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A Germline PALB2 Pathogenic Variant identified in a Pediatric High Grade Glioma

scientific article published on 18 June 2020

A Novel Inositol Pyrophosphate Phosphatase in Saccharomyces cerevisiae: Siw14 PROTEIN SELECTIVELY CLEAVES THE β-PHOSPHATE FROM 5-DIPHOSPHOINOSITOL PENTAKISPHOSPHATE (5PP-IP5).

artículo científico publicado en 2016

A pilot precision medicine trial for children with diffuse intrinsic pontine glioma-PNOC003: A report from the Pacific Pediatric Neuro-Oncology Consortium

artículo científico publicado en 2019

A transcriptome-based classifier to determine molecular subtypes in medulloblastoma

scientific article published on 29 October 2020

Abstracts

article by L. Bie et al published 1 April 2013 in Neuro-Oncology

Activating mutations in BRAF characterize a spectrum of pediatric low-grade gliomas

artículo científico publicado en 2010

Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase ⬇️

artículo científico publicado el 2 de febrero de 2011

Ancestry and frequency of genetic variants in the general population are confounders in the characterization of germline variants linked to cancer

scientific article published on 06 May 2020

Assessment of the USCENTCOM Medical Distribution Structure

artículo científico publicado en 2012

Author Correction: The landscape of genomic alterations across childhood cancers

artículo científico publicado en 2018

BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas.

artículo científico publicado en 2016

CRAF gene fusions in pediatric low-grade gliomas define a distinct drug response based on dimerization profiles.

artículo científico

Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy

artículo científico publicado en 2018

Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer

scientific article published on 02 October 2019

DIPG-15. PNOC-003: CLINICAL IMPACT OF A PRECISION MEDICINE STRATEGY FOR CHILDREN WITH DIFFUSE INTRINSIC PONTINE GLIOMA ⬇️

DIPG-30. ISOFORM SPECIFIC OVEREXPRESSION OF WILMS’ TUMOR PROTEIN IN DIFFUSE INTRINSIC PONTINE GLIOMAS

artículo científico publicado en 2019

DIPG-32. CLINICALLY RELEVANT AND MINIMALLY INVASIVE TUMOR SURVEILLANCE IN PEDIATRIC GLIOMAS USING LIQUID BIOME

DIPG-34. PRECLINICAL PRECISION TESTING OF PNOC003 BIOPSY DERIVED MODELS OF DIPG

artículo científico publicado en 2019

DIPG-35. OPEN DIPG INITIATIVE: A PLATFORM FOR ACCELERATING DISCOVERY THROUGH DATA ACCESS, CONSOLIDATION AND HARMONIZATION

artículo científico publicado en 2019

DIPG-40. PNOC-003: PRECISION MEDICINE TRIAL FOR CHILDREN WITH DIFFUSE INTRINSIC PONTINE GLIOMA.

artículo científico publicado en 2017

DIPG-51. BLACKFYNN: A SECURE, CLOUD-BASED PLATFORM FOR SHARING AND ANALYZING RESEARCH READY DATA FOR PEDIATRIC CNS CANCERS

artículo científico publicado en 2018

DIPG-53. COMPREHENSIVE CLINICAL AND MOLECULAR ANALYSIS OF PEDIATRIC THALAMIC GLIOMA

DIPG-76. PNOC-003: PRECISION MEDICINE TRIAL FOR CHILDREN WITH DIFFUSES INTRINSIC PONTINE GLIOMA: PRELIMINARY EXPERIENCE WITH MULTI-AGENT PERSONALIZED THERAPY RECOMMENDATIONS

Development and Clinical Validation of a Large Fusion Gene Panel for Pediatric Cancers

artículo científico publicado en 2019

Dual HDAC and PI3K inhibition abrogates NFκB- and FOXM1-mediated DNA damage response to radiosensitize pediatric high-grade gliomas.

