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A Graph Based Framework to Model Virus Integration Sites

artículo científico publicado en 2015

A Hybrid Vector for Ligand-Directed Tumor Targeting and Molecular Imaging

artículo científico publicado en 2006

A largely random AAV integration profile after LPLD gene therapy

artículo científico publicado en 2013

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

artículo científico publicado en 2003

AAVvector-mediated in vivo reprogramming into pluripotency

artículo científico publicado en 2018

Adeno-associated Vector Toxicity-To Be or Not to Be?

artículo científico publicado en 2015

Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle

artículo científico publicado en 2008

Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.

artículo científico publicado en 2012

An unbiased genome-wide analysis of zinc-finger nuclease specificity

artículo científico publicado en 2011

Analysis of the clonal repertoire of gene-corrected cells in gene therapy

artículo científico publicado en 2012

Analyzing the number of common integration sites of viral vectors--new methods and computer programs

artículo científico publicado en 2011

Biodistribution of LV-TSTA transduced rat bone marrow cells used for "ex-vivo" regional gene therapy for bone repair

artículo científico publicado en 2015

Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites

artículo científico publicado en 2012

Biosafety considerations using gamma-retroviral vectors in gene therapy

artículo científico publicado en 2013

Cell cycle status of CD34(+) hemopoietic stem cells determines lentiviral integration in actively transcribed and development-related genes

artículo científico publicado en 2014

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

artículo científico publicado en 2006

Chance or necessity? Insertional mutagenesis in gene therapy and its consequences

artículo científico publicado en 2004

Clonal evidence for the transduction of CD34+ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial

artículo científico publicado en 2004

Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates

artículo científico publicado en 2003

Common integration sites of published datasets identified using a graph-based framework

artículo científico publicado en 2015

Comparative clonal analysis of reconstitution kinetics after transplantation of hematopoietic stem cells gene marked with a lentiviral SIN or a γ-retroviral LTR vector

artículo científico publicado en 2012

Comparative next-generation sequencing of adeno-associated virus inverted terminal repeats.

artículo científico publicado en 2014

Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant

artículo científico publicado en 2014

Comparison of lentiviral and sleeping beauty mediated αβ T cell receptor gene transfer

artículo científico publicado en 2013

Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells.

artículo científico publicado en 2003

Comprehensive genomic access to vector integration in clinical gene therapy

artículo científico publicado en 2009

Comprehensive genomic characterization of gene therapy-induced T-cell acute lymphoblastic leukemia

artículo científico publicado en 2020

Control of chronic lymphocytic leukemia development by clonally-expanded CD8+ T-cells that undergo functional exhaustion in secondary lymphoid tissues

artículo científico publicado en 2018

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

artículo científico publicado en 2006

Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning

artículo científico publicado en 2011

Corrigendum to "Oncogenesis Following Delivery of a Nonprimate Lentiviral Gene Therapy Vector to Fetal and Neonatal Mice".

artículo científico publicado en 2005

Detection of retroviral integration sites by linear amplification-mediated PCR and tracking of individual integration clones in different samples

artículo científico publicado en 2009

Dissecting the genomic complexity underlying medulloblastoma

artículo científico publicado en 2012

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells

artículo científico publicado en 2004

Distinct types of tumor-initiating cells form human colon cancer tumors and metastases

scientific article published on 01 October 2011

Effective gene therapy with nonintegrating lentiviral vectors

artículo científico publicado en 2006

Efficient Nuclease-Directed Integration of Lentivirus Vectors into the Human Ribosomal DNA Locus

artículo científico publicado en 2020

Efficient characterization of retro-, lenti-, and foamyvector-transduced cell populations by high-accuracy insertion site sequencing.

artículo científico publicado en 2003

Efficient marking of human cells with rapid but transient repopulating activity in autografted recipients

artículo científico publicado en 2005

Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV

artículo científico publicado en 2015

Evaluation of TCR Gene Editing Achieved by TALENs, CRISPR/Cas9, and megaTAL Nucleases

artículo científico publicado en 2015

Evidence of similar effects of short-term culture on the initial repopulating activity of mobilized peripheral blood transplants assessed in NOD/SCID-beta2microglobulin(null) mice and in autografted patients

scientific article published on 01 January 2005

Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo

artículo científico publicado en 2012

Fanconi anemia gene editing by the CRISPR/Cas9 system

artículo científico publicado en 2015

From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease.

