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A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells.

artículo científico publicado en 2015

A SCID-hu in vivo model of human Waldenström macroglobulinemia

artículo científico publicado en 2005

A clinically relevant SCID-hu in vivo model of human multiple myeloma

artículo científico publicado en 2005

A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias.

artículo científico publicado en 2015

A drug repurposing screening reveals a novel epigenetic activity of hydroxychloroquine

artículo científico publicado en 2019

A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma

artículo científico publicado en 2009

A p53-dependent tumor suppressor network is induced by selective miR-125a-5p inhibition in multiple myeloma cells.

artículo científico publicado en 2014

A peroxisome proliferator-activated receptor gamma (PPARG) polymorphism is associated with zoledronic acid-related osteonecrosis of the jaw in multiple myeloma patients: analysis by DMET microarray profiling.

artículo científico publicado en 2011

A retrospective analysis of pegylated liposomal doxorubicin in ovarian cancer: do we still need it?

artículo científico publicado en 2013

A systematic review and meta-analysis of randomized trials on the role of targeted therapy in the management of advanced gastric cancer: Evidence does not translate?

artículo científico publicado en 2015

Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

artículo científico publicado en 2006

Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model

artículo científico publicado en 2007

Allometric Scaling Approaches for Predicting Human Pharmacokinetic of a Locked Nucleic Acid Oligonucleotide Targeting Cancer-Associated miR-221

artículo científico publicado en 2019

An Anti-BCMA RNA Aptamer for miRNA Intracellular Delivery

scientific article published on 28 October 2019

Analysis of miRNA, mRNA, and TF interactions through network-based methods.

artículo científico publicado en 2015

Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma

artículo científico publicado en 2009

Anti-cancer activity of dose-fractioned mPE +/- bevacizumab regimen is paralleled by immune-modulation in advanced squamous NSLC patients.

artículo científico publicado en 2017

Anti-tumor Activity and Epigenetic Impact of the Polyphenol Oleacein in Multiple Myeloma

scientific article published on 16 July 2019

Association between gene and miRNA expression profiles and stereotyped subset #4 B-cell receptor in chronic lymphocytic leukemia

artículo científico publicado en 2015

Aurora Kinase A expression predicts platinum-resistance and adverse outcome in high-grade serous ovarian carcinoma patients

artículo científico publicado en 2016

Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo

artículo científico publicado en 2005

BRCA1/2 Molecular Assay for Ovarian Cancer Patients: A Survey through Italian Departments of Oncology and Molecular and Genomic Diagnostic Laboratories

artículo científico publicado en 2019

BRCA1/2 genetic background-based therapeutic tailoring of human ovarian cancer: hope or reality?

scientific article published on 13 October 2009

Bergamot Polyphenols Improve Dyslipidemia and Pathophysiological Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease

artículo científico publicado en 2020

Biological and clinical relevance of miRNA expression signatures in primary plasma cell leukemia.

artículo científico publicado en 2013

Bortezomib-induced "BRCAness" sensitizes multiple myeloma cells to PARP inhibitors

artículo científico publicado en 2011

CD36 is rapidly and transiently upregulated on phytohemagglutinin (PHA)‐stimulated peripheral blood lymphocytes. Analysis by a new monoclonal antibody (UN7) ⬇️

artículo científico publicado el 1 de junio de 1998

Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma

artículo científico publicado en 2012

Circulating biomarkers in osteosarcoma: new translational tools for diagnosis and treatment.

artículo científico publicado en 2017

Clinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: A comparison of cellular, cytogenetic, molecular, and clinical features.

artículo científico publicado en 2013

Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu In vivo model of human multiple myeloma

artículo científico publicado en 2005

Cytotoxic activity of the maytansinoid immunoconjugate B-B4-DM1 against CD138+ multiple myeloma cells

artículo científico publicado en 2004

Cytotoxic drugs up-regulate epidermal growth factor receptor (EGFR) expression in colon cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent cell-mediated-cytotoxicity (ADCC).

