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A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells.

artículo científico publicado en 2015

A drug repurposing screening reveals a novel epigenetic activity of hydroxychloroquine

artículo científico publicado en 2019

A p53-dependent tumor suppressor network is induced by selective miR-125a-5p inhibition in multiple myeloma cells.

artículo científico publicado en 2014

A peroxisome proliferator-activated receptor gamma (PPARG) polymorphism is associated with zoledronic acid-related osteonecrosis of the jaw in multiple myeloma patients: analysis by DMET microarray profiling.

artículo científico publicado en 2011

A retrospective analysis of pegylated liposomal doxorubicin in ovarian cancer: do we still need it?

artículo científico publicado en 2013

A systematic review and meta-analysis of randomized trials on the role of targeted therapy in the management of advanced gastric cancer: Evidence does not translate?

artículo científico publicado en 2015

Allometric Scaling Approaches for Predicting Human Pharmacokinetic of a Locked Nucleic Acid Oligonucleotide Targeting Cancer-Associated miR-221

artículo científico publicado en 2019

Alpha-interferon and its effects on signalling pathways within cells

artículo científico publicado en 2004

Analysis of miRNA, mRNA, and TF interactions through network-based methods.

artículo científico publicado en 2015

Anti-cancer activity of dose-fractioned mPE +/- bevacizumab regimen is paralleled by immune-modulation in advanced squamous NSLC patients.

artículo científico publicado en 2017

Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma

scientific article published on 16 July 2019

Aurora Kinase A expression predicts platinum-resistance and adverse outcome in high-grade serous ovarian carcinoma patients

artículo científico publicado en 2016

BRCA1/2 Molecular Assay for Ovarian Cancer Patients: A Survey through Italian Departments of Oncology and Molecular and Genomic Diagnostic Laboratories

artículo científico publicado en 2019

BRCA1/2 genetic background-based therapeutic tailoring of human ovarian cancer: hope or reality?

scientific article published on 13 October 2009

Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu In vivo model of human multiple myeloma

artículo científico publicado en 2005

Could PD-1/PDL1 immune checkpoints be linked to HLA signature?

scientific article published on 09 December 2019

Cytotoxic drugs up-regulate epidermal growth factor receptor (EGFR) expression in colon cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent cell-mediated-cytotoxicity (ADCC).

artículo científico publicado en 2010

DMET-analyzer: automatic analysis of Affymetrix DMET data

artículo científico publicado en 2012

DMETTM Genotyping: Tools for Biomarkers Discovery in the Era of Precision Medicine

artículo científico publicado en 2020

DMET™ (Drug Metabolism Enzymes and Transporters): a pharmacogenomic platform for precision medicine.

artículo científico publicado en 2016

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma.

artículo científico publicado en 2012

Detection of RAS mutations in circulating tumor DNA: a new weapon in an old war against colorectal cancer. A systematic review of literature and meta-analysis

artículo científico publicado en 2019

Development and validation of bioanalytical methods for LNA-i-miR-221 quantification in human plasma and urine by LC-MS/MS

scientific article published on 29 June 2020

Differences in the availability of new anti-cancer drugs for Italian patients treated in different regions. Results of analysis conducted by the Italian Society Of Medical Oncology (AIOM)

artículo científico publicado el 1 de noviembre de 2010

Differential expression of UN1, early thymocyte-associated sialoglycoprotein, in breast normal tissue, benign disease and carcinomas

artículo científico publicado en 2002

Differential sensitivity of BRCA1-mutated HCC1937 human breast cancer cells to microtubule-interfering agents.