artículo científico publicado en 2018

Duplication of 7q34 in pediatric low-grade astrocytomas detected by high-density single-nucleotide polymorphism-based genotype arrays results in a novel BRAF fusion gene

artículo científico publicado en 2008

EXTH-58. EFFECTS OF TORC1/2 INHIBITOR MLN0128 ALONE AND IN COMBINATION WITH MEK INHIBITION IN BRAF MUTATED GLIOMA MODELS AND

Elucidating diphosphoinositol polyphosphate function with nonhydrolyzable analogues

artículo científico publicado en 2014

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas

artículo científico publicado en 2014

FKBP12, the 12-kDa FK506-binding protein, is a physiologic regulator of the cell cycle

artículo científico publicado en 2001

GENE-12. THE CHILDREN’S BRAIN TUMOR TISSUE CONSORTIUM (CBTTC) INFRASTRUCTURE FACILITATES COLLABORATIVE RESEARCH IN PEDIATRIC CENTRAL NERVOUS SYSTEM TUMORS.

artículo científico publicado en 2017

GENE-15. CAVATICA- A PEDIATRIC GENOMIC CLOUD EMPOWERING DATA DISCOVERY THROUGH THE PEDIATRIC BRAIN TUMOR ATLAS.

artículo científico publicado en 2017

GENE-18. PAN-OMIC ANALYSIS OF DIFFUSE INTRINSIC PONTINE GLIOMA FROM CHILDREN ENROLLED IN THE PNOC003 PRECISION MEDICINE TRIAL IDENTIFIES OPPORTUNITIES AND CHALLENGES IN CLINICAL IMPLEMENTATION OF A MULTI-OMICS SEQUENCING APPROACH

artículo científico publicado en 2019

GENE-19. DEEP PROTEOMIC SURVEY ACROSS SEVEN CHILDHOOD BRAIN TUMORS

artículo científico publicado en 2019

Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis

artículo científico publicado en 2008

Genomic Analysis of Dysembryoplastic Neuroepithelial Tumor Spectrum Reveals a Diversity of Molecular Alterations Dysregulating the MAPK and PI3K/mTOR Pathways

scientific article published on 01 December 2019

Genomic characterization of a PPP1CB-ALK fusion with fusion gene amplification in a congenital glioblastoma

scientific article published on 11 December 2020

HG-115PRECISION MEDICINE APPROACH FOR CHILDREN WITH DIFFUSE INTRINSIC PONTINE GLIOMA.

artículo científico publicado en 2016

HG-59ACVR1-MUTANT DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGs) ACQUIRE ABERRANT ACTIVIN-MEDIATED BMP PATHWAY ACTIVATION.

artículo científico publicado en 2016

HG-74DEVELOPMENT OF ROBUST IN VITRO AND IN VIVO PRE-CLINICAL MODELS FOR DIFFUSE INTRINSIC PONTINE GLIOMA.

artículo científico publicado en 2016

HGG-24. COMPREHENSIVE GENOMIC ANALYSIS OF PEDIATRIC GLIOMAS UNCOVERS NOVEL MUTATIONS IN HISTONE-ENCODING GENES

artículo científico publicado en 2019

HGG-24. MOLECULAR, PATHOLOGICAL, RADIOLOGICAL AND IMMUNE PROFILING OF NON-BRAINSTEM PAEDIATRIC HIGH GRADE GLIOMA FROM THE HERBY PHASE II RANDOMISED TRIAL

artículo científico publicado en 2018

HGG-33. PATIENT DERIVED CELL LINES TO STUDY ATRX AND ALT IN PEDIATRIC BRAIN TUMORS

HGG-36. NFκB AND FOXM1 MEDIATE ANTI-CANCER ACTIVITY OF DUAL HDAC AND PI3K INHIBITION IN PEDIATRIC HIGH GRADE GLIOMA AND DIPG

HGG-40. HIGH GRADE GLIOMA CELL LINE COHORT AS AN EXAMPLE OF CHILDREN’S BRAIN TUMOR TISSUE CONSORTIUM TUMOR SPECIMEN PROCESSING PIPELINE