artículo científico publicado en 2010

DMET-analyzer: automatic analysis of Affymetrix DMET data

artículo científico publicado en 2012

DMETTM Genotyping: Tools for Biomarkers Discovery in the Era of Precision Medicine

artículo científico publicado en 2020

DMET™ (Drug Metabolism Enzymes and Transporters): a pharmacogenomic platform for precision medicine.

artículo científico publicado en 2016

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma.

artículo científico publicado en 2012

Delivery of miR-34a by chitosan/PLGA nanoplexes for the anticancer treatment of multiple myeloma

artículo científico publicado en 2015

Development and validation of bioanalytical methods for LNA-i-miR-221 quantification in human plasma and urine by LC-MS/MS

scientific article published on 29 June 2020

Differential sensitivity of BRCA1-mutated HCC1937 human breast cancer cells to microtubule-interfering agents.

artículo científico publicado en 2005

Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients.

artículo científico publicado en 2015

Distinctive germline expression of class I human leukocyte antigen (HLA) alleles and DRB1 heterozygosis predict the outcome of patients with non-small cell lung cancer receiving PD-1/PD-L1 immune checkpoint blockade

scientific article published on 01 June 2020

Dose-Finding Study and Pharmacokinetics Profile of the Novel 13-Mer Antisense miR-221 Inhibitor in Sprague-Dawley Rats

artículo científico publicado en 2020

Dose/dense metronomic chemotherapy with fractioned cisplatin and oral daily etoposide enhances the anti-angiogenic effects of bevacizumab and has strong antitumor activity in advanced non-small-cell-lung cancer patients.

artículo científico publicado en 2010

Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity.

artículo científico publicado en 2018

Dysfunctional T regulatory cells in multiple myeloma

artículo científico publicado en 2005

Early blood rise in auto-antibodies to nuclear and smooth muscle antigens is predictive of prolonged survival and autoimmunity in metastatic-non-small cell lung cancer patients treated with PD-1 immune-check point blockade by nivolumab

scientific article published on 16 May 2019

Editorial: [Hot Topic: New Approaches in the Treatment of Multiple Myeloma: From Target-based Agents to the New Era of microRNAs (Dedicated to the Memory of Prof. Salvatore Venuta)] ⬇️

artículo científico publicado el 1 de septiembre de 2012

Emerging pathways as individualized therapeutic target of multiple myeloma.

artículo científico

Enumeration of interleukin-10-positive B cells from peripheral blood of patients with chronic lymphocytic leukemia

artículo científico publicado en 2014

Epigenetic modifications in multiple myeloma: recent advances on the role of DNA and histone methylation

artículo científico publicado en 2016

Error-prone DNA repair pathways as determinants of immunotherapy activity: an emerging scenario for cancer treatment

scientific article published on 07 May 2020

Establishment of BCWM.1 cell line for Waldenström's macroglobulinemia with productive in vivo engraftment in SCID-hu mice.

artículo científico publicado en 2007

Evidence of novel miR-34a-based therapeutic approaches for multiple myeloma treatment.

artículo científico publicado en 2017

Exploiting MYC-induced PARPness to target genomic instability in multiple myeloma

scientific article published on 20 February 2020

Expression Pattern and Biological Significance of the lncRNA ST3GAL6-AS1 in Multiple Myeloma

artículo científico publicado en 2020

From target therapy to miRNA therapeutics of human multiple myeloma: theoretical and technological issues in the evolving scenario.

artículo científico

Functional Analysis of microRNA in Multiple Myeloma

artículo científico publicado en 2015

GOLFIG Chemo-Immunotherapy in Metastatic Colorectal Cancer Patients. A Critical Review on a Long-Lasting Follow-Up

scientific article published on 08 November 2019

Gemcitabine, oxaliplatin, levofolinate, 5-fluorouracil, granulocyte-macrophage colony-stimulating factor, and interleukin-2 (GOLFIG) versus FOLFOX chemotherapy in metastatic colorectal cancer patients: the GOLFIG-2 multicentric open-label randomized

artículo científico publicado en 2014

Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib*

article

Genetics and molecular profiling of multiple myeloma: novel tools for clinical management?