artículo científico publicado en 2013

GENE-IS: Time-Efficient and Accurate Analysis of Viral Integration Events in Large-Scale Gene Therapy Data

artículo científico publicado en 2016

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

artículo científico publicado en 2007

Gene therapy for Fanconi anemia: one step closer to the clinic.

artículo científico publicado en 2012

Gene therapy for Wiskott-Aldrich Syndrome-Long-term reconstitution and clinical benefits, but increased risk for leukemogenesis

artículo científico publicado en 2014

Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity

artículo científico publicado en 2014

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

artículo científico publicado en 2004

Gene therapy: therapeutic gene causing lymphoma

artículo científico publicado en 2006

Generation of lentivirus-induced dendritic cells under GMP-compliant conditions for adaptive immune reconstitution against cytomegalovirus after stem cell transplantation

artículo científico publicado en 2015

Genetic subclone architecture of tumor clone-initiating cells in colorectal cancer.

artículo científico publicado en 2017

Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification

artículo científico publicado en 2017

Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing ⬇️

artículo científico publicado el 8 de julio de 2010

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

artículo científico publicado en 2010

Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation.

artículo científico publicado en 2010

Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy

artículo científico publicado en 2009

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

artículo científico publicado en 2006

Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk

artículo científico publicado en 2011

High-definition mapping of retroviral integration sites defines the fate of allogeneic T cells after donor lymphocyte infusion

artículo científico publicado en 2010

High-resolution analysis of the human T-cell receptor repertoire

artículo científico publicado en 2015

High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).

artículo científico publicado en 2007

High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies

artículo científico publicado en 2015

Hot spots of retroviral integration in human CD34+ hematopoietic cells

artículo científico publicado en 2007

Identification of NY-BR-1-specific CD4(+) T cell epitopes using HLA-transgenic mice

artículo científico publicado en 2014

Identity, potency, in vivo viability, and scaling up production of lentiviral vector-induced dendritic cells for melanoma immunotherapy

artículo científico publicado en 2012

Impact of raltegravir on HIV-1 RNA and DNA forms following initiation of antiretroviral therapy in treatment-naive patients

artículo científico

In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanised Mouse Model and Its Progress Can Be Monitored Using MRI Techniques

artículo científico publicado en 2019

In Utero Transfer of Adeno-Associated Viral Vectors Produces Long-Term Factor IX Levels in a Cynomolgus Macaque Model.

artículo científico publicado en 2017

Induced pluripotent mesenchymal stromal cell clones retain donor-derived differences in DNA methylation profiles.

artículo científico publicado en 2012

Insertion site pattern: global approach by linear amplification-mediated PCR and mass sequencing

artículo científico publicado en 2012

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy

artículo científico publicado en 2011

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

artículo científico publicado en 2008

Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk

artículo científico publicado en 2012

Integration frequency and intermolecular recombination of rAAV vectors in non-human primate skeletal muscle and liver

artículo científico publicado en 2012

Integration of retroviral vectors

artículo científico

Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell

artículo científico publicado en 2011

Integration-deficient lentiviral vectors expressing codon-optimized R338L human FIX restore normal hemostasis in Hemophilia B mice

scientific article published on 14 August 2013

Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer

artículo científico publicado en 2013

Interaction of vectors and parental viruses with the host genome

artículo científico publicado en 2016

In Vivo Tracking of Human Hematopoiesis Reveals Patterns of Clonal Dynamics during Early and Steady-State Reconstitution Phases

artículo científico publicado en 2016

Is IL2RG oncogenic in T-cell development?: X-SCID transgene leukaemogenicity (reply)

artículo científico publicado en 2006

Lentiviral Vector Promoter is Decisive for Aberrant Transcript Formation

artículo científico

Lentiviral hematopoietic cell gene therapy for X-linked adrenoleukodystrophy

artículo científico publicado en 2012

Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy

artículo científico publicado en 2013

Lentiviral hematopoietic stem cell gene therapy in patients with Wiskott-Aldrich syndrome.

