Lista de obras -

A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.

artículo científico publicado en 2006

A timely characterization of vasopressin-sensitive adenylyl cyclase isoforms in the mouse inner medullary collecting duct

artículo científico publicado en 2009

Absence of PKC-alpha attenuates lithium-induced nephrogenic diabetes insipidus

artículo científico publicado en 2014

Activation of protein kinase Cα increases phosphorylation of the UT-A1 urea transporter at serine 494 in the inner medullary collecting duct

artículo científico publicado en 2015

Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1.

artículo científico publicado en 2011

Allosteric sites of phosphodiesterase-5 sequester cyclic GMP.

artículo científico publicado en 2004

Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation

artículo científico publicado en 2004

Candesartan augments compensatory changes in medullary transport proteins in the diabetic rat kidney

artículo científico publicado en 2008

Chronic lithium treatment induces novel patterns of pendrin localization and expression

artículo científico publicado en 2018

Chronic use of chloroquine disrupts the urine concentration mechanism by lowering cAMP levels in the inner medulla ⬇️

artículo científico publicado el 11 de julio de 2012

Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice.

artículo científico publicado en 2011

Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors

artículo científico publicado en 2007

Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts.

artículo científico publicado en 2009

Expression of transporters involved in urine concentration recovers differently after cessation of lithium treatment

artículo científico publicado en 2009

Forskolin stimulates phosphorylation and membrane accumulation of UT-A3.

artículo científico publicado en 2007

Genes and proteins of urea transporters

artículo científico publicado en 2014

High lung PDE5: a strong basis for treating pulmonary hypertension with PDE5 inhibitors

artículo científico publicado en 2005

Lack of an effect of collecting duct-specific deletion of adenylyl cyclase 3 on renal Na+ and water excretion or arterial pressure.

artículo científico publicado en 2014

Lack of protein kinase C-α leads to impaired urine concentrating ability and decreased aquaporin-2 in angiotensin II-induced hypertension ⬇️

artículo científico publicado el 4 de abril de 2012

Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC

scientific article published on 12 December 2018

Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions ⬇️

artículo científico publicado el 1 de abril de 2011

Metal ion stimulators of PDE5 cause similar conformational changes in the enzyme as does cGMP or sildenafil ⬇️

artículo científico publicado el 25 de diciembre de 2010

Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts.

artículo científico publicado en 2016

Molecular mechanisms of urea transport in health and disease

artículo científico publicado en 2012

Molecular properties of mammalian proteins that interact with cGMP: protein kinases, cation channels, phosphodiesterases, and multi-drug anion transporters

artículo científico publicado en 2005

Novel activators of aquaporin 2 membrane expression for the treatment of nephrogenic diabetes insipidus: less is more. Focus on "High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concen

artículo científico publicado en 2014

Phosphorylation increases affinity of the phosphodiesterase-5 catalytic site for tadalafil

artículo científico publicado en 2008

Phosphorylation of UT-A1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells

artículo científico publicado en 2010

Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation

artículo científico publicado en 2008

Phosphorylation of phosphodiesterase-5 is promoted by a conformational change induced by sildenafil, vardenafil, or tadalafil

artículo científico publicado en 2007

Purinergic signaling is enhanced in the absence of UT-A1 and UT-A3

artículo científico publicado en 2021

Radiolabeled ligand binding to the catalytic or allosteric sites of PDE5 and PDE11.

artículo científico publicado en 2005

Regulation of renal urea transport by vasopressin

artículo científico publicado en 2011

Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function

artículo científico publicado en 2015

The role of nitric oxide in the dysregulation of the urine concentration mechanism in diabetes mellitus

artículo científico publicado en 2012

Transgenic Restoration of Urea Transporter A1 Confers Maximal Urinary Concentration in the Absence of Urea Transporter A3.

artículo científico publicado en 2015

Urea transport in the kidney

artículo científico publicado en 2011

Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity

artículo científico publicado en 2008

Urine concentration in the diabetic mouse requires both urea and water transporters

artículo científico publicado en 2012

Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5).

artículo científico publicado en 2004

Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts

artículo científico publicado en 2006

Vasopressin regulation of multisite phosphorylation of UT-A1 in the inner medullary collecting duct

artículo científico publicado en 2014

[3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP.

artículo científico publicado en 2003

miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export

scientific article published on 11 December 2013

Lista de obras de

A 46-amino acid segment in phosphodiesterase-5 GAF-B domain provides for high vardenafil potency over sildenafil and tadalafil and is involved in phosphodiesterase-5 dimerization.