artículo científico publicado en 2006

HLA Expression Correlates to the Risk of Immune Checkpoint Inhibitor-Induced Pneumonitis

scientific article published on 25 August 2020

HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells

artículo científico publicado en 2005

Identification by Differential Display of Transcripts Regulated during Hematopoietic Differentiation ⬇️

artículo científico publicado el 1 de enero de 1998

Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance

artículo científico publicado en 2009

Identification of polymorphic variants associated with erlotinib-related skin toxicity in advanced non-small cell lung cancer patients by DMET microarray analysis.

artículo científico publicado en 2015

Identifying Long Noncoding RNA Dependencies Using CRISPR <i>Interference</i> (CRISPRi)-Based Platform in Multiple Myeloma

artículo científico publicado en 2021

Immune-modulating effects of the newest cetuximab-based chemoimmunotherapy regimen in advanced colorectal cancer patients.

artículo científico publicado en 2012

Immunity feedback and clinical outcome in colon cancer patients undergoing chemoimmunotherapy with gemcitabine + FOLFOX followed by subcutaneous granulocyte macrophage colony-stimulating factor and aldesleukin (GOLFIG-1 Trial).

artículo científico publicado en 2008

Immunologic microenvironment and personalized treatment in multiple myeloma.

artículo científico publicado en 2013

Immunomodulatory activity of microRNAs: potential implications for multiple myeloma treatment

artículo científico publicado en 2017

Immunotherapy of colorectal cancer: new perspectives after a long path.

artículo científico publicado en 2016

Impact of natural dietary agents on multiple myeloma prevention and treatment: molecular insights and potential for clinical translation

In vitro and in vivo activity of a novel locked nucleic acid (LNA)-inhibitor-miR-221 against multiple myeloma cells.

artículo científico publicado en 2014

In vitro and in vivo activity of the maytansinoid immunoconjugate huN901-N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine against CD56+ multiple myeloma cells

artículo científico publicado en 2004

In vitro and in vivo anti-tumor activity of miR-221/222 inhibitors in multiple myeloma

artículo científico publicado en 2013

In vivo activity of gemcitabine-loaded PEGylated small unilamellar liposomes against pancreatic cancer

artículo científico publicado en 2009

In vivo activity of miR-34a mimics delivered by stable nucleic acid lipid particles (SNALPs) against multiple myeloma

artículo científico publicado en 2014

In vivo and in vitro cytotoxicity of R-etodolac with dexamethasone in glucocorticoid-resistant multiple myeloma cells.

artículo científico publicado en 2006

In vivo anti-myeloma activity and modulation of gene expression profile induced by valproic acid, a histone deacetylase inhibitor.

artículo científico publicado en 2008

Influence of the Fabrication Accuracy of Hot-Embossed PCL Scaffolds on Cell Growths

artículo científico publicado en 2020

Inhibition of EZH2 triggers the tumor suppressive miR-29b network in multiple myeloma

artículo científico publicado en 2017

Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts

artículo científico publicado en 2015

Integrated analysis of microRNAs, transcription factors and target genes expression discloses a specific molecular architecture of hyperdiploid multiple myeloma

artículo científico publicado en 2015

Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion

artículo científico publicado en 2011

Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation

artículo científico publicado en 2015

Is ovarian cancer a targetable disease? A systematic review and meta-analysis and genomic data investigation

artículo científico publicado en 2016

Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo

artículo científico publicado en 2009

JunB is a key regulator of multiple myeloma bone marrow angiogenesis

artículo científico publicado en 2021

LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?

scientific article published on 01 July 2020

Long non-coding RNA NEAT1 shows high expression unrelated to molecular features and clinical outcome in multiple myeloma

artículo científico publicado en 2018

Long non-coding RNA NEAT1 targeting impairs the DNA repair machinery and triggers anti-tumor activity in multiple myeloma

scientific article published on 19 August 2019

Loss of BRCA1 function increases the antitumor activity of cisplatin against human breast cancer xenografts in vivo

artículo científico publicado en 2009

MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches.