artículo científico publicado en 2005

Disparity in the “time to patient access” to new anti-cancer drugs in Italian regions. Results of a survey conducted by the Italian Society of Medical Oncology (AIOM) ⬇️

artículo científico publicado el 1 de julio de 2011

Distinctive germline expression of class I human leukocyte antigen (HLA) alleles and DRB1 heterozygosis predict the outcome of patients with non-small cell lung cancer receiving PD-1/PD-L1 immune checkpoint blockade

scientific article published on 01 June 2020

Dose-Finding Study and Pharmacokinetics Profile of the Novel 13-Mer Antisense miR-221 Inhibitor in Sprague-Dawley Rats

artículo científico publicado en 2020

Dose/dense metronomic chemotherapy with fractioned cisplatin and oral daily etoposide enhances the anti-angiogenic effects of bevacizumab and has strong antitumor activity in advanced non-small-cell-lung cancer patients.

artículo científico publicado en 2010

Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity.

artículo científico publicado en 2018

EGF-R small inhibitors and anti-EGF-R antibodies: advantages and limits of a new avenue in anticancer therapy.

artículo científico publicado en 2006

Early blood rise in auto-antibodies to nuclear and smooth muscle antigens is predictive of prolonged survival and autoimmunity in metastatic-non-small cell lung cancer patients treated with PD-1 immune-check point blockade by nivolumab

scientific article published on 16 May 2019

Emerging pathways as individualized therapeutic target of multiple myeloma.

artículo científico

Enumeration of interleukin-10-positive B cells from peripheral blood of patients with chronic lymphocytic leukemia

artículo científico publicado en 2014

Error-prone DNA repair pathways as determinants of immunotherapy activity: an emerging scenario for cancer treatment

scientific article published on 07 May 2020

Evidence of novel miR-34a-based therapeutic approaches for multiple myeloma treatment.

artículo científico publicado en 2017

Exploiting MYC-induced PARPness to target genomic instability in multiple myeloma

scientific article published on 20 February 2020

From target therapy to miRNA therapeutics of human multiple myeloma: theoretical and technological issues in the evolving scenario.

artículo científico

Functional Analysis of microRNA in Multiple Myeloma

artículo científico publicado en 2015

GOLFIG Chemo-Immunotherapy in Metastatic Colorectal Cancer Patients. A Critical Review on a Long-Lasting Follow-Up

scientific article published on 08 November 2019

Gemcitabine and cisplatin following surgical treatment of urinary bladder carcinosarcoma.

artículo científico publicado en 2004

Gemcitabine, oxaliplatin, levofolinate, 5-fluorouracil, granulocyte-macrophage colony-stimulating factor, and interleukin-2 (GOLFIG) versus FOLFOX chemotherapy in metastatic colorectal cancer patients: the GOLFIG-2 multicentric open-label randomized

artículo científico publicado en 2014

Genetics and molecular profiling of multiple myeloma: novel tools for clinical management?

artículo científico publicado en 2006

HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis

scientific article published on 25 August 2020

How to Increase the Efficacy of Immunotherapy in NSCLC and HNSCC: Role of Radiation Therapy, Chemotherapy, and Other Strategies

artículo científico publicado en 2018

IL-2 signals through Sgk1 and inhibits proliferation and apoptosis in kidney cancer cells

artículo científico publicado en 2007

Identification of polymorphic variants associated with erlotinib-related skin toxicity in advanced non-small cell lung cancer patients by DMET microarray analysis.

artículo científico publicado en 2015

Immune-modulating effects of the newest cetuximab-based chemoimmunotherapy regimen in advanced colorectal cancer patients.

artículo científico publicado en 2012

Immunity feedback and clinical outcome in colon cancer patients undergoing chemoimmunotherapy with gemcitabine + FOLFOX followed by subcutaneous granulocyte macrophage colony-stimulating factor and aldesleukin (GOLFIG-1 Trial).

artículo científico publicado en 2008

Immunologic microenvironment and personalized treatment in multiple myeloma.

artículo científico publicado en 2013

Immunomodulatory activity of microRNAs: potential implications for multiple myeloma treatment

artículo científico publicado en 2017

Immunomodulatory properties of anticancer monoclonal antibodies: is the 'magic bullet' still a reliable paradigm?

