Lista de obras -

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

scholarly article

3'-deoxy-3'-[18F]fluorothymidine positron emission tomography is a sensitive method for imaging the response of BRAF-dependent tumors to MEK inhibition

artículo científico publicado en 2007

A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation-Positive Solid Tumors

scientific article published on 10 September 2019

A Secondary Mutation in Confers Resistance to RAF Inhibition in a -Mutant Brain Tumor

artículo científico publicado en 2018

A clinically and genomically annotated nerve sheath tumor biospecimen repository

scientific article published on 19 June 2020

A novel RBMX-TFE3 gene fusion in a highly aggressive pediatric renal perivascular epithelioid cell tumor

artículo científico publicado en 2019

Activation of receptor tyrosine kinases mediates acquired resistance to MEK inhibition in malignant peripheral nerve sheath tumors

scientific article published on 17 November 2020

Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase-Driven Leukemias and Other Malignancies

artículo científico publicado en 2017

Author Correction: The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling

artículo científico publicado en 2019

BRAF Mutations and the Utility of RAF and MEK Inhibitors in Primary Brain Tumors

scientific article published on 28 August 2019

BRAF V600E-mutated metastatic pediatric Wilms tumor with complete response to targeted RAF/MEK inhibition

scientific article published on 01 April 2020

BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell lines

artículo científico publicado en 2008

Combination MEK and mTOR inhibitor therapy is active in models of glioblastoma

scientific article published on 01 January 2020

Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer

artículo científico publicado en 2015

Combined inhibition of SHP2 and MEK is effective in models of NF1-deficient malignant peripheral nerve sheath tumors

artículo científico publicado en 2020

DICER1-associated metastatic abdominopelvic primitive neuroectodermal tumor with an EWSR1 rearrangement in a 16-yr-old female

artículo científico publicado en 2020

Dermatologic adverse events in pediatric patients receiving targeted anticancer therapies: a pooled analysis.

artículo científico publicado en 2015

Eosinophilic Solid and Cystic (ESC) Renal Cell Carcinomas Harbor TSC Mutations: Molecular Analysis Supports an Expanding Clinicopathologic Spectrum

artículo científico publicado en 2018

FLT3-IRAK dual targeting: an exciting new therapeutic option guided by adaptive activation of immune response pathways

artículo científico publicado en 2020

From Genes to -Omics: The Evolving Molecular Landscape of Malignant Peripheral Nerve Sheath Tumor

artículo científico publicado en 2020

Genetic predictors of MEK dependence in non-small cell lung cancer

artículo científico publicado en 2008

Genomic and biological characterization of exon 4 KRAS mutations in human cancer

artículo científico publicado en 2010

Identification of Unique MEK-Dependent Genes in GNAQ Mutant Uveal Melanoma Involved in Cell Growth, Tumor Cell Invasion, and MEK Resistance ⬇️

artículo científico publicado el 1 de julio de 2012

Ifosfamide dose-intensification for patients with metastatic Ewing sarcoma

artículo científico publicado en 2015

Improving Detection of Cancer Predisposition Syndromes in Pediatric Oncology

artículo científico publicado en 2020

Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways that Define Tumor Heterogeneity in NF1

artículo científico publicado en 2020

Interferon α/β Enhances the Cytotoxic Response of MEK Inhibition in Melanoma

artículo científico publicado en 2015

Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence

artículo científico publicado en 2014

Metanephric Adenoma-Epithelial Wilms Tumor Overlap Lesions: An Analysis of BRAF Status

scientific article published on 01 September 2019

Models from experiments: combinatorial drug perturbations of cancer cells

artículo científico publicado en 2008

New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target

artículo científico publicado en 2004

Paradoxical activation of T cells via augmented ERK signaling mediated by a RAF inhibitor

artículo científico publicado en 2014

Personalized Medicine in the Oncology Clinic: Implementation and Outcomes of the Johns Hopkins Molecular Tumor Board

artículo científico publicado en 2017

Perturbation biology nominates upstream-downstream drug combinations in RAF inhibitor resistant melanoma cells

artículo científico publicado en 2015

Perturbation biology: inferring signaling networks in cellular systems

artículo científico publicado en 2013

Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition

scientific article published on 03 June 2019

Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

artículo científico publicado en 2012

Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas ⬇️

artículo científico publicado el 13 de noviembre de 2012

Size-based detection of sarcoma circulating tumor cells and cell clusters

artículo científico publicado en 2017

Socioeconomic and health care coverage disparities in children, adolescents, and young adults with sarcoma

scientific article published on 17 September 2020

Special Issue: "Genomics and Models of Nerve Sheath Tumors"

artículo científico publicado en 2020

Sporadic Malignant Glomus Tumor of the Brachial Plexus With Response to Targeted Therapy Directed Against Oncogenic BRAF

artículo científico publicado en 2018

Targeted therapy for soft tissue sarcomas in adolescents and young adults

artículo científico publicado en 2017

Targeting Oncogenic BRAF in Human Cancer ⬇️

artículo científico publicado el 1 de enero de 2012

Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response

artículo científico publicado en 2010

Telomere alterations in neurofibromatosis type 1-associated solid tumors

scientific article published on 28 August 2019

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner ⬇️

artículo científico publicado el 28 de julio de 2010

The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.