artículo científico publicado en 2013

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

artículo científico publicado en 2011

Lentiviral vector integration profiles differ in rodent postmitotic tissues

artículo científico publicado en 2011

Lentiviral vector transduction of NOD/SCID repopulating cells results in multiple vector integrations per transduced cell: risk of insertional mutagenesis

artículo científico publicado en 2002

Lentiviral vector-based insertional mutagenesis identifies genes associated with liver cancer

artículo científico publicado en 2013

Lentiviral-Mediated Gene Therapy in Fanconi Anemia-A Mice Reveals Long-Term Engraftment and Continuous Turnover of Corrected HSCs.

artículo científico publicado en 2015

Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors

artículo científico publicado en 2010

Leukemias following retroviral transfer of multidrug resistance 1 (MDR1) are driven by combinatorial insertional mutagenesis.

artículo científico publicado en 2005

Linear amplification mediated PCR--localization of genetic elements and characterization of unknown flanking DNA.

artículo científico publicado en 2014

Liver-directed lentiviral gene therapy in a dog model of hemophilia B.

artículo científico publicado en 2015

Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia

artículo científico publicado en 2004

Long-term episomal transgene expression from mitotically stable integration-deficient lentiviral vectors.

artículo científico publicado en 2014

Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs

article

Mapping the precision of genome editing.

artículo científico publicado en 2015

Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model

artículo científico publicado en 2003

Molecular evidence of lentiviral vector-mediated gene transfer into human self-renewing, multi-potent, long-term NOD/SCID repopulating hematopoietic cells

artículo científico publicado en 2002

Murine leukemia induced by retroviral gene marking

artículo científico publicado en 2002

Next-generation sequencing of cancer consensus genes in lymphoma

artículo científico publicado en 2013

Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice

artículo científico publicado en 2005

Parallel assessment of globin lentiviral transfer in induced pluripotent stem cells and adult hematopoietic stem cells derived from the same transplanted β-thalassemia patient

artículo científico publicado en 2013

Patient-derived xenografts of gastrointestinal cancers are susceptible to rapid and delayed B-lymphoproliferation

artículo científico publicado en 2016

Pharmacologically regulated in vivo selection in a large animal

artículo científico publicado en 2002

Phase I open label liver-directed gene therapy clinical trial for acute intermittent porphyria

artículo científico publicado en 2016

Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells.

artículo científico publicado en 2015

Polyclonal long-term repopulating stem cell clones in a primate model

artículo científico publicado en 2002

Preclinical evaluation of efficacy and safety of an improved lentiviral vector for the treatment of β-thalassemia and sickle cell disease

artículo científico publicado en 2015

Preclinical safety and efficacy of human CD34(+) cells transduced with lentiviral vector for the treatment of Wiskott-Aldrich syndrome

artículo científico publicado en 2012

Presence of a trs-Like Motif Promotes Rep-Mediated Wild-Type Adeno-Associated Virus Type 2 Integration.

artículo científico publicado en 2015

Publisher Correction: In Utero Gene Therapy (IUGT) Using GLOBE Lentiviral Vector Phenotypically Corrects the Heterozygous Humanised Mouse Model and Its Progress Can Be Monitored Using MRI Techniques

artículo científico publicado en 2019

Real-time definition of non-randomness in the distribution of genomic events

artículo científico publicado en 2007

Recombinant AAV Integration Is Not Associated With Hepatic Genotoxicity in Nonhuman Primates and Patients

scientific article published on 07 March 2016

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells ⬇️

artículo científico publicado en 2005

Reply to "Wild-type AAV Insertions in Hepatocellular Carcinoma Do Not Inform Debate Over Genotoxicity Risk of Vectorized AAV"

artículo científico publicado en 2016

Reply to: NGS library preparation may generate artifactual integration sites of AAV vectors.