artículo científico publicado en 2011

Immunotherapy of colorectal cancer: new perspectives after a long path.

artículo científico publicado en 2016

Impact of natural dietary agents on multiple myeloma prevention and treatment: molecular insights and potential for clinical translation

Impact of use of oral anticancer drugs on activity of Italian oncology practices: results of a survey conducted by the Italian Society of Medical Oncology (AIOM).

artículo científico publicado en 2013

In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells.

artículo científico publicado en 2014

In vitro and in vivo anti-tumor activity of miR-221/222 inhibitors in multiple myeloma

artículo científico publicado en 2013

In vivo activity of gemcitabine-loaded PEGylated small unilamellar liposomes against pancreatic cancer

artículo científico publicado en 2009

In vivo activity of miR-34a mimics delivered by stable nucleic acid lipid particles (SNALPs) against multiple myeloma

artículo científico publicado en 2014

In vivo anti-myeloma activity and modulation of gene expression profile induced by valproic acid, a histone deacetylase inhibitor.

artículo científico publicado en 2008

Inflammatory status affects the antitumor activity of poly-epitope-peptide vaccination against the thymidylate synthase in metastatic colo-rectal cancer patients enrolled in TSPP/VAC-1 Phase Ib trial.

artículo científico publicado en 2015

Influence of the Fabrication Accuracy of Hot-Embossed PCL Scaffolds on Cell Growths

artículo científico publicado en 2020

Inhibition of EZH2 triggers the tumor suppressive miR-29b network in multiple myeloma

artículo científico publicado en 2017

Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts

artículo científico publicado en 2015

Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma

artículo científico publicado en 2015

Is ovarian cancer a targetable disease? A systematic review and meta-analysis and genomic data investigation

artículo científico publicado en 2016

Liposomal pegylated doxorubicin plus vinorelbine combination as first-line chemotherapy for metastatic breast cancer in elderly women > or = 65 years of age.

artículo científico publicado en 2007

Loss of BRCA1 function increases the antitumor activity of cisplatin against human breast cancer xenografts in vivo

artículo científico publicado en 2009

Low-dose recombinant IL-2 induces psychological changes: monitoring by Minnesota Multiphasic Personality Inventory (MMPI).

artículo científico publicado en 2002

MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches.

artículo científico publicado en 2018

MicroRNA and multiple myeloma: from laboratory findings to translational therapeutic approaches

artículo científico

MicroRNAs in multiple myeloma and related bone disease

artículo científico publicado en 2015

MicroRNAs: Novel Crossroads between Myeloma Cells and the Bone Marrow Microenvironment

artículo científico publicado en 2016

Mir-221/222 are promising targets for innovative anticancer therapy.

artículo científico publicado en 2016

Mir-34: a new weapon against cancer?

artículo científico

Mouse models of multiple myeloma: technologic platforms and perspectives.

artículo científico publicado en 2018

Myeloid-derived suppressor cells in multiple myeloma: pre-clinical research and translational opportunities

artículo científico

Nanoparticle albumin bound Paclitaxel in the treatment of human cancer: nanodelivery reaches prime-time?

artículo científico publicado en 2013

Nanotechnologies to use bisphosphonates as potent anticancer agents: the effects of zoledronic acid encapsulated into liposomes

artículo científico publicado en 2011

Network meta-analysis of randomized trials in multiple myeloma: efficacy and safety in relapsed/refractory patients

artículo científico publicado en 2017

New pharmacokinetic and pharmacodynamic tools for interferon-alpha (IFN-alpha) treatment of human cancer.

artículo científico publicado en 2005

Non Coding RNAs: A New Avenue for the Self-Tailoring of Blood Cancer Treatment.