artículo científico publicado en 2018

MYD88-independent growth and survival effects of Sp1 transactivation in Waldenstrom macroglobulinemia.

scientific article published on 12 March 2014

MicroRNA and multiple myeloma: from laboratory findings to translational therapeutic approaches

artículo científico

MicroRNAs in multiple myeloma and related bone disease

artículo científico publicado en 2015

MicroRNAs in the pathobiology of multiple myeloma

artículo científico publicado en 2012

MicroRNAs: Novel Crossroads between Myeloma Cells and the Bone Marrow Microenvironment

artículo científico publicado en 2016

Mir-221/222 are promising targets for innovative anticancer therapy.

artículo científico publicado en 2016

Mir-34: a new weapon against cancer?

artículo científico

Molecular profiling of multiple myeloma: from gene expression analysis to next-generation sequencing

artículo científico

Molecular targets for the treatment of multiple myeloma.

artículo científico

Mouse Models as a Translational Platform for the Development of New Therapeutic Agents in Multiple Myeloma ⬇️

artículo científico publicado el 1 de septiembre de 2012

Mouse models of multiple myeloma: technologic platforms and perspectives.

artículo científico publicado en 2018

Myeloid-derived suppressor cells in multiple myeloma: pre-clinical research and translational opportunities

artículo científico

Nanoparticle albumin bound Paclitaxel in the treatment of human cancer: nanodelivery reaches prime-time?

artículo científico publicado en 2013

Nanotechnologies to use bisphosphonates as potent anticancer agents: the effects of zoledronic acid encapsulated into liposomes

artículo científico publicado en 2011

Network meta-analysis of randomized trials in multiple myeloma: efficacy and safety in relapsed/refractory patients

artículo científico publicado en 2017

Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model

artículo científico publicado en 2007

New pharmacokinetic and pharmacodynamic tools for interferon-alpha (IFN-alpha) treatment of human cancer.

artículo científico publicado en 2005

Non Coding RNAs: A New Avenue for the Self-Tailoring of Blood Cancer Treatment.

artículo científico publicado en 2016

Non-coding RNA: a novel opportunity for the personalized treatment of multiple myeloma

artículo científico publicado en 2013

Non-coding RNAs in cancer: platforms and strategies for investigating the genomic "dark matter"

artículo científico publicado en 2020

Novel therapeutic approaches based on the targeting of microenvironment-derived survival pathways in human cancer: experimental models and translational issues.

artículo científico publicado en 2007

OSAnalyzer: A Bioinformatics Tool for the Analysis of Gene Polymorphisms Enriched with Clinical Outcomes

artículo científico publicado en 2016

On the way of the new strategies aimed to improve the efficacy of PD-1/PD-L1 immune checkpoint blocking mAbs in small cell lung cancer

scientific article published on 01 October 2020

PYRROLO[2',3':3,4]CYCLOHEPTA[1,2-d][1,2]OXAZOLES, A NEW CLASS OF ANTIMITOTIC AGENTS, ACTIVE AGAINST MULTIPLE MALIGNANT CELL TYPES

artículo científico publicado en 2020

Pegylated liposomal doxorubicin in the management of ovarian cancer: a systematic review and metaanalysis of randomized trials

artículo científico publicado en 2014

Pembrolizumab-Induced Psoriasis in Metastatic Melanoma: Activity and Safety of Apremilast, a Case Report

artículo científico publicado en 2020

Pharmacogenomics Biomarker Discovery and Validation for Translation in Clinical Practice

artículo científico publicado en 2020

Pharmacokinetics and Pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in Mice and Non-human Primates

artículo científico publicado en 2016

Phase I trial of thymidylate synthase poly-epitope peptide (TSPP) vaccine in advanced cancer patients.

artículo científico publicado en 2015

Phase Ib study of poly-epitope peptide vaccination to thymidylate synthase (TSPP) and GOLFIG chemo-immunotherapy for treatment of metastatic colorectal cancer patients.

artículo científico publicado en 2015

Physicochemical features and transfection properties of chitosan/poloxamer 188/poly(D,L-lactide-co-glycolide) nanoplexes.