artículo científico publicado en 2014

Retroviral gene therapy for X-linked chronic granulomatous disease: results from phase I/II trial

artículo científico publicado en 2011

Retroviral vectors: post entry events and genomic alterations

artículo científico publicado en 2011

Safety and liver transduction efficacy of rAAV5-cohPBGD in nonhuman primates: a potential therapy for acute intermittent porphyria

artículo científico publicado en 2013

Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor

artículo científico publicado en 2015

Selective survival of peripheral blood lymphocytes in children with HIV-1 following delivery of an anti-HIV gene to bone marrow CD34(+) cells

artículo científico publicado en 2005

Short-term repopulating cells with myeloid potential in human mobilized peripheral blood do not have a side population (SP) phenotype

artículo científico publicado en 2006

Sleeping beauty transposition from nonintegrating lentivirus

artículo científico publicado en 2009

Spatial-Temporal Variations in Atmospheric Factors Contribute to SARS-CoV-2 Outbreak

artículo científico publicado en 2020

Spatial-temporal variations of atmospheric factors contribute to SARS-CoV-2 outbreak

artículo científico publicado en 2020

Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration

scientific article published on 06 September 2019

Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression

artículo científico publicado en 2007

Stable human FIX expression after 0.9G intrauterine gene transfer of self-complementary adeno-associated viral vector 5 and 8 in macaques

artículo científico publicado en 2011

Stable long-term blood formation by stem cells in murine steady-state hematopoiesis

artículo científico publicado en 2012

Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting.

artículo científico publicado en 2011

Stem-cell gene therapy for the Wiskott-Aldrich syndrome

artículo científico publicado en 2010

Successful Combination of Sequential Gene Therapy and Rescue Allo-HSCT in Two Children with X-CGD - Importance of Timing

artículo científico publicado en 2015

Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia

scientific article published on 09 September 2019

Succession of transiently active tumor-initiating cell clones in human pancreatic cancer xenografts

artículo científico publicado en 2017

Systematic comparative study of computational methods for T-cell receptor sequencing data analysis

artículo científico publicado en 2017

TALEN-based gene correction for epidermolysis bullosa.

artículo científico publicado en 2013

TCR sequences and tissue distribution discriminate the subsets of naïve and activated/memory Treg cells in mice

artículo científico publicado en 2015

Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia

artículo científico publicado en 2013

The Clonal Fate of Live Cells

artículo científico publicado en 2017

The Conjugative Relaxase TrwC Promotes Integration of Foreign DNA in the Human Genome

artículo científico publicado en 2017

The Contained Self-Reactive Peripheral T Cell Repertoire: Size, Diversity, and Cellular Composition

artículo científico publicado en 2015

The LAM-PCR Method to Sequence LV Integration Sites

artículo científico publicado en 2016

The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis

artículo científico publicado en 2012

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

artículo científico publicado en 2009

The inherent differentiation program of short-term hematopoietic repopulating cells changes during human ontogeny

artículo científico publicado en 2010

The β-globin locus control region in combination with the EF1α short promoter allows enhanced lentiviral vector-mediated erythroid gene expression with conserved multilineage activity

artículo científico publicado en 2012

Therapeutic expression of human clotting factors IX and X following adeno-associated viral vector-mediated intrauterine gene transfer in early-gestation fetal macaques

artículo científico publicado en 2018

Thymus-autonomous T cell development in the absence of progenitor import

artículo científico publicado en 2012

Tracking genetically engineered lymphocytes long-term reveals the dynamics of T cell immunological memory.

artículo científico publicado en 2015

Transgenic expression of human glial cell line-derived neurotrophic factor from integration-deficient lentiviral vectors is neuroprotective in a rodent model of Parkinson's disease

artículo científico publicado en 2014

Transient expression of genes delivered to newborn rat liver using recombinant adeno-associated virus 2/8 vectors

artículo científico publicado en 2009

Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo

artículo científico publicado en 2014

VSeq-Toolkit: Comprehensive Computational Analysis of Viral Vectors in Gene Therapy

scientific article published on 30 March 2020

Vector integration and tumorigenesis

artículo científico publicado en 2014

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

artículo científico publicado en 2007

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