A timely characterization of vasopressin-sensitive adenylyl cyclase isoforms in the mouse inner medullary collecting duct

Absence of PKC-alpha attenuates lithium-induced nephrogenic diabetes insipidus

Activation of protein kinase Cα increases phosphorylation of the UT-A1 urea transporter at serine 494 in the inner medullary collecting duct

Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1.

Allosteric sites of phosphodiesterase-5 sequester cyclic GMP.

Binding of tritiated sildenafil, tadalafil, or vardenafil to the phosphodiesterase-5 catalytic site displays potency, specificity, heterogeneity, and cGMP stimulation

Candesartan augments compensatory changes in medullary transport proteins in the diabetic rat kidney

Chronic lithium treatment induces novel patterns of pendrin localization and expression

Chronic use of chloroquine disrupts the urine concentration mechanism by lowering cAMP levels in the inner medulla ⬇️

Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice.

Conversion of phosphodiesterase-5 (PDE5) catalytic site to higher affinity by PDE5 inhibitors

Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts.

Expression of transporters involved in urine concentration recovers differently after cessation of lithium treatment

Forskolin stimulates phosphorylation and membrane accumulation of UT-A3.

Genes and proteins of urea transporters

High lung PDE5: a strong basis for treating pulmonary hypertension with PDE5 inhibitors

Lack of an effect of collecting duct-specific deletion of adenylyl cyclase 3 on renal Na+ and water excretion or arterial pressure.

Lack of protein kinase C-α leads to impaired urine concentrating ability and decreased aquaporin-2 in angiotensin II-induced hypertension ⬇️

Lack of urea transporters, UT-A1 and UT-A3, increases nitric oxide accumulation to dampen medullary sodium reabsorption through ENaC

Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions ⬇️

Metal ion stimulators of PDE5 cause similar conformational changes in the enzyme as does cGMP or sildenafil ⬇️

Metformin, an AMPK activator, stimulates the phosphorylation of aquaporin 2 and urea transporter A1 in inner medullary collecting ducts.

Molecular mechanisms of urea transport in health and disease

Molecular properties of mammalian proteins that interact with cGMP: protein kinases, cation channels, phosphodiesterases, and multi-drug anion transporters

Novel activators of aquaporin 2 membrane expression for the treatment of nephrogenic diabetes insipidus: less is more. Focus on "High-throughput chemical screening identifies AG-490 as a stimulator of aquaporin 2 membrane expression and urine concen

Phosphorylation increases affinity of the phosphodiesterase-5 catalytic site for tadalafil

Phosphorylation of UT-A1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells

Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation

Phosphorylation of phosphodiesterase-5 is promoted by a conformational change induced by sildenafil, vardenafil, or tadalafil

Purinergic signaling is enhanced in the absence of UT-A1 and UT-A3

Radiolabeled ligand binding to the catalytic or allosteric sites of PDE5 and PDE11.

Regulation of renal urea transport by vasopressin

Smooth Muscle-Targeted Overexpression of Peroxisome Proliferator Activated Receptor-γ Disrupts Vascular Wall Structure and Function

The role of nitric oxide in the dysregulation of the urine concentration mechanism in diabetes mellitus

Transgenic Restoration of Urea Transporter A1 Confers Maximal Urinary Concentration in the Absence of Urea Transporter A3.

Urea transport in the kidney

Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity

Urine concentration in the diabetic mouse requires both urea and water transporters

Vardenafil: structural basis for higher potency over sildenafil in inhibiting cGMP-specific phosphodiesterase-5 (PDE5).

Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts

Vasopressin regulation of multisite phosphorylation of UT-A1 in the inner medullary collecting duct

[3H]sildenafil binding to phosphodiesterase-5 is specific, kinetically heterogeneous, and stimulated by cGMP.

miR-23a is decreased during muscle atrophy by a mechanism that includes calcineurin signaling and exosome-mediated export