artículo científico publicado en 2016

Non-coding RNA: a novel opportunity for the personalized treatment of multiple myeloma

artículo científico publicado en 2013

Non-coding RNAs in cancer: platforms and strategies for investigating the genomic "dark matter"

artículo científico publicado en 2020

Novel therapeutic approaches based on the targeting of microenvironment-derived survival pathways in human cancer: experimental models and translational issues.

artículo científico publicado en 2007

OSAnalyzer: A Bioinformatics Tool for the Analysis of Gene Polymorphisms Enriched with Clinical Outcomes

artículo científico publicado en 2016

On the way of the new strategies aimed to improve the efficacy of PD-1/PD-L1 immune checkpoint blocking mAbs in small cell lung cancer

scientific article published on 01 October 2020

Pegylated liposomal doxorubicin in the management of ovarian cancer: a systematic review and metaanalysis of randomized trials

artículo científico publicado en 2014

Pembrolizumab-Induced Psoriasis in Metastatic Melanoma: Activity and Safety of Apremilast, a Case Report

artículo científico publicado en 2020

Pharmacogenomic Profiling of ADME Gene Variants: Current Challenges and Validation Perspectives

article

Pharmacogenomics Biomarker Discovery and Validation for Translation in Clinical Practice

artículo científico publicado en 2020

Pharmacokinetics and Pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in Mice and Non-human Primates

artículo científico publicado en 2016

Pharmacological inhibition of HSP90 and ras activity as a new strategy in the treatment of HNSCC.

artículo científico publicado en 2013

Phase I trial of thymidylate synthase poly-epitope peptide (TSPP) vaccine in advanced cancer patients.

artículo científico publicado en 2015

Phase II study of temozolomide plus pegylated liposomal doxorubicin in the treatment of brain metastases from solid tumours

artículo científico publicado en 2005

Phase II trial of bevacizumab and dose/dense chemotherapy with cisplatin and metronomic daily oral etoposide in advanced non-small-cell-lung cancer patients

artículo científico publicado en 2011

Phase Ib study of poly-epitope peptide vaccination to thymidylate synthase (TSPP) and GOLFIG chemo-immunotherapy for treatment of metastatic colorectal cancer patients.

artículo científico publicado en 2015

Polymorphic Variants in NR1I3 and UGT2B7 Predict Taxane Neurotoxicity and Have Prognostic Relevance in Patients With Breast Cancer: A Case-Control Study

scientific article published on 28 March 2019

Radiomics predicts survival of patients with advanced non-small cell lung cancer undergoing PD-1 blockade using Nivolumab

scientific article published on 16 December 2019

Radiotherapy prolongs the survival of advanced non-small-cell lung cancer patients undergone to an immune-modulating treatment with dose-fractioned cisplatin and metronomic etoposide and bevacizumab (mPEBev).

artículo científico publicado en 2017

Recommendations for the implementation of BRCA testing in ovarian cancer patients and their relatives

scientific article published on 25 May 2019

Recommendations for the implementation of BRCA testing in the care and treatment pathways of ovarian cancer patients

artículo científico publicado en 2016

Regulatory (FoxP3+) T-cell tumor infiltration is a favorable prognostic factor in advanced colon cancer patients undergoing chemo or chemoimmunotherapy

artículo científico publicado en 2010

Replacement of miR-155 Elicits Tumor Suppressive Activity and Antagonizes Bortezomib Resistance in Multiple Myeloma

artículo científico publicado en 2019

Role of gemcitabine-based combination therapy in the management of advanced pancreatic cancer: a meta-analysis of randomised trials

artículo científico publicado en 2012

Role of systemic chemotherapy in the management of resected or resectable colorectal liver metastases: a systematic review and meta-analysis of randomized controlled trials

artículo científico

Second-line treatment of non small cell lung cancer by biweekly gemcitabine and docetaxel +/- granulocyte-macrophage colony stimulating factor and low dose aldesleukine.

