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A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

artículo científico publicado en 2012

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

artículo científico publicado en 2012

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

artículo científico publicado en 2008

Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

artículo científico publicado en 2009

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

artículo científico publicado en 2012

Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system

artículo científico publicado en 2015

Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain.

artículo científico publicado en 2004

Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain

artículo científico publicado en 2013

Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging

scientific article published on 30 November 2020

Clearance of amyloid-beta by circulating lipoprotein receptors

artículo científico publicado en 2007

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

artículo científico publicado en 2015

Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier

artículo científico publicado en 2008

Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

artículo científico publicado en 2017

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

artículo científico publicado en 2013

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

artículo científico publicado en 2016

Impaired Lipoprotein Receptor-Mediated Peripheral Binding of Plasma Amyloid-β is an Early Biomarker for Mild Cognitive Impairment Preceding Alzheimer's Disease

artículo científico publicado el 1 de enero de 2011

Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice

artículo científico publicado en 2010

Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury

artículo científico publicado en 2014

Impairment of paravascular clearance pathways in the aging brain

artículo científico publicado en 2014

LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

artículo científico publicado en 2004

Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance

artículo científico publicado en 2013

Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.

artículo científico publicado en 2012

Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities

artículo científico publicado en 2012

Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain

artículo científico publicado el 5 de octubre de 2010

Methamphetamine causes sustained depression in cerebral blood flow

artículo científico publicado en 2010

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

scientific article published on March 2009

Neurovascular pathways and Alzheimer amyloid beta-peptide

artículo científico publicado en 2005

P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model

artículo científico publicado en 2005

Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain

artículo científico publicado en 2013

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

artículo científico publicado el 4 de noviembre de 2010

Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.

artículo científico publicado en 2010

Role of the Blood-Brain Barrier in the Pathogenesis of Alzheimers Disease

artículo científico publicado en 2007

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

artículo científico publicado en 2005

SARS-CoV-2: is there neuroinvasion?

scientific article published in 2021

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

artículo científico publicado en 2009

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype

artículo científico publicado en 2007

Sleep drives metabolite clearance from the adult brain

artículo científico publicado en 2013

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

artículo científico publicado en 2016

The Effect of Body Posture on Brain Glymphatic Transport

artículo científico publicado en 2015

The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy

artículo científico publicado en 2014

The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy

artículo científico publicado en 2014

Transport of L-[125I]thyroxine by in situ perfused ovine choroid plexus: inhibition by lead exposure.

scientific article published on March 2003

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

artículo científico publicado en 2006

Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease

artículo científico publicado en 2007

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain

artículo científico publicado en 2008