artículo científico publicado en 2014

Polymorphic Variants in NR1I3 and UGT2B7 Predict Taxane Neurotoxicity and Have Prognostic Relevance in Patients With Breast Cancer: A Case-Control Study

scientific article published on 28 March 2019

Promises and Challenges of MicroRNA-based Treatment of Multiple Myeloma ⬇️

artículo científico publicado el 1 de septiembre de 2012

Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.

artículo científico publicado en 2004

Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response

artículo científico publicado en 2012

Purification and characterization of a human sialoglycoprotein antigen expressed in immature thymocytes and fetal tissues ⬇️

artículo científico publicado el 1 de mayo de 1998

Radiomics predicts survival of patients with advanced non-small cell lung cancer undergoing PD-1 blockade using Nivolumab

scientific article published on 16 December 2019

Radiotherapy prolongs the survival of advanced non-small-cell lung cancer patients undergone to an immune-modulating treatment with dose-fractioned cisplatin and metronomic etoposide and bevacizumab (mPEBev).

artículo científico publicado en 2017

Recommendations for the implementation of BRCA testing in ovarian cancer patients and their relatives

scientific article published on 25 May 2019

Recommendations for the implementation of BRCA testing in the care and treatment pathways of ovarian cancer patients

artículo científico publicado en 2016

Regulatory (FoxP3+) T-cell tumor infiltration is a favorable prognostic factor in advanced colon cancer patients undergoing chemo or chemoimmunotherapy

artículo científico publicado en 2010

Replacement of miR-155 Elicits Tumor Suppressive Activity and Antagonizes Bortezomib Resistance in Multiple Myeloma

artículo científico publicado en 2019

Role of gemcitabine-based combination therapy in the management of advanced pancreatic cancer: a meta-analysis of randomised trials

artículo científico publicado en 2012

Role of systemic chemotherapy in the management of resected or resectable colorectal liver metastases: a systematic review and meta-analysis of randomized controlled trials

artículo científico

SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma

artículo científico publicado en 2005

Safety and efficacy of vorinostat, bortezomib, doxorubicin and dexamethasone in a phase I/II study for relapsed or refractory multiple myeloma (VERUMM study: vorinostat in elderly, relapsed and unfit multiple myeloma)

scholarly article by Johannes M Waldschmidt et al published October 2018 in Haematologica

Significant biological role of sp1 transactivation in multiple myeloma

artículo científico publicado en 2011

Single nucleotide polymorphisms of ABCC5 and ABCG1 transporter genes correlate to irinotecan-associated gastrointestinal toxicity in colorectal cancer patients: a DMET microarray profiling study

artículo científico publicado en 2011

Small nucleolar RNAs as new biomarkers in chronic lymphocytic leukemia

artículo científico publicado en 2013

Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro

artículo científico publicado en 2014

Synthesis and preliminary evaluation of the anti-cancer activity on A549 lung cancer cells of a series of unsaturated disulfides.

artículo científico publicado en 2018

Synthetic miR-34a mimics as a novel therapeutic agent for multiple myeloma: in vitro and in vivo evidence.

artículo científico publicado en 2012

Systematic review and meta-analysis on targeted therapy in advanced pancreatic cancer

artículo científico publicado en 2016

Systemic inflammatory status at baseline predicts bevacizumab benefit in advanced non-small cell lung cancer patients

artículo científico publicado en 2013

Systemic inflammatory status predict the outcome of k-RAS WT metastatic colorectal cancer patients receiving the thymidylate synthase poly-epitope-peptide anticancer vaccine.

artículo científico publicado en 2018

Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis

artículo científico publicado en 2007

Targeting PI3K and RAD51 in Barrett's adenocarcinoma: impact on DNA damage checkpoints, expression profile and tumor growth ⬇️

artículo científico publicado el 1 de marzo de 2012

Targeting miR-21 inhibits in vitro and in vivo multiple myeloma cell growth

artículo científico publicado en 2013

Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)

artículo científico publicado en 2006

Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity.

artículo científico publicado en 2014

The Cyclophilin A-CD147 complex promotes the proliferation and homing of multiple myeloma cells.