artículo científico publicado en 2009

Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal toxicity in colorectal cancer patients: a DMET microarray profiling study

artículo científico publicado en 2011

Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro

artículo científico publicado en 2014

Synergistic antitumor activity of epidermal growth factor receptor tyrosine kinase inhibitor gefitinib and IFN-alpha in head and neck cancer cells in vitro and in vivo

artículo científico publicado en 2006

Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in vitro and in vivo evidence.

artículo científico publicado en 2012

Systematic review and meta-analysis on targeted therapy in advanced pancreatic cancer

artículo científico publicado en 2016

Systemic inflammatory status at baseline predicts bevacizumab benefit in advanced non-small cell lung cancer patients

artículo científico publicado en 2013

Systemic inflammatory status predict the outcome of k-RAS WT metastatic colorectal cancer patients receiving the thymidylate synthase poly-epitope-peptide anticancer vaccine.

artículo científico publicado en 2018

Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth

artículo científico publicado en 2013

Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity.

artículo científico publicado en 2014

The Era of PARP inhibitors in ovarian cancer: "Class Action" or not? A systematic review and meta-analysis

artículo científico publicado en 2018

The IASLC Lung Cancer Staging Project: revision proposal of pleural effusion and controlateral nodule staging

artículo científico publicado en 2008

The IL-6 receptor super-antagonist Sant7 enhances antiproliferative and apoptotic effects induced by dexamethasone and zoledronic acid on multiple myeloma cells.

artículo científico publicado en 2002

The MITO CERV-2 trial: A randomized phase II study of cetuximab plus carboplatin and paclitaxel, in advanced or recurrent cervical cancer

scientific article published on 09 April 2019

The Non-Coding RNA Landscape of Plasma Cell Dyscrasias

scientific article published on 30 January 2020

The best strategy for RAS wild-type metastatic colorectal cancer patients in first-line treatment: A classic and Bayesian meta-analysis

artículo científico publicado en 2018

The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate

artículo científico publicado en 2004

The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways

artículo científico publicado en 2007

The potential role of miRNAs in multiple myeloma therapy

artículo científico publicado en 2018

Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma

Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma.

artículo científico publicado en 2016

Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92

scientific article published on 11 July 2018

Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma

scientific article published on 21 March 2019

Transferrin-conjugated SNALPs encapsulating 2'-O-methylated miR-34a for the treatment of multiple myeloma.

artículo científico publicado en 2014

Tumor infiltrating T lymphocytes expressing FoxP3, CCR7 or PD-1 predict the outcome of prostate cancer patients subjected to salvage radiotherapy after biochemical relapse

artículo científico publicado en 2016

Tumor infiltration by T lymphocytes expressing chemokine receptor 7 (CCR7) is predictive of favorable outcome in patients with advanced colorectal carcinoma

artículo científico publicado en 2011

Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer

artículo científico publicado en 2012

Type I interferons: ancient peptides with still under-discovered anti-cancer properties.

artículo científico

mTOR inhibitors, a new era for metastatic luminal HER2-negative breast cancer? A systematic review and a meta-analysis of randomized trials

artículo científico publicado en 2016

miR-125b Upregulates miR-34a and Sequentially Activates Stress Adaption and Cell Death Mechanisms in Multiple Myeloma

artículo científico publicado en 2019

miR-21 antagonism abrogates Th17 tumor promoting functions in multiple myeloma

artículo científico publicado en 2020

miR-22 suppresses DNA ligase III addiction in multiple myeloma

artículo científico publicado en 2018

miR-221 stimulates breast cancer cells and cancer-associated fibroblasts (CAFs) through selective interference with the A20/c-Rel/CTGF signaling.

artículo científico publicado en 2018

miR-29b induces SOCS-1 expression by promoter demethylation and negatively regulates migration of multiple myeloma and endothelial cells

artículo científico publicado en 2013

miR-29b negatively regulates human osteoclastic cell differentiation and function: implications for the treatment of multiple myeloma-related bone disease

artículo científico publicado en 2013

miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies.

artículo científico

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