artículo científico publicado en 2014

The promise of signal transduction in genetically driven sarcomas of the nerve

artículo científico publicado en 2017

Therapeutic potential of NTRK3 inhibition in desmoplastic small round cell tumor

scientific article published on 23 November 2020

Therapeutic strategies for targeting BRAF in human cancer

artículo científico publicado en 2007

Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244)

artículo científico

Lista de obras de

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

3'-deoxy-3'-[18F]fluorothymidine positron emission tomography is a sensitive method for imaging the response of BRAF-dependent tumors to MEK inhibition

A Phase I and Pharmacokinetic Study of Oral Dabrafenib in Children and Adolescent Patients with Recurrent or Refractory BRAF V600 Mutation-Positive Solid Tumors

A Secondary Mutation in Confers Resistance to RAF Inhibition in a -Mutant Brain Tumor

A clinically and genomically annotated nerve sheath tumor biospecimen repository

A novel RBMX-TFE3 gene fusion in a highly aggressive pediatric renal perivascular epithelioid cell tumor

Activation of receptor tyrosine kinases mediates acquired resistance to MEK inhibition in malignant peripheral nerve sheath tumors

Adaptation to TKI Treatment Reactivates ERK Signaling in Tyrosine Kinase-Driven Leukemias and Other Malignancies

Author Correction: The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling

BRAF Mutations and the Utility of RAF and MEK Inhibitors in Primary Brain Tumors

BRAF V600E-mutated metastatic pediatric Wilms tumor with complete response to targeted RAF/MEK inhibition

BRAFV600E mutation is associated with preferential sensitivity to mitogen-activated protein kinase kinase inhibition in thyroid cancer cell lines

Combination MEK and mTOR inhibitor therapy is active in models of glioblastoma

Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer

Combined inhibition of SHP2 and MEK is effective in models of NF1-deficient malignant peripheral nerve sheath tumors

DICER1-associated metastatic abdominopelvic primitive neuroectodermal tumor with an EWSR1 rearrangement in a 16-yr-old female

Dermatologic adverse events in pediatric patients receiving targeted anticancer therapies: a pooled analysis.

Eosinophilic Solid and Cystic (ESC) Renal Cell Carcinomas Harbor TSC Mutations: Molecular Analysis Supports an Expanding Clinicopathologic Spectrum

FLT3-IRAK dual targeting: an exciting new therapeutic option guided by adaptive activation of immune response pathways

From Genes to -Omics: The Evolving Molecular Landscape of Malignant Peripheral Nerve Sheath Tumor

Genetic predictors of MEK dependence in non-small cell lung cancer

Genomic and biological characterization of exon 4 KRAS mutations in human cancer

Identification of Unique MEK-Dependent Genes in GNAQ Mutant Uveal Melanoma Involved in Cell Growth, Tumor Cell Invasion, and MEK Resistance ⬇️

Ifosfamide dose-intensification for patients with metastatic Ewing sarcoma

Improving Detection of Cancer Predisposition Syndromes in Pediatric Oncology

Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways that Define Tumor Heterogeneity in NF1

Interferon α/β Enhances the Cytotoxic Response of MEK Inhibition in Melanoma

Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence

Metanephric Adenoma-Epithelial Wilms Tumor Overlap Lesions: An Analysis of BRAF Status

Models from experiments: combinatorial drug perturbations of cancer cells

New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target

Paradoxical activation of T cells via augmented ERK signaling mediated by a RAF inhibitor

Personalized Medicine in the Oncology Clinic: Implementation and Outcomes of the Johns Hopkins Molecular Tumor Board

Perturbation biology nominates upstream-downstream drug combinations in RAF inhibitor resistant melanoma cells

Perturbation biology: inferring signaling networks in cellular systems

Rare BRAF mutations in pancreatic neuroendocrine tumors may predict response to RAF and MEK inhibition

Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas ⬇️

Size-based detection of sarcoma circulating tumor cells and cell clusters

Socioeconomic and health care coverage disparities in children, adolescents, and young adults with sarcoma

Special Issue: "Genomics and Models of Nerve Sheath Tumors"

Sporadic Malignant Glomus Tumor of the Brachial Plexus With Response to Targeted Therapy Directed Against Oncogenic BRAF

Targeted therapy for soft tissue sarcomas in adolescents and young adults

Targeting Oncogenic BRAF in Human Cancer ⬇️

Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response

Telomere alterations in neurofibromatosis type 1-associated solid tumors

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner ⬇️

The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.

The promise of signal transduction in genetically driven sarcomas of the nerve

Therapeutic potential of NTRK3 inhibition in desmoplastic small round cell tumor

Therapeutic strategies for targeting BRAF in human cancer

Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244)