artículo científico publicado en 2015

The Era of PARP inhibitors in ovarian cancer: "Class Action" or not? A systematic review and meta-analysis

artículo científico publicado en 2018

The IASLC Lung Cancer Staging Project: revision proposal of pleural effusion and controlateral nodule staging

artículo científico publicado en 2008

The IL-6 receptor super-antagonist Sant7 enhances antiproliferative and apoptotic effects induced by dexamethasone and zoledronic acid on multiple myeloma cells.

artículo científico publicado en 2002

The Non-Coding RNA Landscape of Plasma Cell Dyscrasias

scientific article published on 30 January 2020

The best strategy for RAS wild-type metastatic colorectal cancer patients in first-line treatment: A classic and Bayesian meta-analysis

artículo científico publicado en 2018

The farnesyl transferase inhibitor R115777 (Zarnestra) synergistically enhances growth inhibition and apoptosis induced on epidermoid cancer cells by Zoledronic acid (Zometa) and Pamidronate

artículo científico publicado en 2004

The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways

artículo científico publicado en 2007

The oral protein-kinase C beta inhibitor enzastaurin (LY317615) suppresses signalling through the AKT pathway, inhibits proliferation and induces apoptosis in multiple myeloma cell lines.

artículo científico publicado en 2008

The potential role of miRNAs in multiple myeloma therapy

artículo científico publicado en 2018

Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma

Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma.

artículo científico publicado en 2016

Therapeutic vulnerability of multiple myeloma to MIR17PTi, a first-in-class inhibitor of pri-miR-17-92

scientific article published on 11 July 2018

Trabectedin triggers direct and NK-mediated cytotoxicity in multiple myeloma

scientific article published on 21 March 2019

Transcriptional characterization of a prospective series of primary plasma cell leukemia revealed signatures associated with tumor progression and poorer outcome.

artículo científico publicado en 2013

Transferrin-conjugated SNALPs encapsulating 2'-O-methylated miR-34a for the treatment of multiple myeloma.

artículo científico publicado en 2014

Tumor infiltrating T lymphocytes expressing FoxP3, CCR7 or PD-1 predict the outcome of prostate cancer patients subjected to salvage radiotherapy after biochemical relapse

artículo científico publicado en 2016

Tumor infiltration by T lymphocytes expressing chemokine receptor 7 (CCR7) is predictive of favorable outcome in patients with advanced colorectal carcinoma

artículo científico publicado en 2011

Tumor infiltration by chemokine receptor 7 (CCR7)(+) T-lymphocytes is a favorable prognostic factor in metastatic colorectal cancer

artículo científico publicado en 2012

Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: preclinical efficacy of the novel, orally available inhibitor dasatinib

artículo científico publicado en 2008

mTOR inhibitors, a new era for metastatic luminal HER2-negative breast cancer? A systematic review and a meta-analysis of randomized trials

artículo científico publicado en 2016

miR-125b Upregulates miR-34a and Sequentially Activates Stress Adaption and Cell Death Mechanisms in Multiple Myeloma

artículo científico publicado en 2019

miR-21 antagonism abrogates Th17 tumor promoting functions in multiple myeloma

artículo científico publicado en 2020

miR-22 suppresses DNA ligase III addiction in multiple myeloma

artículo científico publicado en 2018

miR-221 stimulates breast cancer cells and cancer-associated fibroblasts (CAFs) through selective interference with the A20/c-Rel/CTGF signaling.

artículo científico publicado en 2018

miR-29b induces SOCS-1 expression by promoter demethylation and negatively regulates migration of multiple myeloma and endothelial cells

artículo científico publicado en 2013

miR-29b negatively regulates human osteoclastic cell differentiation and function: implications for the treatment of multiple myeloma-related bone disease

artículo científico publicado en 2013

miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies.

artículo científico

microRNAome Expression in Chronic Lymphocytic Leukemia: Comparison with Normal B-cell Subsets and Correlations with Prognostic and Clinical Parameters

scientific article published on 10 June 2014

p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications.

artículo científico publicado en 2008

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