Harmonization of postmortem donations for pediatric brain tumors and molecular characterization of diffuse midline gliomas

artículo científico publicado en 2020

IMMU-04. DEVELOPMENT OF GPC2-DIRECTED CHIMERIC ANTIGEN RECEPTOR THERAPY FOR PEDIATRIC BRAIN TUMORS WITH IN VITRO TRANSCRIBED mRNA

IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

article published in 2019

Immunotherapy for pediatric brain tumors: past and present

artículo científico publicado en 2019

Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity

artículo científico publicado en 2005

Inositol polyphosphate multikinase is a physiologic PI3-kinase that activates Akt/PKB.

artículo científico publicado en 2011

Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms.

artículo científico publicado en 2016

Inositol pyrophosphates regulate cell death and telomere length through phosphoinositide 3-kinase-related protein kinases

artículo científico publicado en 2005

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

artículo científico publicado en 2017

Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma

artículo científico publicado en 2019

LAB-TUMOR MODELS (IN VIVO/IN VITRO)

LG-02MYB-QKI REARRANGEMENTS IN ANGIOCENTRIC GLIOMA DRIVE TUMORIGENICITY THROUGH A TRIPARTITE MECHANISM.

artículo científico publicado en 2016

LG-06EFFECTS OF TORC1/2 INHIBITOR MLN0128 ALONE AND IN COMBINATION WITH MEK INHIBITION IN BRAF MUTATED GLIOMA CELLS.

artículo científico publicado en 2015

LG-25PEDIATRIC LOW-GRADE GLIOMAS WITH CRAF GENE FUSIONS RESPOND DIFFERENTIALLY TO TARGETED THERAPEUTICS BASED ON DIMERIZATION PROFILES.

artículo científico publicado en 2016

LG-64COMBINATORIAL TARGETING OF ONCOGENIC FGFR1 GENE REARRANGEMENTS IN PEDIATRIC GLIOMAS.

artículo científico publicado en 2016

LGG-09. PEDIATRIC LOW-GRADE GLIOMAS WITH CRAF GENE FUSIONS ARE THERAPEUTICALLY DISTINCT FROM BRAF-FUSIONS BASED ON DIMERIZATION MEDIATED BY N-TERMINAL FUSION PARTNER.

artículo científico publicado en 2017

LGG-14. THE GENETIC LANDSCAPE OF DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMORS

artículo científico publicado en 2019

LGG-25. NOVEL FGFR2 FUSIONS DRIVE ONCOGENESIS VIA MAPK AND PI3K/mTOR PATHWAY ACTIVATION IN DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMORS

LGG-57. FUNCTIONAL CHARACTERIZATION AND EFFECTIVE TARGETING OF NRF1-BRAF AND ATG7-RAF1 FUSIONS IDENTIFIED IN ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA PATIENTS WITHOUT BRAF p.V600E MUTATION

MYB-QKI drives childhood brain tumors via tripartite mechanism.

artículo científico publicado en 2016

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

artículo científico publicado en 2016

Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial.

artículo científico publicado en 2018

New Equipping Strategies for Combat Support Hospitals

artículo científico publicado en 2012

Novel FGFR2-INA fusion identified in two low-grade mixed neuronal-glial tumors drives oncogenesis via MAPK and PI3K/mTOR pathway activation.

artículo científico publicado en 2018

Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways.

artículo científico publicado en 2017

PDTM-40. PEDIATRIC LOW-GRADE GLIOMAS WITH GENE FUSIONS ARE THERAPEUTICALLY DISTINCT FROM BRAF-FUSIONS BASED ON DIMERIZATION MEDIATED BY N-TERMINAL FUSION PARTNER

artículo científico publicado en 2017

Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas ⬇️

artículo científico publicado el 26 de marzo de 2013

Pediatric high-grade glioma resources from the Children's Brain Tumor Tissue Consortium

artículo científico publicado en 2020

Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas.

