibition of tryspsin,plasmin and thrombin by amidinophenyl-, amidinobenzyl- and beta-(amidinophenyl)ethylarylketons

artículo científico publicado el 1 de enero de 1976

Synthetic inhibitors of serine proteinases. Part 19: On the inhibitory effect of amidinobenzylidene derivatives of benzo-condensed cycloalkanones on trypsin, plasmin and thrombin (author's transl)

artículo científico publicado el 1 de enero de 1979

Synthetic inhibitors of serine proteinases. Part 21: Studies on the structure-activity relationships in bisamidines (author's transl)

artículo científico publicado el 1 de diciembre de 1979

Synthetic inhibitors of serine proteinases. Part 26: Inhibition of trypsin, plasmin and thrombin by amides of N alpha-arylsulfonylated 2-amino-4-(4-amidino-phenyl) butyric acid and 2-amino-5-amidinophenyl valeric acids (author's transl)

artículo científico publicado en 1982

Synthetic inhibitors of serine proteinases. XXIII. Inhibition of factor Xa by diamidines

artículo científico publicado en 1980

Synthetic inhibitors of thrombin and factor Xa: from bench to bedside

artículo científico publicado en 1999

Synthetic low-molecular weight thrombin inhibitors: the ideal antithrombotic drug? An introduction

artículo científico publicado en 1995

Synthetic serin protease inhibitors. 1. Inhibition of trypsin, plasmin and thrombin by amidino- and guanidinobenzoic acid esters

artículo científico publicado el 1 de mayo de 1973

Synthetic serine protease inhibitors. 29. Synthesis of alpha-arylsulphonylamino-beta-(4-amidinophenyl)ethyl-chloromethylketones and their inhibitory activity against trypsin, plasmin and thrombin

artículo científico publicado en 1983

Synthetic serine proteinase inhibitors. 30. Synthesis of alpha-benzoylamino-4-amidinocinnamic acid and alpha-(4-amidinobenzoylamino) cinnamic acid amides, and their inhibitory effect on trypsin-like enzymes

artículo científico publicado el 1 de diciembre de 1983

Synthetic urokinase inhibitors as potential anti-invasive drugs.

artículo científico publicado en 2001

The X-ray crystal structure of thrombin in complex with N alpha-2-naphthylsulfonyl-L-3-amidino-phenylalanyl-4-methylpiperidide: the beneficial effect of filling out an empty cavity

scientific article published on 01 January 1995

The ability of thrombin inhibitors to reduce the thrombin activity generated in plasma on extrinsic and intrinsic activation

scientific article published on 01 March 1997

The crystal structures of 3-TAPAP in complexes with the urokinase-type plasminogen activator and picrate

artículo científico publicado en 2005

The hirudin standard

artículo científico publicado en 1990

The mechanism of reaction of heparin

artículo científico publicado en 1977

The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage

artículo científico publicado en 2002

The structure of the human betaII-tryptase tetramer: fo(u)r better or worse

artículo científico publicado en 1999

The three-dimensional structure of recombinant leech-derived tryptase inhibitor in complex with trypsin. Implications for the structure of human mast cell tryptase and its inhibition

artículo científico publicado en 1997

Thrombin inhibitors identified by computer-assisted multiparameter design

artículo científico publicado en 2005

Thrombin potential and thrombin generation after exhaustive exercise

artículo científico publicado en 2002

Transport of peptidomimetic thrombin inhibitors with a 3-amidino-phenylalanine structure: permeability and efflux mechanism in monolayers of a human intestinal cell line (Caco-2).

artículo científico publicado en 2001

Trypsin activity is not involved in premature, intrapancreatic trypsinogen activation

artículo científico publicado en 2002

Trypsin- and SLIGRL-induced vascular relaxation and the inhibition by benzamidine derivatives

artículo científico publicado el 1 de noviembre de 1997

Trypsinogen activation in rat pancreatic acinar cells hyperstimulated by caerulein ⬇️

artículo científico publicado el 31 de diciembre de 1997

Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies

artículo científico publicado en 2000

Use of chromogenic substrates in the clarification of disorders in the early stages of blood coagulation

artículo científico publicado el 1 de enero de 1982

Use of synthetic inhibitors in coagulation physiological tests with peptide substrates

artículo científico publicado el 1 de enero de 1982

ZZ made EZ: influence of inhibitor configuration on enzyme selectivity.

artículo científico publicado en 2003

[Benzoyl-kallikrein: kallikrein activity and kinin generation in plasma]

[Determination of factor XII and plasma prekallikrein with chromozym PK]

scientific article published on 01 October 1982

[Factor-XIII-research: Pioneer achievement and progress]

artículo científico publicado en 2002

[From fibrinogen and hirudin to synthetic anticoagulants. Rational design of thrombin inhibitors]

artículo científico publicado en 2004

[Synthesis of N-alpha-(arylsulfonyl)-4-amidino-phenylalanyl-prolines and N-alpha-(arylsulfonylglycyl)-4-amidino-phenylalanyl-prolines and testing of them as inhibitors of serine proteinases. 33. Synthetic inhibitors of serine proteinases]

scientific article published on 01 June 1988

[Synthetic inhibitors of serine proteinases. 2. Inhibitory effect of amidino benzoic acid homologues and of their esters in comparison with trypsin, plasmin and thrombin]

artículo científico publicado en 1974

[Synthetic inhibitors of serine proteinases. 27. The inhibitory effects of amides of 4-amidinophenylacetic acid and 4-amidinophenoxyacetic acid]

artículo científico publicado en 1981

[Synthetic inhibitors of serine proteinases. 28. The inhibitory effect of esters of N-alpha-arylsulfonyl-4-amidinophenylalanine against trypsin, plasmin and thrombin]

artículo científico publicado en 1982

[Synthetic inhibitors of serine proteinases. 3. Inhibitory effect of basic ally substituted phenyl carbonic acid esters in comparison with trypsin, plasmin and thrombin]

artículo científico publicado en 1974

[Synthetic inhibitors of serine proteinases. 32. Inhibition of trypsin, plasmin and thrombin by amides of N-alpha-substituted 4-amidinophenylalanine. Effect of various amino acids and blocking groups of the n-alpha residue on inhibitory activity]

scientific article published on 01 February 1987

[Synthetic inhibitors of serine proteinases. 4.: Inhibitory effect of substituted anilides of 3- and 4- amidino benzoic acid and amidino-anilides of different benzoic- and benzene sulfonic acids]

artículo científico publicado en 1974

[Synthetic inhibitors of serine proteinases. Part 24: Inhibition of trypsin, plasmin and thrombin by cyclic amides of N alpha-arylsulfonylamidinophenyl-glycines (author's transl)]

artículo científico publicado en 1981

[Synthetic inhibitors of serine proteinases. Part 25: Inhibition of trypsin, plasmin and thrombin by amides of N alpha-substituted amidinophenylalanines and 3-amidinophenyl-3-aminopropionic acids (author's transl)]

artículo científico publicado en 1981

[Synthetic serine proteinase inhibitors. 6. Inhibition of trypsin, plasmin and thrombin by phenylpyruvic acids containing various basic groups]

artículo científico publicado en 1974

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