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A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing

article

A mechanistic framework for integrating chemical structure and high-throughput screening results to improve toxicity predictions

article

A novel approach: chemical relational databases, and the role of the ISSCAN database on assessing chemical carcinogenicity.

artículo científico publicado en 2008

A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents

artículo científico publicado en 2009

ACToR — Aggregated Computational Toxicology Resource

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

artículo científico publicado en 2011

Advancing exposure characterization for chemical evaluation and risk assessment.

artículo científico publicado en 2010

Aggregating data for computational toxicology applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System

artículo científico publicado en 2012

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

artículo científico publicado en 2016

Bioactivity screening of environmental chemicals using imaging-based high-throughput phenotypic profiling

artículo científico publicado en 2019

CERAPP: Collaborative Estrogen Receptor Activity Prediction Project

artículo científico publicado en 2016

Chemical effects in biological systems--data dictionary (CEBS-DD): a compendium of terms for the capture and integration of biological study design description, conventional phenotypes, and 'omics data

artículo científico publicado en 2005

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

scientific article published on 07 February 2020

Comment on "On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens".

artículo científico publicado en 2017

Comparative mutagenicity of halomethanes and halonitromethanes in Salmonella TA100: structure-activity analysis and mutation spectra

artículo científico publicado en 2004

Computational Tools for ADMET Profiling

Computational toxicology--a state of the science mini review

artículo científico publicado en 2007

Concentration-response evaluation of ToxCast compounds for multivariate activity patterns of neural network function

artículo científico publicado en 2019

Conversion of Developmental Neurotoxicity (DNT) information into a structure-searchable relational database

EADB: an estrogenic activity database for assessing potential endocrine activity.

artículo científico publicado en 2013

EPA's non-targeted analysis collaborative trial (ENTACT): genesis, design, and initial findings

artículo científico publicado en 2018

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

artículo científico publicado en 2016

Endocrine profiling and prioritization of environmental chemicals using ToxCast data

artículo científico publicado en 2010

Evaluation of high-throughput genotoxicity assays used in profiling the US EPA ToxCast chemicals

artículo científico publicado en 2009

Exposure science and the U.S. EPA National Center for Computational Toxicology

artículo científico publicado en 2008

Genetic toxicology in the 21st century: reflections and future directions

artículo científico publicado en 2011

Genotoxicity and metabolism of the source-water contaminant 1,1-dichloropropene: activation by GSTT1-1 and structure-activity considerations

artículo científico publicado en 2005

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition

scientific article published on 28 February 2019

Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

artículo científico publicado en 2010

In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project

artículo científico publicado en 2010

Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity

article

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.

artículo científico publicado en 2015

Integrating tools for non-targeted analysis research and chemical safety evaluations at the US EPA.

artículo científico publicado en 2017

Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment

artículo científico publicado en 2011

Linking high resolution mass spectrometry data with exposure and toxicity forecasts to advance high-throughput environmental monitoring

artículo científico publicado en 2016

Mutagenicity in Salmonella of halonitromethanes: a recently recognized class of disinfection by-products in drinking water

artículo científico publicado en 2004

New publicly available chemical query language, CSRML, to support chemotype representations for application to data mining and modeling

artículo científico publicado en 2015

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

artículo científico publicado en 2013

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

artículo científico publicado en 2014

Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays

artículo científico publicado en 2013

Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential

artículo científico publicado en 2014

QSAR modeling: where have you been? Where are you going to?

artículo científico publicado en 2014

Rapid experimental measurements of physicochemical properties to inform models and testing

artículo científico publicado en 2018

Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells

artículo científico publicado en 2013

Screening the ToxCast phase II libraries for alterations in network function using cortical neurons grown on multi-well microelectrode array (mwMEA) plates.

artículo científico publicado en 2017

Suspect Screening Analysis of Chemicals in Consumer Products

artículo científico publicado en 2018

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

artículo científico publicado en 2017

The Next Generation Blueprint of Computational Toxicology at the U.S. Environmental Protection Agency

artículo científico publicado en 2019

The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology

artículo científico publicado en 2020

The ToxCast program for prioritizing toxicity testing of environmental chemicals

artículo científico publicado en 2006

The expanding role of predictive toxicology: an update on the (Q)SAR models for mutagens and carcinogens

artículo científico publicado en 2007

The toxicity data landscape for environmental chemicals

artículo científico publicado en 2008

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

artículo científico publicado en 2016

ToxCast: Predicting Toxicity Potential Through High-Throughput Bioactivity Profiling

article

Toxicity data informatics: supporting a new paradigm for toxicity prediction

artículo científico publicado en 2008

Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management.

artículo científico publicado en 2012

Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity

artículo científico publicado en 2008

Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity

artículo científico publicado el 27 de octubre de 2010

Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure

artículo científico publicado en 2015

Using prepared mixtures of ToxCast chemicals to evaluate non-targeted analysis (NTA) method performance

artículo científico publicado en 2019

Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization

artículo científico publicado en 2020

Wikipedia on the CompTox Chemicals Dashboard: Connecting Resources to Enrich Public Chemical Data

artículo científico publicado en 2022