artículo científico publicado en 2014

Phosphorylation of proteins by inositol pyrophosphates

artículo científico publicado en 2004

Plain-language medical vocabulary for precision diagnosis

artículo científico publicado en 2018

Protein pyrophosphorylation by inositol pyrophosphates is a posttranslational event

artículo científico publicado en 2007

Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response

artículo científico publicado en 2018

Sclerosing Epithelioid Fibrosarcoma of the Bone With Rare EWSR1-CREB3L3 Translocation Driving Upregulation of the PI3K/mTOR Signaling Pathway

artículo científico publicado en 2019

Shared ACVR1 mutations in FOP and DIPG: Opportunities and challenges in extending biological and clinical implications across rare diseases

artículo científico

Spinal cord ependymomas and myxopapillary ependymomas in the first 2 decades of life: a clinicopathological and immunohistochemical characterization of 19 cases ⬇️

artículo científico publicado el 1 de junio de 2012

TBIO-27. GABRIELLA MILLER KIDS FIRST DATA RESOURCE CENTER ADVANCING GENETIC RESEARCH IN CHILDHOOD CANCER AND STRUCTURAL BIRTH DEFECTS THROUGH LARGE SCALE INTEGRATED DATA-DRIVEN DISCOVERY AND CLOUD-BASED PLATFORMS FOR COLLABORATIVE ANALYSIS

TBIO-28. DISEASEXPRESS, A CANCER DATA ANALYTICS AND VISUALIZATION TOOL FOR IDENTIFYING IMMUNOTHERAPEUTIC TARGETS IN PEDIATRIC BRAIN TUMORS AND OTHER CANCERS

TBIO-29. PedcBioPortal, A CANCER DATA VISUALIZATION TOOL FOR INTEGRATIVE PEDIATRIC CANCER ANALYSES

artículo científico publicado en 2018

THER-34. MEK BLOCKADE SYNERGISTICALLY INCREASES THE ANTI-TUMOR EFFECTS OF mTOR INHIBITION IN GLIOMAS

artículo científico publicado en 2019

TMOD-18. AN INTEGRATED SET OF PEDIATRIC HIGH GRADE GLIOMA RESOURCES FOR TRANSLATIONAL STUDIES

TMOD-19. GABRIELLA MILLER KIDS FIRST DATA RESOURCE CENTER: LARGE-SCALE HARMONIZED CLINICAL AND GENOMIC DATA PLATFORM TO SUPPORT CHILDHOOD CANCER AND STRUCTURAL BIRTH DEFECT RESEARCH

artículo científico publicado en 2019

TMOD-20. THE PEDIATRIC BRAIN TUMOR ATLAS: AN INITIATIVE BY THE CHILDREN’S BRAIN TUMOR TISSUE CONSORTIUM AND PACIFIC PEDIATRIC NEUROONCOLOGY CONSORTIUM

TR-06COMBINATORIAL PATHWAY TARGETING APPROACHES FOR BRAF-FUSIONS ASSOCIATED WITH PEDIATRIC LOW-GRADE GLIOMAS.

artículo científico publicado en 2015

TR-08TARGETED COMBINATORIAL APPROACH FOR TREATMENT OF PEDIATRIC LOW GRADE GLIOMAS IN THE CONTEXT OF BRAFV600E AND KIAA1549:BRAF MUTATIONS.

artículo científico publicado en 2015

TRTH-31. EFFECTS OF TORC1/2 INHIBITOR MLN0128 ALONE AND IN COMBINATION WITH MEK INHIBITION IN BRAF MUTATED GLIOMA CELLS.

artículo científico publicado en 2017

The InsP7 phosphatase Siw14 regulates inositol pyrophosphate levels to control localization of the general stress response transcription factor Msn2

artículo científico publicado en 2019

The genetic landscape of the childhood cancer medulloblastoma

artículo científico publicado en 2011

The landscape of genomic alterations across childhood cancers

artículo científico publicado en 2018

Transcriptome signatures associated with meningioma progression

artículo científico publicado en 2019

UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization

artículo científico publicado en 2002

annoFuse: an R Package to annotate, prioritize, and interactively explore putative oncogenic RNA fusions

artículo científico publicado en 2020

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